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11. 发明申请

US20090118723A1 COOLANT INJECTION TUBE 有权
标题翻译：冷却液注射管
公开(公告)号：US20090118723A1
公开(公告)日：2009-05-07
申请号：US12269493
申请日：2008-11-12
申请人： Jean-Pierre LALONDE , Marwan ABBOUD , Teresa Ann MIHALIK , Jean-Pierre DESMARAIS , Dan WITTENBERGER
发明人： Jean-Pierre LALONDE , Marwan ABBOUD , Teresa Ann MIHALIK , Jean-Pierre DESMARAIS , Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00318 , A61B2017/22038 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device includes a steering element defining a passage for a guide wire. A fluid injection tube defining a proximal and a distal end is also included, wherein a portion of the fluid injection tube is contoured about a portion of the steering element. A plurality of injection ports may be disposed in the portion of the fluid injection tube contoured about the steering element.
摘要翻译：医疗装置包括限定用于导丝的通道的操纵元件。还包括限定近端和远端的流体注入管，其中流体注入管的一部分围绕转向元件的一部分成形。多个注射口可以设置在围绕转向元件成形的流体注射管的部分中。

12. 发明申请

US20120035601A1 CRYOGENIC MEDICAL MAPPING AND TREATMENT DEVICE 有权
标题翻译：低温医学绘图和治疗装置
公开(公告)号：US20120035601A1
公开(公告)日：2012-02-09
申请号：US12849468
申请日：2010-08-03
申请人： Dan WITTENBERGER
发明人： Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0022 , A61B2018/00375 , A61B2018/00839 , A61B2018/0212 , A61B2018/1497
摘要： A medical device and method are provided for mapping and therapeutic treatment, which may include a source of cryogenic fluid, a balloon or other expandable member in fluid communication with the source of cryogenic fluid, and a plurality of electrodes on the expandable member. The medical device may include a catheter or elongate body, and the electrodes may take the form of longitudinal strips. The expandable member may take the form of an inner and outer balloon, and the electrodes may be on the outer balloon. The electrodes may be on a proximal or distal conical portion of the expandable member, or both. An electrical insulator may be provided covering a portion of the electrodes.
摘要翻译：提供了用于映射和治疗治疗的医疗装置和方法，其可以包括与低温流体源流体连通的低温流体，球囊或其它可膨胀构件的源，以及可扩张构件上的多个电极。医疗装置可以包括导管或细长体，并且电极可以采取纵向条的形式。可膨胀构件可以采取内部和外部气球的形式，并且电极可以在外部气球上。电极可以在可扩张构件的近端或远端圆锥形部分上，或两者。可以提供覆盖一部分电极的电绝缘体。

13. 发明申请

US20110196359A1 CATHETER WITH CRYOGENIC AND ELECTRICAL HEATING ABLATION 有权
标题翻译：具有低温和电加热的导管
公开(公告)号：US20110196359A1
公开(公告)日：2011-08-11
申请号：US13088709
申请日：2011-04-18
申请人： Steven G. ARLESS , Fredric L. MILDER , Marwan ABBOUD , Dan WITTENBERGER , Sean CARROLL
发明人： Steven G. ARLESS , Fredric L. MILDER , Marwan ABBOUD , Dan WITTENBERGER , Sean CARROLL
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.
摘要翻译：导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。可以操作RF电极以温热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织。

14. 发明申请

US20100204687A1 MESH LEAK DETECTION SYSTEM FOR A MEDICAL DEVICE 有权
标题翻译：用于医疗设备的MESH泄漏检测系统
公开(公告)号：US20100204687A1
公开(公告)日：2010-08-12
申请号：US12767012
申请日：2010-04-26
申请人： Marwan ABBOUD , Dan WITTENBERGER
发明人： Marwan ABBOUD , Dan WITTENBERGER
IPC分类号： A61B18/02 , A61M25/10
CPC分类号： G01M3/02 , A61B18/02 , A61B2017/00119 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/0147 , A61M25/10 , A61M2205/15
摘要： The present invention provides a surgical device including an elongate body defining a fluid flow path therethrough. An expandable element may be coupled to the elongate body and placed in fluid communication with the fluid flow path. Moreover, the surgical device may include a first leak detection element at least partially surrounding a portion of the expandable element, and a second leak detection element may be provided in fluid communication with the fluid flow path. In addition, a console may be provided, where the console may be in communication with the first and second leak detection elements. Further, a supply of cryogenic fluid as well as a vacuum source may be provided in fluid communication with the fluid flow path.
摘要翻译：本发明提供一种手术装置，其包括限定通过其中的流体流动通道的细长主体。可膨胀元件可以联接到细长主体并且被放置成与流体流动路径流体连通。此外，手术装置可以包括至少部分地围绕可膨胀元件的一部分的第一泄漏检测元件，并且第二泄漏检测元件可以设置成与流体流动路径流体连通。此外，可以提供控制台，其中控制台可以与第一和第二泄漏检测元件通信。此外，可以提供与流体流动路径流体连通的低温流体以及真空源的供应。

