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11. 发明申请

US20120215009A1 Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds 有权
标题翻译：制备胺的方法及其用于制备1,3-二取代吡唑化合物的方法
公开(公告)号：US20120215009A1
公开(公告)日：2012-08-23
申请号：US13504558
申请日：2010-10-28
申请人： Maximilian Dochnahl , Michael Keil , Roland Goetz
发明人： Maximilian Dochnahl , Michael Keil , Roland Goetz
IPC分类号： C07D231/14 , C07C241/00
CPC分类号： C07D231/14
摘要： Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds.
摘要翻译：制备胺的方法及其用于制备1,3-二取代吡唑化合物的方法。

12. 发明授权

US08362273B2 Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds 有权
标题翻译：制备胺的方法及其用于制备1,3-二取代吡唑化合物的方法
公开(公告)号：US08362273B2
公开(公告)日：2013-01-29
申请号：US13504558
申请日：2010-10-28
申请人： Maximilian Dochnahl , Michael Keil , Roland Goetz
发明人： Maximilian Dochnahl , Michael Keil , Roland Goetz
IPC分类号： C07D231/10 , C07C241/00 , C07C243/00
CPC分类号： C07D231/14
摘要： Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds.
摘要翻译：制备胺的方法及其用于制备1,3-二取代吡唑化合物的方法。

13. 发明授权

US08541611B2 Bifunctional phenyl iso(thio)cyanates, processes and intermediates products for their preparation 失效
标题翻译：双官能苯基异（硫代）氰酸酯，其制备方法和中间体产品
公开(公告)号：US08541611B2
公开(公告)日：2013-09-24
申请号：US13535544
申请日：2012-06-28
申请人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
发明人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
IPC分类号： C07C331/28
CPC分类号： C07D213/76 , C07C303/34 , C07C307/06 , C07C331/28 , C07C2601/14 , C07D207/20 , C07D211/18 , C07D211/70 , C07D295/26 , C07D307/52 , C07D319/06 , C07D333/20
摘要： A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
摘要翻译：描述式I的苯基异（硫代）氰酸酯的方法，其中将式II化合物或其HCl加合物与W是氧或硫的光气反应剂和Ar和A如权利要求1中所定义的相同。此外，本发明涉及苯基异（硫代）氰酸酯用于制备作物保护剂的用途。

14. 发明申请

US20110004002A1 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates 有权
标题翻译：制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法
公开(公告)号：US20110004002A1
公开(公告)日：2011-01-06
申请号：US12919842
申请日：2009-02-27
申请人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
发明人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
IPC分类号： C07D231/14 , C07C69/66
CPC分类号： C07D231/14 , C07C67/343 , C07C69/72
摘要： A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting where M is a sodium or potassium ion, and without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
摘要翻译：由烷基4,4-二氟乙酰乙酸酯（I）的粗反应混合物制备R为甲基或乙基的2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI）的方法，通过a）使M 钠离子或钾离子，无另外的溶剂以形成烯醇化物（Ⅴ）b）通过酸从烯醇化物（Ⅴ）中释出相应的4,4-二氟乙酰乙酸烷基酯（Ⅰ），c）除去由阳离子M形成的盐和酸阴离子作为固体，以及d）将（I）从粗反应混合物中分离出来，转化为2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI），以及（VI）用于制备1-甲基-3-二氟甲基 - 吡唑-3-基羧酸酯VII

15. 发明授权

US07820846B2 Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their preparation 有权
标题翻译：双官能苯基（硫代）氰酸酯，其制备方法和中间体产品
公开(公告)号：US07820846B2
公开(公告)日：2010-10-26
申请号：US10532931
申请日：2003-10-29
申请人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
发明人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
IPC分类号： C07C255/50
CPC分类号： C07D213/76 , C07C303/34 , C07C307/06 , C07C331/28 , C07C2601/14 , C07D207/20 , C07D211/18 , C07D211/70 , C07D295/26 , C07D307/52 , C07D319/06 , C07D333/20
摘要： A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
摘要翻译：描述式I的苯基异（硫代）氰酸酯的方法，其中将式II化合物或其HCl加合物与W是氧或硫的光气反应剂和Ar和A如权利要求1中所定义的相同。此外，本发明涉及苯基异（硫代）氰酸酯用于制备作物保护剂的用途。

