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11. 发明申请

US20070213663A1 Balloon catheter with molded stepped balloon 审中-公开
标题翻译：气球导管与模制步骤气球
公开(公告)号：US20070213663A1
公开(公告)日：2007-09-13
申请号：US11726168
申请日：2007-03-21
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61M29/02
CPC分类号： A61M25/104 , A61F2/958 , A61F2250/0039 , A61M25/10 , A61M25/1002 , A61M25/1029 , A61M2025/1059 , A61M2025/1075
摘要： A balloon catheter suitable for deploying a stent utilizes a balloon molded with a stepped diameter profile.
摘要翻译：适用于展开支架的球囊导管利用一种具有阶梯直径轮廓的球囊。

12. 发明授权

US07252674B2 Expandable ablation burr 失效
标题翻译：可扩展消融毛刺
公开(公告)号：US07252674B2
公开(公告)日：2007-08-07
申请号：US10770336
申请日：2004-02-02
申请人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B17/32
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include an expandable polymeric balloon having a partially abrasive exterior surface. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes systems that are pulled proximally to remove portions of a lesion located in a patient's vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end. The burr may create a seal when expanded to block the ablated particulate so that an aspiration system can remove the particulate from the vasculature. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath.
摘要翻译：粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。毛刺可以包括具有部分研磨外表面的可膨胀聚合气囊。毛刺的最大膨胀由膨胀机构控制。公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。另外，本发明还包括向近侧拉动以去除位于病人脉管系统中的病变部分的系统。该系统包括具有设置在近端的磨料的消融毛刺。当膨胀时，毛刺可以产生密封，以阻止消融的颗粒，使得吸气系统可以从脉管系统中除去颗粒。或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封件。

13. 发明申请

US20070106212A1 Balloon catheter formed of random copolymerized nylons 有权
标题翻译：气球导管由无规共聚尼龙形成
公开(公告)号：US20070106212A1
公开(公告)日：2007-05-10
申请号：US11545441
申请日：2006-10-10
申请人： Lixiao Wang , Ping Huang
发明人： Lixiao Wang , Ping Huang
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00
CPC分类号： A61L29/06 , Y10T428/1334 , Y10T428/1352 , Y10T428/31725 , Y10T428/31739 , C08L77/06
摘要： A catheter having a balloon comprised of a polymer material comprising first monomer units of an alkyl amide having 2 to 6 carbon atoms and second monomer units of an alkyl amide having 7 to 12 carbon atoms. The first and second monomer units are copolymerized with each other in a random fashion to form a random copolyamide polymer.
摘要翻译：一种导管，其具有包含聚合物材料的气囊，所述聚合物材料包含具有2至6个碳原子的烷基酰胺的第一单体单元和具有7至12个碳原子的烷基酰胺的第二单体单元。第一和第二单体单元以任意方式彼此共聚以形成无规共聚酰胺聚合物。

14. 发明授权

US07128862B2 Biaxially oriented multilayer polymer tube for medical devices 有权
公开(公告)号：US07128862B2
公开(公告)日：2006-10-31
申请号：US10335743
申请日：2003-01-02
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： B29C47/06 , B29C47/24
CPC分类号： B29C47/065 , A61M25/0009 , A61M25/0045 , B29C47/0023 , B29C47/24 , B29C47/261 , B29L2031/7542
摘要： A tubular extruded member particularly suitable for use in medical devices such as intravascular catheters and guide wires, wherein the extruded tubular member includes multiple layers having biaxial helical orientation in different directions. A counter-rotation extrusion process may be used to orient the layers in different biaxial helical directions. The counter-rotation extrusion process provides orientation in two different circumferential directions in addition to a longitudinal direction. By combining the dual direction or biaxial helical orientation with multiple layers, different layers of the tubular member may be tailored to have the desired mechanical properties.

