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11. 发明授权

US5291775A Scanning force microscope with integrated optics and cantilever mount 失效
标题翻译：具有集成光学和悬臂安装的扫描力显微镜
公开(公告)号：US5291775A
公开(公告)日：1994-03-08
申请号：US845919
申请日：1992-03-04
申请人： Ronald C. Gamble , Paul G. West
发明人： Ronald C. Gamble , Paul G. West
IPC分类号： G01B11/30 , B01L7/00 , G01B7/34 , G01B21/30 , G01N37/00 , G01Q10/00 , G01Q20/02 , G01Q30/14 , G01Q60/24 , G01Q70/02 , H01J37/28 , G01B5/28 , G01N23/00
CPC分类号： G01Q30/14 , B82Y35/00 , G01Q20/02 , G01Q60/38 , G01Q70/02 , Y10S977/87
摘要： The scanning force microscope includes integrated optics for viewing the optical lever arm, probe and sample to be examined. The scanning force microscope includes an improved mount for the probe, which is magnetically secured to the body of the scanning force microscope, to improve ease of handling and mounting the probe assembly. In one preferred embodiment the scanning force microscope, also includes a base portion with a fluid cell for receiving a sample in a sealed gas or liquid environment.
摘要翻译：扫描力显微镜包括用于观察光学杠杆臂，探针和待检测样品的集成光学器件。扫描力显微镜包括用于探针的改进的安装件，其被磁性地固定到扫描力显微镜的主体，以提高操纵和安装探针组件的容易性。在一个优选实施例中，扫描力显微镜还包括具有用于在密封气体或液体环境中接收样品的流体池的基部。

12. 发明授权

US5043107A Preparation small unilamellar vesicles including polyene antifungal antibiotics 失效
标题翻译：制备小单层囊泡，包括多烯抗真菌抗生素
公开(公告)号：US5043107A
公开(公告)日：1991-08-27
申请号：US427732
申请日：1989-10-27
申请人： Jill Adler-Moore , Ronald C. Gamble , Richard T. Proffitt
发明人： Jill Adler-Moore , Ronald C. Gamble , Richard T. Proffitt
IPC分类号： A61K9/127 , A61K9/133
CPC分类号： A61K9/1271 , A61K31/7048 , Y10S436/829 , Y10S514/885 , Y10T428/2984
摘要： Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low ionic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the anti-fungal antibiotic to treat systemic fungal infections.
摘要翻译：描述由包含多烯抗真菌抗生素的磷脂小单层颗粒组成的制剂以及使用这些组合物治疗全身性真菌感染的方法。在优选的实施方案中，颗粒是囊泡形式，其包含多烯抗真菌抗生素，优选两性霉素B和/或制霉菌素，卵磷脂酰胆碱和胆固醇，优选摩尔比为约0.2（AMB）：2（PL）： 1（CHOL）。这些囊泡也可以具有胺改性的表面。将囊泡悬浮在约6.0至约8.0的pH下的低离子强度的糖/三溶液中，并且可以施用以递送抗真菌抗生素以治疗全身性真菌感染。

13. 发明授权

US4753788A Method for preparing small vesicles using microemulsification 失效
标题翻译：使用微乳液制备小囊泡的方法
公开(公告)号：US4753788A
公开(公告)日：1988-06-28
申请号：US696727
申请日：1985-01-31
申请人： Ronald C. Gamble
发明人： Ronald C. Gamble
IPC分类号： A61K51/00 , A61K9/10 , A61K9/127 , A61K9/133 , A61K45/08 , B01J13/00 , B01J13/02 , A61K43/00 , A61K49/00
CPC分类号： A61K9/1277 , Y10S436/829
摘要： A method is provided for preparing small (less than 2000 .ANG.) lipid vesicles in commercial quantities by microemulsifying lipid compositions using very high shear forces generated in a homogenizing apparatus operated at high pressures at a selected temperature. These vesicles are suitable for various biological applications including targeting of tumors in a body for diagnosis and treatment.
摘要翻译：提供了一种通过使用在选定温度下以高压操作的均质化装置中产生的非常高的剪切力微乳化脂质组合物来制备商业量的小（小于2000安格姆）脂质囊泡的方法。这些囊泡适用于各种生物学应用，包括靶向体内肿瘤用于诊断和治疗。

