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11. 发明授权

US09067031B2 Metered dose valves and dispensers 有权
标题翻译：计量剂量阀和分配器
公开(公告)号：US09067031B2
公开(公告)日：2015-06-30
申请号：US12444864
申请日：2007-10-19
申请人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
发明人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
IPC分类号： A61M11/00 , A61M15/00 , B65D83/54 , B65D83/14
CPC分类号： A61M15/009 , A61M2205/75 , B65D83/54 , B65D83/754
摘要： A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, the at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.
摘要翻译：一种用于加压计量剂量分配器的计量剂量阀，用于分配计量剂量的气溶胶制剂，其包含悬浮在液化推进剂中的药物颗粒，任选地与一种或多种赋形剂组合，所述阀包括计量室和至少一种多孔的，可流体渗透的，颗粒状的半渗透体，所述至少一个多孔体位于所述阀的内部导管的区域内，例如位于所述计量室内，或预计量室和/或内部通道上游的计量室。

12. 发明申请

US20120132203A1 DRY POWDER INHALERS 有权
标题翻译：干粉吸入器
公开(公告)号：US20120132203A1
公开(公告)日：2012-05-31
申请号：US13320762
申请日：2010-05-18
申请人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
发明人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译：干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内，载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。

13. 发明授权

US5740793A Dry powder inhalation device with elongate carrier for power 失效
标题翻译：干粉吸入装置，带细长载体供电
公开(公告)号：US5740793A
公开(公告)日：1998-04-21
申请号：US471612
申请日：1995-06-06
申请人： Peter D. Hodson , David K. Smith , David J. Velasquez , Anthony C.L. Wass , Clyde D. Calhoun
发明人： Peter D. Hodson , David K. Smith , David J. Velasquez , Anthony C.L. Wass , Clyde D. Calhoun
IPC分类号： A61K9/14 , A61K45/08 , A61K47/30 , A61M15/00 , A61M15/02 , A61M16/00 , A61P11/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0045 , A61M15/0006 , A61M15/0016 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0066 , A61M15/0078 , A61M15/0085 , A61M15/0091 , A61M15/02 , A61M2016/0024 , A61M2202/064 , A61M2205/8206
摘要： A dry powder inhalation device comprising a housing defining a chamber in communication with a patient port in the form of a mouthpiece or nasal adaptor, and an elongate carrier bearing a powdered medicament, the device being constructed and arranged such that areas of predetermined size of the elongate carrier may sequentially be exposed within the chamber, the device comprising one or more air inlets such that when a patient inhales through the patient port an air flow is established from the air inlet(s) to the patient port through the chamber such that particles of the powdered medicament of respirable size from said exposed area of the elongate carrier are entrained within the air flow.
摘要翻译：一种干粉吸入装置，其特征在于，包括壳体，所述壳体限定与所述口部或鼻部适配器形式的患者端口连通的室，以及承载有粉末状药物的细长载体，所述装置被构造和布置成使得预定尺寸的细长的载体可以顺序地在腔室内暴露，该装置包括一个或多个空气入口，使得当患者通过患者端口吸入时，通过腔室从空气入口到患者端口建立空气流，使得颗粒的来自所述细长载体的所述暴露区域的可吸入尺寸的粉末状药物被夹带在空气流中。

14. 发明授权

US5469843A Inhalation device 失效
标题翻译：吸入装置
公开(公告)号：US5469843A
公开(公告)日：1995-11-28
申请号：US240675
申请日：1994-05-04
申请人： Peter D. Hodson
发明人： Peter D. Hodson
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： A61M15/0091 , A61M11/002 , A61M15/0045 , A61M15/0051 , A61M2202/064
摘要： The present invention relates to a dry powder inhaler having one or more deaglommeration channels through which an airstream containing entrained medicament particles passes. Each channel has a substantially constant cross-sectional area and a bend having a radius of curvature of no greater than 10 mm.
摘要翻译： PCT No.PCT / US92 / 09505 Sec。 371日期：1994年5月4日 102（e）日期1994年5月4日PCT提交1992年11月6日PCT公布。公开号WO93 / 09832 日本专利日本：1993年5月27日。本发明涉及具有一个或多个脱胶通道的干粉吸入器，通过该通道，含有夹带药物颗粒的气流通过该吸入器。每个通道具有基本恒定的横截面面积和具有不大于10mm的曲率半径的弯曲部。

15. 发明授权

US07299801B2 Metering valve for a metered dose inhaler providing consistent delivery 有权
公开(公告)号：US07299801B2
公开(公告)日：2007-11-27
申请号：US10655419
申请日：2003-09-04
申请人： Peter D. Hodson
发明人： Peter D. Hodson
IPC分类号： A61M11/00
CPC分类号： B65D83/54 , A61M15/009
摘要： The present invention relates to a novel design for a metering valve that provides improved consistency of formulation delivery. Generally, the metering valve includes (a) a valve stem that generally defines a longitudinal axis and includes a body portion having a metering surface, wherein the longitudinal axis and a plane tangential to at least a portion of the metering surface define an angle from about 2° to about 90°; and (b) a valve body having an internal chamber defined at least in part by the body wall and includes a metering portion configured to substantially conform to the metering surface of the valve stem.

