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11. 发明授权

US07928227B2 2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效
标题翻译：可用于治疗高增殖性，血管生成和炎症性疾病的2-氧代-1,3,5-三氢三氮杂衍生物
公开(公告)号：US07928227B2
公开(公告)日：2011-04-19
申请号：US10788405
申请日：2004-03-01
申请人： Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人： Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号： C07D251/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/53 , A61P19/02
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

12. 发明申请

US20100016295A1 Preparation and Use of Biphenyl Amino Acid Derivatives for the Treatment of Obesity 审中-公开
标题翻译：联苯氨基酸衍生物治疗肥胖症的制备与应用
公开(公告)号：US20100016295A1
公开(公告)日：2010-01-21
申请号：US11989506
申请日：2006-07-31
申请人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号： A61K31/198 , C07D211/60 , A61P3/04 , A61K31/44 , C07C229/02 , C07D207/00 , A61K31/40 , C07D261/18 , A61K31/42 , C07D307/00 , A61K31/34 , C07D209/42 , C07D279/12 , A61K31/54 , C07D265/30 , A61K31/5375 , C07D241/04 , A61K31/4965
CPC分类号： C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要： This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些联苯氨基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。

13. 发明授权

US07235576B1 Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors 有权
标题翻译： ω-羧基芳基取代的二苯脲作为raf激酶抑制剂
公开(公告)号：US07235576B1
公开(公告)日：2007-06-26
申请号：US10042203
申请日：2002-01-11
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号： A61K31/17 , A61K31/44 , C07D213/30 , C07C275/18 , C07C275/34
CPC分类号： C07D209/48 , C07D213/75 , C07D213/81 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译：本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。

14. 发明授权

US06960601B2 Preparation and use of imidazole derivatives for treatment of obesity 失效
公开(公告)号：US06960601B2
公开(公告)日：2005-11-01
申请号：US10255049
申请日：2002-09-24
申请人： Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
发明人： Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC分类号： A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/445
CPC分类号： C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
摘要： This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

15. 发明授权

US06919371B2 2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译：用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物
公开(公告)号：US06919371B2
公开(公告)日：2005-07-19
申请号：US10666903
申请日：2003-09-17
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译：本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。

16. 发明授权

US5646876A Method and apparatus for reducing rounding error when evaluating binary floating point polynomials 失效
标题翻译：评估二进制浮点多项式时减少舍入误差的方法和装置
公开(公告)号：US5646876A
公开(公告)日：1997-07-08
申请号：US424032
申请日：1995-04-18
申请人： Roger A. Smith
发明人： Roger A. Smith
IPC分类号： G06F7/552 , G06F7/38
CPC分类号： G06F7/552 , G06F2207/5523 , G06F7/483 , G06F7/49947
摘要： Rounding error can be reduced when evaluating binary floating point polynomials utilizing a Floating Point Unit (58) by first computing the sum of products of second and higher order polynomial terms. Next, the Floating Point Unit (58) adds a zero.sup.th level term to the product of a first order coefficient and an independent variable to form a "Big" term. The Floating Point Unit (58) calculates as a "Little" term the rounding error resulting from the computation of the "Big" term. The "Little" term is then added to the sum of products of higher order terms to form an "Intermediate" term. Finally, the Floating Point Unit (58) adds the "Big" term to the "Intermediate" term to form the polynomial result corrected by the rounding error introduced by the computation of the low order terms.
摘要翻译：当使用浮点单元（58）评估二进制浮点多项式时，首先计算第二和更高阶多项式项的乘积之和，可以减少舍入误差。接下来，浮点单元（58）将零级水平项添加到一阶系数和独立变量的乘积以形成“大”项。浮点单元（58）计算出由“大”项计算产生的舍入误差的“小”项。然后将“小”术语加到高阶项的总和中以形成“中级”术语。最后，浮点单元（58）将“大”项添加到“中间”项，形成通过计算低阶项引入的舍入误差校正的多项式结果。

