专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20070198087A1 Methods and Devices for Rotator Cuff Repair 有权
标题翻译：旋转器袖带修复的方法和装置
公开(公告)号：US20070198087A1
公开(公告)日：2007-08-23
申请号：US11671102
申请日：2007-02-05
申请人： Struan Coleman , David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
发明人： Struan Coleman , David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
IPC分类号： A61F2/08 , A61F5/00 , A61B17/04
CPC分类号： A61F2/08 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0642 , A61B2017/00893 , A61L27/18 , A61L2430/10 , C08L67/04
摘要： Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscipiclly, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti-adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The device are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
摘要翻译：已经开发了用于肌腱和韧带修复的包括肩袖修复的插入和增大装置以及使用关节镜方法进行递送的方法。所述装置优选衍生自生物相容性聚羟基链烷酸酯，优选衍生自4-羟基丁酸酯的共聚物或均聚物。这些装置可以被关节镜递送，并提供额外的益处，例如支持手术修复，高初始强度，在体内延长的强度保持力，柔韧性，抗粘连性，改善的生物相容性，体内重塑健康组织的能力，最小化疾病传播的风险或增强感染的选择，包括足够高的强度的选项，以防止缝合线拔出或植入装置的其他脱离，最终吸收消除异物反应的未来风险或干扰后续程序，竞争性成本，长期机械稳定性。该装置还特别适用于儿科人群，其最终吸收不应阻碍生长。

12. 发明申请

US20110318395A1 POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS 有权
标题翻译：聚羟基烷基酯医用纺织品和纤维
公开(公告)号：US20110318395A1
公开(公告)日：2011-12-29
申请号：US13228056
申请日：2011-09-08
申请人： David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
发明人： David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
IPC分类号： A61K9/00 , A61K35/12 , A61K35/34 , A61K35/36 , A61K35/38 , A61B17/03 , A61K35/30 , D03D15/00 , D03D19/00 , D04H13/00 , D04C1/00 , C08G63/06 , A61K35/32
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04
摘要： Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
摘要翻译：已经开发了具有延长的强度保持性的可吸收聚酯纤维，辫子和外科网。这些装置优选衍生自生物相容性共聚物或4-羟基丁酸酯的均聚物。这些装置提供比目前可获得的更广泛的体内强度保留性能，并且可以提供额外的益处，例如抗粘附性能，降低的感染风险或由吸收和最终消除装置而产生的其他手术后问题，以及有竞争力的成本。这些装置还可以特别适用于儿科人群，其吸收不应阻碍生长，并在所有患者群体中提供长期机械稳定性的伤口愈合。所述装置可以另外与自体，同种异体和/或异种组织组合，以提供具有改进的机械，生物和处理性质的植入物。

13. 发明授权

US08034270B2 Polyhydroxyalkanoate medical textiles and fibers 有权
标题翻译：聚羟基链烷酸酯医用纺织品和纤维
公开(公告)号：US08034270B2
公开(公告)日：2011-10-11
申请号：US10835926
申请日：2004-04-30
申请人： David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
发明人： David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
IPC分类号： D01D5/088 , D01D5/16 , D01F6/62 , D02G3/02
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04
摘要： Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
摘要翻译：已经开发了具有延长的强度保持性的可吸收聚酯纤维，辫子和外科网。这些装置优选衍生自生物相容性共聚物或4-羟基丁酸酯的均聚物。这些装置提供比目前可获得的更广泛的体内强度保留性能，并且可以提供额外的益处，例如抗粘附性能，降低的感染风险或由吸收和最终消除装置而产生的其他手术后问题，以及有竞争力的成本。这些装置还可以特别适用于儿科人群，其吸收不应阻碍生长，并在所有患者群体中提供长期机械稳定性的伤口愈合。所述装置可以另外与自体，同种异体和/或异种组织组合，以提供具有改进的机械，生物和处理性质的植入物。

