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11. 发明申请

US20110081393A1 COOLING SENSATION AGENT COMPOSITION, SENSORY STIMULATION AGENT COMPOSITION AND USE OF THE SAME 失效
标题翻译：冷却感觉剂组合物，感觉刺激剂组合物及其用途
公开(公告)号：US20110081393A1
公开(公告)日：2011-04-07
申请号：US12898939
申请日：2010-10-06
申请人： Yasuhiro Komatsuki , Tomoko Yamamoto , Takashi Aida , Kenya Ishida
发明人： Yasuhiro Komatsuki , Tomoko Yamamoto , Takashi Aida , Kenya Ishida
IPC分类号： A61K31/225 , C07C69/40 , A61K9/00 , A61K9/70 , A61P27/00 , A61P17/00
CPC分类号： C07C69/34 , A61K8/37 , A61K31/225 , A61K2800/244 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q19/00 , C07C69/40 , C07C69/42 , C07C2601/14
摘要： Disclosed is a cooling sensation agent composition or sensory stimulation agent composition which contains at least one of diester compounds of dicarboxylic acid represented by the formula (1) wherein A represents CH2 or CH═CH, n represents an integer of 0 to 4 when A is CH2, or 1 when A is CH═CH, B is an alcohol residue having 10 to 18 carbon atoms and containing a para-menthane skeleton, which may have a substituent, and C is an alcohol residue having 6 to 18 carbon atoms, which may have a substituent as well as a flavor or fragrance composition, a beverage, a food product, a perfume or cosmetic product, a toiletry product, daily utensil products or groceries, a fiber, a fiber product, clothes, clothing or a medicine, wherein the cooling sensation agent composition or the sensory stimulation agent composition is compounded.
摘要翻译：公开了一种冷却感觉剂组合物或感觉刺激剂组合物，其含有由式（1）表示的二羧酸二酯化合物中的至少一种，其中A表示CH 2或CH = CH，n表示0至4的整数，当A为 CH 2或1，当A为CH = CH时，B为具有10至18个碳原子的醇残基，并含有可具有取代基的对位薄荷烷骨架，C为具有6至18个碳原子的醇残基，可以具有取代基以及香料或香料组合物，饮料，食品，香料或化妆品，化妆品，日用具产品或杂货，纤维，纤维制品，衣服，衣服或药物，其中所述冷却感觉剂组合物或所述感觉刺激剂组合物复合。

12. 发明申请

US20110118500A1 METHOD FOR PRODUCING OPTICALLY ACTIVE a-IONONE 有权
标题翻译：用于生产光学活性α-离子的方法
公开(公告)号：US20110118500A1
公开(公告)日：2011-05-19
申请号：US13012199
申请日：2011-01-24
申请人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
发明人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
IPC分类号： C07C69/78 , C07C69/533 , C07C69/63 , C07C69/24 , C07C69/708
CPC分类号： C12P7/26 , A23L2/56 , A23L27/204 , A61K8/37 , A61Q11/00 , A61Q13/00 , C07B53/00 , C07B2200/07 , C07C403/08 , C07C403/12 , C07C403/14 , C07C2601/16 , C12G3/06 , C12P41/004
摘要： Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.
摘要翻译：本发明提供了一种低成本地生产光学活性α-紫罗兰酮的方法，其具有高产率和高不对称产率，并且在短时间内具有良好的可加工性，以及包含通过上述方法获得的光学活性α-紫罗兰酮的香料组合物。一种光学活性α-紫罗兰酮的制造方法，其特征在于，使作为旋光异构体的混合物的α-紫罗烯酮与酯化反应，水解得到的α-紫罗烯酮烯醇酯; 一种光学活性α-紫罗兰酮的制造方法，其特征在于，将α-紫罗烯酮作为光学异构体的混合物进行不对称还原，使得所得光学活性α-离子酚与酯化反应，得到光学活性α-离子醇酯，水解根据需要纯化后得到的光学活性α-离子醇酯，然后氧化所得光学活性α-离子醇; 和包含这样得到的光学活性α-紫罗兰酮的香料组合物。

13. 发明授权

US07902404B2 Method for producing optically active α-ionone 有权
公开(公告)号：US07902404B2
公开(公告)日：2011-03-08
申请号：US11991966
申请日：2006-09-13
申请人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
发明人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
IPC分类号： C07C45/42
CPC分类号： C12P7/26 , A23L2/56 , A23L27/204 , A61K8/37 , A61Q11/00 , A61Q13/00 , C07B53/00 , C07B2200/07 , C07C403/08 , C07C403/12 , C07C403/14 , C07C2601/16 , C12G3/06 , C12P41/004
摘要： Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.

