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11. 发明申请

US20060114469A1 Method and system for determining the position and alignment of a surface of an object in relation to a laser beam 有权
标题翻译：用于确定物体表面相对于激光束的位置和对准的方法和系统
公开(公告)号：US20060114469A1
公开(公告)日：2006-06-01
申请号：US11271089
申请日：2005-11-12
申请人： Christopher Horvath , Ruben Zadoyan , Ferenc Raksi , Zsolt Bor , Guy Holland , Tibor Juhasz
发明人： Christopher Horvath , Ruben Zadoyan , Ferenc Raksi , Zsolt Bor , Guy Holland , Tibor Juhasz
IPC分类号： G01B9/02
CPC分类号： G01B11/272 , A61F9/008 , A61F9/00825 , A61F9/009 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , B23K26/04 , G01B9/02 , G01B11/00
摘要： The present invention generally relates to a method and system for determining the position and alignment of a plane in relation to an intersecting axis and using that known position and alignment to allow for corrections to be made when using the plane as a reference plane. More particularly, the invention relates to a method and system for determining the angle of tilt of a planar surface in relation to a laser beam, and using the determined angle of tilt to calculate a correction factor to be applied to the laser beam. Briefly stated, the method and system ultimately calculates a correction factor, z-offset, that is applied when using the laser beam in a procedure.
摘要翻译：本发明一般涉及用于确定平面相对于交叉轴线的位置和对准的方法和系统，并且使用该已知位置和对准来允许在使用该平面作为参考平面时进行校正。更具体地，本发明涉及一种用于确定平面相对于激光束的倾斜角度的方法和系统，并且使用确定的倾斜角度来计算要施加到激光束的校正因子。简而言之，该方法和系统最终计算在过程中使用激光束时应用的校正因子z偏移。

12. 发明授权

US07027233B2 Closed-loop focal positioning system and method 有权
标题翻译：闭环焦点定位系统及方法
公开(公告)号：US07027233B2
公开(公告)日：2006-04-11
申请号：US10827837
申请日：2004-04-20
申请人： Peter Goldstein , Carlos G. Suarez , Scott A. DeLong , R. K. Webb , Tibor Juhasz
发明人： Peter Goldstein , Carlos G. Suarez , Scott A. DeLong , R. K. Webb , Tibor Juhasz
IPC分类号： G02B15/14
CPC分类号： A61F9/009 , A61F9/008 , A61F9/00802 , A61F9/00825 , A61F2009/00844 , A61F2009/00855 , A61F2009/00872 , A61F2009/00891 , G02B7/10 , G02B7/28
摘要： A closed-loop focusing system and method positions a focusing assembly to a desired positioned. A feedback positioning device, such as a linear encoder, provides an actual or “read” value for the linear movement of the focusing assembly. The desired position is compared to the actual position of the focusing assembly. If the two values are outside of a predetermined tolerance or valid range, then an audible or visual warning will be given. When a laser source is utilized with the focusing system, laser operation will be prevented if the two values are outside of an acceptable range. However, if the difference between the desired position and the actual position are within an acceptable range, the focusing assembly is repositioned to allow real-time systematic correction of the position of the focusing assembly.
摘要翻译：闭环聚焦系统和方法将聚焦组件定位到期望的位置。诸如线性编码器的反馈定位装置为聚焦组件的线性运动提供实际或“读取”值。将所需位置与聚焦组件的实际位置进行比较。如果两个值超出了预定的公差或有效范围，则会发出声音或视觉警告。当激光源与聚焦系统一起使用时，如果两个值在可接受的范围之外，则将防止激光操作。然而，如果期望位置和实际位置之间的差在可接受的范围内，则聚焦组件被重新定位以允许对聚焦组件的位置的实时系统校正。