15. 发明申请

US20120232374A1 MULTI-ARRAY MONOPHASIC ACTION POTENTIAL MEDICAL DEVICE 有权
标题翻译：多阵列单因素行动潜能医疗器械
公开(公告)号：US20120232374A1
公开(公告)日：2012-09-13
申请号：US13044698
申请日：2011-03-10
申请人： Randell L. WERNETH , Meleze HOCINI , Mark T. STEWART , Dan WITTENBERGER , Timothy J. CORVI , Michael LAU , Vinod SHARMA
发明人： Randell L. WERNETH , Meleze HOCINI , Mark T. STEWART , Dan WITTENBERGER , Timothy J. CORVI , Michael LAU , Vinod SHARMA
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/0422 , A61B18/1492 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.
摘要翻译：一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。

16. 发明申请

US20110184399A1 PARTIALLY COMPLIANT BALLOON DEVICE 有权
标题翻译：部分合适的气球装置
公开(公告)号：US20110184399A1
公开(公告)日：2011-07-28
申请号：US12694938
申请日：2010-01-27
申请人： Dan WITTENBERGER
发明人： Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00375 , A61B2018/0212
摘要： A medical device is provided, having an elongate body defining a distal portion and a proximal portion; a first expandable member disposed on the distal portion of the elongate body and defining a cooling chamber therein, the first expandable member having a first rigidity; a second expandable member disposed around the first expandable member to define an interstitial region therebetween, where the second expandable member has a second rigidity less than the first rigidity; a gel disposed within the interstitial region; a coolant flow path in fluid communication with the cooling chamber; and a cryogenic coolant source in fluid communication with the coolant flow path.
摘要翻译：提供了一种医疗装置，其具有限定远侧部分和近端部分的细长主体; 第一可膨胀构件，其设置在细长主体的远端部分上并且在其中限定冷却室，第一可膨胀构件具有第一刚性; 第二可膨胀构件，其围绕所述第一可膨胀构件设置以在其间限定间隙区域，其中所述第二可膨胀构件具有小于所述第一刚性的第二刚性; 布置在间隙区内的凝胶; 与冷却室流体连通的冷却剂流动路径; 以及与冷却剂流动路径流体连通的低温冷却剂源。

17. 发明申请

US20110098761A1 METHOD AND SYSTEM FOR PREVENTING NERVE INJURY DURING A MEDICAL PROCEDURE 有权
标题翻译：用于在医疗过程中预防神经损伤的方法和系统
公开(公告)号：US20110098761A1
公开(公告)日：2011-04-28
申请号：US12604882
申请日：2009-10-23
申请人： Dan WITTENBERGER , Nicolas COULOMBE
发明人： Dan WITTENBERGER , Nicolas COULOMBE
IPC分类号： A61N1/00 , A61B5/00
CPC分类号： A61B18/02 , A61B5/04012 , A61B5/0488 , A61B5/0492 , A61B5/0535 , A61B5/0803 , A61B5/0809 , A61B5/4035 , A61B5/6853 , A61B17/320068 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B2017/22038 , A61B2018/00214 , A61B2018/0022 , A61B2018/0212 , A61B2018/1861 , A61N1/08 , A61N1/36014 , A61N1/3702 , G06F19/00
摘要： A method of treating tissue is provided, including positioning a stimulation device proximate a phrenic nerve; stimulating the phrenic nerve with the stimulation device; measuring a physiological response to the stimulation; defining a threshold physiological response value based at least in part on the measured physiological response; positioning a thermal treatment element proximate to an arrhythmogenic cardiac tissue region; applying a thermal treatment regimen to the cardiac tissue region with the medical device; measuring a physiological parameter during the thermal treatment regimen application; and conveying the measured physiological parameter to a controller, the controller comparing the measured physiological parameter to the defined physiological response value threshold, the controller adjusting the thermal treatment regimen in response to the comparison of the measured physiological parameter to the defined physiological response value threshold.
摘要翻译：提供一种治疗组织的方法，包括将刺激装置定位在膈神经附近; 用刺激装置刺激膈神经; 测量刺激的生理反应; 至少部分地基于所测量的生理反应定义阈值生理反应值; 将热处理元件放置在致心律失常心脏组织区域附近; 用医疗装置将热处理方案应用于心脏组织区域; 在热处理方案应用中测量生理参数; 以及将所测量的生理参数输送到控制器，所述控制器将所测量的生理参数与所述确定的生理响应值阈值进行比较，所述控制器响应于所测量的生理参数与所述生理响应值阈值的比较来调节热处理方案。

