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11. 发明申请

US20080287550A1 Sertraline hydrochloride form II and methods for the preparation thereof 审中-公开
公开(公告)号：US20080287550A1
公开(公告)日：2008-11-20
申请号：US12151081
申请日：2008-05-02
申请人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime
发明人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime
IPC分类号： A61K31/135 , C07C211/19 , A61P25/24
CPC分类号： C07C209/68 , C07B2200/13 , C07C209/84 , C07C211/42 , C07C2602/10 , C07C2602/28 , C07C211/62
摘要： The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be produced from sertraline hydrochloride solvate and hydrate forms, and crystallized from new solvent systems. Pharmaceutical compositions containing sertraline hydrochloride Form II and methods of treatment using such pharmaceutical compositions are also disclosed.

12. 发明授权

US07196222B2 Sertraline hydrochloride form II and methods for the preparation thereof 有权
标题翻译：舍曲林盐酸盐Ⅱ型及其制备方法
公开(公告)号：US07196222B2
公开(公告)日：2007-03-27
申请号：US10861271
申请日：2004-06-04
申请人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime
发明人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime
IPC分类号： C07C211/19
CPC分类号： C07C209/68 , C07B2200/13 , C07C209/84 , C07C211/42 , C07C2602/10 , C07C2602/28 , C07C211/62
摘要： The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be produced from sertraline hydrochloride solvate and hydrate forms, and crystallized from new solvent systems. Pharmaceutical compositions containing sertraline hydrochloride Form II and methods of treatment using such pharmaceutical compositions are also disclosed.
摘要翻译：本发明涉及盐酸舍曲林的II型及其制备方法。根据本发明，盐酸舍曲林盐酸盐形式II可直接从舍曲林碱或舍曲林扁桃酸产生。它也可以由盐酸舍曲林溶剂合物和水合物形式产生，并从新的溶剂体系中结晶。还公开了含有舍曲林盐酸盐形式II的药物组合物和使用这种药物组合物的治疗方法。

13. 发明申请

US20070038005A1 Sertraline hydrochloride form II and methods for the preparation thereof 失效
公开(公告)号：US20070038005A1
公开(公告)日：2007-02-15
申请号：US11580589
申请日：2006-10-12
申请人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime
发明人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime
IPC分类号： C07C211/42
CPC分类号： C07C209/68 , C07B2200/13 , C07C209/84 , C07C211/42 , C07C2602/10 , C07C2602/28 , C07C211/62
摘要： The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be produced from sertraline hydrochloride solvate and hydrate forms, and crystallized from new solvent systems. Pharmaceutical compositions containing sertraline hydrochloride Form II and methods of treatment using such pharmaceutical compositions are also disclosed.

14. 发明申请

US20060241189A1 Sertraline hydrochloride polymorphs 审中-公开
公开(公告)号：US20060241189A1
公开(公告)日：2006-10-26
申请号：US11415830
申请日：2006-05-01
申请人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime , Claude Singer , Evgeni Valdman
发明人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime , Claude Singer , Evgeni Valdman
IPC分类号： A61K31/135 , C07C211/42
CPC分类号： C07C209/84 , A61K31/135 , C07C211/42 , C07C2602/10
摘要： The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.

15. 发明授权

US07022881B2 Sertraline hydrochloride polymorphs 有权
标题翻译：舍曲林盐酸多晶型物
公开(公告)号：US07022881B2
公开(公告)日：2006-04-04
申请号：US10861274
申请日：2004-06-04
申请人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime , Claude Singer , Evgeni Valdman
发明人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime , Claude Singer , Evgeni Valdman
IPC分类号： C07C211/00
CPC分类号： C07C209/84 , A61K31/135 , C07C211/42 , C07C2602/10
摘要： The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.
摘要翻译：本发明涉及舍曲林盐酸盐的形式II，III，V，VI，VII，VIII，IX和X及其制备方法。根据本发明，盐酸舍曲林多晶型II可以通过将盐酸舍曲林多晶型VI制成非质子有机溶剂来制备。舍曲林盐酸盐多晶型III可以通过加热舍曲林盐酸盐多晶型物V和VI来制备。舍曲林盐酸盐形成V和VI可以通过结晶从舍曲林盐酸盐或舍曲林碱产生。盐酸舍曲林形式VII可以通过将盐酸舍曲林多晶型V悬浮在水中，然后过滤来制备。盐酸舍曲林形式VIII和IX可以通过将舍曲林碱悬浮在水中然后酸化和过滤来制备。舍曲林盐酸盐形式X可以通过在加热下将舍曲林盐酸舍曲林悬浮在苄醇中，然后过滤来制备。

