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11. 发明申请

US20100147687A1 SYSTEMS AND METHODS FOR TRANSPORTING PARTICLES 有权
公开(公告)号：US20100147687A1
公开(公告)日：2010-06-17
申请号：US12712916
申请日：2010-02-25
申请人： Armin R. Völkel , David Biegelsen , Philip D. Floyd , Greg Anderson , Fred Endicott , Eric Peeters , Jaan Noolandi , Karen A. Moffat , Peter M. Kazmaier , Maria McDougall , Daniel G. Bobrow
发明人： Armin R. Völkel , David Biegelsen , Philip D. Floyd , Greg Anderson , Fred Endicott , Eric Peeters , Jaan Noolandi , Karen A. Moffat , Peter M. Kazmaier , Maria McDougall , Daniel G. Bobrow
IPC分类号： C07K1/26
CPC分类号： B03C5/028
摘要： Various particle transport systems and components for use in such systems are described. The systems utilize one or more traveling wave grids to selectively transport, distribute, separate, or mix different populations of particles. Numerous systems configured for use in two dimensional and three dimensional particle transport are described.

12. 发明授权

US07695602B2 Systems and methods for transporting particles 有权
标题翻译：运输颗粒的系统和方法
公开(公告)号：US07695602B2
公开(公告)日：2010-04-13
申请号：US10988158
申请日：2004-11-12
申请人： Armin R. Völkel , David Biegelsen , Philip D. Floyd , Greg Anderson , Fred Endicott , Eric Peeters , Jaan Noolandi , Karen A. Moffat , Peter M. Kazmaier , Maria McDougall , Daniel G. Bobrow
发明人： Armin R. Völkel , David Biegelsen , Philip D. Floyd , Greg Anderson , Fred Endicott , Eric Peeters , Jaan Noolandi , Karen A. Moffat , Peter M. Kazmaier , Maria McDougall , Daniel G. Bobrow
IPC分类号： B01D59/42 , B41J2/41
CPC分类号： B03C5/028
摘要： Various particle transport systems and components for use in such systems are described. The systems utilize one or more traveling wave grids to selectively transport, distribute, separate, or mix different populations of particles. Numerous systems configured for use in two dimensional and three dimensional particle transport are described.
摘要翻译：描述了用于这种系统的各种粒子输送系统和部件。该系统利用一个或多个行波网来选择性地输送，分配，分离或混合不同粒子群。描述了配置用于二维和三维粒子传输的许多系统。

13. 发明申请

US20110184513A1 Artificial corneal implant 审中-公开
标题翻译：人造角膜植入物
公开(公告)号：US20110184513A1
公开(公告)日：2011-07-28
申请号：US12928819
申请日：2010-12-20
申请人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher N. Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco , Laura Hartmann
发明人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher N. Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco , Laura Hartmann
IPC分类号： A61F2/14
CPC分类号： A61L27/3804 , A61F2/142 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L2430/16 , C12N5/0621 , C12N2533/30
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，其中第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附于生物分子。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

14. 发明申请

US20110166247A1 Interpenetrating polymer network hydrogel contact lenses 审中-公开
标题翻译：互穿聚合物网络水凝胶隐形眼镜
公开(公告)号：US20110166247A1
公开(公告)日：2011-07-07
申请号：US12928820
申请日：2010-12-20
申请人： David Myung , Jaan Noolandi , Christopher N. Ta , Curtis W. Frank , Laura Hartmann
发明人： David Myung , Jaan Noolandi , Christopher N. Ta , Curtis W. Frank , Laura Hartmann
IPC分类号： G02C7/04 , C08L33/02 , C08L77/00
CPC分类号： G02B1/043 , C08F290/062 , C08J3/075 , C08J3/246 , C08J2333/02 , C08J2371/02 , C08L33/02 , C08L71/02 , C08L2205/04 , C08L2205/05 , C08L101/04 , C08F220/06 , C08F222/1006
摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylamide and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酰胺，亲水单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

