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11. 发明授权

US4390111A Sealable vial 失效
标题翻译：密封小瓶
公开(公告)号：US4390111A
公开(公告)日：1983-06-28
申请号：US346488
申请日：1982-02-08
申请人： Arthur J. Robbins , Paul B. Robbins , Dennis C. Thompson
发明人： Arthur J. Robbins , Paul B. Robbins , Dennis C. Thompson
IPC分类号： B01L3/14 , B65D41/04 , B65D41/28 , B65D43/16 , B65D43/18 , B65D51/18
CPC分类号： B01L3/50825 , B65D41/0414 , B65D41/28
摘要： The present invention is an improved sealable vial for storage of materials. The vial includes a tubular body portion sealed at one end and provided with an aperture at the opposite end. The tubular body is further provided with a male spiral thread about the aperture end and a tapered section extending inward from the aperture. A sealing insert is attached to the body for positioning in either a closed position wherein it seals the aperture or an open position wherein the aperture is open. A cap fits over the sealing insert in the closed position and seals the vial. The cap includes female threads which mate with the male threads of the tubular body to secure the closure.The vial is particularly adapted for cryogenic storage of organic samples. The vial is also adaptable to other applications wherein complete sealing is required under wide temperature and pressure range conditions. The improved seals provided by the interface between the sealing insert and the tubular body prevent leakage into or out of the vial.
摘要翻译：本发明是用于存储材料的改进的可密封小瓶。小瓶包括在一端密封并在相对端设置有孔的管状主体部分。管状体还设置有围绕孔端的阳螺纹线和从孔径向内延伸的锥形部分。密封插入件附接到主体，用于定位在关闭位置，其中密封孔或打开位置，其中孔是敞开的。盖子在封闭位置上装在密封插入件上并密封小瓶。该盖包括与螺纹管的外螺纹配合的内螺纹以固定封闭件。该小瓶特别适用于有机样品的低温储存。该小瓶也适用于在宽温度和压力范围条件下需要完全密封的其它应用。由密封插入件和管状体之间的界面提供的改进的密封件防止泄漏进入或流出小瓶。

12. 发明授权

US6146594A Syringe array with adjustable needle spacing 有权
标题翻译：注射器阵列，可调节针距
公开(公告)号：US6146594A
公开(公告)日：2000-11-14
申请号：US344750
申请日：1999-06-25
申请人： David De Graaff , Kevin Heyes , David J. Wright , Paul B. Robbins
发明人： David De Graaff , Kevin Heyes , David J. Wright , Paul B. Robbins
IPC分类号： B01L3/02 , B01L9/00 , G01N35/10 , G01N1/16
CPC分类号： B01L9/54 , B01L3/0217 , G01N35/1067 , G01N2035/1069
摘要： A syringe array (10) for holding a plurality of syringes (12), each syringe having a barrel (14), a plunger (18) and a needle (16), the syringe array (10) including a distal assembly (50) which holds the plungers (18) of the plurality of syringes (12) and by which all of the plurality of plungers (18) are urged to move in unison, a pivot assembly (52) wherein a portion of each the barrels (14) of the plurality of syringes (12) is pivotally attached to a pivot (92, 94) and a proximal assembly (48) wherein each needle (16) of the plurality of syringes (12) is positioned with a controlled center-to-center spacing (100, 102) from each other. An adjusting portion (62, 64, 70) of the syringe array (10) is adjustable to controllably change the needle center-to-center spacing from a first spacing (100) to at least a second spacing (102) as the barrel portions (14) are allowed to rotate about the pivots (92, 94).
摘要翻译：一种用于保持多个注射器（12）的注射器阵列（10），每个注射器具有枪管（14），柱塞（18）和针（16），所述注射器阵列（10）包括远端组件（50）其保持多个注射器（12）的柱塞（18）并且所有多个柱塞（18）被促使其一致地移动;枢轴组件（52），其中每个筒体（14）的一部分所述多个注射器（12）的枢轴（92,94）和近侧组件（48）枢转地连接到所述多个注射器（12）中，其中所述多个注射器（12）中的每个针（16）被定位成受控的中心到中心间距（100,102）彼此。注射器阵列（10）的调节部分（62,60,70）是可调节的，以将针头的中心到中心间隔从第一间隔（100）可控地改变为至少第二间隔（102），因为镜筒部分（14）允许围绕枢轴（92,94）旋转。

13. 发明授权

US4755356A Locking microcentrifuge tube 失效
标题翻译：锁紧微量离心管
公开(公告)号：US4755356A
公开(公告)日：1988-07-05
申请号：US821828
申请日：1986-01-23
申请人： Paul B. Robbins , Arthur J. Robbins , Thomas R. Sutton
发明人： Paul B. Robbins , Arthur J. Robbins , Thomas R. Sutton
IPC分类号： B01L3/14 , B65D41/18 , B65D55/16 , G01N21/03
CPC分类号： B01L3/50825 , B65D41/185 , B65D55/16
摘要： A locking microcentrifuge tube (10) is provided which is capable of being sealed in either of two manners, one being a friction-fit seal which is easily opened and the other being a "locked" seal for higher stress applications. The tube body (12) is adapted to mate with the cap (14) at an aperture (24) such that the plug portion (36) of the cap (14) and the aperture (24) form the friction-fit seal at the early stages of insertion. A collar (26) is provided about the aperture (24) on the tube body (12). The collar (26) is formed to include one or more circumferential projections (28, 30). The cap (14) is formed to include depressions (32, 34) adapted to mate with the projections (28, 30) upon full insertion of the plug portion (36) to create the "locked" seal. The cap (14) is secured to the tube body (12) by a hinge (38) and a tab (40). The primary usage of the locking microcentrifuge tube (10) is in biomedical laboratory analysis. The tube (10) may be manufactured in various volumes and shapes to adapt to different microcentrifuges and desired sample sizes.
摘要翻译：提供了一种可以以两种方式之一进行密封的锁定微型离心管（10），一种是容易打开的摩擦配合密封件，另一种是用于更高应力应用的“锁定”密封件。管主体（12）适于在孔（24）处与帽（14）配合，使得帽（14）的插头部分（36）和孔（24）在孔（24）处形成摩擦配合密封早期插入阶段。围绕管体（12）上的孔（24）设置套环（26）。轴环（26）形成为包括一个或多个圆周突起（28,30）。盖（14）形成为包括在插头部分（36）完全插入时适于与突起（28,30）配合以形成“锁定”密封件的凹陷（32,34）。盖（14）通过铰链（38）和突片（40）固定到管体（12）。锁定微量离心管（10）的主要用途是在生物医学实验室分析。管（10）可以以各种体积和形状制造以适应不同的微量离心机和期望的样品尺寸。