17. 发明授权

US09647454B2 Methods and apparatus for determining conditions of power lines 有权
公开(公告)号：US09647454B2
公开(公告)日：2017-05-09
申请号：US13546689
申请日：2012-07-11
申请人： Muhammad A. Afzal , Venkat Pothamsetty , Roger A. Smith , Rebecca W. Ross
发明人： Muhammad A. Afzal , Venkat Pothamsetty , Roger A. Smith , Rebecca W. Ross
IPC分类号： H02J3/00 , H02J13/00 , G01R15/14
CPC分类号： H02J3/00 , G01R15/142 , H02J13/00 , H02J2003/001 , H02J2003/007 , Y02E60/74 , Y02E60/76 , Y04S10/30 , Y04S10/525 , Y04S40/22
摘要： Techniques for determining conditions of power lines in a power distribution system based on measurements collected by a plurality of sensor units deployed in the power distribution system. Techniques include obtaining first transformed data associated with a first set of one or more measurements collected by a first sensor unit in the plurality of sensor units and second transformed data associated with a second set of one or more measurements collected by a second sensor unit in the plurality of sensor units, and determining, by using at least one processor and based at least in part on one or more features calculated from the first transformed data and the second transformed data, at least one condition of at least one power line in the power distribution system.

18. 发明申请

US20120178780A1 RAF KINASE INHIBITORS 审中-公开
标题翻译： RAF激酶抑制剂
公开(公告)号：US20120178780A1
公开(公告)日：2012-07-12
申请号：US13424111
申请日：2012-03-19
申请人： Jill E. WOOD , Hanno Wild , Daniel H. Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
发明人： Jill E. WOOD , Hanno Wild , Daniel H. Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger A. Smith , Cheri Blum
IPC分类号： A61K31/381 , A61K31/4155 , A61K31/437 , A61K31/34 , A61K31/40 , A61K31/404 , A61K31/427 , A61K31/4025 , C07D333/38 , C07D417/12 , C07D409/12 , C07D307/68 , C07D207/34 , C07D471/04 , A61P35/00 , A61K31/433
CPC分类号： C07D207/34 , C07D307/68 , C07D333/38 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译：治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。

19. 发明申请

US20100234307A1 PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开
标题翻译：联苯胺酸衍生物用于治疗肥胖症的制备和使用
公开(公告)号：US20100234307A1
公开(公告)日：2010-09-16
申请号：US12775249
申请日：2010-05-06
申请人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号： A61K38/06 , C07D211/34 , A61K38/05 , A61P3/04 , C07C229/14 , C07D207/48 , A61K31/401 , C07C311/46 , A61K31/198 , C07D209/42
CPC分类号： C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要： This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些联苯氨基酸化合物，组合物和用于治疗或预防肥胖症和相关疾病的方法。

20. 发明申请

US20100110894A1 AUTOMATIC PROVISIONING OF A REMOTE TEST HEAD OF A COMBINED IP/TELEPHONY/CABLE NETWORK 审中-公开
标题翻译：组合IP /电话/电缆网络的远程测试头的自动提供
公开(公告)号：US20100110894A1
公开(公告)日：2010-05-06
申请号：US12441972
申请日：2007-09-19
申请人： Roger A. Smith
发明人： Roger A. Smith
IPC分类号： H04L12/26
CPC分类号： H04L43/50 , H04L12/2856 , H04L12/4641
摘要： In a telecommunications network that includes: a Digital Subscriber Line Access Multiplexer (DSLAM) (4) that has a DSLAM ID assigned thereto, a test head (2) coupled to the DSLAM (4) including a VLAN ID and a MAC address, and an auto-provisioning server (10), a public IP network is created between the auto-provisioning server (10) and a Test Operations Support System (OSS) (14) coupled to the telecommunications network. A private IP network is created between the test head (2) and the auto-provisioning server (10). The auto-provisioning server (10) acts as a gateway for the dispatch of data from the test head (2) to the Test OSS, and vice versa, across the private VLAN network and the public IP network.
摘要翻译：在电信网络中，包括：具有分配给其的DSLAM ID的数字用户线路接入复用器（DSLAM）（4），耦合到包括VLAN ID和MAC地址的DSLAM（4）的测试头（2），以及自动配置服务器（10），在自动配置服务器（10）和耦合到电信网络的测试操作支持系统（OSS）（14）之间创建公共IP网络。在测试头（2）和自动配置服务器（10）之间创建专用IP网络。自动配置服务器（10）充当用于从专用VLAN网络和公共IP网络将数据从测试头（2）发送到测试OSS的网关，反之亦然。

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