15. 发明授权

US06977103B2 Dimensionally stable balloons 有权
标题翻译：尺寸稳定的气球
公开(公告)号：US06977103B2
公开(公告)日：2005-12-20
申请号：US09885568
申请日：2001-06-20
申请人： John Jianhua Chen , Lixiao Wang , Yiqun Wang , Albert C. C. Chin
发明人： John Jianhua Chen , Lixiao Wang , Yiqun Wang , Albert C. C. Chin
IPC分类号： A61F2/06 , A61F2/84 , A61L29/12 , A61L29/14 , A61M25/00 , A61M25/10 , B29C47/00 , A61M29/00
CPC分类号： A61M25/1029 , A61F2/958 , A61L29/126 , A61L29/14 , A61M25/10 , A61M2025/1084 , B29C47/0004 , B29C47/0023 , B29K2077/00 , B29K2105/06 , B29K2105/14 , B29L2022/00 , B29L2031/7542 , Y10T428/1352
摘要： An inflatable medical balloon comprises a polymer matrix material and a plurality of fibers distributed in the matrix material. The plurality of fibers operatively adhere to the matrix material and provide reinforcement thereof. The fibers may be parallel or angularly oriented relative to the longitudinal balloon axis, and may be helically disposed thereabout. The fibers may be composed of material which has a greater tensile strength than the matrix material. The fibers may be microfibers formed by phase separation of a melt blend material during extrusion or polymer cores coextruded with the matrix material and surrounded thereby. The balloon may be formed of alternating layers of fiber-free polymer and layers of fiber-containing polymer.
摘要翻译：可膨胀的医用气囊包括聚合物基体材料和分布在基体材料中的多根纤维。多个纤维可操作地粘附到基质材料上并提供加强。纤维可以相对于纵向气囊轴线平行或成角度地定向，并且可以螺旋地设置在其周围。纤维可以由具有比基体材料更大的拉伸强度的材料构成。纤维可以是通过在挤出期间熔融共混材料的相分离形成的微纤维，或者与基体材料共挤出的聚合物芯体并被其包围。球囊可以由无纤维聚合物和含纤维聚合物层的交替层形成。

16. 发明申请

US20050256450A1 Catheter for the delivery of therapeutic agents to tissues 有权
标题翻译：用于将治疗剂递送至组织的导管
公开(公告)号：US20050256450A1
公开(公告)日：2005-11-17
申请号：US11185801
申请日：2005-07-21
申请人： Maria Palasis , James Barry , Louis Ellis , Gary Hendrickson , Kent Harrison , Lixiao Wang
发明人： Maria Palasis , James Barry , Louis Ellis , Gary Hendrickson , Kent Harrison , Lixiao Wang
IPC分类号： A61B17/00 , A61B17/32 , A61B17/34 , A61B19/00 , A61F2/02 , A61L29/16 , A61M25/00 , A61M31/00 , A61M37/00
CPC分类号： A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/320084 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0004 , A61M2025/0089
摘要： A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.
摘要翻译：提供了用于放置原位植入物的导管。该导管可以包括具有近端和远端的第一细长轴，具有近端和远端的第二细长轴，设置在第一轴的远端处的第一尖锐的远侧末端和第二尖锐远端设置在第二轴的远端。根据本发明，第一轴和第二轴也可以在第一轴的远端处彼此固定。此外，根据其他教导，第一锐化的远侧末端可以在实践本发明的导管中延伸超过第二锋利的远侧末端。

17. 发明申请

US20050165301A1 Medical devices visible by magnetic resonance imaging 有权
标题翻译：磁共振成像可见的医疗器械
公开(公告)号：US20050165301A1
公开(公告)日：2005-07-28
申请号：US10763690
申请日：2004-01-23
申请人： Scott Smith , Steven Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
发明人： Scott Smith , Steven Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
IPC分类号： A61B19/00 , A61M25/00 , A61M25/01 , G01R33/28 , A61B5/05
CPC分类号： G01R33/285 , A61B2090/3954 , A61M25/0043 , A61M25/0127 , G01R33/286
摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要翻译：描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。导电路径能够连接到电流源。医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

18. 发明授权

US06869443B2 Biodegradable drug delivery vascular stent 失效
标题翻译：生物降解药物输送血管支架
公开(公告)号：US06869443B2
公开(公告)日：2005-03-22
申请号：US10108904
申请日：2002-03-28
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
摘要翻译：支架包括用于插入活体血管内腔的大体管状形状的主体。管状主体包括基本上可生物降解的基质，其具有包围基质内的空隙的胶原IV和层粘连蛋白。管状主体还包括与基质接触以增强基质的可生物降解的强化材料。管状主体基本上被药物饱和。