16. 发明申请

US20100087640A1 Method for production of aryl-substituted annelated pyrimidines 审中-公开
标题翻译：芳基取代的环状嘧啶的制备方法
公开(公告)号：US20100087640A1
公开(公告)日：2010-04-08
申请号：US12521877
申请日：2008-01-10
申请人： Bernd Wolf , Volker Maywald , Michael Keil , Manuel Budich , Michael Rack , Manfred Ehresmann
发明人： Bernd Wolf , Volker Maywald , Michael Keil , Manuel Budich , Michael Rack , Manfred Ehresmann
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to a process for preparing aryl-substituted fused pyrimidines of the general formula (I) in which L1 to L5 are H, halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy etc.; Y1 to Y3 are C—RY or N; RY is H or optionally substituted C1-C4-alkyl or two adjacent RY together form a ring; X is OH, Cl or Br; which comprises (i) the reaction of a 2-phenylmalonate with a compound (III) or a tautomer thereof, in the presence of a suitable base, where the alcohol, released during the reaction, of the formula R—OH is continuously removed from the reaction mixture under reduced pressure; giving a compound of the formula (I) or a salt thereof in which X is OH, and, if X in the compounds of the general formula (I) is chlorine or bromine, (ii) the reaction of the compounds of the formula (I) obtained in step (i) or the salts with a halogenating agent.
摘要翻译：本发明涉及制备通式（I）的芳基取代的稠合嘧啶的方法，其中L 1至L 5为H，卤素，CN，NO 2，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4 - 烷氧基，C1-C4-卤代烷氧基等; Y1至Y3为C-RY或N; RY为H或任选取代的C 1 -C 4烷基或两个相邻的RY一起形成环; X是OH，Cl或Br; 其包括（i）2-苯基丙二酸酯与化合物（III）或其互变异构体在合适的碱的存在下反应，其中反应期间释放的醇与式R-OH的连续从减压下的反应混合物; 得到其中X是OH的式（I）化合物或其盐，并且如果通式（I）的化合物中的X是氯或溴，则（ii）式（I）化合物 I）或与卤化剂的盐。

17. 发明授权

US5446199A Preparation of halomethylbenzoyl cyanides and novel halomethylbenzoyl cyanides 失效
标题翻译：制备卤代甲基苯甲酰氰和新的卤代甲基苯甲酰氰
公开(公告)号：US5446199A
公开(公告)日：1995-08-29
申请号：US216416
申请日：1994-03-23
申请人： Heinz Isak , Thomas Wettling , Michael Keil , Bernd Wolf , Reinhard Doetzer
发明人： Heinz Isak , Thomas Wettling , Michael Keil , Bernd Wolf , Reinhard Doetzer
IPC分类号： C07C253/14 , C07C255/32 , C07C255/40
CPC分类号： C07C255/40 , C07C253/14
摘要： A process for preparing halomethylbenzoyl cyanides IPh-CO-CN I(Ph=phenyl radical substituted by chloromethyl or bromomethyl which, if desired, can additionally carry 1-4 further radicals) by reacting halomethylbenzoyl chlorides IIPh-CO-Cl IIwith an alkali metal cyanide or transition metal cyanide, if appropriate in an organic diluent, and novel halomethylbenzoyl cyanides I' ##STR1## (X=halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, CF.sub.3, C.sub.1 -C.sub.5 -alkyl-(C.sub.1 -C.sub.5 -alkyl)hydroxyimino or C.sub.1 -C.sub.5 -alkyl-(C.sub.2 -C.sub.5 -alkenyl)hydroxyimino; m=0 to 4 and Y=chloromethyl or bromomethyl) are described.The halomethylbenzoyl cyanides I are important intermediates for the synthesis of plant protection agents.
摘要翻译：制备卤代甲基苯甲酰基氰化物I Ph-CO-CNI（Ph =被氯甲基或溴甲基取代的苯基，如果需要，还可以另外携带1-4个基团），卤代甲基苯甲酰氯II Ph-CO-ClII与碱金属氰化物或过渡金属氰化物，如果合适，在有机稀释剂中，和新的卤代甲基苯甲酰氰I'（X =卤素，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，CF 3，C 1 -C 5烷基 - （ C 1 -C 5 - 烷基）羟基亚氨基或C 1 -C 5 - 烷基 - （C 2 -C 5 - 烯基）羟基亚氨基; m = 0至4，Y =氯甲基或溴甲基）。卤代甲基苯甲酰氰I是合成植物保护剂的重要中间体。