16. 发明授权

US06500987B1 Sertraline hydrochloride polymorphs 有权
标题翻译：舍曲林盐酸多晶型物
公开(公告)号：US06500987B1
公开(公告)日：2002-12-31
申请号：US09448985
申请日：1999-11-24
申请人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime , Claude Singer , Evgeni Valdman
发明人： Eduard Schwartz , Tamar Nidam , Anita Liberman , Marioara Mendelovici , Judith Aronhime , Claude Singer , Evgeni Valdman
IPC分类号： C07C21100
CPC分类号： C07C209/84 , A61K31/135 , C07C211/42 , C07C2602/10
摘要： The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.
摘要翻译：本发明涉及舍曲林盐酸盐的形式II，III，V，VI，VII，VIII，IX和X及其制备方法。根据本发明，盐酸舍曲林多晶型II可以通过将盐酸舍曲林多晶型VI制成非质子有机溶剂来制备。舍曲林盐酸盐多晶型III可以通过加热舍曲林盐酸盐多晶型物V和VI来制备。舍曲林盐酸盐形成V和VI可以通过结晶从舍曲林盐酸盐或舍曲林碱产生。盐酸舍曲林形式VII可以通过将舍曲林氯化物多晶型V悬浮在水中，然后过滤来制备。盐酸舍曲林形式VIII和IX可以通过将舍曲林碱悬浮在水中然后酸化和过滤来制备。舍曲林盐酸盐形式X可以通过在加热下将舍曲林盐酸舍曲林悬浮在苄醇中，然后过滤来制备。

17. 发明申请

US20080027223A1 POLYMORPHS OF ESZOPICLONE MALATE 审中-公开
标题翻译：异黄酮黄酮的多聚体
公开(公告)号：US20080027223A1
公开(公告)日：2008-01-31
申请号：US11690580
申请日：2007-03-23
申请人： Alex Mainfeld , Shlomit Wizel , Marioara Mendelovici , Anita Liberman , Tamas Koltai
发明人： Alex Mainfeld , Shlomit Wizel , Marioara Mendelovici , Anita Liberman , Tamas Koltai
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides crystalline Eszopiclone malate form II, crystalline Eszopiclone form V, processes from preparing the crystalline Eszopiclone malate form II or V, pharmaceutical compositions comprising the crystalline Eszopiclone malate form II or V and methods of treating insomnia comprising administering the crystalline Eszopiclone malate form II or V.
摘要翻译：本发明提供结晶埃索替普罗苹果酸盐形式II，结晶埃索普洛尔形式V，从制备结晶依佐匹克隆苹果酸盐形式II或V的方法，包含结晶异山梨酸丙酮酸形式II或V的药物组合物和治疗失眠症的方法，包括施用结晶埃索普洛尔苹果酸盐形式 II或V.

18. 发明申请

US20080091020A1 Polymorphic forms of ziprasidone HCI and processes for their preparation 审中-公开
标题翻译：齐拉西酮HCl的多晶型及其制备方法
公开(公告)号：US20080091020A1
公开(公告)日：2008-04-17
申请号：US11999453
申请日：2007-12-03
申请人： Tamas Koltai , Lilach Hedvati , Marioara Mendelovici , Tamar Nidam
发明人： Tamas Koltai , Lilach Hedvati , Marioara Mendelovici , Tamar Nidam
IPC分类号： C07D417/14
CPC分类号： C07D417/12 , A61K31/496
摘要： Provided are various polymorphic forms of ziprasidone HCl and processes for their preparation.
摘要翻译：提供齐拉西酮HCl的各种多晶型物及其制备方法。

19. 发明申请

US20070213404A1 Processes for preparation of polymorphic form II of sertraline hydrochloride 审中-公开
标题翻译：制备盐酸舍曲林多晶型II的方法
公开(公告)号：US20070213404A1
公开(公告)日：2007-09-13
申请号：US11801663
申请日：2007-05-09
申请人： Ronen Borochovitch , Marioara Mendelovici , Tamar Nidam , Ruth Tenengauzer , Julia Hrakovsky , Judith Aronhime
发明人： Ronen Borochovitch , Marioara Mendelovici , Tamar Nidam , Ruth Tenengauzer , Julia Hrakovsky , Judith Aronhime
IPC分类号： A61K31/135 , C07C211/38
CPC分类号： C07C209/84 , C07C2602/10 , C07C211/42
摘要： Provided are processes for preparation of crystalline sertraline hydrochloride Form II substantilly free of other polymorphic forms of sertraline hydrochloride, preferably on an industrial scale.
摘要翻译：提供制备结晶的舍曲林盐酸盐形式II的方法，其基本上不含其他多晶型的舍曲林盐酸盐，优选在工业规模上。

20. 发明授权

US07667037B2 Processes for preparation of ziprasidone 失效
标题翻译：齐拉西酮制备方法
公开(公告)号：US07667037B2
公开(公告)日：2010-02-23
申请号：US10973498
申请日：2004-10-25
申请人： Gideon Pilarsky , Natalia Shenkar , Marioara Mendelovici , Tamar Nidam , Anna Balanov
发明人： Gideon Pilarsky , Natalia Shenkar , Marioara Mendelovici , Tamar Nidam , Anna Balanov
IPC分类号： C07D237/14 , C07D237/04 , C07D417/14 , C07D401/14
CPC分类号： C07D417/12
摘要： Provided are processes for preparing ziprasidone from CEI and BIPT.
摘要翻译：提供了从CEI和BIPT制备齐拉西酮的方法。

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