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1. 发明授权

US08835422B2 Substituted imidazoheterocycle derivatives 有权
标题翻译：取代的咪唑并杂环衍生物
公开(公告)号：US08835422B2
公开(公告)日：2014-09-16
申请号：US13126201
申请日：2009-12-01
申请人： Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
发明人： Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
IPC分类号： A61K31/553 , C07D498/04 , C07D487/04
CPC分类号： C07D487/04 , A61K31/553 , C07D498/04
摘要： The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译：本发明提供了具有通式I的通式结构的取代的咪唑并杂环：其中Y选自-O - ， - OCRgRh - ， - CRgRhO-，-CRgRh-， - （CRgRh）2 - ， - NR1 - ，CRRRNRi-和 -NRiCRgRh-。还提供了式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂并用于预防和治疗大麻素受体相关疾病和病症，例如疼痛，炎症和瘙痒。

2. 发明申请

US20110118302A1 PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开
标题翻译：联苯胺-4-甲酰氨基酸衍生物用于治疗肥胖症的制备和使用
公开(公告)号：US20110118302A1
公开(公告)日：2011-05-19
申请号：US12836035
申请日：2010-07-14
申请人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
发明人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
IPC分类号： A61K31/437 , A61K31/428 , A61P3/04 , A61P3/10 , A61P3/00 , A61P3/08 , A61P9/10 , A61P9/00 , A61P9/12
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D513/04
摘要： This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些联苯-4-基羰基氨基酸化合物，组合物和治疗或预防肥胖症及相关疾病的方法。

3. 发明申请

US20100234307A1 PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开
标题翻译：联苯胺酸衍生物用于治疗肥胖症的制备和使用
公开(公告)号：US20100234307A1
公开(公告)日：2010-09-16
申请号：US12775249
申请日：2010-05-06
申请人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号： A61K38/06 , C07D211/34 , A61K38/05 , A61P3/04 , C07C229/14 , C07D207/48 , A61K31/401 , C07C311/46 , A61K31/198 , C07D209/42
CPC分类号： C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要： This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些联苯氨基酸化合物，组合物和用于治疗或预防肥胖症和相关疾病的方法。

4. 发明授权

US06699860B2 Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists 失效
标题翻译：二取代氨基甲基 - 苯并二氢吡喃衍生物β-3肾上腺素受体激动剂
公开(公告)号：US06699860B2
公开(公告)日：2004-03-02
申请号：US10008928
申请日：2001-12-07
申请人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
发明人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
IPC分类号： C07D40112
CPC分类号： C07D405/12 , C07D311/58 , C07D407/04 , C07D409/04 , C07D417/04
摘要： This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.
摘要翻译：本发明涉及可用于治疗β-3受体介导的病症的新型二取代氨基甲基苯并二氢吡喃衍生物。

