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1. 发明申请

US20130338650A1 NONLINEAR OPTICAL PHOTODYNAMIC THERAPY (NLO-PDT) OF THE CORNEA 有权
公开(公告)号：US20130338650A1
公开(公告)日：2013-12-19
申请号：US13919547
申请日：2013-06-17
申请人： James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyui Chai , Moritz Winkler
发明人： James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyui Chai , Moritz Winkler
IPC分类号： A61F9/008
CPC分类号： A61F9/00802 , A61F9/008 , A61F9/00804 , A61F9/00825 , A61F2009/00872 , A61F2009/00893 , A61F2009/00895 , A61N5/062
摘要： The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.

2. 发明申请

US20090285892A1 METHODS AND SYSTEMS FOR EXPANDING AC133+ CELLS AND DIRECTING DIFFERENTIATION 失效
标题翻译：用于扩增AC133 +细胞和指导差异的方法和系统
公开(公告)号：US20090285892A1
公开(公告)日：2009-11-19
申请号：US12351630
申请日：2009-01-09
申请人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin Mclntosh , Hiranmoy Das , Yukang Zhao
发明人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin Mclntosh , Hiranmoy Das , Yukang Zhao
IPC分类号： A61K9/00 , A61K35/12 , C12N5/08 , C12N5/06 , C12M1/00
CPC分类号： C12N5/0075 , A61K2035/124 , B82Y5/00 , B82Y30/00 , C12N5/0641 , C12N5/0647 , C12N5/069 , C12N5/0691 , C12N2500/25 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2506/11 , C12N2510/02 , C12N2533/30
摘要： The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.
摘要翻译：本发明尤其提供用于扩展CD133 +细胞的方法和系统。本发明进一步提供用于增加有需要的受试者（例如缺血性心肌）中缺血组织的血流量的方法和系统。本发明还提供了用于指导扩增的CD133 +细胞分化的方法和系统。本发明还提供了在有需要的受试者中用分化细胞治疗受试者的方法和系统。

3. 发明授权

US06298754B1 Wrench for firefighters 失效
标题翻译：消防员扳手
公开(公告)号：US06298754B1
公开(公告)日：2001-10-09
申请号：US09426026
申请日：1999-10-25
申请人： Donald J. Brown
发明人： Donald J. Brown
IPC分类号： B25B1300
CPC分类号： B25B13/48
摘要： A wrench tool suitable for use by firefighting personnel. The tool has an elongated handle, and a spanner part at a first end of the handle. The spanner part has a projecting claw for operatively engaging a pin on the circumference of a pipe or a hose coupling ring to be rotated by the tool. A wrench part, at a second end of the tool handle opposite the first end, has jaws arranged for adjustable relative movement to grip an object to be turned by the tool. The range of movement of the jaws includes a position at which the jaws are set to receive and safely grip an outside levering tool for producing increased leverage when operating the spanner part of the tool.
摘要翻译：适用于消防人员的扳手工具。该工具具有细长的把手和在手柄的第一端的扳手部分。扳手部分具有突出的爪，用于可操作地接合管的圆周上的销或由工具旋转的软管接合环。扳手部分在工具手柄的与第一端相对的第二端处具有布置成用于可调节的相对运动的夹爪，以夹持由工具转动的物体。夹爪的运动范围包括一个位置，在该位置处，夹钳被设置成接收并安全地夹紧外部杠杆工具，以在操作工具的扳手部分时产生增加的杠杆作用。

4. 发明授权

US4152852A Transparency viewer assembly 失效
标题翻译：透明度查看器组件
公开(公告)号：US4152852A
公开(公告)日：1979-05-08
申请号：US868984
申请日：1978-01-12
申请人： Donald J. Brown
发明人： Donald J. Brown
IPC分类号： G02B27/02
CPC分类号： G02B27/024
摘要： A pair of illuminated transparency viewers may be mounted on a supporting frame assembly so that one viewer generally provides a horizontally oriented viewing surface and the other viewer generally provides a vertically oriented viewing surface. The frame assembly includes a base portion adapted to receive the legs of one of the viewers and an upright portion adapted to receive the legs of the other viewer. The base portion and the upright portion each have a U-shaped cross section to define an open channel into which the respective legs of the viewers are inserted and secured by appropriate means. Two frame assemblies are utilized to mount the viewers which have two leg assemblies, each of which, in turn, has a leg pivotally mounted for movement between retracted and extended positions.
摘要翻译：一对照明的透明度观察器可以安装在支撑框架组件上，使得一个观察者通常提供水平定向的观察表面，而另一个观察者通常提供垂直定向的观察表面。框架组件包括适于接纳观看者中的一个的腿的基部和适于接收另一观看者的腿的直立部分。基部和直立部分各自具有U形横截面以限定开放通道，观察者的相应腿部通过适当的装置插入并固定到该通道中。使用两个框架组件来安装具有两个腿组件的观察者，每个腿组件又具有枢转地安装用于在缩回位置和伸展位置之间移动的腿部。