14. 发明授权

US08053592B2 Method for producing optically active α-ionone 有权
标题翻译：光学活性α-紫罗兰酮的制造方法
公开(公告)号：US08053592B2
公开(公告)日：2011-11-08
申请号：US13012199
申请日：2011-01-24
申请人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
发明人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
IPC分类号： C07C69/78 , C07C69/533 , C07C69/63
CPC分类号： C12P7/26 , A23L2/56 , A23L27/204 , A61K8/37 , A61Q11/00 , A61Q13/00 , C07B53/00 , C07B2200/07 , C07C403/08 , C07C403/12 , C07C403/14 , C07C2601/16 , C12G3/06 , C12P41/004
摘要： Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.
摘要翻译：本发明提供了一种低成本地生产光学活性α-紫罗兰酮的方法，其具有高产率和高不对称产率，并且在短时间内具有良好的可加工性，以及包含通过上述方法获得的光学活性α-紫罗兰酮的香料组合物。一种光学活性α-紫罗兰酮的制造方法，其特征在于，使作为旋光异构体的混合物的α-紫罗烯酮与酯化反应，水解得到的α-紫罗烯酮烯醇酯; 一种光学活性α-紫罗兰酮的制造方法，其特征在于，将α-紫罗烯酮作为光学异构体的混合物进行不对称还原，使得所得光学活性α-离子酚与酯化反应，得到光学活性α-离子醇酯，水解根据需要纯化后得到的光学活性α-离子醇酯，然后氧化所得光学活性α-离子醇; 和包含这样得到的光学活性α-紫罗兰酮的香料组合物。

15. 发明申请

US20090216039A1 Method for Producing Optically Active Alpha-Ionone 有权
标题翻译：生产光学活性α-紫罗兰酮的方法
公开(公告)号：US20090216039A1
公开(公告)日：2009-08-27
申请号：US11991966
申请日：2006-09-13
申请人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
发明人： Tetsuya Yamamoto , Kenji Yagi , Kenya Ishida
IPC分类号： C12P7/26 , C07C69/75 , C07C45/42
CPC分类号： C12P7/26 , A23L2/56 , A23L27/204 , A61K8/37 , A61Q11/00 , A61Q13/00 , C07B53/00 , C07B2200/07 , C07C403/08 , C07C403/12 , C07C403/14 , C07C2601/16 , C12G3/06 , C12P41/004
摘要： Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.
摘要翻译：本发明提供了一种低成本地生产光学活性α-紫罗兰酮的方法，其具有高产率和高不对称产率，并且在短时间内具有良好的可加工性，以及包含通过上述方法获得的光学活性α-紫罗兰酮的香料组合物。一种光学活性α-紫罗兰酮的制造方法，其特征在于，使作为光学异构体的混合物的α-紫罗兰酮与酯化剂反应，水解得到的α-紫罗兰酮烯醇酯; 制备光学活性α-紫罗兰酮的方法，包括将α-紫罗烯酮作为光学异构体的混合物进行不对称还原，使得到的光学活性α-离子酚与酯化反应得到光学活性α-离子醇酯，水解根据需要纯化后得到的光学活性α-离子醇酯，然后氧化得到的光学活性α-离子醇; 和包含由此获得的光学活性α-紫罗兰酮的香料组合物。

16. 发明授权

US08586009B2 Process for producing (3S)-I-menthyl 3-hydroxybutyrate and sensate composition 有权
标题翻译：（3S）-1-羟基丁酸薄荷酯的制备方法和感官组成
公开(公告)号：US08586009B2
公开(公告)日：2013-11-19
申请号：US13601434
申请日：2012-08-31
申请人： Kazuma Hojo , Takashi Aida , Kenya Ishida
发明人： Kazuma Hojo , Takashi Aida , Kenya Ishida
IPC分类号： A23L1/226 , A61K8/37 , A61Q19/00
CPC分类号： A61K8/37 , A23G4/06 , A23L27/203 , A23L27/88 , A61K2800/244 , A61Q5/02 , A61Q11/00 , A61Q19/00 , C07B2200/07 , C07C67/31 , C07C2601/14 , C11B9/0034 , C07C69/675
摘要： Disclosed is a method for producing (3S)-l-menthyl 3-hydroxybutyrate of the following formula (I) by subjecting l-menthyl acetoacetate to asymmetric hydrogenation. The compound may be used as a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling.
摘要翻译：公开了通过使1-薄荷酰乙酰乙酸酯进行不对称氢化制备下式（I）的（3S）-1-薄荷基-3-羟基丁酸酯的方法。该化合物可以用作不具有不期望的刺激感，苦味等的冷却组分或感觉组分，并且具有优异的刷新感和凉爽感。

