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11. 发明授权

US5512579A Aminobenzoic acid derivatives 失效
标题翻译：氨基苯甲酸衍生物
公开(公告)号：US5512579A
公开(公告)日：1996-04-30
申请号：US275704
申请日：1994-07-18
申请人： Shuhei Miyazawa , Yorohisa Hoshino , Hisashi Shibata , Kazuo Hirota , Takaaki Kameyama , Shinya Abe , Takashi Yamanaka
发明人： Shuhei Miyazawa , Yorohisa Hoshino , Hisashi Shibata , Kazuo Hirota , Takaaki Kameyama , Shinya Abe , Takashi Yamanaka
IPC分类号： A61K31/40 , A61K31/403 , A61K31/435 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K31/535 , A61K31/55 , A61K31/625 , A61P1/00 , A61P1/08 , A61P1/12 , A61P1/14 , A61P25/20 , A61P25/22 , A61P43/00 , C07D207/14 , C07D209/00 , C07D211/58 , C07D221/22 , C07D221/24 , C07D223/32 , C07D451/02 , C07D451/04 , C07D451/14 , C07D471/08 , C07D471/18 , C07D491/08 , C07D498/08 , C07D295/04
CPC分类号： C07D451/02 , C07D207/14 , C07D211/58 , C07D221/24 , C07D451/04 , C07D451/14 , C07D471/08 , C07D491/08 , C07D498/08
摘要： To provide a compound which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio. An aminobenzoic acid derivative represented by the general formula (I) or (II) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1 represents a group represented by the formula: ##STR2## {wherein A represents a group represented by formula --CH.sub.2 --X--CH.sub.2 -- (wherein X represents O, >N--R.sup.6 or >CHR.sup.7 (wherein R.sup.6 represents lower alkyl and R.sup.7 represents hydrogen or lower alkoxy)), etc.; D and E each represents a group represented by formula --(CH.sub.2).sub.3 --, etc., and R.sup.2 represents lower alkyl. etc.}; R.sup.9 represents alkynyl; R.sup.10 represents amino, etc.; R.sup.11 represents halogen; R.sup.12 and R.sup.13 each represent lower alkyl; a is an integer of 1 to 5; and b is an integer of 0 to 5!.
摘要翻译：提供以良好平衡的活性比表现出5-羟色胺拮抗作用和乙酰胆碱释放促进活性的化合物。（I）或（II）表示的氨基苯甲酸衍生物或其药理学上可接受的盐：其中R1表示由下式表示的基团：其中A表示由式-CH 2 -X-CH 2 - （其中X表示O，> N-R 6或> CHR 7（其中R 6表示低级烷基，且R 7表示氢或低级烷氧基））等表示的基团。 D和E各自表示由式 - （CH 2）3 - 等表示的基团，并且R 2表示低级烷基。等等。}; R9代表炔基; R10表示氨基等。 R11表示卤素; R 12和R 13各自表示低级烷基; a为1〜5的整数， b为0〜5的整数]。

12. 发明申请

US20050004149A1 Pyrimidine compound and medicinal composition thereof 失效
公开(公告)号：US20050004149A1
公开(公告)日：2005-01-06
申请号：US10492905
申请日：2002-10-22
申请人： Hitoshi Harada , Osamu Asano , Masato Ueda , Shuhei Miyazawa , Yoshihiko Kotake , Yasuhiro Kabasawa , Masahiro Yasuda , Nobuyuki Yasuda , Daisuke Iida , Junichi Nagakawa , Kazuo Hirota , Makoto Nakagawa
发明人： Hitoshi Harada , Osamu Asano , Masato Ueda , Shuhei Miyazawa , Yoshihiko Kotake , Yasuhiro Kabasawa , Masahiro Yasuda , Nobuyuki Yasuda , Daisuke Iida , Junichi Nagakawa , Kazuo Hirota , Makoto Nakagawa
IPC分类号： A61K31/506 , A61P1/00 , A61P1/10 , A61P3/04 , A61P3/10 , A61P9/12 , A61P11/06 , A61P13/02 , A61P19/10 , A61P25/16 , A61P25/28 , A61P43/00 , C07D401/04 , C07D405/14 , C07D409/14 , C07
CPC分类号： C07D405/14 , A61K31/506 , C07D401/04 , C07D409/14
摘要： The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R1 and R2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a cycloalkenyl group having three to eight carbon atoms which may be substituted, a 5 to 14-membered non-aromatic heterocyclic group which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, an acyl group having one to six carbon atoms which may be substituted or an alkylsulfonyl group having one to six carbon atoms which may be substituted; R3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, a nitrogen atom which may be substituted, an oxygen atom which may be substituted or a sulfur atom which may be substituted; R4 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted or a 5 to 14-membered non-aromatic heterocyclic group having at least one or more unsaturated bonds which may be substituted; and R5 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted or a 5 to 14-membered aromatic heterocyclic group which may be substituted.