13. 发明授权

US06751033B2 Closed-loop focal positioning system and method 有权
标题翻译：闭环焦点定位系统及方法
公开(公告)号：US06751033B2
公开(公告)日：2004-06-15
申请号：US09976555
申请日：2001-10-12
申请人： Peter Goldstein , Carlos G. Suarez , Scott A. DeLong , R. Kyle Webb , Tibor Juhasz
发明人： Peter Goldstein , Carlos G. Suarez , Scott A. DeLong , R. Kyle Webb , Tibor Juhasz
IPC分类号： G02B702
CPC分类号： G02B7/28 , A61F9/008 , A61F9/00802 , A61F9/00825 , A61F9/009 , A61F2009/00844 , A61F2009/00855 , A61F2009/00872 , A61F2009/00891
摘要： A closed-loop focusing system and method positions a focusing assembly to a desired positioned. A feedback positioning device, such as a linear encoder, provides an actual or “read” value for the linear movement of the focusing assembly. The desired position is compared to the actual position of the focusing assembly. If the two values are outside of a predetermined tolerance or valid range, then an audible or visual warning will be given. Furthermore, when a laser source is utilized with the focusing system, then laser operation will be prevented where the two values are outside of tolerance.
摘要翻译：闭环聚焦系统和方法将聚焦组件定位到期望的位置。诸如线性编码器的反馈定位装置为聚焦组件的线性运动提供实际或“读取”值。将所需位置与聚焦组件的实际位置进行比较。如果两个值超出了预定的公差或有效范围，则会发出声音或视觉警告。此外，当与聚焦系统一起使用激光源时，在两个值超出公差的情况下，将防止激光操作。

14. 发明授权

US08845624B2 Adaptive patient interface 有权
标题翻译：自适应患者接口
公开(公告)号：US08845624B2
公开(公告)日：2014-09-30
申请号：US12824107
申请日：2010-06-25
申请人： Ferenc Raksi , Tibor Juhasz
发明人： Ferenc Raksi , Tibor Juhasz
IPC分类号： A61B18/18 , A61F9/009
CPC分类号： A61F9/009
摘要： A patient interface for an ophthalmic system can include an attachment module, attachable to the ophthalmic system, and a contact module, configured to accommodate a viscoelastic substance between the patient interface and a procedure eye. The viscoelastic substance can include a fluid, a liquid, a gel, a cream, an artificial tear, a film, an elastic material, or a viscous material. The refractive index of the viscoelastic substance can be within a range of approximately 1.24-1.52 at an operating wavelength of the ophthalmic system. The patient interface can further include input ports, output ports, and a suction system. It can be an integrated design or a multi-piece patient interface. The viscoelastic substance can be provided by injection, on the cornea, at the contact module, or in a space bounded by soft elastic films or membranes, such as in a bag.
摘要翻译：用于眼科系统的患者界面可以包括可连接到眼科系统的附接模块，以及接触模块，其构造成在患者界面和手术眼之间容纳粘弹性物质。粘弹性物质可以包括流体，液体，凝胶，霜，人造泪，膜，弹性材料或粘性材料。在眼科系统的工作波长下，粘弹性物质的折射率可以在约1.24-1.52的范围内。患者界面还可以包括输入端口，输出端口和抽吸系统。它可以是一体化设计或多片式患者界面。粘弹性物质可以通过注射，角膜，接触模块，或由柔软的弹性膜或膜（例如袋子）限定的空间来提供。

15. 发明申请

US20080082088A1 SYSTEM AND METHOD FOR RESECTING CORNEAL TISSUE 审中-公开
标题翻译：用于检查角膜组织的系统和方法
公开(公告)号：US20080082088A1
公开(公告)日：2008-04-03
申请号：US11469941
申请日：2006-09-05
申请人： Ronald M. Kurtz , Gagik Jotyan , Tibor Juhasz , Melvin A. Sarayba
发明人： Ronald M. Kurtz , Gagik Jotyan , Tibor Juhasz , Melvin A. Sarayba
IPC分类号： A61B18/18
CPC分类号： A61F2/142 , A61F9/00831 , A61F9/009 , A61F9/013 , A61F2009/00857 , A61F2009/00872
摘要： A system and method for resecting and transplanting corneal tissue is disclosed. In a recipient cornea, a resection depth from the anterior surface of the recipient cornea is determined based upon a biomechanical model of the recipient cornea. A resection incision for resecting a posterior portion of the recipient cornea is made at the resection depth. Preferably, the incision is made using a surgical laser. Optionally, a contact lens may be placed against the anterior surface of the recipient cornea, wherein the shape of the anterior surface is conformed to the shape of the contact lens.
摘要翻译：公开了一种切割和移植角膜组织的系统和方法。在受体角膜中，根据接受者角膜的生物力学模型确定来自接受者角膜前表面的切除深度。在切除深度处进行切除接受者角膜后部的切除切口。优选地，使用手术激光器进行切口。可选地，隐形眼镜可以抵靠接受者角膜的前表面放置，其中前表面的形状符合隐形眼镜的形状。

