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11. 发明授权

US07385691B2 Integrated modular system and method for enhanced Raman spectroscopy 有权
标题翻译：用于增强拉曼光谱的集成模块化系统和方法
公开(公告)号：US07385691B2
公开(公告)日：2008-06-10
申请号：US11044676
申请日：2005-01-27
申请人： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
发明人： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01J3/44 , H01L31/02325 , H01L31/105
摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed on the substrate or apart from the substrate. The molecular analysis device also include a radiation receiver disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.
摘要翻译：公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。拉曼增强结构可以设置在基板上或者离开基板。分子分析装置还包括设置在基板上并被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射的辐射接收器。

12. 发明申请

US20060275778A1 Method and apparatus for molecular analysis using nanoelectronic circuits 有权
标题翻译：使用纳米电子电路进行分子分析的方法和装置
公开(公告)号：US20060275778A1
公开(公告)日：2006-12-07
申请号：US11144586
申请日：2005-06-03
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Philip Kuekes
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Philip Kuekes
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y10/00 , G01N27/414
摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.
摘要翻译：公开了用于检测生物聚合物的组成部分的装置和方法。分子分析装置包括分子传感器和分子引导件。分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。分子传感器产生响应于相互作用的电子效应。分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

13. 发明申请

US20120107569A1 PREVENTING ADHESION BETWEEN NANOSTRUCTURES 有权
标题翻译：防止纳米结构之间的粘合
公开(公告)号：US20120107569A1
公开(公告)日：2012-05-03
申请号：US12916239
申请日：2010-10-29
申请人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
发明人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
IPC分类号： B32B3/30 , B05D3/06 , B05D3/02 , B05D1/36 , B05D3/00
CPC分类号： G01N21/658 , B81B3/0005 , Y10T428/24355 , Y10T428/24612
摘要： A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.
摘要翻译：用于表面增强拉曼散射（SERS）的器件。该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。低摩擦膜是为了防止多个纳米结构之间的粘附。

14. 发明申请

US20070252982A1 Raman signal-enhancing structures and devices 有权
标题翻译：拉曼信号增强结构和器件
公开(公告)号：US20070252982A1
公开(公告)日：2007-11-01
申请号：US11413910
申请日：2006-04-28
申请人： Shih-Yuan Wang , R. Williams , Raymond Beausoleil , Theodore Kamins , Zhiyong Li , Wei Wu
发明人： Shih-Yuan Wang , R. Williams , Raymond Beausoleil , Theodore Kamins , Zhiyong Li , Wei Wu
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01J3/44
摘要： Raman systems include a radiation source, a radiation detector, and a Raman device or signal-enhancing structure. Raman devices include a tunable resonant cavity and a Raman signal-enhancing structure coupled to the cavity. The cavity includes a first reflective member, a second reflective member, and an electro-optic material disposed between the reflective members. The electro-optic material exhibits a refractive index that varies in response to an applied electrical field. Raman signal-enhancing structures include a substantially planar layer of Raman signal-enhancing material having a major surface, a support structure extending from the major surface, and a substantially planar member comprising a Raman signal-enhancing material disposed on an end of the support structure opposite the layer of Raman signal-enhancing material. The support structure separates at least a portion of the planar member from the layer of Raman signal-enhancing material by a selected distance of less than about fifty nanometers.
摘要翻译：拉曼系统包括辐射源，辐射检测器和拉曼器件或信号增强结构。拉曼器件包括耦合到空腔的可调谐谐振腔和拉曼信号增强结构。空腔包括第一反射构件，第二反射构件和设置在反射构件之间的电光材料。电光材料表现出响应于所施加的电场而变化的折射率。拉曼信号增强结构包括具有主表面的基本平坦的拉曼信号增强材料层，从主表面延伸的支撑结构和包括设置在支撑结构的端部上的拉曼信号增强材料的基本上平面的构件与拉曼信号增强材料层相对。支撑结构将平面构件的至少一部分与拉曼信号增强材料层分开小于约五十纳米的选定距离。