18. 发明申请

US20120101485A1 BALLOON CATHETER WITH DEFORMABLE FLUID DELIVERY CONDUIT 有权
标题翻译：具有可变流体输送管道的气球导管
公开(公告)号：US20120101485A1
公开(公告)日：2012-04-26
申请号：US12910492
申请日：2010-10-22
申请人： Dan WITTENBERGER
发明人： Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00214 , A61B2018/0022 , A61B2018/00345 , A61B2018/00375 , A61B2018/00577 , A61B2018/0212 , A61B2018/0268 , A61M25/0147
摘要： A medical device, including an elongate body having a proximal portion and a distal portion; a shaft at least partially disposed within the elongate body; an expandable element at the distal portion of the elongate body; and a fluid delivery conduit defining a deflectable segment movably coupled to the shaft, the deflectable segment being transitionable from a substantially linear configuration to a substantially curvilinear configuration.
摘要翻译：一种医疗装置，包括具有近端部分和远端部分的细长体; 至少部分地设置在所述细长主体内的轴; 在所述细长体的远端部分处的可膨胀元件; 以及流体输送导管，其限定可移动地联接到所述轴的可偏转段，所述可偏转段可从基本线性构型转变到基本上曲线形状。

19. 发明申请

US20120065631A1 CATHETER WITH CRYOGENIC AND ELECTRICAL HEATING ABLATION 有权
标题翻译：具有低温和电加热的导管
公开(公告)号：US20120065631A1
公开(公告)日：2012-03-15
申请号：US13301978
申请日：2011-11-22
申请人： Steven G. ARLESS , Fredric L. MILDER , Marwan ABBOUD , Dan WITTENBERGER , Sean CARROLL
发明人： Steven G. ARLESS , Fredric L. MILDER , Marwan ABBOUD , Dan WITTENBERGER , Sean CARROLL
IPC分类号： A61B18/02 , A61B18/18 , A61B18/14
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.
摘要翻译：导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。可以操作RF电极以温热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织。

20. 发明申请

US20120029495A1 ENDOLUMINAL ABLATION CRYOBALLOON AND METHOD 有权
标题翻译：内膜剥离CRYOBALLOON和方法
公开(公告)号：US20120029495A1
公开(公告)日：2012-02-02
申请号：US12845492
申请日：2010-07-28
申请人： Dan WITTENBERGER
发明人： Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00255 , A61B2018/00642 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/00863 , A61B2018/0212 , A61B2090/064
摘要： A method of ablating tissue is provided, including positioning an expandable element of a catheter in a blood vessel; inflating the expandable element with a volume of refrigerant to substantially occlude the blood vessel; measuring the volume of refrigerant used to inflate the expandable element; correlating the measured volume to an inflated dimension of the expandable element; defining at least one of a target pressure within the expandable element and a target flow rate for refrigerant delivery to the expandable element based at least in part on the inflated dimension; regulating refrigerant delivery to the expandable element to attain the at least one defined target pressure within the expandable element or defined target flow rate for fluid delivery to the expandable element; and ablating at least a portion of the blood vessel with the expandable element.
摘要翻译：提供一种消融组织的方法，包括将导管的可扩张元件定位在血管中; 用一定体积的制冷剂使可膨胀元件充气以基本上封闭血管; 测量用于使可膨胀元件膨胀的制冷剂的体积; 将测量的体积与可膨胀元件的膨胀尺寸相关联; 至少部分地基于所述膨胀的尺寸限定所述可膨胀元件内的目标压力中的至少一个和用于制冷剂输送到所述可膨胀元件的目标流量; 调节向所述可膨胀元件的制冷剂输送以达到所述可膨胀元件内的所述至少一个限定的目标压力或用于流体输送到所述可膨胀元件的限定的目标流速; 以及用所述可扩张元件烧蚀所述血管的至少一部分。

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