5. 发明授权

US4072404A Control mechanism for positioning projection screen in closed position 失效
标题翻译：定位投影屏幕处于关闭位置的控制机构
公开(公告)号：US4072404A
公开(公告)日：1978-02-07
申请号：US647870
申请日：1976-01-09
申请人： Donald J. Brown
发明人： Donald J. Brown
IPC分类号： G03B21/58 , G03B21/56 , A47G5/02 , A47H1/00
CPC分类号： G03B21/58
摘要： A projection screen apparatus includes an elongate roller, a flexible screen which is wound on the roller when it is in a closed position and unwound from the roller when it is in an exposed position, an electric drive motor connected to the roller for rotating the roller to move the screen between exposed and closed positions, a first switch for actuating the drive motor to move the screen toward a closed position, and a second switch for stopping the drive motor and the roller when the screen is in a fully closed position. A free marginal end portion of the screen engages a lever which moves the second switch to an inoperative position to interrupt the electric circuit leading to the drive motor.
摘要翻译：投影屏幕装置包括细长的滚筒，柔性屏幕，当它处于关闭位置时被卷绕在滚筒上并且当它处于暴露位置时从滚筒展开;连接到滚轮的电动驱动马达用于旋转滚筒将屏幕在曝光和关闭位置之间移动，用于致动驱动电动机以使屏幕朝向关闭位置移动的第一开关，以及当屏幕处于完全关闭位置时用于停止驱动电动机和辊的第二开关。屏幕的自由边缘端部与将第二开关移动到不工作位置的杠杆接合以中断通向驱动马达的电路。

6. 发明授权

US08669106B2 Erythrocytes differentiated in vitro from nanofiber expanded CD133+ cells 失效
标题翻译：体外从纳米纤维扩增的CD133 +细胞分化的红细胞
公开(公告)号：US08669106B2
公开(公告)日：2014-03-11
申请号：US12351630
申请日：2009-01-09
申请人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin McIntosh , Hiranmoy Das , Yukang Zhao
发明人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin McIntosh , Hiranmoy Das , Yukang Zhao
IPC分类号： C12N5/00
CPC分类号： C12N5/0075 , A61K2035/124 , B82Y5/00 , B82Y30/00 , C12N5/0641 , C12N5/0647 , C12N5/069 , C12N5/0691 , C12N2500/25 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2506/11 , C12N2510/02 , C12N2533/30
摘要： The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.
摘要翻译：本发明尤其提供用于扩展CD133 +细胞的方法和系统。本发明进一步提供用于增加有需要的受试者（例如缺血性心肌）中缺血组织的血流量的方法和系统。本发明还提供了用于指导扩增的CD133 +细胞分化的方法和系统。本发明还提供了在有需要的受试者中用分化细胞治疗受试者的方法和系统。

7. 发明授权

US4232487A Abrading device 失效
标题翻译：磨损装置
公开(公告)号：US4232487A
公开(公告)日：1980-11-11
申请号：US909537
申请日：1978-05-25
申请人： Donald J. Brown
发明人： Donald J. Brown
IPC分类号： B24C3/06 , B24C5/02 , B24C7/00
CPC分类号： B24C5/02 , B24C3/065
摘要： An abrasive surface treating device includes a gun connected to a pressurized air source, a housing containing a supply of abrasive material, an abrasive delivery line connected to the gun and having an aperture adjacent the housing outlet, a shroud to capture spent abrasive, and a vacuum source to draw spent abrasive and debris from the shroud back to the interior of the housing. The delivery of air at high velocity through the gun draws air through the abrasive delivery line via the aperture and thereby draws abrasive from the housing into the air stream flowing from the aperture to the gun so that the abrasive may be propelled against a work surface. The effective size of the aperture may be changed to alter the flow rate of various abrasive materials. In addition, the gun and abrasive delivery line may be connected to an adapter which, in turn, receives a shroud member having a configuration selected in accordance with the shape of the work surface.
摘要翻译：研磨表面处理装置包括连接到加压空气源的枪，包含磨料的供应的壳体，连接到枪的磨料输送管线和邻近壳体出口的孔，用于捕获废磨料的护罩和真空源将废旧的磨料和碎屑从护罩上回到壳体的内部。通过喷枪高速输送空气将空气通过研磨剂输送管线通过孔，从而将研磨剂从壳体吸入从孔到喷枪的气流中，使得磨料可以被推向工作表面。可以改变孔径的有效尺寸以改变各种磨料的流速。另外，喷枪和磨料输送管线可以连接到适配器，该适配器又接收具有根据工作表面的形状选择的配置的护罩构件。