15. 发明授权

US07909867B2 Interpenetrating polymer network hydrogel corneal prosthesis 有权
标题翻译：互穿聚合物网络水凝胶角膜假体
公开(公告)号：US07909867B2
公开(公告)日：2011-03-22
申请号：US11639049
申请日：2006-12-13
申请人： David Myung , Christopher Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi
发明人： David Myung , Christopher Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi
IPC分类号： A61F2/14
CPC分类号： C12N5/0621 , A61F2/142 , A61F2/15 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2430/16 , C12N2533/30 , C12N2533/54 , C08L71/02 , C08L33/08
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

16. 发明授权

US06930668B2 Color-enabled electrophoretic display and medium 失效
标题翻译：支持彩色电泳显示和介质
公开(公告)号：US06930668B2
公开(公告)日：2005-08-16
申请号：US10345436
申请日：2003-01-15
申请人： Jaan Noolandi , James H. Sharp
发明人： Jaan Noolandi , James H. Sharp
IPC分类号： G02F1/167 , G09G3/34 , G02B26/00
CPC分类号： G09G3/344 , G02F1/167 , G09G2310/02
摘要： A display medium including a plurality of electrically photosensitive particles positioned within at least one ambipolar shell to form at least one first composite particle, and a plurality of white particles encapsulated in a plurality of insulating shells to form a plurality of second composite particles. A photoelectrophoretic display and method of photoelectrophoretic imaging are also disclosed.
摘要翻译：一种显示介质，包括位于至少一个双极壳内的多个电光敏颗粒以形成至少一个第一复合颗粒，以及多个白色颗粒，其被封装在多个绝缘壳中以形成多个第二复合颗粒。还公开了光电泳显示器和光电泳成像方法。

17. 发明申请

US20050118067A1 Device to print biofluids 审中-公开
标题翻译：打印生物流体的设备
公开(公告)号：US20050118067A1
公开(公告)日：2005-06-02
申请号：US10503693
申请日：2003-02-12
申请人： Jaan Noolandi
发明人： Jaan Noolandi
IPC分类号： B01L3/00 , B01L3/02 , C40B60/14
CPC分类号： B01L3/0268 , B01J2219/00315 , B01J2219/0036 , B01L3/50853 , B01L2300/04 , B01L2400/027 , C40B60/14 , Y10T436/2575
摘要： An apparatus and method of printing microarrays by ejecting droplets of electrically conducting liquids from wells (12) onto a substrate (21) on top of a charged plate (20) using electrodes (18) inserted into the wells (12).
摘要翻译：一种通过使用插入孔（12）中的电极（18）将来自阱（12）的液滴喷射到带电板（20）顶部上的衬底（21）上的打印微阵列的装置和方法。

18. 发明授权

US06861034B1 Priming mechanisms for drop ejection devices 有权
标题翻译：液滴喷射装置的启动机构
公开(公告)号：US06861034B1
公开(公告)日：2005-03-01
申请号：US09721388
申请日：2000-11-22
申请人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
IPC分类号： C12M1/00 , B01L3/02 , B05B1/04 , B05B17/06 , B01L3/00 , B41J23/00 , B41J29/38
CPC分类号： B05B17/0607 , B01L3/0268
摘要： Provided is a priming mechanism for priming a biofluid drop ejection device having a drop ejection opening leading to an ejection reservoir. The priming mechanism includes a vacuum unit which generates a vacuum force, connected to a vacuum nozzle. The vacuum nozzle is located over the drop ejection opening. A disposable sleeve or tubing is attached to the vacuum nozzle and is placed in operational contact with the drop ejection opening. A fluid height detection sensor is positioned to sense a fluid height within at least one of the disposable tubing and the vacuum nozzle. Upon sensing a predetermined fluid height, by the fluid height detection sensor, the priming operation is completed, and the primer mechanism is removed from the operational contact with the drop ejection opening.
摘要翻译：提供了一种用于起动生物流体液滴喷射装置的起动机构，其具有通向喷射储存器的液滴喷射开口。起动机构包括产生与真空喷嘴连接的真空力的真空单元。真空喷嘴位于液滴喷射口的上方。一次性套筒或管道连接到真空喷嘴并且与液滴喷射口处于操作接触。液体高度检测传感器被定位成感测至少一个一次性管道和真空喷嘴中的流体高度。通过流体高度检测传感器感测到预定的流体高度时，完成起动操作，并且将底漆机构从与液滴喷射口的操作接触部分移开。