16. 发明授权

US06623476B2 Device and method for reducing corneal induced aberrations during ophthalmic laser surgery 有权
标题翻译：在眼科激光手术中减少角膜诱发畸形的装置和方法
公开(公告)号：US06623476B2
公开(公告)日：2003-09-23
申请号：US09834979
申请日：2001-04-13
申请人： Tibor Juhasz , Ronald M. Kurtz , Carlos G. Suarez
发明人： Tibor Juhasz , Ronald M. Kurtz , Carlos G. Suarez
IPC分类号： A61B1820
CPC分类号： A61F9/009 , A61F2009/00872
摘要： A disposable lens for reconfiguring the cornea of an eye for ophthalmic laser surgery includes a lens which has a flat anterior surface that is formed opposite a contact surface. A skirt surrounds the contact surface and extends outwardly therefrom to define a chamber. The skirt is formed with a groove which creates a suction channel between the skirt and the contact surface in the chamber. In its operation, the lens is positioned over the cornea and a vacuum pump is selectively activated to create a partial vacuum in the suction channel. Due to this partial vacuum, the cornea is drawn into the chamber where it is urged against the contact surface of the lens. The result of this is that the cornea is flattened into a configuration where the introduction of spherical aberration and coma into a light beam passing into the cornea is reduced or eliminated.
摘要翻译：用于重新配置用于眼科激光手术的眼睛角膜的一次性透镜包括具有与接触表面相对形成的平坦前表面的透镜。裙部围绕接触表面并从其向外延伸以限定腔室。裙部形成有凹槽，其在裙部和腔室中的接触表面之间产生吸入通道。在其操作中，透镜位于角膜上方，并且选择性地激活真空泵以在吸入通道中产生部分真空。由于这种部分真空，角膜被拉入腔室中，其被迫抵靠透镜的接触表面。其结果是，角膜被平坦化成将通过角膜的光束引入球面像差和昏迷的结构减少或消除。

17. 发明授权

US09095414B2 Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea 有权
标题翻译：非线性光学光动力疗法（NLO-PDT）的角膜
公开(公告)号：US09095414B2
公开(公告)日：2015-08-04
申请号：US13919547
申请日：2013-06-17
申请人： James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyui Chai , Moritz Winkler
发明人： James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyui Chai , Moritz Winkler
IPC分类号： A61B18/20 , A61F9/008 , A61F9/01 , A61N5/06
CPC分类号： A61F9/00802 , A61F9/008 , A61F9/00804 , A61F9/00825 , A61F2009/00872 , A61F2009/00893 , A61F2009/00895 , A61N5/062
摘要： The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.
摘要翻译：实施例包括组织的非线性光学光动力学治疗方法，包括以下步骤：为双光子激发荧光组织暴露提供脉冲红外激光，并且将聚焦平面上的组织内的脉冲红外激光选择性聚焦以激活光敏剂在组织中高度分辨的轴向和横向空间结构域内产生自由基。本发明还涉及一种用于执行包括用于提供双光子激发的荧光束组织暴露的脉冲红外激光的组织的非线性光学光学治疗的装置，用于选择性地和可控地移动组织和束相对于彼此的扫描仪，以及用于选择性地将脉冲红外激光在聚焦平面中的一个点聚焦在组织内以激活光敏剂以在组织内的高度分辨的轴向和横向空间域内产生自由基的光学元件。

18. 发明申请

US20120330291A1 NONLINEAR OPTICAL PHOTODYNAMIC THERAPY (NLO-PDT) OF THE CORNEA 审中-公开
标题翻译： CORNEA的非线性光学光电疗法（NLO-PDT）
公开(公告)号：US20120330291A1
公开(公告)日：2012-12-27
申请号：US13523058
申请日：2012-06-14
申请人： James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyul Chai , Moritz Winkler
发明人： James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyul Chai , Moritz Winkler
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00825 , A61F2009/00872 , A61F2009/00893 , A61F2009/00895
摘要： The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.
摘要翻译：实施例包括组织的非线性光学光动力学治疗方法，包括以下步骤：为双光子激发荧光组织暴露提供脉冲红外激光，并且将聚焦平面上的组织内的脉冲红外激光选择性聚焦以激活光敏剂在组织中高度分辨的轴向和横向空间结构域内产生自由基。本发明还涉及一种用于执行包括用于提供双光子激发的荧光束组织暴露的脉冲红外激光的组织的非线性光学光学治疗的装置，用于选择性地和可控地移动组织和束相对于彼此的扫描仪，以及用于选择性地将脉冲红外激光在聚焦平面中的一个点聚焦在组织内以激活光敏剂以在组织内的高度分辨的轴向和横向空间域内产生自由基的光学元件。