5. 发明授权

US06221865B1 Inhibitors of protein isoprenyl transferases 失效
标题翻译：蛋白质异戊二烯转移酶抑制剂
公开(公告)号：US06221865B1
公开(公告)日：2001-04-24
申请号：US09073795
申请日：1998-05-07
申请人： Said M. Sebti , Andrew D. Hamilton , Kenneth J. Barr , Stephen A. Fakhoury , Stephen J. O'Connor , Saul H. Rosenberg , Wang Shen , Bryan K. Sorensen , Gerard M. Sullivan , James T. Wasicak , Kenneth J. Henry , Le Wang
发明人： Said M. Sebti , Andrew D. Hamilton , Kenneth J. Barr , Stephen A. Fakhoury , Stephen J. O'Connor , Saul H. Rosenberg , Wang Shen , Bryan K. Sorensen , Gerard M. Sullivan , James T. Wasicak , Kenneth J. Henry , Le Wang
IPC分类号： A61K315377
CPC分类号： C07C237/36 , C07B2200/07 , C07C239/20 , C07C271/22 , C07C317/50 , C07C323/59 , C07C323/60 , C07C327/42 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2603/18 , C07C2603/24 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/267 , C07D209/48 , C07D211/14 , C07D211/42 , C07D211/52 , C07D211/58 , C07D213/30 , C07D213/32 , C07D213/34 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/82 , C07D213/89 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D235/06 , C07D237/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D249/08 , C07D253/06 , C07D257/04 , C07D261/02 , C07D263/22 , C07D263/32 , C07D265/30 , C07D277/30 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/587 , C07D279/12 , C07D295/084 , C07D295/13 , C07D295/155 , C07D295/185 , C07D307/54 , C07D307/81 , C07D317/30 , C07D317/60 , C07D333/18 , C07D333/20 , C07D333/24 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/08 , C07F9/5333
摘要： Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2—, and (i) heterocyclic-L2—; R2 is selected from (a) (b) —C(O)NH—CH(R14)—C(O)OR15, (d) —C(O)NH—CH(R14)—C(O)NHSO2R16, (e) —C(O)NH—CH(R14)-tetrazolyl, (f) —C(O)NH-heterocyclic, and (g) —C(O)NH—CH(R14)—C(O)NR17R18; R3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, and —P(W)RR3RR3′; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) —L4—N(R5)—L5—, (b) —L4—O—L5—, (c) —L4—S(O)n—L5—(d) —L4—L6—C(W)—N(R5)—L5—, (e) —L4—L6—S(O)m—N(R5)—L5—, (f) —L4—N(R5)—C(W)—L7—L5—, (g) —L4—N(R5)—S(O)p—L7—L5—, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, (j) optionally substituted alkynylene (k) a covalent bond, (l) and (m) are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases.
摘要翻译：具有式的化合物或其药学上可接受的盐，其中R 1是（a）氢，（b）低级烷基，（c）烯基，（d）烷氧基，（e）硫代烷氧基，（f）卤素，（g）卤代烷基，（h）芳基-L2-和（i）杂环-L2-; R 2选自（a）（b）-C（O）NH-CH（R 14）-C（O）OR 15，（d）-C（O）NH-CH（R 14）-C（O）NHSO 2 R 16 e）-C（O）NH-CH（R14） - 四唑基，（f）-C（O）NH-杂环基和（g）-C（O）NH-CH（R14）-C（O）NR17R18; R 3是取代或未取代的杂环或芳基，取代或未取代的环烷基或环烯基，和-P（W）RR 3 R R 3'; R4是氢，低级烷基，卤代烷基，卤素，芳基，芳基烷基，杂环或（杂环）烷基; （a）-L4-N（R5）-L5-，（b）-L4-O-L5-，（c）-L4-S（O）n-L5-（d） - L4-L6-C（W）-N（R5）-L5-，（e）-L4-L6-S（O）mN（R5）-L5-，（f）-L4-N（R5）-C W）-L7-L5-，（g）-L4-N（R5）-S（O）p-L7-L5-，（h）任选取代的亚烷基，（i）任选取代的亚烯基，（j）任选取代的亚炔基（k）共价键，（1）和（m）是蛋白质异戊二烯基转移酶的抑制剂。还公开了蛋白质异戊二烯转移酶抑制组合物和抑制蛋白质异戊二烯转移酶的方法。

6. 发明授权

US08266096B2 Vendor portfolio management in support of vendor relationship management analysis, planning and evaluation 有权
标题翻译：供应商投资组合管理，以支持供应商关系管理分析，规划和评估
公开(公告)号：US08266096B2
公开(公告)日：2012-09-11
申请号：US12604611
申请日：2009-10-23
申请人： Jorge A. Navarrete , Stephen J. O'Connor , Peter P. Dai , Johri Dhanotra , Hubert Yau Kin Siu , Charudutt Nagori , Ashish Kalani
发明人： Jorge A. Navarrete , Stephen J. O'Connor , Peter P. Dai , Johri Dhanotra , Hubert Yau Kin Siu , Charudutt Nagori , Ashish Kalani
IPC分类号： G06F7/00
CPC分类号： G06Q10/06
摘要： Various examples include a system and methods in support of vendor relationship management, analysis, planning and evaluation including dealing with collections of vendors called vendor portfolios. In various examples the system includes a database, vendor portfolio definer, a vendor portfolio populator, and a vendor portfolio analyzer. The database houses vendor data. In various examples the vendor portfolio definer allows vendor portfolios to be created, meta data, including complex documents, to be associated with vendor portfolios, and user access permissions to be assigned to vendor portfolios. In various examples the vendor portfolio populator facilitates user selection of the vendors that will make up the collection of vendors in the vendor portfolio. The vendor portfolio analyzer analyzes a business metric using vendor portfolios. In various examples the vendor portfolio analyzer allows user to perform what-if analysis on vendor portfolios. In various examples the vendor portfolio definer includes a risk management definer, the vendor portfolio populator includes a risk management screener, and the vendor portfolio analyzer includes a risk manager to facilitate managing vendors base on the organizational risk they pose. In various examples the database contains information about obligations owed to and from a vendor and the vendor portfolio analyzer includes an obligation analyzer to analyze the organizational impact of vendor obligations.
摘要翻译：各种示例包括支持供应商关系管理，分析，规划和评估的系统和方法，包括处理称为供应商组合的供应商集合。在各种示例中，系统包括数据库，供应商投资组合定义者，供应商投资组合投资者和供应商投资组合分析器。数据库包含供应商数据。在各种示例中，供应商组合定义器允许创建供应商投资组合，将元数据（包括复杂文档）与供应商投资组合相关联，以及将用户访问权限分配给供应商投资组合。在各种示例中，供应商组合填充器促进用户选择将组成供应商组合中的供应商的供应商。供应商投资组合分析器使用供应商投资组合分析业务指标。在各种示例中，供应商投资组合分析器允许用户对供应商投资组合进行假设分析。在各种示例中，供应商投资组合定义者包括风险管理定义者，供应商投资组合投资者包括风险管理筛选器，供应商投资组合分析器包括风险管理器，以便根据其所构成的组织风险来管理供应商。在各种示例中，数据库包含有关供应商的义务的信息，供应商投资组合分析器包括分析供应商义务的组织影响的义务分析器。