14. 发明授权

US6001309A Jet droplet device 失效
标题翻译：喷射液滴装置
公开(公告)号：US6001309A
公开(公告)日：1999-12-14
申请号：US79871
申请日：1998-05-15
申请人： Ronald C. Gamble , Thomas P. Theriault , John Baldeschwieler
发明人： Ronald C. Gamble , Thomas P. Theriault , John Baldeschwieler
IPC分类号： C12N15/09 , B01J19/00 , B01L3/02 , C40B50/14 , C40B60/14 , G01N1/28 , G01N35/10
CPC分类号： B01L3/0268 , B01J19/0046 , B82Y30/00 , B01J2219/00378 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01L2200/04 , C40B50/14 , C40B60/14 , G01N2001/282 , G01N2035/1041
摘要： Devices and methods are provided for precise reduction of arrays of microspots. A pulse jetting device is employed having a capillary of micron dimensions, with a portion of the capillary proximal to the jetting orifice circumferentially surrounded by a piezoelectric transducer. By appropriate design of the capillary, orifice and piezoelectric transducer, droplets can be formed on a surface, separated by as little as 80 microns center-to-center, and having at least about a 15 micron spacing at the border. The subject substrate arrays can be used for providing miniaturized arrays of reagents, such as nucleic acids, for detecting the presence of homologous sequences in a sample.
摘要翻译：提供了设备和方法来精确地减少微孢子体阵列。使用脉冲喷射装置具有微米尺寸的毛细管，毛细管的一部分靠近喷射孔，周向地被压电换能器包围。通过毛细管，孔口和压电换能器的适当设计，液滴可以形成在中心至中心微小至80微米的表面上，并且在边界处具有至少约15微米的间距。主题衬底阵列可用于提供用于检测样品中同源序列的存在的小型试剂阵列，例如核酸。

15. 发明授权

US5981733A Apparatus for the chemical synthesis of molecular arrays 失效
标题翻译：用于化学合成分子阵列的装置
公开(公告)号：US5981733A
公开(公告)日：1999-11-09
申请号：US714867
申请日：1996-09-16
申请人： Ronald C. Gamble , Thomas P. Theriault , John D. Baldeschwieler
发明人： Ronald C. Gamble , Thomas P. Theriault , John D. Baldeschwieler
IPC分类号： B01J19/00 , C40B40/06 , C40B60/14 , C07H21/00
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00391 , B01J2219/00475 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y02P20/582
摘要： An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of the substrate and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.
摘要翻译：用于自动合成分子阵列的装置。喷射装置与反应室一起使用以将合成中使用的试剂分配到基材上。定位系统将基板从射流移动到反应室。控制器控制衬底的移动和试剂的应用，使得根据预定程序进行合成。该装置将根据在合成前立即由操作者选择的图案在微米级斑点的阵列中合成核苷酸。

