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    • 4. 发明授权
    • Sertraline hydrochloride polymorphs
    • 舍曲林盐酸多晶型物
    • US07022881B2
    • 2006-04-04
    • US10861274
    • 2004-06-04
    • Eduard SchwartzTamar NidamAnita LibermanMarioara MendeloviciJudith AronhimeClaude SingerEvgeni Valdman
    • Eduard SchwartzTamar NidamAnita LibermanMarioara MendeloviciJudith AronhimeClaude SingerEvgeni Valdman
    • C07C211/00
    • C07C209/84A61K31/135C07C211/42C07C2602/10
    • The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.
    • 本发明涉及舍曲林盐酸盐的形式II,III,V,VI,VII,VIII,IX和X及其制备方法。 根据本发明,盐酸舍曲林多晶型II可以通过将盐酸舍曲林多晶型VI制成非质子有机溶剂来制备。 舍曲林盐酸盐多晶型III可以通过加热舍曲林盐酸盐多晶型物V和VI来制备。 舍曲林盐酸盐形成V和VI可以通过结晶从舍曲林盐酸盐或舍曲林碱产生。 盐酸舍曲林形式VII可以通过将盐酸舍曲林多晶型V悬浮在水中,然后过滤来制备。 盐酸舍曲林形式VIII和IX可以通过将舍曲林碱悬浮在水中然后酸化和过滤来制备。 舍曲林盐酸盐形式X可以通过在加热下将舍曲林盐酸舍曲林悬浮在苄醇中,然后过滤来制备。
    • 5. 发明授权
    • Sertraline hydrochloride polymorphs
    • 舍曲林盐酸多晶型物
    • US06500987B1
    • 2002-12-31
    • US09448985
    • 1999-11-24
    • Eduard SchwartzTamar NidamAnita LibermanMarioara MendeloviciJudith AronhimeClaude SingerEvgeni Valdman
    • Eduard SchwartzTamar NidamAnita LibermanMarioara MendeloviciJudith AronhimeClaude SingerEvgeni Valdman
    • C07C21100
    • C07C209/84A61K31/135C07C211/42C07C2602/10
    • The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.
    • 本发明涉及舍曲林盐酸盐的形式II,III,V,VI,VII,VIII,IX和X及其制备方法。 根据本发明,盐酸舍曲林多晶型II可以通过将盐酸舍曲林多晶型VI制成非质子有机溶剂来制备。 舍曲林盐酸盐多晶型III可以通过加热舍曲林盐酸盐多晶型物V和VI来制备。 舍曲林盐酸盐形成V和VI可以通过结晶从舍曲林盐酸盐或舍曲林碱产生。 盐酸舍曲林形式VII可以通过将舍曲林氯化物多晶型V悬浮在水中,然后过滤来制备。 盐酸舍曲林形式VIII和IX可以通过将舍曲林碱悬浮在水中然后酸化和过滤来制备。 舍曲林盐酸盐形式X可以通过在加热下将舍曲林盐酸舍曲林悬浮在苄醇中,然后过滤来制备。