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11. 发明申请

US20060106062A1 Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors 失效
标题翻译：用作PDE4抑制剂的取代的2-喹啉基 - 恶唑
公开(公告)号：US20060106062A1
公开(公告)日：2006-05-18
申请号：US11130359
申请日：2005-05-16
申请人： Rongze Kuang , David Blythin , Neng-Yang Shih , Ho-Jane Shue , Xiao Chen , Jianhua Cao , Danlin Gu , Ying Huang , John Schwerdt , Pauline Ting , Shing-Chun Wong , Li Xiao
发明人： Rongze Kuang , David Blythin , Neng-Yang Shih , Ho-Jane Shue , Xiao Chen , Jianhua Cao , Danlin Gu , Ying Huang , John Schwerdt , Pauline Ting , Shing-Chun Wong , Li Xiao
IPC分类号： A61K31/4709 , C07D417/02 , C07D413/02 , C07D43/02
CPC分类号： C07D405/14 , C07D401/04 , C07D405/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention claims compounds of the formula wherein is a 5-membered heteroaryl; X is S or O; R1 is H, alkyl, cycloalkyl, cylcoalkylalkyl-, —CH2F, —CHF2, —CF3, —C(O)alkyl or —C(O)NR18R19; R3 and R4H, alkyl, hydroxyalkyl or —C(O)Oalkyl; R5 and R6 are H, alkyl, hydroxyalkyl, alkoxyalkyl, mercaptoalkyl, —CH2F, —CHF2, —CF3, —C(O)OH or —C(O)Oalkyl; R7 is H, alkyl, alkenyl, hydroxyalkyl, cycloalkyl, alkoxyalkyl, aminoalkyl, (R17-phenyl)alkyl or —CH2—C(O)—O-alkyl; and R8 comprises alkyl, heteroaryl, phenyl or cycloalkyl, or heterocycloalkyl, all optionally substituted, or a cycloalkyl- or heterocycloalkyl-substituted amide; or R7 and R8 and the nitrogen to which they are attached together form an optionally substituted ring; and the remaining variables are as defined in the specification. Also claimed are pharmaceutical compositions, the use of the compounds as PDE4 inhibitors, and combinations with other actives.
摘要翻译：本发明要求具有下式的化合物其中是5元杂芳基; X是S或O; R 1是H，烷基，环烷基，环烷基烷基 - ，-CH 2 F，-CHF 2，-CF 3， -C（O）烷基或-C（O）NR 18 R 19; R 3和R 4 H，烷基，羟烷基或-C（O）O烷基; R 5和R 6是H，烷基，羟基烷基，烷氧基烷基，巯基烷基，-CH 2 F 2，-CHF 2， -CF 3，-C（O）OH或-C（O）O烷基; R 7是H，烷基，烯基，羟基烷基，环烷基，烷氧基烷基，氨基烷基，（R 17 - 苯基）烷基或-CH 2 - C（O）-O-烷基; 和R 8包括烷基，杂芳基，苯基或环烷基，或杂环烷基，全部被取代，或环烷基 - 或杂环烷基取代的酰胺; 或R 7和R 8和它们所连接的氮一起形成任选取代的环; 其余变量如本说明书中所定义。还要求保护的是药物组合物，化合物作为PDE4抑制剂的用途，以及与其它活性物质的组合。

12. 发明申请

US20050182095A1 Piperdine derivatives useful as CCR3 antagonists 失效
标题翻译：哌啶衍生物可用作CCR3拮抗剂
公开(公告)号：US20050182095A1
公开(公告)日：2005-08-18
申请号：US11049460
申请日：2005-02-02
申请人： Pauline Ting , Jianhua Cao , Youhao Dong , Eric Gilbert , Ying Huang , Joseph Kelly , Stuart McCombie , Neng-Yang Shih
发明人： Pauline Ting , Jianhua Cao , Youhao Dong , Eric Gilbert , Ying Huang , Joseph Kelly , Stuart McCombie , Neng-Yang Shih
IPC分类号： A61K31/444 , A61K31/4545 , A61K31/4709 , C07D211/18 , C07D211/58 , C07D401/04 , C07D401/14 , C07D413/14 , C07D471/04 , C07D41/14
CPC分类号： C07D401/14 , C07D211/18 , C07D211/58 , C07D401/04 , C07D471/04
摘要： The use of CCR3 antagonists of the formula I or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula II, pharmaceutical compositions comprising them, and their use in the treatment of asthma, wherein R, Ra, X, Xa, R1, R2, R2a, R14, R14a, R16 and n are as defined in the specification.
摘要翻译：公开了使用式I的CCR3拮抗剂或其药学上可接受的盐治疗哮喘，以及式II的新型化合物，包含它们的药物组合物及其在治疗哮喘中的用途，其中R， X 1，X 1，X 2，...，R 2，R 2，R 2， >，R 14，R 14a，R 16和n如说明书中所定义。

