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1. 发明申请

US20110184513A1 Artificial corneal implant 审中-公开
标题翻译：人造角膜植入物
公开(公告)号：US20110184513A1
公开(公告)日：2011-07-28
申请号：US12928819
申请日：2010-12-20
申请人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher N. Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco , Laura Hartmann
发明人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher N. Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco , Laura Hartmann
IPC分类号： A61F2/14
CPC分类号： A61L27/3804 , A61F2/142 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L2430/16 , C12N5/0621 , C12N2533/30
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，其中第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附于生物分子。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

2. 发明申请

US20110166247A1 Interpenetrating polymer network hydrogel contact lenses 审中-公开
标题翻译：互穿聚合物网络水凝胶隐形眼镜
公开(公告)号：US20110166247A1
公开(公告)日：2011-07-07
申请号：US12928820
申请日：2010-12-20
申请人： David Myung , Jaan Noolandi , Christopher N. Ta , Curtis W. Frank , Laura Hartmann
发明人： David Myung , Jaan Noolandi , Christopher N. Ta , Curtis W. Frank , Laura Hartmann
IPC分类号： G02C7/04 , C08L33/02 , C08L77/00
CPC分类号： G02B1/043 , C08F290/062 , C08J3/075 , C08J3/246 , C08J2333/02 , C08J2371/02 , C08L33/02 , C08L71/02 , C08L2205/04 , C08L2205/05 , C08L101/04 , C08F220/06 , C08F222/1006
摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylamide and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酰胺，亲水单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

3. 发明申请

US20110182968A1 Interpenetrating polymer network hydrogel corneal prosthesis 审中-公开
标题翻译：互穿聚合物网络水凝胶角膜假体
公开(公告)号：US20110182968A1
公开(公告)日：2011-07-28
申请号：US12928818
申请日：2010-12-20
申请人： David Myung , Christopher N. Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi , Laura Hartmann
发明人： David Myung , Christopher N. Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi , Laura Hartmann
IPC分类号： A61K9/00 , A61K35/12 , A61K38/02 , A61K38/16 , A61K31/197 , A61K31/70 , A61K31/7052 , A61K39/395 , A61K38/18 , A61P27/02
CPC分类号： A61F2/142 , A61L27/26 , A61L27/3804 , A61L27/3869 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/414 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C12N2533/50 , C12N2533/54 , C12N2535/10 , C08L33/08 , C08L71/02
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylamide, PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酰胺，PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

4. 发明申请

US20090117166A1 Sequential coupling of biomolecule layers to polymers 审中-公开
标题翻译：生物分子层与聚合物的顺序耦合
公开(公告)号：US20090117166A1
公开(公告)日：2009-05-07
申请号：US12228884
申请日：2008-08-15
申请人： David Myung , Stayce Beck , Jaan Noolandi , Christopher N. Ta , Jennifer R. Cochran , Curtis W. Frank
发明人： David Myung , Stayce Beck , Jaan Noolandi , Christopher N. Ta , Jennifer R. Cochran , Curtis W. Frank
IPC分类号： A61F2/04 , A61K9/10 , A61K38/39 , A61K38/30 , A61K38/18
CPC分类号： A61L27/34 , A61L15/32 , A61L27/14 , A61L27/48 , C08L89/00
摘要： A bio-mimetic or bio-implantable material based on a sequential process of coupling biomolecule layers to a polymer layer is provided. In general, the material could be based on two or more biomolecule layers starting with one of the layers covalently linked to the polymer layer via cross-linkers and the other layers sequentially and covalently linked using cross-linkers to the previously added layer. The polymer layer could be a hydrogel or an interpenetrating polymer network hydrogel. The first layer of biomolecules could be a collagen type, fibronectin, laminin, extracellular matrix protein, or any combinations thereof. The second layer of biomolecules typically is a growth factor, protein or stimulant. The cross-linkers are either water soluble or insoluble bifunctional cross-linkers or azide-active-ester crosslinkers. The material and process as taught in this invention are useful in the field of tissue engineering and wound healing.
摘要翻译：提供了基于将生物分子层耦合到聚合物层的顺序方法的生物模拟或生物可植入材料。通常，该材料可以基于两个或更多个生物分子层，其起始于通过交联剂共价连接到聚合物层的层之一，并且其它层使用交联剂顺序并共价连接到先前添加的层。聚合物层可以是水凝胶或互穿聚合物网络水凝胶。第一层生物分子可以是胶原型，纤连蛋白，层粘连蛋白，细胞外基质蛋白或其任何组合。第二层生物分子通常是生长因子，蛋白质或兴奋剂。交联剂是水溶性或不溶性双功能交联剂或叠氮化物 - 活性酯交联剂。本发明教导的材料和方法可用于组织工程和伤口愈合领域。

