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11. 发明申请

US20060193886A1 Medical devices with nanoporous layers and topcoats 审中-公开
标题翻译：具有纳米多孔层和面漆的医疗器械
公开(公告)号：US20060193886A1
公开(公告)日：2006-08-31
申请号：US11352417
申请日：2006-02-10
申请人： Gary Owens , Whye-Kei Lye , Matthew Hudson , Brian Wamhoff , Joshua Spradlin , Kareen Looi
发明人： Gary Owens , Whye-Kei Lye , Matthew Hudson , Brian Wamhoff , Joshua Spradlin , Kareen Looi
IPC分类号： A61K48/00 , A61F2/06 , A61K31/727 , A61K39/395 , A61K31/496 , A61K31/519 , A61K31/497
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

12. 发明申请

US20050070989A1 Medical devices having porous layers and methods for making the same 审中-公开
标题翻译：具有多孔层的医疗装置及其制造方法
公开(公告)号：US20050070989A1
公开(公告)日：2005-03-31
申请号：US10918853
申请日：2004-08-13
申请人： Whye-Kei Lye , Michael Reed , Gary Owens , Brian Wamhoff , Matthew Hudson , Kareen Looi
发明人： Whye-Kei Lye , Michael Reed , Gary Owens , Brian Wamhoff , Matthew Hudson , Kareen Looi
IPC分类号： A61F2/86 , A61F2/06
CPC分类号： A61L31/082 , A61F2/86 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/606 , A61L2420/02
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常去除混合物或合金的其它组分。

13. 发明申请

US20060276879A1 Medical devices having porous layers and methods for making the same 审中-公开
标题翻译：具有多孔层的医疗装置及其制造方法
公开(公告)号：US20060276879A1
公开(公告)日：2006-12-07
申请号：US11432288
申请日：2006-05-11
申请人： Whye-Kei Lye , Michael Reed , Gary Owens , Brian Wamhoff , Joshua Spradlin , Matthew Hudson
发明人： Whye-Kei Lye , Michael Reed , Gary Owens , Brian Wamhoff , Joshua Spradlin , Matthew Hudson
IPC分类号： A61F2/82 , B01J19/00
CPC分类号： A61L31/082 , A61F2/86 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/606 , A61L2420/02
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。

14. 发明授权

US07713573B2 Method for loading nanoporous layers with therapeutic agent 有权
标题翻译：用治疗剂负载纳米多孔层的方法
公开(公告)号：US07713573B2
公开(公告)日：2010-05-11
申请号：US11352436
申请日：2006-02-10
申请人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61L33/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

15. 发明申请

US20100260922A1 Method for loading nanoporous layers with therapeutic agent 有权
公开(公告)号：US20100260922A1
公开(公告)日：2010-10-14
申请号：US12660282
申请日：2010-02-23
申请人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61L31/16
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

16. 发明授权

US08449602B2 Methods for using a stent having nanoporous layers 有权
标题翻译：使用具有纳米多孔层的支架的方法
公开(公告)号：US08449602B2
公开(公告)日：2013-05-28
申请号：US11352426
申请日：2006-02-10
申请人： Whye-Kei Lye , Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Joshua Spradlin , Kareen Looi
发明人： Whye-Kei Lye , Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Joshua Spradlin , Kareen Looi
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： Implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents are described. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy to create the pores of the porous layer. The porous layer may be adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. The medical device may be a vascular stent having at least one porous layer adapted to resist stenosis or cellular proliferation.
摘要翻译：描述了具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法以及用治疗剂装载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种成分，而不会通常除去混合物或合金的其它组分以产生多孔层的孔。多孔层可适用于粘合非金属涂层，包括药物洗脱聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。医疗装置可以是具有适于抵抗狭窄或细胞增殖的至少一个多孔层的血管支架。