16. 发明授权

US5874554A Methods and solvent vehicles for reagent delivery in oligonucleotide synthesis using automated pulse jetting devices 失效
标题翻译：使用自动脉冲喷射装置的寡核苷酸合成中的试剂递送的方法和溶剂载体
公开(公告)号：US5874554A
公开(公告)日：1999-02-23
申请号：US767233
申请日：1996-12-13
申请人： Ronald C. Gamble , Thomas P. Theriault , Scott C. Winder
发明人： Ronald C. Gamble , Thomas P. Theriault , Scott C. Winder
IPC分类号： B01J19/00 , C07H21/00 , C40B40/06 , C40B60/14 , C07H19/00 , C08G63/48
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： Solvent vehicles and methods of their use in the pulse jet delivery of reagents in automated oligonucleotide synthesis by the solid-phase phosphoramidite method are provided. For pulse jet delivery of the activated monomer, acetonitrile in combination with at least one stabilizer co-solvent is employed as the solvent vehicle, where the stabilizer co-solvent is an inert, organic solvent having a boiling point of at least 100.degree. C. For pulse jet delivery of the detritylation reagent, a mono- or disubstituted methane is employed as the solvent vehicle, where substituents have a molecular weight greater than 36 daltons. Use of the solvent vehicles according to the subject invention provides for reduced reagent precipitation in the pulse jet tubes and improved results.
摘要翻译：提供溶剂车辆及其在通过固相亚磷酰胺方法的自动寡核苷酸合成中脉冲喷射输送试剂中的方法。对于活化单体的脉冲喷射输送，使用乙腈与至少一种稳定剂助溶剂组合作为溶剂载体，其中稳定剂助溶剂是沸点至少为100℃的惰性有机溶剂。对于去离子试剂的脉冲喷射输送，使用单取代或二取代的甲烷作为溶剂载体，其中取代基的分子量大于36道尔顿。根据本发明的溶剂载体的使用提供了脉冲喷射管中减少的试剂沉淀和改进的结果。

17. 发明授权

US5406832A Synchronous sampling scanning force microscope 失效
标题翻译：同步采样扫描力显微镜
公开(公告)号：US5406832A
公开(公告)日：1995-04-18
申请号：US86592
申请日：1993-07-02
申请人： Ronald C. Gamble , Paul E. West , Marc R. Schuman
发明人： Ronald C. Gamble , Paul E. West , Marc R. Schuman
IPC分类号： G01B21/30 , G01Q10/00 , G01Q10/06 , G01Q60/32 , G01B5/28 , G01N23/00
CPC分类号： G01Q10/06 , B82Y35/00 , Y10S977/85 , Y10S977/851
摘要： The synchronous sampling scanning force microscope includes a reflective cantilever arm having a free end which is oscillated at a frequency different from the resonance frequency of the cantilever arm. The motion of the oscillating cantilever arm is measured, to generate a deflection signal indicative of the amplitude of deflection or phase shift of the cantilever arm. Selected portions of cycles of the output signal are sampled, for generating output signal data indicative of deflection of the near and far excursions of the probe. The method and apparatus permit monitoring of compliance of the surface of the specimen by multiple sampling at a rate greater than the period of oscillation of the cantilever probe of the microscope.
摘要翻译：同步采样扫描力显微镜包括反射悬臂，其具有以与悬臂的共振频率不同的频率振荡的自由端。测量振荡悬臂的运动，以产生指示悬臂的偏转或相移幅度的偏转信号。对输出信号的周期的选定部分进行采样，以产生指示探针的近距离和远距偏移的输出信号数据。该方法和装置允许以大于显微镜的悬臂探头的振荡周期的速率进行多次采样来监测样品表面的顺应性。

18. 发明授权

US4581222A Membrane immune assay 失效
标题翻译：膜免疫测定
公开(公告)号：US4581222A
公开(公告)日：1986-04-08
申请号：US465360
申请日：1983-02-09
申请人： John D. Baldeschwieler , Ronald C. Gamble , Albert M. Lin , George W. Tin
发明人： John D. Baldeschwieler , Ronald C. Gamble , Albert M. Lin , George W. Tin
IPC分类号： G01N33/534 , A61K43/00 , G01T1/00
CPC分类号： G01N33/534 , Y10S436/804 , Y10S436/827
摘要： An immunoassay method for detection of antigen is disclosed. The method employs complement mediated lysis of vesicles loaded with In-111 or other gamma-emitting cation, and quantitative detection of the lysis by gamma-ray perturbed angular correlation (PAC) spectroscopy. The vesicles are labeled with a substance competitive to the antigen to be measured, and the concentration of the antigen in the sample measured by assessing the diminution in lysis due to the presence of the competing antigen.The method may also be used to assess the immunologic competence of a subject by injecting suitably sensitized vesicles and monitoring the in vivo lysis pattern by (PAC).
摘要翻译：公开了一种用于检测抗原的免疫测定方法。该方法使用负载有In-111或其他γ发射阳离子的囊泡的补体介导的裂解，以及通过γ射线扰动角度相关（PAC）光谱定量检测裂解。囊泡用与要测量的抗原竞争的物质标记，并且通过评估由于竞争性抗原的存在引起的裂解减少来测量样品中抗原的浓度。该方法还可以用于通过注射适当敏化的囊泡和通过（PAC）监测体内裂解模式来评估受试者的免疫能力。

