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11. 发明申请

US20120045479A1 Dry Powder Formulations, Vaccines and Methods 审中-公开
标题翻译：干粉配方，疫苗和方法
公开(公告)号：US20120045479A1
公开(公告)日：2012-02-23
申请号：US13124701
申请日：2009-10-15
申请人： Robert E. Sievers , Robert L. Garcea , Stephen P. Cape
发明人： Robert E. Sievers , Robert L. Garcea , Stephen P. Cape
IPC分类号： A61K39/12 , A61K47/18 , A61P31/20 , A61K9/14
CPC分类号： C07K14/005 , A61K9/0075 , A61K39/00 , A61K39/12 , A61K47/10 , A61K47/183 , A61K2039/544 , A61K2039/6031 , C12N2710/20022 , C12N2710/20034
摘要： Respirable dry powder formulations comprise myo-inositol and leucine. Dry powder human papillomavirus (HPV) vaccine formulations comprise a least one HPV capsid protein and a carrier comprising myo-inositol and leucine. Methods of administering an HPV vaccine to an individual comprise inhalation administration to the individual of a dry powder HPV vaccine formulation comprising a least one HPV capsid protein and a carrier comprising myo-inositol and leucine.
摘要翻译：可呼吸的干粉配方包含肌醇和亮氨酸。干粉人乳头状瘤病毒（HPV）疫苗制剂包含至少一种HPV衣壳蛋白和包含肌醇和亮氨酸的载体。向个体施用HPV疫苗的方法包括向个体吸入给予包含至少一种HPV衣壳蛋白的干粉末HPV疫苗制剂和包含肌醇和亮氨酸的载体。

12. 发明申请

US20100269819A1 Human Powered Dry Powder Inhaler and Dry Powder Inhaler Compositions 审中-公开
标题翻译：人力干粉吸入器和干粉吸入器组合物
公开(公告)号：US20100269819A1
公开(公告)日：2010-10-28
申请号：US12377254
申请日：2007-08-14
申请人： Robert E. Sievers , Jessica A. Best , Stephen P. Cape
发明人： Robert E. Sievers , Jessica A. Best , Stephen P. Cape
IPC分类号： A61M11/00
CPC分类号： A61M15/00 , A61K9/0075 , A61K9/1623 , A61K9/1652 , A61M11/003 , A61M11/008 , A61M15/0086 , A61M15/0088 , A61M16/0078 , A61M16/0084 , A61M16/0093 , A61M16/1055 , A61M16/1065 , A61M2202/064
摘要： In one embodiment, a human-powered dry powder inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet at a pressure of about 1-40 psi; an inflatable reservoir operable to receive an air pulse discharged from the human-powered compressible component to provide an aerosol of a dry powder pharmaceutical formulation in the reservoir, the reservoir including an outlet valve; and a receiving mask in communication with the outlet valve and operable to receive an aerosol of dry powder from the reservoir and to deliver the aerosol to at least a mouth or nose of a patient. In another embodiment, the inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet of a polymeric pressure release valve at a pressure of about 1-40 psi; and a receiving mask in communication with the outlet of the compressible component and operable to deliver an aerosol of dry powder to at least a mouth or nose of a patient. Methods for delivery of a dry powder pharmaceutical formulation to a patient are conducted in the absence of electrical power and circuitry and pre-pressurized propellant gas. Suitable dry powder pharmaceutical formulations may include myo-inositol and/or maltodextrin as a carrier and active ingredients such as vaccines or siRNA.
摘要翻译：在一个实施例中，人力干粉吸入器包括人力动力可压缩部件，其可操作以在约1-40psi的压力下排出出口处的空气脉冲; 充气储存器，其可操作以接收从人力可压缩部件排出的空气脉冲，以在储存器中提供干粉末药物制剂的气溶胶，所述储存器包括出口阀; 以及与所述出口阀连通并且可操作以从所述储存器接收干燥粉末的气溶胶并将所述气溶胶输送到患者的至少一个口或鼻部的接收面罩。在另一个实施例中，吸入器包括人力动力的可压缩部件，其可操作以在约1-40psi的压力下排出聚合物压力释放阀的出口处的空气脉冲; 以及接收面罩，其与所述可压缩部件的出口连通并且可操作以将干粉的气溶胶输送到患者的至少一个口或鼻部。在没有电力和电路和预加压推进剂气体的情况下，将干粉药物制剂递送到患者的方法进行。合适的干粉药物制剂可以包括肌醇和/或麦芽糖糊精作为载体和活性成分例如疫苗或siRNA。