13. 发明授权

US5292901A Benzodioxole derivatives 失效
标题翻译：苯并二恶醇衍生物
公开(公告)号：US5292901A
公开(公告)日：1994-03-08
申请号：US832220
申请日：1992-02-06
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04 , A61K31/36
CPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/10 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译：新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基，其是羧烷基硫代烷基等，并且有效治疗肝脏疾病。

14. 发明授权

US5475024A Benzodioxole derivatives 失效
标题翻译：苯并二恶醇衍生物
公开(公告)号：US5475024A
公开(公告)日：1995-12-12
申请号：US166019
申请日：1993-10-14
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04 , A61K31/36
CPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/10 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译：新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基，其是羧烷基硫代烷基等，并且有效治疗肝脏疾病。

15. 发明授权

US5110956A Benzodioxale derivatives 失效
标题翻译： BENZODIOXALE DERIVATIVES
公开(公告)号：US5110956A
公开(公告)日：1992-05-05
申请号：US517444
申请日：1990-04-23
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： A61K31/335 , C07D317/46 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04
CPC分类号： C07D405/12 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D413/12 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译：提供苯并间二氧杂环戊烯衍生物在苯环中具有取代基，羧基烷基硫代烷基等。这样的衍生物有效治疗肝脏疾病。还提供了包含这些衍生物的组合物以及这些衍生物用于制备药物的用途。

16. 发明授权

US06174935B1 Dental adhesive kit 失效
标题翻译：牙科粘合剂套件
公开(公告)号：US06174935B1
公开(公告)日：2001-01-16
申请号：US09213774
申请日：1998-12-17
申请人： Kaori Matsunae , Shoji Akahane , Kazuo Hirota
发明人： Kaori Matsunae , Shoji Akahane , Kazuo Hirota
IPC分类号： A61K6083
CPC分类号： C09J4/00 , A61K6/0029 , C08F290/067 , C09J4/06 , C08F222/1006 , C08F220/28 , C08L33/00
摘要： A dental adhesive kit is disclosed, comprising a combination of: (i) a self-etching primer comprising (A) from 1.0 to 50% by weight of a methacrylate or acrylate having an acidic group and having at least one unsaturated double bond, (B) from 1.0 to 98% by weight of a water-soluble organic solvent, and (C) from 1.0 to 90% by weight of water; and (ii) a bonding agent comprising (D) from 10 to 90% by weight of a methacrylate or acrylate having neither acidic group nor hydroxyl group and having at least one unsaturated double bond, (E) from 10 to 90% by weight of a methacrylate or acrylate not having an acidic group but having a hydroxyl group and having at least one unsaturated double bond, (F) from 0.1 to 5.0% by weight of a photopolymerization initiator, (G) from 0.1 to 5.0% by weight of a photopolymerization accelerator, and (H) from 1.0 to 60% by weight of a filler. The dental adhesive kit of the invention is useful for making the adhesive properties of a resin-based adhesive firm and reliable by a simple handling in adhering a dental restorative material to an enamel and a dentin.
摘要翻译：公开了一种牙科粘合剂试剂盒，其包含以下组合：（i）自蚀刻底漆，其包含（A）1.0至50重量％的具有酸性基团并且具有至少一个不饱和双键的甲基丙烯酸酯或丙烯酸酯， B）1.0〜98重量％的水溶性有机溶剂，（C）1.0〜90重量％的水; 和（ii）粘合剂，其包含（D）10至90重量％的不具有酸性基团和羟基并且具有至少一个不饱和双键的甲基丙烯酸酯或丙烯酸酯，（E）10至90重量％不具有酸性基团但具有羟基且具有至少一个不饱和双键的甲基丙烯酸酯或丙烯酸酯，（F）0.1〜5.0重量％的光聚合引发剂，（G）0.1〜5.0重量％光聚合促进剂和（H）1.0〜60重量％的填料。本发明的牙科粘合剂试剂盒可用于通过简单的处理使牙科修复剂粘附，使树脂基粘合剂的粘合性能牢固且可靠搪瓷和牙本质的材料。