19. 发明授权

US4310505A Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances 失效
标题翻译：含有碳水化合物表面的脂质囊泡作为治疗和诊断物质的淋巴导向载体
公开(公告)号：US4310505A
公开(公告)日：1982-01-12
申请号：US92342
申请日：1979-11-08
申请人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
发明人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
IPC分类号： A61K51/00 , A61K9/127 , A61K47/00 , A61K49/00 , A61K43/00 , B01J13/00
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271 , Y10T428/2984
摘要： Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-L-fucopyranoside; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 1-thio-.alpha.-D-mannopyranoside; 6-(5-cholesten-3-yloxy)hexyl 2-acetamido-2-deoxy-1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.beta.-D-galactopyranoside; or 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.alpha.-D-mannopyranoside; cholesterol and distearoyl phospatidylcholine, and an effective amount of physiologically compatible radioactive tracer, cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to the human host and have been found to release the contents of the vesicles in a predetermined manner, i.e., controlled release, and in some cases, to be rapidly concentrated in the lymphatic system and/or liver, lungs or spleen of the host.
摘要翻译：包含脂质双层的脂质囊泡，其包括细胞表面受体的类似物，例如磷酸二鲸蜡酯; 硬脂胺 6-（5-胆甾烯-3β-氧代）己基1-硫代-β-L-吡喃葡萄糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-α-D-吡喃甘露糖苷; 6-（5-胆甾烯-3-基氧基）己基2-乙酰氨基-2-脱氧-1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-β-D-吡喃半乳糖苷; 或6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-α-D-吡喃甘露糖苷; 胆固醇和二硬脂酰磷脂酰胆碱，以及有效量的生理相容的放射性示踪剂，细胞毒性剂或治疗剂作为囊泡的一部分。本发明的囊泡可以施用于人宿主，并且已经被发现以预定的方式（即控制释放）释放囊泡的内容物，并且在一些情况下快速浓缩在淋巴系统和/或肝脏中，肺或脾脏的主机。

20. 发明授权

US5949070A Scanning force microscope with integral laser-scanner-cantilever and independent stationary detector 失效
标题翻译：具有整体激光扫描仪 - 悬臂和独立静态探测器的扫描力显微镜
公开(公告)号：US5949070A
公开(公告)日：1999-09-07
申请号：US783416
申请日：1997-01-14
申请人： Ronald C. Gamble
发明人： Ronald C. Gamble
IPC分类号： G01Q10/00 , G01Q60/04 , G01B7/34 , G01Q20/02 , G01Q30/14 , G01Q70/02 , H01J37/352
CPC分类号： G01B7/34 , B82Y35/00 , G01Q20/02 , G01Q30/14 , G01Q70/02 , Y10S977/87
摘要： A scanning force microscope is disclosed which includes integrated optics for viewing the optical lever arm, probe and sample to be examined. The scanning force microscope includes a simplified mounting of laser and related adjustments and the locating of a detector independent of the scanner, to improve ease of handling and providing convenient locations for adjustments. In one preferred embodiment of the scanning force microscope, the surface of samples may be imaged while the cantilever portion of the scanner is immersed in liquids without special set-up or special adapters.
摘要翻译：公开了一种扫描力显微镜，其包括用于观察光学杠杆臂，待检查的探针和样品的集成光学元件。扫描力显微镜包括简化的激光安装和相关调整以及独立于扫描仪的检测器的定位，以提高操作的便利性并提供便于调节的位置。在扫描力显微镜的一个优选实施例中，可以将扫描仪的悬臂部分浸没在没有特殊装置或特殊适配器的液体中的同时，将样品的表面进行成像。

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