14. 发明申请

US20120150285A1 MEDICAL DEVICES CONTAINING DRY SPUN NON-WOVENS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含有聚-4-羟基丁酸酯和共聚物的干性非纺织物的医疗装置
公开(公告)号：US20120150285A1
公开(公告)日：2012-06-14
申请号：US13160942
申请日：2011-06-15
申请人： Ryan Cahil , Kai Guo , David P. Martin , Said Rizk
发明人： Ryan Cahil , Kai Guo , David P. Martin , Said Rizk
IPC分类号： A61F2/06 , D04H13/00
CPC分类号： D04H1/4382 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , A61L2300/00 , D04H1/42 , D04H1/435 , D04H1/56 , D04H3/16 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 μm to 50 μm, and thickness from 10 μm to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01 μm to 50 μm, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下性质的一种或多种的可吸收聚合干纺非织造物的连续加工方法：高破裂强度，平均直径为0.01μm至50μm的细纤维，以及10μm至10mm的厚度。通过在卷材收集过程中控制无纺布纤维的粘性，可以改善纤维内聚力。聚合物优选为聚羟基链烷酸酯，更优选为4-羟基丁酸酯聚合物或共聚物。聚-4-羟基丁酸酯的无纺布是最优选的。无纺布具有平均直径范围为0.01μm至50μm的细纤维，并通过干纺处理得到，其中将聚合物溶液注入到高速空气流中，压力为1至 500 psi用于溶剂剥离和聚合物链衰减。无纺布可以用于各种目的，包括制造医疗装置。

15. 发明授权

US08747468B2 Coatings for the manufacture and application of polyhydroxyalkanoate medical devices 有权
标题翻译：用于制造和应用聚羟基链烷酸酯医疗器械的涂料
公开(公告)号：US08747468B2
公开(公告)日：2014-06-10
申请号：US13070211
申请日：2011-03-23
申请人： David P. Martin , Said Rizk , Jon I. Montcrieff , Dennis W. Connelly
发明人： David P. Martin , Said Rizk , Jon I. Montcrieff , Dennis W. Connelly
IPC分类号： A61F2/12 , D03D15/00 , B29C47/00
CPC分类号： A61F2/0063 , A61B17/04 , A61F2/12 , A61L17/105 , A61L17/145 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , D01D5/096 , D01F6/625 , D01G99/005 , D04C1/06 , D04C1/12 , D06L1/12 , D06L1/14 , D06M10/025 , D06M15/15 , D06M15/333 , D06M15/53 , D06M2200/40 , D10B2509/04 , Y10T428/2967 , Y10T428/298 , C08L67/04
摘要： Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures.
摘要翻译：已经开发了可应用于聚羟基链烷酸酯（PHA）聚合物的生物相容性涂层和旋涂，以及由PHA聚合物制成的医疗装置。涂层赋予PHA聚合物更好的润滑性，特别是由这些材料制成的纤维和辫子，使涂料成为医疗设备如PHA编织缝线的理想选择。旋涂可用于PHA纤维，以促进其制造，也可用于将其转化为其他产品，包括医用纺织品。纺丝整理用于保护复丝纤维束，并且在挤出之后保持它们完整，并且还赋予纤维束和单丝纤维润滑性，使得它们在随后的加工步骤中特别是在纺织加工中不被损坏。涂层减少例如编织缝线的组织阻力。

16. 发明申请

US20120053689A1 COATINGS FOR THE MANUFACTURE AND APPLICATION OF POLYHYDROXYALKANOATE MEDICAL DEVICES 有权
标题翻译：聚羟基烷酸酯医疗器械的制造和应用涂料
公开(公告)号：US20120053689A1
公开(公告)日：2012-03-01
申请号：US13070211
申请日：2011-03-23
申请人： David P. Martin , Said Rizk , Jon I. Montcrieff , Dennis W. Connelly
发明人： David P. Martin , Said Rizk , Jon I. Montcrieff , Dennis W. Connelly
IPC分类号： A61F2/12 , D03D15/00 , B29C47/00 , B29C70/22 , A61B17/04 , D02G3/02 , D02G3/36
CPC分类号： A61F2/0063 , A61B17/04 , A61F2/12 , A61L17/105 , A61L17/145 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , D01D5/096 , D01F6/625 , D01G99/005 , D04C1/06 , D04C1/12 , D06L1/12 , D06L1/14 , D06M10/025 , D06M15/15 , D06M15/333 , D06M15/53 , D06M2200/40 , D10B2509/04 , Y10T428/2967 , Y10T428/298 , C08L67/04
摘要： Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures.
摘要翻译：已经开发了可应用于聚羟基链烷酸酯（PHA）聚合物的生物相容性涂层和旋涂，以及由PHA聚合物制成的医疗装置。涂层赋予PHA聚合物更好的润滑性，特别是由这些材料制成的纤维和辫子，使涂料成为医疗设备如PHA编织缝线的理想选择。旋涂可用于PHA纤维，以促进其制造，也可用于将其转化为其他产品，包括医用纺织品。纺丝整理用于保护复丝纤维束，并且在挤出之后保持它们完整，并且还赋予纤维束和单丝纤维润滑性，使得它们在随后的加工步骤中特别是在纺织加工中不被损坏。涂层减少例如编织缝线的组织阻力。