5. 发明授权

US08821583B2 Interpenetrating polymer network hydrogel 有权
标题翻译：互穿聚合物网络水凝胶
公开(公告)号：US08821583B2
公开(公告)日：2014-09-02
申请号：US12070336
申请日：2008-02-15
申请人： David Myung , Laura Hartmann , Jean Noolandi , Christopher N. Ta , Curtis W. Frank
发明人： David Myung , Laura Hartmann , Jean Noolandi , Christopher N. Ta , Curtis W. Frank
IPC分类号： A61F2/08 , A61L27/52 , A61L27/38
CPC分类号： A61K47/48784 , A61K47/58 , A61K47/60 , A61K47/6903 , A61L27/38 , A61L27/52
摘要： A strain-hardened interpenetrating polymer network (IPN) hydrogel is provided. The interpenetrating polymer network hydrogel is based on two different networks. The first network is a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups. The second network is a non-silicone network of ionizable monomers. The second network has been polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. An aqueous salt solution having a neutral pH is used to ionize and swell the second network in the interpenetrating polymer network. The swelling of the second network is constrained by the first network, and this constraining effect results in an increase in effective physical cross-links within the interpenetrating polymer network, and, in turn, an increase its elastic modulus. The strain-hardened interpenetrating polymer network hydrogel is attractive and useful for medical, industrial, and personal hygiene purposes.
摘要翻译：提供了应变硬化的互穿聚合物网络（IPN）水凝胶。互穿聚合物网络水凝胶基于两个不同的网络。第一个网络是通过其端基聚合化学交联的预制亲水非离子遥爪大分子单体的非硅氧烷网络。第二个网络是可离子化单体的无硅网络。第二网络已经在第一网络的存在下被聚合和化学交联，并且与第一网络形成了物理交叉连接。使用具有中性pH的盐水溶液使互穿聚合物网络中的第二网络离子化并溶胀。第二网络的膨胀由第一网络约束，并且这种约束效应导致互穿聚合物网络内的有效物理交联的增加，并且进而增加其弹性模量。应变硬化的互穿聚合物网络水凝胶对于医疗，工业和个人卫生目的是有吸引力和有用的。

6. 发明授权

US07909867B2 Interpenetrating polymer network hydrogel corneal prosthesis 有权
标题翻译：互穿聚合物网络水凝胶角膜假体
公开(公告)号：US07909867B2
公开(公告)日：2011-03-22
申请号：US11639049
申请日：2006-12-13
申请人： David Myung , Christopher Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi
发明人： David Myung , Christopher Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi
IPC分类号： A61F2/14
CPC分类号： C12N5/0621 , A61F2/142 , A61F2/15 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2430/16 , C12N2533/30 , C12N2533/54 , C08L71/02 , C08L33/08
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

7. 发明授权

US07857849B2 Artificial corneal implant 有权
标题翻译：人造角膜植入物
公开(公告)号：US07857849B2
公开(公告)日：2010-12-28
申请号：US11243952
申请日：2005-10-04
申请人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco
发明人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco
IPC分类号： A61F2/14
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，其中第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附于生物分子。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