17. 发明授权

US5063257A Dental glass ionomer cement compositions 失效
标题翻译：牙科玻璃离子水泥组合物
公开(公告)号：US5063257A
公开(公告)日：1991-11-05
申请号：US448298
申请日：1989-12-11
申请人： Shoji Akahane , Satoshi Tosaki , Yukiharu Kusayanagi , Shigenobu Kusakai , Kazuo Hirota , Kentaro Tomioka
发明人： Shoji Akahane , Satoshi Tosaki , Yukiharu Kusayanagi , Shigenobu Kusakai , Kazuo Hirota , Kentaro Tomioka
IPC分类号： A61K6/06 , A61K6/083 , C08F2/44 , C08F2/50
CPC分类号： A61K6/0835 , A61K6/0091 , Y10S522/908
摘要： A dental glass ionomer cement composition comprises:(a) 5 to 100 parts by weight of a polymer of an .alpha.-.beta. unsaturated carboxylic acid having a weight average molecular weight of 5,000 to 40,000,(b) 5 to 100 parts by weight of a fluoroaluminosilicate glass powder having an average particle size of 0.02 to 10 .mu.m and a specific gravity of 2.4 to 4.0 and capable of reacting with said "polymer of an .alpha.-.beta. unsaturated carboxylic acid having a weight average molecular weight of 5,000 to 40,000",(c) 5 to 100 parts by weight of a polymerizable unsaturated organic compound having at least one CH.sub.2 .dbd.C(R1)--COO--group wherein R1=H or CH.sub.3,(d) 0.01 to 5 parts by weight of a polymerization catalyst,(e) 2 to 50 parts by weight of water,(f) 0.01 to 20 parts by weight of a surface active agent, and(g) 0.01 to 5 parts by weight of a reducing agent, and optionally h. 0 to 50 parts by weight of an inorganic filler having an average particle size of 0.02 to 10 .mu.m and undergoing no reaction with said "polymer of an .alpha.-.beta. unsaturated carboxylic acid having a weight average molecular weight of 5,000 to 40,000".
摘要翻译：牙科玻璃离聚物粘合剂组合物包含：（a）5至100重量份的重均分子量为5,000至40,000的α-β不饱和羧酸的聚合物，（b）5至100重量份的平均粒径为0.02〜10μm，比重为2.4〜4.0，能够与所述“重均分子量为5,000〜40,000的α-β不饱和羧酸的聚合物”反应的氟铝硅酸盐玻璃粉末，（c）5至100重量份具有至少一个CH 2 = C（R 1）-COO-基团的可聚合不饱和有机化合物，其中R1 = H或CH3，（d）0.01至5重量份的聚合催化剂，（e）2至50重量份的水，（f）0.01至20重量份的表面活性剂，和（g）0.01至5重量份的还原剂，以及任选的h。 0〜50重量份平均粒径为0.02〜10μm的无机填料，并且与所述“所述重均分子量为5,000〜40,000的α-β不饱和羧酸的聚合物不反应”。

18. 发明授权

US4972369A Magnetic bubble memory module with interconnection member 失效
标题翻译：具有互连构件的磁性气泡存储模块
公开(公告)号：US4972369A
公开(公告)日：1990-11-20
申请号：US432327
申请日：1989-11-06
申请人： Yutaka Akiba , Kazuo Hirota , Nobuo Kishiro , Toshio Futami , Tatsuo Hamamoto
发明人： Yutaka Akiba , Kazuo Hirota , Nobuo Kishiro , Toshio Futami , Tatsuo Hamamoto
IPC分类号： G11C19/08
CPC分类号： G11C19/085
摘要： According to one embodiment of the present invention, a magnetic bubble memory module comprising a flexible printed circuits substrate (FPC3), on which a magnetic bubble memory chip (CHI) is mounted and electrically connected, with interconnecting patterns(9a) electrically connecting the chip (CHI) with external connecting leads, terminals or pins as well as bias coil winding (BIC2) for applying bias field to the chip (CHI), thereby reducing the number of components as well as fabricating steps because of the formation of the bias coil (BIC2) with the printed circuits substrate (FPC3).
摘要翻译：根据本发明的一个实施例，一种包括柔性印刷电路基板（FPC3）的磁性气泡存储模块，其上安装有电磁连接的磁性气泡存储芯片（CHI）和电气连接的互连图案（9a），电连接芯片（CHI），外部连接引线，端子或引脚以及用于向芯片（CHI）施加偏置场的偏置线圈绕组（BIC2），从而由于偏置线圈的形成而减少了部件数量以及制造步骤（BIC2）与印刷电路基板（FPC3）。