17. 发明申请

US20110190866A1 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
标题翻译：聚合，可降解药水和涂层
公开(公告)号：US20110190866A1
公开(公告)日：2011-08-04
申请号：US13057974
申请日：2009-07-17
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
IPC分类号： A61F2/84 , A61F2/82 , B05D7/00
CPC分类号： A61L31/18 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/606 , C08L67/04
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或脱胶的情况下扩展，并且可以用作药物掺入的涂层基质。

18. 发明授权

US07179883B2 Medical devices and applications of polyhydroxyalkanoate polymers 有权
标题翻译：聚羟基链烷酸酯聚合物的医疗装置和应用
公开(公告)号：US07179883B2
公开(公告)日：2007-02-20
申请号：US11020896
申请日：2004-12-22
申请人： Simon F. Williams , David P. Martin , Frank A. Skraly
发明人： Simon F. Williams , David P. Martin , Frank A. Skraly
IPC分类号： C08G63/08
CPC分类号： A61L27/58 , A61F2/07 , A61F2210/0004 , A61K31/715 , A61L17/12 , A61L27/18 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/00 , C08G63/06 , C08J9/26 , C08J2201/0444 , C08J2201/0482 , C08J2367/04 , C08K5/0033 , C08L67/04 , C12P7/625 , Y10S606/911
摘要： Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.
摘要翻译：由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生装置，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。聚羟基链烷酸酯可以含有由单体的混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以化学改性，以改变降解速率。聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。

19. 发明授权

US07025980B1 Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation 有权
公开(公告)号：US07025980B1
公开(公告)日：2006-04-11
申请号：US09661773
申请日：2000-09-14
申请人： Simon F. Williams , David P. Martin
发明人： Simon F. Williams , David P. Martin
IPC分类号： A61F2/02
CPC分类号： C12P7/625 , A61L27/18 , C08L67/04
摘要： Polyhydroxyalkanoate materials are provided which are suitable for repair of soft tissue, augmentation, and as viscosupplements in animals, particularly humans. The materials comprise liquid polyhydroxyalkanoate polymer compositions or polyhydroxyalkanoate microdispersions. Devices also are provided for storage and delivery of the polyhydroxyalkanoate compositions in vivo. Methods are provided for repairing or augmenting soft tissue in animals using the materials. In a preferred embodiment, the method include the steps of (a) selecting the animal soft tissue to be repaired or augmented; and (b) placing an injectable, liquid polyhydroxyalkanoate polymer or a polyhydroxyalkanoate microdispersion into the animal soft tissue, preferably using a minimally-invasive method such as injection. In another embodiment, the liquid polyhydroxyalkanoate polymer compositions or polyhydroxyalkanoate microdispersions are used as viscosupplements.

20. 发明授权

US06623730B1 Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate 有权
标题翻译：包含γ-羟基丁酸酯的聚合物和低聚物的治疗用途
公开(公告)号：US06623730B1
公开(公告)日：2003-09-23
申请号：US09661948
申请日：2000-09-14
申请人： Simon F. Williams , David P. Martin
发明人： Simon F. Williams , David P. Martin
IPC分类号： A61K31765
CPC分类号： A61K31/19 , A61K31/765
摘要： Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.
摘要翻译：提供含有GHB并在体内施用后产生GHB的低聚物和聚合物组合物。还提供了用于储存和递送这些聚合物和低聚物的装置。这些低聚物和聚合物组合物可用于各种应用中。组合物可用于治疗例如发作性睡病，慢性精神分裂症，紧张性精神分裂症，非典型精神病，慢性脑综合征，神经症，酒精中毒，药物成瘾和戒断，帕金森病和其他神经药理学疾病，高血压，缺血的患者的治疗，循环衰竭，放射线暴露，癌症和心肌梗死。组合物的其它用途包括麻醉诱导，镇静，生长激素生成，性欲升高，厌食症，欣快，平滑肌松弛，肌肉量产和睡眠，包括快速眼动睡眠。在另一个实施方案中，低聚物和聚合物可以用于产生不发作的发作。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式