19. 发明申请

US20120281185A1 IMAGE-PROCESSOR-CONTROLLED MISALIGNMENT-REDUCTION FOR OPHTHALMIC SYSTEMS 有权
标题翻译：用于眼科系统的图像处理器控制的失真减少
公开(公告)号：US20120281185A1
公开(公告)日：2012-11-08
申请号：US13098586
申请日：2011-05-02
申请人： Tibor Juhasz , Ferenc Raksi , Guy Holland
发明人： Tibor Juhasz , Ferenc Raksi , Guy Holland
IPC分类号： A61B3/15
CPC分类号： G02B7/004 , A61B3/102 , A61B3/152 , G02B7/005
摘要： An ophthalmic system is provided that includes an ophthalmic imaging device to generate an image of a portion of an imaged eye of a patient, an image processor to determine a misalignment of the imaged eye and the imaging device by processing the generated image, and to generate a control signal according to the determined misalignment, and a misalignment-reduction system to receive the control signal, and to generate a misalignment-reduction response. The misalignment-reduction system can include a fixation light system or a gantry. In some cases a locator light system may provide additional alignment information for the image processor.
摘要翻译：提供了一种眼科系统，其包括眼科成像装置以产生患者的成像眼睛的一部分的图像，图像处理器，用于通过处理所生成的图像来确定成像眼睛和成像装置的未对准，并且生成根据所确定的未对准的控制信号，以及用于接收控制信号的未对准减小系统，并产生未对准减小响应。不对准减小系统可以包括固定光系统或台架。在某些情况下，定位器光系统可以为图像处理器提供附加的对准信息。

20. 发明授权

US06373571B1 Disposable contact lens for use with an ophthalmic laser system 有权
标题翻译：用于眼科激光系统的一次性隐形眼镜
公开(公告)号：US06373571B1
公开(公告)日：2002-04-16
申请号：US09266451
申请日：1999-03-11
申请人： Tibor Juhasz , Ronald M. Kurtz
发明人： Tibor Juhasz , Ronald M. Kurtz
IPC分类号： G01B1100
CPC分类号： A61F9/009 , A61B2090/3937
摘要： A device for use in laser ophthalmic surgery includes a laser system, a disposable contact lens and an adjustable retainer ring for mounting the contact lens on the laser system. In order to properly align the disposable contact lens to the laser system, reference marks on the contact lens are brought into coincidence with predetermined focal points along the laser beam paths. To this end, the laser system successively directs a laser beam along at least three predetermined paths to respective predetermined focal points, and the contact lens is positioned across these predetermined paths. Along each predetermined path, the laser beam is activated to establish a series of laser marks on the contact lens. If the laser marks, predetermined focal points and reference marks are all coincident, then the contact lens is properly aligned with the laser system. If there is any displacement between any laser mark and reference mark, however, the retainer ring is adjusted to align all reference marks with all predetermined focal points to align the lens to the laser system.
摘要翻译：用于激光眼科手术的装置包括激光系统，一次性隐形眼镜和用于将隐形眼镜安装在激光系统上的可调保持环。为了将一次性隐形眼镜适当地对准激光系统，隐形眼镜上的参考标记与沿着激光束路径的预定焦点一致。为此，激光系统将激光束沿着至少三个预定路径连续地引导到相应的预定焦点，并且隐形眼镜定位在这些预定路径上。沿着每个预定路径，激光束被激活以在隐形眼镜上建立一系列激光标记。如果激光标记，预定焦点和参考标记全部重合，则隐形眼镜与激光系统正确对准。然而，如果在任何激光标记和参考标记之间存在任何位移，则调节保持环以将所有参考标记与所有预定的焦点对准，以将透镜对准激光系统。

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