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11. 发明申请

US20070135395A1 Novel method for the preparation of intermediates useful for the synthesis fo vitamin d analogues 审中-公开
标题翻译：用于制备维生素d类似物合成有用的中间体的新方法
公开(公告)号：US20070135395A1
公开(公告)日：2007-06-14
申请号：US10588800
申请日：2005-03-23
申请人： Erik Hansen , Thomas Sabroe , Martin Calverley , Henrik Pedersen , Heinz-Josef Deussen
发明人： Erik Hansen , Thomas Sabroe , Martin Calverley , Henrik Pedersen , Heinz-Josef Deussen
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： C07C401/00 , C07C2601/02 , C07D333/72
摘要： The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.
摘要翻译：本发明涉及制备可用于合成卡波头三醇的中间体的新方法。本发明进一步涉及用所述方法生产卡培三酚或卡泊三醇一水合物生产的中间体的用途。

12. 发明授权

US07172887B2 Methods for producing citric acid using host cells deficient in oxaloacetate hydrolase 有权
标题翻译：使用缺乏草酰乙酸水解酶的宿主细胞产生柠檬酸的方法
公开(公告)号：US07172887B2
公开(公告)日：2007-02-06
申请号：US11122506
申请日：2005-05-04
申请人： Carsten Mailand Hjort , Henrik Pedersen
发明人： Carsten Mailand Hjort , Henrik Pedersen
IPC分类号： C12P7/48 , C12N15/63 , C12N1/15
CPC分类号： C12Q1/6895 , C12N9/14
摘要： The present invention relates to isolated nucleic acid sequences encoding polypeptides having oxaloacetate hydrolase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.
摘要翻译：本发明涉及编码具有草酰乙酸水解酶活性的多肽的分离的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的重组方法。

13. 发明申请

US20060246450A1 Ligational encoding of small molecules 有权
标题翻译：小分子的编码编码
公开(公告)号：US20060246450A1
公开(公告)日：2006-11-02
申请号：US10549619
申请日：2004-03-22
申请人： Thomas Franch , Soeren Jacobsen , Torben Rasmussen , Soeren Neve , Henrik Pedersen , Alex Gouliaev
发明人： Thomas Franch , Soeren Jacobsen , Torben Rasmussen , Soeren Neve , Henrik Pedersen , Alex Gouliaev
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07H21/04 , C12N15/1068 , C12P21/02 , C40B40/06 , C40B50/04
摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.
摘要翻译：本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关的抗密码子，以及ii）将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。

14. 发明申请

US20060166197A1 Building block capable of transferring a functional entity 审中-公开
标题翻译：能够传递功能实体的构建块
公开(公告)号：US20060166197A1
公开(公告)日：2006-07-27
申请号：US10507842
申请日：2003-03-14
申请人： Alex Gouliaev , Justin Ho , Jakob Felding , Christian Sams , Henrik Pedersen , Kim Jensen , Anders Hansen , Mikkel Lundorf , Gitte Husemoen , Thomas Franch , Thomas Thisted
发明人： Alex Gouliaev , Justin Ho , Jakob Felding , Christian Sams , Henrik Pedersen , Kim Jensen , Anders Hansen , Mikkel Lundorf , Gitte Husemoen , Thomas Franch , Thomas Thisted
IPC分类号： C40B40/08 , C07H21/02 , C07F9/6512
CPC分类号： C07D405/04 , C07B2200/11 , C07F9/65586 , C07F9/65616 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/1068 , C12P19/34 , C40B40/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译：具有转移遗传信息的双重能力的构建块，例如，通过识别编码元件并将功能实体传送到接收者反应组。构建块可以设计成具有可调节的可转移性，同时考虑到构件的部件。构建单元可以用于生成单个复合体或不同复合物的文库，其中复合物包含与编码元件连接的编码分子。复合物库可用于寻求药物活性化合物。