13. 发明授权

US4717675A Method for selective conversion of organic compounds and detecting same by gas chromotography and chemiluminescence detection 失效
标题翻译：通过气相色谱和化学发光检测方法选择性转化有机化合物并进行检测
公开(公告)号：US4717675A
公开(公告)日：1988-01-05
申请号：US810883
申请日：1985-12-17
申请人： Robert E. Sievers , Stefan A. Nyarady
发明人： Robert E. Sievers , Stefan A. Nyarady
IPC分类号： B01J19/00 , B01J23/52 , C07C5/42 , C07C5/46 , C07C5/52 , C07C45/29 , C07C45/65 , G01N21/76
CPC分类号： C07C45/29 , B01J23/52 , C07C45/65 , C07C5/42 , C07C5/46 , C07C5/52 , Y10T436/16 , Y10T436/178459 , Y10T436/179228
摘要： In a redox reaction process, the oxidized state of organic compounds is increased through the steps of directing oxides of nitrogen together with a reducing agent selected from oxygenated compounds and aromatic compounds through a catalyst bed in the form of supported gold heated to a temperature sufficient to reduce the oxides of nitrogen present to nitric oxide, after which the higher oxidized forms of organic compounds are recovered. The organic compounds to be oxidized can be separated by chromatography before introduction with one of the oxides of nitrogen into the catalyst bed, and detection of the reducing agent by chemiluminescent measurement of NO.sub.2.sup.* enables determination of the higher oxidized species produced.
摘要翻译：在氧化还原反应过程中，通过将氮氧化物与选自氧化化合物和芳族化合物的还原剂一起通过催化剂床以负载金的形式引导的步骤来增加有机化合物的氧化态，加热到足以将存在的氮氧化物还原成一氧化氮，然后回收较高氧化形式的有机化合物。待氧化的有机化合物可以在引入氮气氧化物之一之前通过色谱法分离到催化剂床中，并且通过化学发光测量NO 2 *检测还原剂能够测定所产生的较高氧化物质。

14. 发明授权

US4514522A Oxygen sorbent 失效
公开(公告)号：US4514522A
公开(公告)日：1985-04-30
申请号：US635320
申请日：1984-07-27
申请人： Robert E. Sievers , John N. Gillis
发明人： Robert E. Sievers , John N. Gillis
IPC分类号： B01J20/22 , C01B13/02 , C07F15/06 , C08F251/02 , C08J9/28 , C08J9/40
CPC分类号： C08J9/28 , B01J20/22 , C01B13/0244 , C01B13/0262 , C07F15/065 , C08F251/02 , C01B2210/0046 , C01B2210/0082
摘要： The present invention discloses a novel and unique family of agents which reversibly binds molecular oxygen at room temperature.

15. 发明授权

US3966411A Analysis for nitrogen compounds by gas chromatography 失效
标题翻译：通过气相色谱分析氮化合物
公开(公告)号：US3966411A
公开(公告)日：1976-06-29
申请号：US566157
申请日：1975-04-08
申请人： William D. Ross , Robert E. Sievers
发明人： William D. Ross , Robert E. Sievers
IPC分类号： G01N30/06 , G01N31/00 , G01N31/08 , G01N31/10 , G01N33/18
CPC分类号： G01N31/00 , G01N30/06 , Y10T436/15 , Y10T436/17 , Y10T436/173076
摘要： The qualitative and quantitative analysis of nitrogen-containing compounds is accomplished by contacting in the presence of an acid a sample containing such a compound with an aromatic hydrocarbon, thereby converting the compound to a stable nitrogen-containing aromatic hydrocarbon. The sample now containing the nitrated aromatic hydrocarbon is then introduced in a carrier gas stream into a chromatographic column. The effluent stream from the column is passed through a gas chromatography detector, and the detector signal response obtained is compared with that produced by known amounts of a reference calibration sample.
摘要翻译：含氮化合物的定性和定量分析通过在酸存在下使含有这种化合物的样品与芳族烃接触来实现，从而将化合物转化为稳定的含氮芳族烃。然后将含有硝化芳烃的样品在载气流中引入色谱柱。将来自塔的流出物流通过气相色谱检测器，并将获得的检测器信号响应与已知量的参考校准样品产生的响应进行比较。