13. 发明申请

US20110224136A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE 审中-公开
标题翻译：二乙酰胆碱酯酶抑制剂
公开(公告)号：US20110224136A1
公开(公告)日：2011-09-15
申请号：US13129830
申请日：2009-11-17
申请人： Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , David Kim , Hyunjin Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Gang Zhou , Nicolas Zorn
发明人： Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , David Kim , Hyunjin Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Gang Zhou , Nicolas Zorn
IPC分类号： A61K38/28 , C07D409/14 , C07D413/14 , C07D401/14 , C07D211/32 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K31/445 , A61K31/454 , A61K31/4545 , A61P3/04 , A61P3/10
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below.
摘要翻译：本发明涉及作为二酰基甘油酰基转移酶（“DGAT”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物和用于治疗或预防心血管疾病，代谢障碍，肥胖症或肥胖相关障碍的化合物的用途，糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。本发明的说明性化合物如下所示。

14. 发明授权

US08716312B2 Inhibitors of diacylglycerol acyltransferase 失效
标题翻译：二酰基甘油酰基转移酶抑制剂
公开(公告)号：US08716312B2
公开(公告)日：2014-05-06
申请号：US13129843
申请日：2009-11-17
申请人： Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
发明人： Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
IPC分类号： A61P3/00 , A61P9/00 , A61K31/445 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04
摘要： The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below:
摘要翻译：本发明涉及作为二酰基甘油酰基转移酶（“DGAT”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物和用于治疗或预防心血管疾病，代谢障碍，肥胖症或肥胖相关障碍的化合物的用途，糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。本发明的说明性化合物如下所示：

15. 发明申请

US20110224193A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE 审中-公开
标题翻译：二乙酰胆碱酯酶抑制剂
公开(公告)号：US20110224193A1
公开(公告)日：2011-09-15
申请号：US13129821
申请日：2009-11-17
申请人： Pauline C. Ting , Robert Aslanian , Jianhua Cao , Mary Ann Caplen , Tin-Yau Chan , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , Heping Wu
发明人： Pauline C. Ting , Robert Aslanian , Jianhua Cao , Mary Ann Caplen , Tin-Yau Chan , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , Heping Wu
IPC分类号： A61K31/5513 , C07D413/14 , A61K31/4545 , A61K31/497 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P3/08
CPC分类号： C07D413/12 , A61K31/422 , A61K31/427 , C07D213/74 , C07D401/04 , C07D403/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D493/10
摘要： The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown with this abstract.
摘要翻译：本发明涉及作为二酰基甘油酰基转移酶（“DGAT”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物和用于治疗或预防心血管疾病，代谢障碍，肥胖症或肥胖相关障碍的化合物的用途，糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。本摘要显示了本发明的说明性化合物。

16. 发明申请

US20110224137A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE 失效
标题翻译：二乙酰胆碱酯酶抑制剂
公开(公告)号：US20110224137A1
公开(公告)日：2011-09-15
申请号：US13129843
申请日：2009-11-17
申请人： Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
发明人： Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
IPC分类号： A61K38/28 , C07D409/14 , C07D243/08 , C07D401/14 , C07D221/00 , C07D211/06 , A61K31/497 , A61K31/551 , A61K31/4545 , A61K31/438 , A61K31/454 , A61P3/04 , A61P3/10
CPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04
摘要： The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: formula (I).
摘要翻译：本发明涉及作为二酰基甘油酰基转移酶（“DGAT”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物和用于治疗或预防心血管疾病，代谢障碍，肥胖症或肥胖相关障碍的化合物的用途，糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。本发明的说明性化合物如下所示：式（I）。

17. 发明授权

US09774767B2 Digital memory card window arrangement for IP camera 有权
公开(公告)号：US09774767B2
公开(公告)日：2017-09-26
申请号：US14953401
申请日：2015-11-29
申请人： Jianhua Cao
发明人： Jianhua Cao
IPC分类号： H04N5/225 , H04L29/08 , H04N5/232 , H04N1/00 , H04N1/21 , H04N7/18
CPC分类号： H04N5/2252 , H04L67/02 , H04N1/00209 , H04N1/00244 , H04N1/2158 , H04N5/23206
摘要： An Internet protocol (IP) camera includes a housing having a capturing window, a capturing unit received in the housing for capturing images as data sets through the capturing window, and a card window arrangement which includes a card slot unit for replaceably receiving a digital memory card to store the data sets therein and a concealing cover detachably coupled at the housing to conceal the card slot unit in a waterproof and dustproof manner without disassembling the housing.