17. 发明申请

US20060122684A1 Expandable body having deployable microstructures and related methods 有权
标题翻译：具有可展开微结构和相关方法的可膨胀体
公开(公告)号：US20060122684A1
公开(公告)日：2006-06-08
申请号：US10521078
申请日：2003-07-11
申请人： Whye-Kei Lye , Michael Reed , Kareen Looi
发明人： Whye-Kei Lye , Michael Reed , Kareen Looi
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/07 , A61F2/848 , A61F2/90 , A61F2/915 , A61F2002/075 , A61F2002/91533 , A61F2002/9155 , A61F2002/91575 , A61F2220/0016 , A61F2230/0013
摘要： Apparatuses, systems and methods for treating a patient by positioning an expandable body (10) having one or more microstructures (14) within a body lumen and penetrating the lumen wall with the microstructures (14). The microstructures are formed in or attached to the lumen through a cacheter or other suitable device. Each microstructure (14) has an end (16) which is attached to the expandable body and a free end (18). Once the apparatus is positioned within the body lumen in a desired location one or more of the microstructures are deployed wherein the free ends project radially outwardly. The free ends of the deployed microstructures penetrate the lumen wall by continued expansion of the body. Additionally, a therapeutic agent may be delivered to the lumen wall by the penetrated microstructures.
摘要翻译：用于通过将具有一个或多个微结构（14）的可扩张体（10）定位在体腔内并用微结构（14）穿透管腔壁来治疗患者的装置，系统和方法。微结构通过缓冲剂或其它合适的装置形成或连接到内腔。每个微结构（14）具有连接到可膨胀体的端部（16）和自由端（18）。一旦将装置定位在所需位置的体腔内，则展开一个或多个微结构，其中自由端径向向外突出。部署的微结构的自由端通过身体的持续膨胀而穿透管腔壁。此外，治疗剂可以通过穿透的微结构递送到管腔壁。

18. 发明申请

US20060271169A1 Stent with nanoporous surface 审中-公开
标题翻译：支架纳米孔表面
公开(公告)号：US20060271169A1
公开(公告)日：2006-11-30
申请号：US11432281
申请日：2006-05-11
申请人： Whye-Kei Lye , Kareen Looi , Michael Reed
发明人： Whye-Kei Lye , Kareen Looi , Michael Reed
IPC分类号： A61F2/82 , A61F2/28
CPC分类号： A61L31/146 , A61F2/86 , A61L31/082 , A61L31/16 , A61L2300/41 , A61L2300/416 , Y10S623/901 , Y10T428/12458
摘要： Methods for fabricating a medical device having at least one porous layer include providing a medical device having at least one alloy and removing at least one component of the alloy to form the porous layer. Although methods may be used to make stent devices with porous layers, any other suitable medical device may be made having one or more porous layers. An alloy may include any suitable combination of metals and sometimes a combination of metal and non-metal. In some embodiments, one or more of the most electrochemically active component(s) of an alloy are removed by the dissolving (or “dealloying”) process, to leave a porous matrix behind. The porous matrix layer may then be infused with one or more therapeutic agents for enhancing treatment of a patient.
摘要翻译：制造具有至少一个多孔层的医疗装置的方法包括提供具有至少一种合金的医疗装置，并除去合金的至少一种成分以形成多孔层。虽然可以使用方法来制备具有多孔层的支架装置，但是可以制造具有一个或多个多孔层的任何其它合适的医疗装置。合金可以包括任何合适的金属组合，有时是金属和非金属的组合。在一些实施方案中，通过溶解（或“脱模”）方法除去合金中最大的电化学活性组分中的一种或多种，以留下多孔基体。然后可以用一种或多种用于增强患者治疗的治疗剂注入多孔基质层。

19. 发明申请

US20060193889A1 Nanoporous layers using thermal dealloying 审中-公开
标题翻译：使用热脱金属的纳米多孔层
公开(公告)号：US20060193889A1
公开(公告)日：2006-08-31
申请号：US11352427
申请日：2006-02-10
申请人： Joshua Spradlin , Whye-Kei Lye , Michael Reed , Matthew Hudson
发明人： Joshua Spradlin , Whye-Kei Lye , Michael Reed , Matthew Hudson
IPC分类号： A61H21/00 , A61F2/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

20. 发明申请

US20100125238A1 Iontophoretic Therapeutic Agent Delivery System 审中-公开
标题翻译：离子电渗治疗剂递送系统
公开(公告)号：US20100125238A1
公开(公告)日：2010-05-20
申请号：US12614399
申请日：2009-11-07
申请人： Whye-Kei Lye , Kareen Looi
发明人： Whye-Kei Lye , Kareen Looi
IPC分类号： A61N1/30
CPC分类号： A61N1/306 , A61M25/09 , A61M31/00
摘要： A system for delivering one or more therapeutic agents contained on or within a delivery segment through a passageway, e.g., a blood vessel, for treatment of a localized region of the passageway, or for treatment of region adjacent to the localized region of the passageway, is provided.
摘要翻译：用于递送通过通道（例如血管）包含在递送部分上或内部的一种或多种治疗剂的系统，用于治疗通道的局部区域，或用于治疗与通道的局部区域相邻的区域，被提供。

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