19. 发明授权

US4673772A Electronic circuit device and method of producing the same 失效
标题翻译：电子电路装置及其制造方法
公开(公告)号：US4673772A
公开(公告)日：1987-06-16
申请号：US784035
申请日：1985-10-04
申请人： Ryohei Satoh , Muneo Oshima , Minoru Tanaka , Suguru Sakaguchi , Akira Murata , Kazuo Hirota
发明人： Ryohei Satoh , Muneo Oshima , Minoru Tanaka , Suguru Sakaguchi , Akira Murata , Kazuo Hirota
IPC分类号： B23K35/14 , H01L21/60 , H01L21/607 , H01L23/485 , H05K3/34 , H01L23/14
CPC分类号： H01L24/10 , H01L24/13 , H01L24/81 , H05K3/3436 , H01L2224/13 , H01L2224/13099 , H01L2224/131 , H01L2224/13116 , H01L2224/13144 , H01L2224/16225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73265 , H01L2224/81801 , H01L2924/00013 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01025 , H01L2924/01027 , H01L2924/01033 , H01L2924/01042 , H01L2924/01046 , H01L2924/01047 , H01L2924/0105 , H01L2924/01051 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/01322 , H01L2924/014 , H01L2924/10253 , H01L2924/14 , H01L2924/15153 , H01L2924/15165 , H01L2924/15787 , H01L2924/16195 , H01L2924/19041 , H01L2924/19043 , H05K2201/10636 , H05K2201/10727 , H05K2201/10992 , H05K2203/0108 , H05K2203/033 , H05K2203/0338 , H05K2203/0405 , H05K2203/0415 , H05K3/3442 , Y02P70/611 , Y02P70/613 , Y10T29/49144
摘要： In connecting an electronic circuit part such as a semiconductor or other part to a substrate for mounting the part with solder, the solder is composed of a high-melting-point solder portion which is subjected to working such as rolling and heat treatment in order to break the cast structure thereof, and a smaller volume of low-melting-point solder portions. The high-melting-point solder portion is connected to both the electronic circuit substrate and the electronic circuit part through the low-point-melting solder portions.This method enables interconnection between objects to be connected without impairing the high ductility and toughness of the high-melting-point solder which is subjected to working and heat treatment. This soldering method ensures highly reliable manufacture of miniaturized high density circuits, such as LSI.
摘要翻译：在将诸如半导体或其他部分的电子电路部分连接到用于用焊料安装部件的基板时，焊料由经受诸如轧制和热处理的加工的高熔点焊料部分组成，以便破坏其铸造结构和较低体积的低熔点焊料部分。高熔点焊料部分通过低熔点焊料部分与电子电路基板和电子电路部分连接。该方法能够连接物体之间的连接，而不会损害经受加工和热处理的高熔点焊料的高延展性和韧性。这种焊接方法确保了LSI等小型化高密度电路的高可靠性制造。

20. 发明授权

US4632824A Compositions applied in the mouth 失效
标题翻译：口中应用的成分
公开(公告)号：US4632824A
公开(公告)日：1986-12-30
申请号：US617817
申请日：1984-06-06
申请人： Kazuo Hirota , Shoji Akahane , Kentaro Tomioka
发明人： Kazuo Hirota , Shoji Akahane , Kentaro Tomioka
IPC分类号： A61K8/96 , A61K6/00 , A61K8/00 , A61K8/33 , A61K8/60 , A61K8/64 , A61K9/68 , A61Q11/00 , A61K7/16 , A61K7/24 , A61K7/26
CPC分类号： A61K8/64 , A61K8/602 , A61Q11/00
摘要： A composition applied in the mouth which has a preventive effect on dental carries and contains such tannic acid derivatives as of solubility resistance to water.
摘要翻译：适用于对口腔具有预防作用的口腔中的组合物，并含有对水的耐溶解性的这种单宁酸衍生物。

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