7. 发明申请

US20100063038A1 Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis 有权
标题翻译：用于治疗与血管发生相关的超增殖性疾病和疾病的取代的4-氨基 - 吡咯并嗪衍生物
公开(公告)号：US20100063038A1
公开(公告)日：2010-03-11
申请号：US12085880
申请日：2006-12-01
申请人： Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
发明人： Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
IPC分类号： A61K31/53 , C07D487/04 , A61K31/5377 , A61K31/541 , C12N5/00 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及用作治疗高增殖和/或血管生成障碍的那些化合物或组合物作为唯一试剂或与其它活性成分组合的用途。

8. 发明授权

US07655129B2 Binding acceleration techniques for the detection of analytes 有权
标题翻译：用于检测分析物的结合加速技术
公开(公告)号：US07655129B2
公开(公告)日：2010-02-02
申请号：US10823503
申请日：2004-04-12
申请人： Gary Blackburn , Stephen E. Creager , Scott Fraser , Bruce D. Irvine , Thomas J. Meade , Stephen J. O'Connor , Robert H. Terbrueggen , Jost G. Vielmetter , Thomas W. Welch
发明人： Gary Blackburn , Stephen E. Creager , Scott Fraser , Bruce D. Irvine , Thomas J. Meade , Stephen J. O'Connor , Robert H. Terbrueggen , Jost G. Vielmetter , Thomas W. Welch
IPC分类号： G01N27/327
CPC分类号： B82Y30/00 , B82Y15/00 , C12Q1/6825 , C12Q2565/629
摘要： The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
摘要翻译：本发明涉及用于加速目标分析物与表面捕获配体结合的组合物和方法。检测通过直接或间接使用与目标分析物相关的电子转移部分（ETM）进行，以允许电子检测ETM。

9. 发明授权

US06277871B1 Inhibitors of protein isoprenyl transferases 失效
标题翻译：蛋白质异戊二烯转移酶抑制剂
公开(公告)号：US06277871B1
公开(公告)日：2001-08-21
申请号：US09442687
申请日：1999-11-18
申请人： Stephen J. O'Connor , Lissa T. J. Nelson
发明人： Stephen J. O'Connor , Lissa T. J. Nelson
IPC分类号： A61K314418
CPC分类号： C07D401/06 , C07D211/78 , C07D405/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel compounds of Formula I which are useful in inhibiting protein isoprenyl transferases and the farnesylation or geranylgeranylation of the oncogene protein Ras and other related small g-proteins, and compositions containing such compounds and methods of using such compounds.
摘要翻译：本发明涉及可用于抑制蛋白质异戊二烯基转移酶和癌基因蛋白Ras和其他相关小g-蛋白质的法呢基化或er牛儿基基化的式I的新化合物，以及含有这些化合物的组合物和使用这些化合物的方法。

10. 发明授权

US5831115A Inhibitors of squalene synthase and protein farnesyltransferase 失效
标题翻译：角鲨烯合成酶和蛋白法呢基转移酶的抑制剂
公开(公告)号：US5831115A
公开(公告)日：1998-11-03
申请号：US626859
申请日：1996-04-11
申请人： David L Arendsen , William R. Baker , Stephen A Fakhoury , Anthony K. L. Fung , David S. Garvey , William J. McClellan , Stephen J. O'Connor , Rajnandan N. Prasad , Todd W. Rockway , Saul H. Rosenberg , Herman H. Stein , Wang Shen , David M. Stout , Gerard M. Sullivan , David J. Augeri
发明人： David L Arendsen , William R. Baker , Stephen A Fakhoury , Anthony K. L. Fung , David S. Garvey , William J. McClellan , Stephen J. O'Connor , Rajnandan N. Prasad , Todd W. Rockway , Saul H. Rosenberg , Herman H. Stein , Wang Shen , David M. Stout , Gerard M. Sullivan , David J. Augeri
IPC分类号： A61K31/195 , A61K31/215 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/433 , A61P3/06 , A61P9/00 , A61P9/08 , A61P31/04 , A61P35/00 , A61P43/00 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C235/82 , C07D271/06 , C07D271/10 , C07D285/10 , C07D333/20 , C07C229/00 , A01N37/10
CPC分类号： C07C235/82 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07D333/20 , C07C2101/04
摘要： The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
摘要翻译：本发明提供了一种式IMA化合物或其药学上可接受的盐，其可用于抑制蛋白法呢基转移酶和癌基因蛋白Ras的法呢基化或抑制从头角鲨烯生产导致胆固醇生物合成的抑制，除了可用于这些方法的中间体之外，本发明化合物的制备，药物组合物以及使用这些化合物的方法。

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