14. 发明授权

US06479020B1 Multi-well apparatus with independently detachable upper and lower covers 失效
标题翻译：具有独立可拆卸的上盖和下盖的多孔设备
公开(公告)号：US06479020B1
公开(公告)日：2002-11-12
申请号：US09498942
申请日：2000-02-04
申请人： James E. Stanchfield , Paul B. Robbins , Chris N. Bailey , David J. Wright
发明人： James E. Stanchfield , Paul B. Robbins , Chris N. Bailey , David J. Wright
IPC分类号： B01L300
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00423 , B01J2219/00585 , B01J2219/00596 , B01L3/5025 , C40B60/14
摘要： An improved multi-well synthesis and filtration apparatus (10) includes a deep-well synthesis block (12) having a plurality of flowthrough wells (24) optionally fitted with filter disks (48) each of the wells (24) being integrally formed in the synthesis block (12), such that any material placed in the wells (24) is in immediate contact with the material of the synthesis block (12), an upper cover (14), a lower cover (16), and a pair of first and second sheet gaskets (18, 20). The first and second sheet gaskets (18, 20) are interposed between the upper and lower covers (14, 16) to seal inlet portions (38) and outlet spouts (40) of the wells (24). The upper and lower covers (14, 16) are independently releasable, and, with the gaskets (18, 20) form a gas tight seal, so that material is retained in the wells (24) when the lower cover (16) is removed, but the upper seal maintained. Apertures (70) in the upper cover (14) provide that the first sheet gasket (18) may be punctured for introduction of materials and/or maintenance of an inert atmosphere. An alternative synthesis block (412) having half the number of wells (424) but configured to be able to use a collection plate (123) of the same array as the first embodiment is also described.
摘要翻译：改进的多孔合成和过滤装置（10）包括深井合成块（12），其具有可选地装配有过滤盘（48）的多个通孔（24），每个孔（24）整体形成在合成块（12），使得放置在孔（24）中的任何材料与合成块（12）的材料，上盖（14），下盖（16）和一对的第一和第二片状垫片（18,20）。第一和第二片状垫片（18,20）介于上盖和下盖（14,16）之间，以密封孔（24）的入口部分（38）和出口（40）。上盖和下盖独立地可拆卸，并且垫圈（18,20）形成气密密封，使得当下盖（16）被移除时材料保留在井（24）中，但保持上密封。上盖（14）中的孔（70）提供了第一片垫片（18）可被穿孔以引入材料和/或维持惰性气氛。具有一半孔数的备选合成块（412） 424）但是被配置为能够使用与第一实施例相同的阵列的收集板（123）。

15. 发明授权

US6054100A Apparatus for multi-well microscale synthesis 失效
标题翻译：多孔微孔合成装置
公开(公告)号：US6054100A
公开(公告)日：2000-04-25
申请号：US972996
申请日：1997-11-18
申请人： James E. Stanchfield , Paul B. Robbins , Chris N. Bailey , David J. Wright
发明人： James E. Stanchfield , Paul B. Robbins , Chris N. Bailey , David J. Wright
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14
CPC分类号： B01L3/50255 , B01J19/0046 , B01L3/5025 , B01J2219/00286 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00423 , B01J2219/00585 , B01J2219/00596 , C40B60/14
摘要： A multi-well synthesis and filtration apparatus (10) dimensionally arrayed in a standard multi-well format for performing multiple chemical reactions includes a deep-well synthesis block (12) with flowthrough wells (24) fitted with filter disks (48), an upper cover (14), and a lower cover (16). First and second sheet gaskets (18 and 20) seal inlet portions (38) and outlet spouts (40) of the wells (24). An optional skirt (26) provides a site for the independently releasable attachment of the upper and lower covers (14 and 16) to the block (12) while maintaining the seal on the unreleased cover. An alternative synthesis apparatus (310) additionally includes a reinforcement assembly (372) to improve the clamping action of the covers (14 and 16) upon the synthesis block (12). A rotating carrier apparatus (200) and a modified oven assembly (202) are provided to enable agitation and heating of multiple synthesis blocks (12) simultaneously.
摘要翻译：尺寸排列成用于执行多个化学反应的标准多孔格式的多孔合成和过滤装置（10）包括具有装配有过滤盘（48）的流通井（24）的深井合成块（12），上盖（14）和下盖（16）。第一和第二片状垫片（18和20）密封孔（24）的入口部分（38）和出口（40）。可选的裙部（26）提供了用于将上盖和下盖（14和16）独立地可拆卸地连接到块（12）的位置，同时保持未未覆盖的盖上的密封。替代合成设备（310）还包括加强组件（372），用于改善盖子（14和16）在合成块（12）上的夹紧动作。提供旋转载体装置（200）和改进的炉组件（202），以同时搅拌和加热多个合成块（12）。

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