15. 发明申请

US20050255574A1 Proteins 失效
标题翻译：蛋白质
公开(公告)号：US20050255574A1
公开(公告)日：2005-11-17
申请号：US11090908
申请日：2005-03-25
申请人： Henrik Pedersen , Charlotte Poulsen , Jorn Soe , Masoud Zargahi
发明人： Henrik Pedersen , Charlotte Poulsen , Jorn Soe , Masoud Zargahi
IPC分类号： A21D8/04 , A23L7/104 , C07K14/415 , C11D3/384 , C11D3/386 , C12N9/00 , C12N9/18 , C12N9/20 , C12N15/55 , C12Q1/44
CPC分类号： A21D8/042 , C07K14/415 , C11D3/384 , C11D3/38627 , C12N9/18 , C12N9/20 , C12Q1/44 , G01N2500/04
摘要： The present invention relates to the isolation of and characterisation of a novel lipase inhibitor and its effect on different lipases. The present invention also relates to the use of a lipase inhibitor as a screen for lipases. The present invention also relates to the use of the inhibitor and/or lipases identified by a lipase inhibitor in food and/or feed technologies.
摘要翻译：本发明涉及新型脂肪酶抑制剂的分离和表征及其对不同脂肪酶的作用。本发明还涉及脂肪酶抑制剂作为脂肪酶筛选的用途。本发明还涉及在食品和/或饲料技术中由脂肪酶抑制剂鉴定的抑制剂和/或脂肪酶的用途。

16. 发明授权

US06936438B2 Method of producing a polypeptide using oxaloacetate hydrolase deficient fungal host cells 有权
标题翻译：使用草酰乙酸水解酶缺陷型真菌宿主细胞产生多肽的方法
公开(公告)号：US06936438B2
公开(公告)日：2005-08-30
申请号：US10336491
申请日：2003-01-03
申请人： Carsten Mailand Hjort , Henrik Pedersen
发明人： Carsten Mailand Hjort , Henrik Pedersen
IPC分类号： C12N1/21 , C12N9/14 , C12N15/55 , C12N21/06 , C12N9/10 , C12N15/63
CPC分类号： C12Q1/6895 , C12N9/14
摘要： The present invention relates to methods of producing a polypeptide comprising culturing a mutant of a parent cell, wherein the mutant produces less oxaloacetate hydrolase than the parent cell, wherein the oxaloacetate hydrolase (i) has an amino acid sequence that has at least 90% identity with amino acids 1-341 of SEQ ID NO: 2: (ii) is encoded by a nucleic acid sequence having at least 90% homology with a nucleotide sequence comprising nuclotides 1157-1411, 1504-1651 and 1764-2383 of SEQ ID NO: 1: (iii) is encoded by a nucleic acid sequence which hybridizes under high stringency conditions with the nucleic acid sequence of SEQ ID NO: 1, the cDNA sequence of SEQ ID NO: 1, the complementary strand of SEQ ID NO: 1, and/or the complementary strand of the cDNA sequence of SEQ ID NO: 1: and/or (iv) a subsequence of one or both of (i) and (ii), wherein the subsequence encodes a fragment that has oxaloacetate hydrolase activity.
摘要翻译：本发明涉及生产多肽的方法，其包括培养亲本细胞的突变体，其中所述突变体比母体细胞产生较少的草酰乙酸水解酶，其中草酰乙酸水解酶（i）具有至少90％同一性的氨基酸序列与SEQ ID NO：2的氨基酸1-341：（ii）由与SEQ ID NO的核苷酸1157-1411,1504-1651和1764-2383的核苷酸序列具有至少90％同源性的核酸序列编码 1：（iii）由高度严格条件下与SEQ ID NO：1的核酸序列，SEQ ID NO：1的cDNA序列，SEQ ID NO：1的互补链杂交的核酸序列编码，和/或SEQ ID NO：1的cDNA序列的互补链和/或（iv）（i）和（ii）中的一个或两个的亚序列，其中所述亚序列编码具有草酰乙酸水解酶活性的片段。