8. 发明授权

US4169658A Picture screen 失效
标题翻译：图片屏幕
公开(公告)号：US4169658A
公开(公告)日：1979-10-02
申请号：US871960
申请日：1978-01-24
申请人： Donald J. Brown
发明人： Donald J. Brown
IPC分类号： G03B21/58 , G03B21/56
CPC分类号： G03B21/58
摘要： A picture screen comprising an upright standard, a leg unit supporting the standard, a roller adapted to receive a picture screen, a picture screen mounted on the roller and adapted to be unwound from a closed position to an open position, an elongated screen casing for receiving the roller and the screen coupled to the upright standard, and casing extensions integrally formed with the screen casing and each being provided with a speaker mounted therein. The speakers project the sound toward the viewer/listener to provide a lifelike effect with the picture projected on the screen.
摘要翻译：一种包括直立标准的图像屏幕，支撑该标准的支腿单元，适于接收图像屏幕的滚筒，安装在滚筒上并适于从关闭位置退绕到打开位置的图像屏幕，用于接收滚筒和连接到直立标准的屏幕，以及与屏幕壳体整体形成的壳体延伸部，并且每个设置有安装在其中的扬声器。扬声器将声音投射到观看者/收听者，以便在屏幕上投射的图像提供逼真的效果。

9. 发明授权

US4395850A Adapter device for tools of an abrasive blasting system 失效
标题翻译：用于喷砂系统工具的适配器
公开(公告)号：US4395850A
公开(公告)日：1983-08-02
申请号：US203717
申请日：1980-11-03
申请人： Donald J. Brown
发明人： Donald J. Brown
IPC分类号： B24C3/06 , B24C5/02 , B24C5/04
CPC分类号： B24C5/02 , B24C3/065
摘要： A surface treating adapter device for use in combination with a recirculating abrading device includes an adapter housing affording a hollow cup-shaped chamber, an aperture in the housing to receive the discharge nozzle of an abrasive gun, an exhaust outlet including means for detachably engaging a low pressure line from the abrading device, interchangeable hollow working tool members, and tubular connecting members releasably and adjustably joining the adapter housing and a selected one of the tool members. The tool members which contact the surface to be abraded are each of varying configuration for accommodating surfaces of varying contour and for making a sealing engagement therewith. The abrading operation is performed within the confines of the tool member being used. Abrasive is introduced through the housing aperture and impinges upon the surface area enclosed by the tool member. The scale and debris, including the spent abrasive, are then drawn through the chamber of the housing and through the exhaust outlet to the abrading device, and there separated.
摘要翻译：一种与再循环研磨装置组合使用的表面处理适配器装置包括：适配器壳体，其提供中空杯状室;壳体中的开口，用于容纳研磨枪的排出喷嘴;排气口，包括用于可拆卸地接合研磨装置的低压管线，可互换的中空加工工具构件和可释放地并可调节地连接适配器壳体和所选择的一个工具构件的管状连接构件。接触被磨削表面的工具构件各自具有不同的构造，用于容纳变化轮廓的表面并与其形成密封接合。在所使用的工具构件的范围内执行研磨操作。研磨剂通过壳体孔引入并撞击在由工具构件包围的表面区域上。然后，包括废磨料的氧化皮和碎屑通过壳体的腔室并通过排气出口被吸入研磨装置，并且分离。

10. 发明授权

US4375740A Portable abrading cabinet device for recycling abrasive blasting system 失效
标题翻译：用于回收喷砂系统的便携式研磨柜装置
公开(公告)号：US4375740A
公开(公告)日：1983-03-08
申请号：US203714
申请日：1980-11-03
申请人： Donald J. Brown
发明人： Donald J. Brown
IPC分类号： B24C3/06 , B24C5/02
CPC分类号： B24C3/065 , B24C5/02
摘要： A portable abrading cabinet device is provided for use in a recycling abrasive blasting system. The cabinet device includes a cup-shaped housing affording an inner blasting chamber. The forward open end of the housing has a peripheral resilient seal to provide airtight engagement with the surface to be abraded. The housing has an inlet aperture for the barrel of a sand blasting gun which delivers rapidly moving abrasive material to the surface to be worked. A funnel-shaped exhaust means in the housing terminates in a fitting which detachably receives a conduit connected to accommodate an external source of vacuum so that spent abrasive and debris may be removed from the inner blasting chamber of the cabinet housing. A transparent window member in the housing permits an operator to observe the abrading operation, the window member being partially shielded by a pair of deflectors which redirect ricocheting abrasive and debris within the cabinet housing. To further aid the observation of the operation, illuminating means are provided within the cabinet. The abrasive is introduced into, and recycled from, the cabinet housing by an appropriate external blasting system.
摘要翻译：提供了一种便携式研磨柜装置，用于回收磨料喷砂系统。橱柜装置包括一个提供内部爆破室的杯形壳体。壳体的前开口端具有外围的弹性密封件，以与待磨损的表面提供气密接合。壳体具有用于喷砂枪的枪管的入口孔，其将快速移动的研磨材料输送到待加工的表面。壳体中的漏斗形排气装置终止于可拆卸地接收连接以适应外部真空源的导管的配件，从而可以将废磨料和碎屑从机壳外壳的内部喷射室移除。壳体中的透明窗构件允许操作者观察研磨操作，窗构件被一对偏转器部分地屏蔽，所述导向器将壳体内的磨料和碎屑重新引导。为了进一步帮助观察操作，在机柜内提供照明装置。研磨剂通过适当的外部爆破系统引入机柜外壳并从其再循环。

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