16. 发明授权

US08517019B2 Method and apparatus for metered dose dispensing 有权
标题翻译：计量剂量分配的方法和装置
公开(公告)号：US08517019B2
公开(公告)日：2013-08-27
申请号：US12281559
申请日：2007-03-01
申请人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
发明人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
IPC分类号： A62B7/00 , A62B9/00 , A61M11/00
CPC分类号： A61M15/009 , A61M15/0065 , A61M15/0073 , G06M1/04
摘要： This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction. The cap is then moved in a second opposite direction, which causes the slider to move in a second opposite linear direction, which in turn causes rotation of the first counter ring through a second arc in the first circumferential direction about the axis of the container. A sum of the first and second arcs of movement of the first counter ring defines a circumferential extent of movement of the first counter ring relative to the cap that indicates a single dose of aerosol medication dispensed from the container.
摘要翻译：本申请公开了一种用于在具有气溶胶容器和致动器的气溶胶分配组件上使用的剂量计数装置。剂量计数器装置用于指示通过在轴向上施加在气溶胶分配组件上的力引起的剂量的气溶胶药物的释放。剂量计数装置具有帽，滑块和第一计数器环。盖沿着容器的轴线沿第一方向移动，这导致滑块相对于容器的轴线在第一线性方向上相对于容器的轴线的移动，这是沿着第一方向的运动的函数。随着滑块在第一直线方向的移动，第一计数器环围绕容器的轴线在第一圆周方向上旋转通过第一弧。然后，盖沿第二相反方向移动，这导致滑块在第二相对的线性方向上移动，这又导致第一计数器环围绕容器的轴线沿第一圆周方向旋转第二弧。第一计数器环的第一和第二运动弧的总和限定了第一计数器环相对于盖的周向运动范围，其指示从容器分配的单剂量的气溶胶药物。

17. 发明申请

US20100229859A1 POWDER FILLING PROCESSES 有权
标题翻译：粉末填充工艺
公开(公告)号：US20100229859A1
公开(公告)日：2010-09-16
申请号：US12293683
申请日：2007-03-22
申请人： Peter D. Hodson , Matthew J. Wilby
发明人： Peter D. Hodson , Matthew J. Wilby
IPC分类号： A61M15/00 , B65B1/20
CPC分类号： A61M15/005 , A61K9/0075 , A61M15/0051 , A61M2202/064 , B05D1/40 , B65H18/28
摘要： A method for filling a plurality of microdepressions in a major surface of a web with finely divided powder in which the web is fed continuously to and through a powder filling stage including a driven roller. At the powder filling stage, the powder, which is fed either onto the web upstream of the roller or to the roller of the powder filling stage, is filled into the microdepressions of the web using the driven roller, wherein said roller is rotating about an axis generally transverse to the direction of web, while the surface speed of the roller and the web speed are different and wherein the roller and web are positioned relative to one another, such that between the upper surface of the web and the outer surface of the roller there is a gap. A method of manufacturing an elongate carrier with microdepressions containing finely divided powder comprising steps filling a plurality of microdepressions in a major surface of a web as described, removing from upper surface of the web excess powder not filled within the microdepressions and remaining on areas of the surface between the depressions, and optionally slitting and/or cutting the web in width and/or length.
摘要翻译：一种用细粉末填充幅材的主表面上的多个微压缩物的方法，其中幅材被连续地供给到并通过包括从动辊的粉末填充阶段。在粉末填充阶段，使用从动辊将送入辊的上游或粉末填充阶段的辊上的粉末填充到幅材的微压缩物中，其中所述辊围绕轴线通常横向于幅材的方向，而辊的表面速度和幅材速度是不同的，并且其中辊和幅材相对于彼此定位，使得在幅材的上表面和纸幅的外表面之间辊子有差距。一种制造细长载体的方法，其具有包含细粉末的微量压缩物，其包括如上所述填充幅材的主表面中的多个微压缩物的步骤，从未填充在微食品中的幅材过量粉末的上表面移除并保留在凹陷之间的表面，并且可选地在宽度和/或长度上切割和/或切割幅材。