17. 发明授权

US06642014B1 Enzyme activity screen with direct substrate replacement 失效
标题翻译：具有直接底物置换的酶活性筛选
公开(公告)号：US06642014B1
公开(公告)日：2003-11-04
申请号：US09395017
申请日：1999-09-13
申请人： Henrik Pedersen , Swen Hölder , Jørgen Kjems , Mette Lund
发明人： Henrik Pedersen , Swen Hölder , Jørgen Kjems , Mette Lund
IPC分类号： G01N33573
CPC分类号： C40B40/02 , C07K2319/00 , C12N9/20 , C12N9/22 , C12N9/2437 , C12N15/1034 , C12N15/1037 , C12N15/113 , C12N2310/121 , C12Q1/00
摘要： A method for in vitro selection, from a library of catalyst molecules, of a catalyst molecule of interest having a relatively more efficient specific catalytic activity of interest, as compared to the rest of the catalyst molecules within said library, and wherein said in vitro selection method is characterised by that it allows multiple catalytic activity turn-overs (i.e. substrate to product catalytic activity turn-overs), by the catalyst molecule of interest, before it is finally collected.
摘要翻译：与所述文库中的其余催化剂分子相比，从感兴趣的相对更有效的特定催化活性的目的催化剂分子的催化分子的文库中体外选择一种方法，其中所述体外选择方法的特征在于，在最终收集之前，其通过感兴趣的催化剂分子允许多重催化活性翻转（即底物至产物催化活性翻转）。

18. 发明授权

US06329186B1 Glucoamylases with N-terminal extensions 失效
标题翻译：具有N-末端延伸的葡糖淀粉酶
公开(公告)号：US06329186B1
公开(公告)日：2001-12-11
申请号：US09455679
申请日：1999-12-07
申请人： Rønfeldt Bjarne Nielsen , Allan Svendsen , Kirsten Bojsen , Jesper Vind , Henrik Pedersen
发明人： Rønfeldt Bjarne Nielsen , Allan Svendsen , Kirsten Bojsen , Jesper Vind , Henrik Pedersen
IPC分类号： C12N900
CPC分类号： C12N9/2428
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability.
摘要翻译：本发明涉及亲本真菌葡糖淀粉酶的变体，其表现出改进的热稳定性。

19. 发明授权

US5703087A Phenyl indole compounds 失效
标题翻译：苯基吲哚化合物
公开(公告)号：US5703087A
公开(公告)日：1997-12-30
申请号：US635905
申请日：1996-11-27
申请人： Jens Kristian Perregaard , Ejner Knud Moltzen , Kim Andersen , Henrik Pedersen , Klaus Peter B.o slashed.ges.o slashed. , Andre Pernet , Barbara Bopp , Darcy Mulford , Kiyoshi Sakamoto
发明人： Jens Kristian Perregaard , Ejner Knud Moltzen , Kim Andersen , Henrik Pedersen , Klaus Peter B.o slashed.ges.o slashed. , Andre Pernet , Barbara Bopp , Darcy Mulford , Kiyoshi Sakamoto
IPC分类号： A61K31/4427 , A61K31/445 , A61P9/12 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to phenylindole compounds of formula I: ##STR1## related to atypical neuroleptic sertindole.
摘要翻译： PCT No.PCT / DK94 / 00407 Sec。 371日期：1996年11月27日 102（e）日期1996年11月27日PCT 1994年10月28日PCT公布。第WO95 / 12591号公报日期：1995年5月11日本发明涉及式I的苯基吲哚化合物：与非典型精神抑制索吲哚有关的（I）。

20. 发明申请

US20180340174A1 METHOD FOR IDENTIFICATION OF MOLECULES WITH DESIRED CHARACTERISTICS 审中-公开
公开(公告)号：US20180340174A1
公开(公告)日：2018-11-29
申请号：US15525681
申请日：2015-11-11
申请人： Mikkel Dybro Lundorf , Henrik Pedersen , NANOCORE APS
发明人： Mikkel Dybro Lundorf , Henrik Pedersen , Tore Dehli
IPC分类号： C12N15/10
摘要： A method for identifying molecules with desired characteristics such as high affinity for a surface or material is described. A particularly useful method covered by the present invention allows identification of molecules which bind a material with high affinity in the presence of fluid or soluble polymers, such that said molecules can be used to produce a composite in which they efficiently anchor a material in a matrix comprising solid forms of a polymer. Compositions/kits useful for identification of molecules with desired characteristics are also described.

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