18. 发明申请

US20170155806A1 Digital Memory Card Window Arrangement for IP Camera 审中-公开
公开(公告)号：US20170155806A1
公开(公告)日：2017-06-01
申请号：US14953401
申请日：2015-11-29
申请人： Jianhua Cao
发明人： Jianhua Cao
IPC分类号： H04N5/225 , H04N7/18 , H04N1/00 , H04N1/21 , H04L29/08 , H04N5/232
CPC分类号： H04N5/2252 , H04L67/02 , H04N1/00209 , H04N1/00244 , H04N1/2158 , H04N5/23206
摘要： An Internet protocol (IP) camera includes a housing having a capturing window, a capturing unit received in the housing for capturing images as data sets through the capturing window, and a card window arrangement which includes a card slot unit for replaceably receiving a digital memory card to store the data sets therein and a concealing cover detachably coupled at the housing to conceal the card slot unit in a waterproof and dustproof manner without disassembling the housing.

19. 发明授权

US09510034B2 Plug and play method and system of viewing live and recorded contents 有权
公开(公告)号：US09510034B2
公开(公告)日：2016-11-29
申请号：US14670402
申请日：2015-03-26
申请人： Jianhua Cao
发明人： Jianhua Cao
IPC分类号： H04N7/16 , H04N7/10 , H04N7/025 , H04N7/173 , H04N21/258 , H04N21/6547 , H04L29/06 , H04L29/08 , H04N21/61 , H04N21/218 , H04N21/2187 , H04N21/643 , H04N21/6334 , H04L29/14 , G08B13/196 , H04L29/12
CPC分类号： H04N21/25816 , G08B13/19656 , H04L61/2514 , H04L61/2575 , H04L61/2589 , H04L63/0428 , H04L63/083 , H04L63/10 , H04L67/10 , H04L69/40 , H04N21/21805 , H04N21/2181 , H04N21/2187 , H04N21/6125 , H04N21/6334 , H04N21/64322 , H04N21/6547
摘要： A plug and play method of viewing live and recorded contents includes the steps of: requesting information of a capturing device by a remote control center; sending an accessing request from an Internet-enabled receiving device to the remote control center through Internet; verifying whether the information of the capturing device matches with the accessing request from the receiving device by the remote control center; and establishing a communication channel between the capturing device and the receiving device to enable contents captured by the capturing device to be transmitted to the receiving device in a live manner through Internet.

20. 发明申请

US20140109363A1 WEAR-RESISTANT CLAMPING PLATE DEVICE FOR STUFFER BOX CRIMPER 有权
标题翻译：耐冲击夹钳装置耐磨夹板
公开(公告)号：US20140109363A1
公开(公告)日：2014-04-24
申请号：US14126180
申请日：2012-06-15
申请人： Baoru Yang , Jianhua Cao
发明人： Baoru Yang , Jianhua Cao
IPC分类号： D02G1/12
CPC分类号： D02G1/12 , F16B2/14
摘要： A cheek plate device for a stuffer box crimper, comprising a bracket, adjusting mechanisms, cheek plates, a base, a pair of nip rollers and thrust devices. The adjusting mechanisms, which can slide relative to the bracket, are arranged on the bracket, the cheek plates are installed on the inner sides of the adjusting mechanisms, a pair of identical brackets, adjusting mechanisms and cheek plates are symmetrically installed on each side of the pair of nip rollers and affixed on the base. The adjusting mechanisms have adjusting blocks and elastic devices, the elastic devices are installed at the ends of the adjusting blocks and push against the thrust devices, the thrust devices push the adjusting blocks via the elastic devices, and the adjusting blocks push the two cheek plates moving towards the sides of the pair of nip rollers.
摘要翻译：一种用于填塞箱卷缩机的颊板装置，包括支架，调节机构，颊板，基座，一对夹辊和推力装置。相对于支架滑动的调节机构布置在支架上，颊板安装在调节机构的内侧，一对相同的支架，调节机构和颊板对称地安装在一对夹辊并固定在基座上。调节机构具有调节块和弹性装置，弹性装置安装在调节块的端部并推压推力装置，推力装置通过弹性装置推动调节块，调节块推动两个颊板朝向一对夹辊的侧面移动。

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