8. 发明申请

US20080269370A1 Strain-hardened interpenetrating polymer network hydrogel 有权
标题翻译：应变硬化互穿聚合物网络水凝胶
公开(公告)号：US20080269370A1
公开(公告)日：2008-10-30
申请号：US12070336
申请日：2008-02-15
申请人： David Myung , Laura Hartman , Jean Noolandi , Christopher N. Ta , Curtis W. Frank
发明人： David Myung , Laura Hartman , Jean Noolandi , Christopher N. Ta , Curtis W. Frank
IPC分类号： G02B1/04
CPC分类号： A61K47/48784 , A61K47/58 , A61K47/60 , A61K47/6903 , A61L27/38 , A61L27/52
摘要： A strain-hardened interpenetrating polymer network (IPN) hydrogel is provided. The interpenetrating polymer network hydrogel is based on two different networks. The first network is a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups. The second network is a non-silicone network of ionizable monomers. The second network has been polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. An aqueous salt solution having a neutral pH is used to ionize and swell the second network in the interpenetrating polymer network. The swelling of the second network is constrained by the first network, and this constraining effect results in an increase in effective physical cross-links within the interpenetrating polymer network, and, in turn, an increase its elastic modulus. The strain-hardened interpenetrating polymer network hydrogel is attractive and useful for medical, industrial, and personal hygiene purposes.
摘要翻译：提供了应变硬化的互穿聚合物网络（IPN）水凝胶。互穿聚合物网络水凝胶基于两个不同的网络。第一个网络是通过其端基聚合化学交联的预制亲水非离子遥爪大分子单体的非硅氧烷网络。第二个网络是可离子化单体的无硅网络。第二网络已经在第一网络的存在下被聚合和化学交联，并且与第一网络形成了物理交叉连接。使用具有中性pH的盐水溶液使互穿聚合物网络中的第二网络离子化并溶胀。第二网络的膨胀由第一网络约束，并且这种约束效应导致互穿聚合物网络内的有效物理交联的增加，并且进而增加其弹性模量。应变硬化的互穿聚合物网络水凝胶对于医疗，工业和个人卫生目的是有吸引力和有用的。

9. 发明授权

US08679190B2 Hydrogel arthroplasty device 有权
标题翻译：水凝胶关节成形术装置
公开(公告)号：US08679190B2
公开(公告)日：2014-03-25
申请号：US13418294
申请日：2012-03-12
申请人： David Myung , Lampros Kourtis , Laura Hartmann , Curtis W. Frank , Stuart B. Goodman , Dennis R. Carter
发明人： David Myung , Lampros Kourtis , Laura Hartmann , Curtis W. Frank , Stuart B. Goodman , Dennis R. Carter
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61F2/34 , A61F2/36 , A61F2/3603 , A61F2/3872 , A61F2/4202 , A61F2/4225 , A61F2/4241 , A61F2/4405 , A61F2002/30075 , A61F2002/30448 , A61F2002/30754 , A61F2002/3619 , A61F2210/0061 , A61F2220/005 , A61F2310/00293 , A61L27/18 , A61L27/34 , A61L27/3843 , A61L27/50 , A61L27/52 , A61L2430/24
摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
摘要翻译：提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络的可离子化单体。第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。使用盐水溶液（中性pH）来电离和膨胀第二网络。第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

10. 发明申请

US20120232657A1 Hydrogel Arthroplasty Device 有权
标题翻译：水凝胶关节成形装置
公开(公告)号：US20120232657A1
公开(公告)日：2012-09-13
申请号：US13418294
申请日：2012-03-12
申请人： David Myung , Lampros Kourtis , Laura Hartmann , Curtis W. Frank , Stuart B. Goodman , Dennis R. Carter
发明人： David Myung , Lampros Kourtis , Laura Hartmann , Curtis W. Frank , Stuart B. Goodman , Dennis R. Carter
IPC分类号： A61F2/02
CPC分类号： A61F2/30756 , A61F2/34 , A61F2/36 , A61F2/3603 , A61F2/3872 , A61F2/4202 , A61F2/4225 , A61F2/4241 , A61F2/4405 , A61F2002/30075 , A61F2002/30448 , A61F2002/30754 , A61F2002/3619 , A61F2210/0061 , A61F2220/005 , A61F2310/00293 , A61L27/18 , A61L27/34 , A61L27/3843 , A61L27/50 , A61L27/52 , A61L2430/24
摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
摘要翻译：提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络的可离子化单体。第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。使用盐水溶液（中性pH）来电离和膨胀第二网络。第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

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