19. 发明授权

US06800438B2 Imager for DNA sequencer 有权
标题翻译：成像器DNA测序仪
公开(公告)号：US06800438B2
公开(公告)日：2004-10-05
申请号：US09750560
申请日：2000-12-28
申请人： Jaan Noolandi , Robert A. Street , Neville Connell
发明人： Jaan Noolandi , Robert A. Street , Neville Connell
IPC分类号： C12Q168
CPC分类号： G01N15/1425 , G01N15/1456 , G01N27/44721 , G01N2015/149
摘要： An improved method for the sequencing of DNA fragments is provided. The method includes using a known process for DNA fragment separation, such as capillary electrophoresis, and imaging the resultant gel plate with a full-width array scanner or a two-dimensional amorphous silicon image sensor array. The DNA sample is placed within a well of the separation apparatus, such as a capillary tube or plurality thereof. The separation apparatus is then placed in a buffer. An electric field is then applied, forming a bias between the ends along which the sample is separated. Once separated, the large area detector scans the entire gel plate and resultant image data is provided. By way of the improved method, the entire gel plate can be scanned at the same time and repeatedly, resulting in greater accuracy and a shorter time to sequence.
摘要翻译：提供了一种改进的DNA片段测序方法。该方法包括使用用于DNA片段分离的已知方法，例如毛细管电泳，并用全宽阵列扫描仪或二维非晶硅图像传感器阵列对所得凝胶板进行成像。将DNA样品置于分离装置的孔内，例如毛细管或其多个孔。然后将分离装置放在缓冲液中。然后施加电场，在样品分离的端部之间形成偏压。一旦分离，大面积检测器扫描整个凝胶板，并提供合成的图像数据。通过改进的方法，可以同时和重复地扫描整个凝胶板，导致更高的精度和更短的顺序时间。

20. 发明授权

US06416157B1 Method of marking a substrate employing a ballistic aerosol marking apparatus 有权
标题翻译：使用弹道气溶胶标记装置标记基板的方法
公开(公告)号：US06416157B1
公开(公告)日：2002-07-09
申请号：US09164124
申请日：1998-09-30
申请人： Eric Peeters , Jaan Noolandi , Raj B. Apte , Philip D. Floyd , Jonathan A. Small , Gregory J. Kovacs , Meng H. Lean , Armin R. Volkel , Steven B. Bolte , An-Chang Shi , Frederick J. Endicott , Gregory B. Anderson , Dan A. Hays , Joel A. Kubby , Warren B. Jackson
发明人： Eric Peeters , Jaan Noolandi , Raj B. Apte , Philip D. Floyd , Jonathan A. Small , Gregory J. Kovacs , Meng H. Lean , Armin R. Volkel , Steven B. Bolte , An-Chang Shi , Frederick J. Endicott , Gregory B. Anderson , Dan A. Hays , Joel A. Kubby , Warren B. Jackson
IPC分类号： B41J214
CPC分类号： B41J2/01 , B41J2/14 , B41J2/211 , B41J2202/02
摘要： A method of marking employs a marking apparatus in which a propellant stream is passed through a channel and directed toward a substrate. Marking material, such as ink, toner, etc., is controllably introduced into the propellant stream and imparted with sufficient kinetic energy thereby to be made incident upon a substrate. At sufficient velocity, and with appropriate marking material, the marking material may be kinetically fused to the substrate. A multiplicity of channels for directing the propellant and marking material allow for high throughput, high resolution marking. Multiple marking materials may be introduced into the channel and mixed therein prior to being made incident on the substrate, or mixed or superimposed on the substrate without registration. One example is single-pass, full-color printing.
摘要翻译：标记方法使用标记装置，其中推进剂流通过通道并指向基底。诸如油墨，调色剂等的标记材料被可控地引入推进剂流中并且赋予足够的动能从而被入射到基底上。在足够的速度下，并且使用适当的标记材料，标记材料可以与基底动力学融合。用于引导推进剂和标记材料的多个通道允许高通量，高分辨率标记。可以将多个标记材料引入通道中并在其入射到基板之前混合，或者混合或叠加在基板上而不进行配准。一个例子是单程，全色打印。

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