18. 发明授权

US08586750B2 Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters 有权
标题翻译：卤素取代的2-（氨基亚甲基）-3-氧代丁酸酯的制备方法
公开(公告)号：US08586750B2
公开(公告)日：2013-11-19
申请号：US12990364
申请日：2009-04-30
申请人： Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
发明人： Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
IPC分类号： C07D295/145 , C07D211/34 , C07D265/30
CPC分类号： C07D295/145 , C07D231/14
摘要： The present invention relates to a process for preparing 2-(aminomethylidene)-4,4-dihalo-3-oxobutyric esters of the formula (I), wherein R1, R2, R3 are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl, and/or R2 together with R3 and the nitrogen atom to which the two radicals are attached are a heterocyclic radical, in which a corresponding 3-aminoacrylic ester is reacted with a halogen-substituted acetyl fluoride in the presence of at least one alkali or alkaline earth metal fluoride; and the further conversion of halogen-substituted 2-(aminomethylidene)-3-oxobutyric esters of the formula (I) to halomethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.
摘要翻译：本发明涉及制备式（I）的2-（氨基亚甲基）-4,4-二卤代-3-氧代丁酸酯的方法，其中R1，R2，R3是C1-C6-烷基，C1-C6-卤代烷基，C 2 -C 6 - 烯基，C 3 -C 10 - 环烷基或苄基，和/或R 2与R 3和两个基团所连接的氮原子是杂环基团，其中相应的3-氨基丙烯酸酯与卤素取代的乙酰氟在至少一种碱金属或碱土金属氟化物的存在下; 以及将式（I）的卤素取代的2-（氨基亚甲基）-3-氧代丁酸酯进一步转化为卤代甲基取代的吡唑-4-基羧酸及其酯。

19. 发明授权

US08357695B2 Hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide 有权
标题翻译： 2-氯-5- [3,6-二氢-3-甲基-2,6-二氧代-4-（三氟甲基）-1-（2H） - 嘧啶基] -4-氟-N - [[甲基（ 1-甲基乙基）氨基]磺酰基]苯甲酰胺
公开(公告)号：US08357695B2
公开(公告)日：2013-01-22
申请号：US12444651
申请日：2007-10-12
申请人： Thomas Schmidt , Joachim Gebhardt , Sandra Löhr , Michael Keil , Jan Hendrik Wevers , Peter Erk , Heidi Emilia Saxell , Gerhard Hamprecht , Guido Mayer , Bernd Wolf , Gerhard Cox , Alfred Michel , Werner Seitz , Cyrill Zagar , Robert Reinhard , Bernd Sievernich
发明人： Thomas Schmidt , Joachim Gebhardt , Sandra Löhr , Michael Keil , Jan Hendrik Wevers , Peter Erk , Heidi Emilia Saxell , Gerhard Hamprecht , Guido Mayer , Bernd Wolf , Gerhard Cox , Alfred Michel , Werner Seitz , Cyrill Zagar , Robert Reinhard , Bernd Sievernich
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/54 , A01N43/54
摘要： The present invention relates to hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]-sulfonyl]benzamide. The invention also relates to a process for the preparation of these hydrates and to plant protection formulations which comprise hydrates of the phenyluracil I.
摘要翻译：本发明涉及2-氯-5- [3,6-二氢-3-甲基-2,6-二氧代-4-（三氟甲基）-1-（2H）嘧啶基] -4-氟-N- [[甲基（1-甲基乙基）氨基] - 磺酰基]苯甲酰胺。本发明还涉及制备这些水合物的方法以及包含苯基尿嘧啶I的水合物的植物保护制剂。

20. 发明授权

US08344157B2 Process for preparing 1,3-disubstituted pyrazolecarboxylic esters 失效
标题翻译： 1,3-二取代吡唑羧酸酯的制备方法
公开(公告)号：US08344157B2
公开(公告)日：2013-01-01
申请号：US13054642
申请日：2009-07-10
申请人： Bernd Wolf , Sebastian Peer Smidt , Volker Maywald , Christopher Koradin , Michael Keil , Thomas Zierke , Michael Rack
发明人： Bernd Wolf , Sebastian Peer Smidt , Volker Maywald , Christopher Koradin , Michael Keil , Thomas Zierke , Michael Rack
IPC分类号： C07D231/10
CPC分类号： C07D233/90
摘要： A process for preparing 1,3-disubstituted pyrazolecarboxylic esters of the formula (I) where X, Y, Z=hydrogen or halogen and R1=C1-C6-alkyl, by metering an enol ether of the formula III where R2 is C1-C6-alkyl at from (−41) to (−80)° C. into an alkyl hydrazine of the formula II H2N—NH-lower alkyl (II).
摘要翻译：通过计量式III的烯醇醚制备其中X，Y，Z =氢或R 1 = C 1 -C 6烷基的式（I）的1,3-二取代吡唑羧酸酯的方法，其中R2是C1- （-41）至（-80）℃的C 6 - 烷基转化为式II的烷基肼H 2 NH-NH-低级烷基（II）。

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