19. 发明授权

US06787095B2 Process for manufacturing polybutylene terephthalate (PBT) catheter balloons 有权
标题翻译：聚对苯二甲酸丁二醇酯（PBT）导管气球的制造方法
公开(公告)号：US06787095B2
公开(公告)日：2004-09-07
申请号：US10179646
申请日：2002-06-24
申请人： Lixiao Wang , Jianhua Chen
发明人： Lixiao Wang , Jianhua Chen
IPC分类号： B29C4700
CPC分类号： A61M25/1029 , A61L29/06 , A61M2025/1031 , C08K3/38 , C08L67/02 , Y10T428/1352 , Y10T428/139 , C08L2666/02
摘要： A processing technique and a composition which allow compositions of PBT polymers or copolymers to be formed into blow molded articles, especially medical balloons such as dilatation or stent placement balloons, from extruded tubular parisons. The process includes a longitudinal stretch step run at a temperature below the Tg of the polymeric material and a radial expansion step run at a temperature above the Tg of the polymeric material. During the longitudinal stretch step, the tubing is subjected to high internal pressure. In the composition a small amount of boric acid is added to the polybutylene terephthalate in a melt blend to give a formulation which has reduced crystallinity after extrusion and which can more readily fashioned into high strength blow molded articles than PBT by itself. Articles, which may be formed using the invention include medical device balloon articles in which the polymer consists essentially of PBT optionally blended with boric acid.
摘要翻译：一种加工技术和组合物，其允许PBT聚合物或共聚物的组合物从挤出的管状型坯形成吹塑制品，特别是医疗气囊如膨胀或支架放置气球。该方法包括在低于聚合物材料的Tg的温度下运行的纵向拉伸步骤和在高于聚合物材料的Tg的温度下运行的径向膨胀步骤。在纵向拉伸步骤期间，管道受到高的内部压力。在组合物中，在熔融共混物中将少量硼酸加入到聚对苯二甲酸丁二醇酯中，得到挤出后结晶度降低且比PBT本身更容易形成高强度吹塑制品的制剂。可以使用本发明形成的制品包括其中聚合物基本上由PBT任选与硼酸共混的医疗装置球囊制品。

20. 发明授权

US06764710B2 Light emitting markers for use with substrates 失效
标题翻译：用于衬底的发光标记
公开(公告)号：US06764710B2
公开(公告)日：2004-07-20
申请号：US09908530
申请日：2001-07-18
申请人： Kenneth M. Merdan , Dachuan Yang , Lixiao Wang
发明人： Kenneth M. Merdan , Dachuan Yang , Lixiao Wang
IPC分类号： A61L2700
CPC分类号： B29C66/91218 , A61L29/14 , A61L31/14 , A61M25/0009 , B29C65/02 , B29C65/14 , B29C65/1403 , B29C65/1406 , B29C65/1409 , B29C65/1412 , B29C65/1416 , B29C65/1425 , B29C65/16 , B29C65/1606 , B29C65/1616 , B29C65/1619 , B29C66/1142 , B29C66/43 , B29C66/43121 , B29C66/534 , B29C66/65 , B29C66/71 , B29C66/742 , B29C66/91221 , B29C66/91411 , B29C2035/0822 , B29C2035/0827 , B29C2035/0844 , B29C2035/085 , B29C2035/0855 , B29K2023/00 , B29K2023/06 , B29K2023/12 , B29K2027/06 , B29K2067/00 , B29K2067/006 , B29K2075/00 , B29K2077/00 , B29K2079/08 , B29K2995/0049 , B29K2995/0056 , B29L2031/7542 , Y10T156/10 , B29K2071/00 , B29K2067/003 , B29K2027/18 , B29K2021/003
摘要： A method of determining whether a substrate has been subjected to an energy source. In one embodiment, the method includes the steps of providing a polymeric surface, providing a light emitting material having a specified emission spectrum that changes upon exposure to an energy source on the surface or embedded in said substrate and applying said energy source to said surface with said light emitting material. This method can be particularly useful for detecting the bond quality in medical devices.
摘要翻译：一种确定衬底是否已经经过能量源的方法。在一个实施方案中，该方法包括以下步骤：提供聚合物表面，提供具有特定发射光谱的发光材料，该特定发射光谱在暴露于表面上的能量源或嵌入在所述衬底中并且将所述能量源施加到所述表面上时，所述发光材料。该方法对于检测医疗器械中的结合质量特别有用。

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