16. 发明授权

US09895321B2 Vaccines, methods of administering vaccines, methods and products for treating and/or delaying onset of dysplastic lesions, and wafers for oral administration 有权
公开(公告)号：US09895321B2
公开(公告)日：2018-02-20
申请号：US13642878
申请日：2011-04-22
申请人： Robert E. Sievers , Stephen P. Cape , David McAdams , J'aime Manion , Pankaj Pathak
发明人： Robert E. Sievers , Stephen P. Cape , David McAdams , J'aime Manion , Pankaj Pathak
IPC分类号： A61K39/395 , A61K31/047 , A61K9/00 , A61K9/16 , A61K9/51 , A61K39/12 , A61K39/165 , A61K45/06 , A61K39/00
CPC分类号： A61K31/047 , A61K9/0056 , A61K9/0075 , A61K9/1647 , A61K9/1688 , A61K9/1694 , A61K9/5153 , A61K9/5192 , A61K39/12 , A61K39/165 , A61K45/06 , A61K2039/54 , A61K2039/542 , A61K2039/543 , A61K2039/544 , A61K2039/60 , C12N2760/18434 , A61K2300/00
摘要： Methods and products for treating and/or delaying onset of dysplastic lesions, and wafers for oral administration employ dry powder compositions including myo-inositol. Methods for administering a vaccine for a virus or bacteria to an individual comprising administering a first portion of the vaccine to the individual via one route and administering a second portion via a second, different route. In a specific embodiment, the first route is sublingually. Vaccines are provided in the form of dry powder compositions comprising a combination of nanoparticles and microparticles, or in the form of a wafer which dissolves in water at room temperature in less than about one minute. Storage stable unit dosages of a vaccine are provided by individually packaging individual unit dosages of a dry powder composition comprising the vaccine and a carrier in blister compartments formed of gas and moisture resistant material.

17. 发明授权

US06630121B1 Supercritical fluid-assisted nebulization and bubble drying 有权
标题翻译：超临界流体辅助雾化和气泡干燥
公开(公告)号：US06630121B1
公开(公告)日：2003-10-07
申请号：US09591213
申请日：2000-06-09
申请人： Robert E. Sievers , Scott P. Sellers , John F. Carpenter
发明人： Robert E. Sievers , Scott P. Sellers , John F. Carpenter
IPC分类号： A61K5100
CPC分类号： B82Y10/00 , A61K9/0075 , A61K9/1694 , B01J2/04 , B82Y40/00 , H01J37/3007 , H01J37/3174 , H01J2237/31776 , Y10S977/916
摘要： A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure on said composition, whereby droplets are formed; and passing said droplets through a flow of heated gas. The process does not require any organic solvent.
摘要翻译：通过形成包含感兴趣物质和超临界或近临界流体的组合物来提供制备物质的细干颗粒的方法; 快速降低所述组合物的压力，从而形成液滴; 并使所述液滴通过加热气体流。该方法不需要任何有机溶剂。

18. 发明授权

US5639441A Methods for fine particle formation 失效
标题翻译：微粒形成方法
公开(公告)号：US5639441A
公开(公告)日：1997-06-17
申请号：US224764
申请日：1994-04-08
申请人： Robert E. Sievers , Uwe Karst
发明人： Robert E. Sievers , Uwe Karst
IPC分类号： A61K9/00 , A61K9/12 , A61K9/16 , A61K49/00 , A61M15/00 , B01F3/00 , B01F3/06 , B01F5/02 , B01J3/00 , B05B7/32 , B05D1/02 , C09K3/30 , C23C16/00
CPC分类号： A61K9/0073 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01J2/04 , B01J3/008 , B05B12/1418 , B05B7/32 , B05D1/025 , A61K9/0075 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 .mu.m.
摘要翻译：提供了用于形成所需物质的细颗粒的方法和装置，包括将所述物质溶解在诸如水的流体中以形成溶液，并将溶液与快速释放时成为气体的第二流体例如超临界二氧化碳混合，以及其中第一流体至少部分地不混溶，并释放压力以形成包含平均直径在约0.1至约6.5μm之间的颗粒的空气传播分散体或气溶胶。