18. 发明授权

US07748378B2 Metering valve for a metered dose inhaler providing consistent delivery 有权
标题翻译：用于计量剂量吸入器的计量阀，提供一致的输送
公开(公告)号：US07748378B2
公开(公告)日：2010-07-06
申请号：US11931647
申请日：2007-10-31
申请人： Peter D. Hodson
发明人： Peter D. Hodson
IPC分类号： A61M11/00
CPC分类号： B65D83/54 , A61M15/009
摘要： The present invention relates to a novel design for a metering valve that provides improved consistency of formulation delivery. Generally, the metering valve includes (a) a valve stem that generally defines a longitudinal axis and includes a body portion having a metering surface, wherein the longitudinal axis and a plane tangential to at least a portion of the metering surface define an angle from about 2° to about 90°; and (b) a valve body having an internal chamber defined at least in part by the body wall and includes a metering portion configured to substantially conform to the metering surface of the valve stem.
摘要翻译：本发明涉及一种计量阀的新型设计，其提供了改进的制剂输送一致性。通常，计量阀包括（a）大体上限定纵向轴线并且包括具有计量表面的主体部分的阀杆，其中纵向轴线和与计量表面的至少一部分切线的平面限定了从约 2°至约90°; 和（b）具有至少部分地由主体壁限定的内部室的阀体，并且包括被配置为基本上符合阀杆的计量表面的计量部分。

19. 发明申请

US20080271733A1 Methods of Providing Medicinal Metal Components Having Through Holes 审中-公开
标题翻译：提供具有通孔的药用金属成分的方法
公开(公告)号：US20080271733A1
公开(公告)日：2008-11-06
申请号：US11721502
申请日：2005-12-07
申请人： Gary Ka Lai Ng , Lin Li , Peter D. Hodson
发明人： Gary Ka Lai Ng , Lin Li , Peter D. Hodson
IPC分类号： A61M15/00 , B23K26/38 , B23K26/14 , B29D22/00
CPC分类号： B23K26/384 , B23K26/142 , Y10T428/13
摘要： A metal component, in particular a metal component of a medicinal device, such as a pharmaceutical aerosol delivery device, having a through hole extending along an axis from a first surface (10) to a second surface (20) of said component and having a sidewall, wherein the sidewall (30) in its planar cross-section along said axis through the first and second surfaces (10) has a geometric form generally corresponding to an arc of a segment (16) of a circle, an oval or an ellipse where the end points (11, 12) of the chord (17) of said segment (16) are located at the points of intersection of the sidewall (30) with the first and second surfaces (10, 20) (a “rounded sidewall”). Methods of providing a metal component with a through hole with a rounded sidewall, said methods comprising the step of directing at the entrance of the hole at the first surface a pulse of laser light having sufficient energy to melt the material in the vicinity of the hole, said laser light being focused and the focal plane of said focused laser light being positioned substantially normal to said axis of through hole between the source of said laser light and the first surface, while providing a flow of gas through the through hole.
摘要翻译：金属部件，特别是药物装置的金属部件，例如药物气溶胶输送装置，具有沿轴线从所述部件的第一表面（10）延伸到第二表面（20）的通孔，并且具有侧壁，其中沿着所述轴线穿过第一和第二表面（10）的平面横截面的侧壁（30）具有几何形状，其几何形状通常对应于圆的段（16）的弧形，椭圆形或椭圆形其中所述段（16）的弦（17）的端点（11,12）位于侧壁（30）与第一和第二表面（10,20）（a“圆形侧壁 “）。提供具有圆形侧壁的通孔的金属部件的方法，所述方法包括以下步骤：在第一表面处的孔的入口处引导具有足够能量的激光脉冲，以熔化孔附近的材料所述激光被聚焦，并且所述聚焦激光的焦平面基本上垂直于所述激光源和所述第一表面之间的所述通孔轴线，同时提供通过所述通孔的气流。

20. 发明授权

US06863195B2 Valve stem for use in a metering valve of a metered dose inhaler 失效
标题翻译：用于定量吸入器计量阀的阀杆
公开(公告)号：US06863195B2
公开(公告)日：2005-03-08
申请号：US10334375
申请日：2002-12-30
申请人： Andrew M. Bryant , Gustavo H. Castro , David J. Greenleaf , Peter D. Hodson , Gary D. Mahon
发明人： Andrew M. Bryant , Gustavo H. Castro , David J. Greenleaf , Peter D. Hodson , Gary D. Mahon
IPC分类号： B65D83/44 , B65D83/14 , G01F11/12 , G01R11/12 , B65D83/00
CPC分类号： B65D83/54 , G01F11/12 , G01R11/12
摘要： Valve stems for use in an aerosol metering valve are described herein. The valve stems include structures designed to limit the likelihood and extent to which a gasket can intrude into an opening in the valve stem. The valve stems described herein also limit the likelihood and extent of damage to the gasket caused by repeated use of the metering valve.
摘要翻译：本文描述了用于气溶胶计量阀的阀杆。阀杆包括设计成限制垫圈可能侵入阀杆中的开口的可能性和程度的结构。本文所述的阀杆还限制了由于重复使用计量阀而导致的垫圈损坏的可能性和程度。

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