15. 发明申请

US20070035717A1 Contact lithography apparatus, system and method 审中-公开
标题翻译：接触光刻设备，系统和方法
公开(公告)号：US20070035717A1
公开(公告)日：2007-02-15
申请号：US11580621
申请日：2006-10-13
申请人： Wei Wu , Shih-Yuan Wang , Zhiyong Li , Robert Walmsley
发明人： Wei Wu , Shih-Yuan Wang , Zhiyong Li , Robert Walmsley
IPC分类号： G03B27/02
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G03F7/7035
摘要： A contact lithography system includes a patterning tool bearing a pattern; a substrate chuck for chucking a substrate to receive the pattern from the patterning tool; where the system deflects a portion of either the patterning tool or the substrate to bring the patterning tool and a portion of the substrate into contact; and a stepper for repositioning either or both of the patterning tool and substrate to align the pattern with an additional portion of the substrate to also receive the pattern. A method of performing contact lithography comprising: deflecting a portion of either a patterning tool or a substrate to bring the patterning tool and a portion of the substrate into contact; and repositioning either or both of the patterning tool and substrate to align a pattern on the patterning tool with an additional portion of the substrate to also receive the pattern.
摘要翻译：接触光刻系统包括具有图案的图案形成工具; 用于夹持基板以从图案形成工具接收图案的基板卡盘; 其中所述系统使所述图案化工具或所述衬底的一部分偏转以使所述图案形成工具和所述衬底的一部分接触; 以及步进器，用于重新定位图案形成工具和衬底中的一个或两个，以使图案与衬底的附加部分对准以也接收图案。一种执行接触光刻的方法，包括：使图案形成工具或衬底的一部分偏转以使所述图案化工具和所述衬底的一部分接触; 以及重新定位所述图案形成工具和衬底中的一个或两个，以将所述图案形成工具上的图案与所述衬底的附加部分对准以也接收所述图案。

16. 发明申请

US20060164636A1 Integrated modular system and method for enhanced Raman spectroscopy 有权
标题翻译：用于增强拉曼光谱的集成模块化系统和方法
公开(公告)号：US20060164636A1
公开(公告)日：2006-07-27
申请号：US11044676
申请日：2005-01-27
申请人： M. Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Williams
发明人： M. Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Williams
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01J3/44 , H01L31/02325 , H01L31/105
摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed on the substrate or apart from the substrate. The molecular analysis device also include a radiation receiver disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.
摘要翻译：公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。拉曼增强结构可以设置在基板上或者离开基板。分子分析装置还包括设置在基板上并被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射的辐射接收器。

17. 发明授权

US08665432B2 Apparatus for performing SERS 有权
标题翻译：用于执行SERS的装置
公开(公告)号：US08665432B2
公开(公告)日：2014-03-04
申请号：US12915148
申请日：2010-10-29
申请人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
发明人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
IPC分类号： G01N21/65
CPC分类号： G01J3/44 , G01N21/658
摘要： An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.
摘要翻译：用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

18. 发明授权

US08208137B2 Molecule detection using Raman light detection 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US08208137B2
公开(公告)日：2012-06-26
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

19. 发明申请

US20120105841A1 APPARATUS FOR PERFORMING SERS 有权
标题翻译：执行人员的设备
公开(公告)号：US20120105841A1
公开(公告)日：2012-05-03
申请号：US12915148
申请日：2010-10-29
申请人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
发明人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658
摘要： An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.
摘要翻译：用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

20. 发明申请

US20120092660A1 APPARATUS FOR PERFORMING SERS 有权
标题翻译：执行人员的设备
公开(公告)号：US20120092660A1
公开(公告)日：2012-04-19
申请号：US12905891
申请日：2010-10-15
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Michael Josef Stuke , Lars Helge Thylen , Fung Suong Ou , Min Hu
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.
摘要翻译：用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中纳米手指以阵列排列在基板上。该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层，手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

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