19. 发明授权

US5089466A Stable mixed metal superconductive oxides containing nitrogen 失效
标题翻译：含氮稳定的混合金属超导氧化物
公开(公告)号：US5089466A
公开(公告)日：1992-02-18
申请号：US216643
申请日：1988-07-08
申请人： Robert E. Sievers , Stephen A. Montzka
发明人： Robert E. Sievers , Stephen A. Montzka
IPC分类号： C23C8/02 , C23C8/08 , C23C8/12 , C23C16/40 , C23C16/56 , H01L39/24
CPC分类号： H01L39/2441 , C23C16/408 , C23C16/56 , C23C8/02 , C23C8/08 , C23C8/12 , Y10S505/78
摘要： Stable mixed metal oxide compositions containing nitrogen are formed by treating an oxygen-deficient perovskite composition with nitrogen dioxide. Preferably, the oxygen-deficient perovskite is of the formula X.sub.a Z.sub.b Cu.sub.c O.sub.h wherein X is a member selected from the group consisting of yttrium, scandium, lanthanum, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, bismuth and thallium, Z is a member selected from the group consisting of barium, strontium, calcium, magnesium and mixtures thereof, a is not less than 1, b is from 0 to 3, c is from 0 to 3, and h is not greater than about 6, and the mixed metal oxides are of the formula X.sub.a Z.sub.b Cu.sub.c N.sub.j O.sub.k where X, Z, a, b and c are as previously defined, j is from about 0.001 to about 3, and k is from about 6 to about 13.
摘要翻译：通过用二氧化氮处理缺氧钙钛矿组合物形成含有氮的稳定的混合金属氧化物组合物。优选地，缺氧钙钛矿具有式XaZbCucOh，其中X是选自钇，钪，镧，钕，钐，铕，钆，铽，镝，钬，铒，ium，镱，镥，铋和铊，Z是选自钡，锶，钙，镁及其混合物的成员，a不小于1，b为0至3，c为0至3，h为不大于约6，并且所述混合金属氧化物具有式XaZbCucNjOk其中X，Z，a，b和c如前所定义，j为约0.001至约3，k为约6至约13。

20. 发明授权

US4251233A Liquid hydrocarbon-soluble rare earth chelates prepared from the novel ligand 2,2,7-trimethyl-3,5-octanedione and fuels containing same 失效
标题翻译：由新配体2,2,7-三甲基-3,5-辛二酮和含有它们的燃料制备的液体烃溶性稀土螯合物
公开(公告)号：US4251233A
公开(公告)日：1981-02-17
申请号：US17459
申请日：1979-03-05
申请人： Robert E. Sievers , Thomas J. Wenzel
发明人： Robert E. Sievers , Thomas J. Wenzel
IPC分类号： C07C45/45 , C07C45/77 , C07C49/12 , C07C49/92 , C10L1/18
CPC分类号： C10L10/10 , C07C45/455 , C07C45/77 , C07C49/12 , C07C49/92 , C10L1/1814 , C10L10/06
摘要： Liquid hydrocarbon-soluble rare earth chelates prepared from the novel ligand 2,2,7-trimethyl-3,5-octanedione when dissolved in fuels such as gasoline and diesel oil prevent formation and/or effect removal of carbonaceous deposits during the combustion thereof. The use of fuels containing these chelates promotes more efficient operations of devices such as internal combustion engines in which the fuels are burned by minimizing or eliminating the accumulation of harmful carbonaceous materials in the combustion chambers and by preventing knocking and/or other undesirable performance characteristics.
摘要翻译：当溶解在诸如汽油和柴油的燃料中时，由新配体2,2,7-三甲基-3,5-辛二酮制备的液体烃溶性稀土螯合物防止在其燃烧期间形成和/或除去碳质沉积物。含有这些螯合物的燃料的使用促进了诸如内燃机的装置的更有效的操作，其中通过最小化或消除燃烧室中的有害碳质材料的积聚并且通过防止爆震和/或其它不期望的性能特征来燃烧燃料。

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