17. 发明授权

US07923585B2 Menthol derivative and cooling agent composition comprising the same 有权
标题翻译：薄荷醇衍生物和包含其的冷却剂组合物
公开(公告)号：US07923585B2
公开(公告)日：2011-04-12
申请号：US11628086
申请日：2004-05-31
申请人： Kenya Ishida , Takashi Aida , Hiroyuki Matsuda , Fumihiro Yanaka
发明人： Kenya Ishida , Takashi Aida , Hiroyuki Matsuda , Fumihiro Yanaka
IPC分类号： C07C43/00 , A61K9/00 , A61K8/02
CPC分类号： A61K8/39 , A61K2800/244 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q19/00 , A61Q19/10 , C07C43/196 , C07C2601/14
摘要： The invention relates to innovative menthol derivatives which are represented by the general formula (I) below and are excellent in a cooling effect and cool retaining effect, cooling agent compositions comprising the menthol derivatives, and sensory stimulation agent compositions containing the cooling agent compositions, as well as fragrance compositions, beverage or food products, cosmetic products, toiletry products, bathing agents, and pharmaceutical products containing the cooling agent compositions or sensory stimulation agent compositions. (general formula (I)) wherein R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 5 carbon atoms; R and R independently represent an alkylene group having 2 to 5 carbon atoms and optionally having a substituent; double dotted line represents a single bond or a double bond; and n is an integer of 1 to 3.
摘要翻译：本发明涉及由以下通式（I）表示并具有优异的冷却效果和冷保留效果的创新薄荷醇衍生物，包含薄荷醇衍生物的冷却剂组合物和含有冷却剂组合物的感觉刺激剂组合物，作为以及香料组合物，饮料或食品，化妆品，化妆品，洗浴剂和含有冷却剂组合物或感觉刺激剂组合物的药物制品。（通式（I））其中R 1表示氢原子，具有1至4个碳原子的烷基或具有1至5个碳原子的酰基; R 2和R 3独立地表示具有2至5个碳原子并且任选具有取代基的亚烷基; 双点划线表示单键或双键; n为1〜3的整数。

18. 发明授权

US07888513B2 Condensation reaction by metal catalyst 有权
标题翻译：金属催化剂的缩合反应
公开(公告)号：US07888513B2
公开(公告)日：2011-02-15
申请号：US12085988
申请日：2006-12-04
申请人： Kazushi Mashima , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
发明人： Kazushi Mashima , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
IPC分类号： C07F15/00 , C07D263/08 , C07D263/52
CPC分类号： C07D263/12 , B01J31/2226 , B01J2531/26 , C07C53/18 , C07C231/02 , C07C253/30 , C07D263/10 , C07D263/14 , C07D263/52 , C07D413/06 , C07F3/003 , C07F7/1892 , C07F9/5022 , C07K1/088 , C07K1/10
摘要： The invention relates to a method for producing an azoline compound represented by the general formula (3): wherein R1 represents an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; R3, R4, R5 and R6 may be the same or different and each represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; two arbitrary groups selected from R3, R4, R5 and R6 may bond to each other to form a ring; and Z1 represents an oxygen atom, a sulfur atom or a selenium atom; comprising reacting a carboxylic acid or a carboxylic acid derivative represented by the general formula (1): R1CO2R2 (1) wherein R1 is as defined above; R2 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R1 and R2 may bond to each other to form a ring; with an aminochalcogenide represented by the general formula (2): wherein R3, R4, R5, R6 and Z1 are as defined above; in the presence of a compound containing a group 12 metal element in the periodic table.
摘要翻译：本发明涉及一种制备由通式（3）表示的唑啉化合物的方法：其中R1表示任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基或任选取代的杂环基; R3，R4，R5和R6可以相同或不同，各自表示氢原子，任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基基团或任选取代的杂环基团; 选自R3，R4，R5和R6中的两个任意基团可以彼此键合形成环; Z1表示氧原子，硫原子或硒原子; 包括使由通式（1）表示的羧酸或羧酸衍生物：R1CO2R2（1）其中R1如上定义; R2表示氢原子，任选取代的烷基或任选取代的芳基; 并且R 1和R 2可以彼此键合形成环; 与通式（2）表示的氨基硫族化物：其中R3，R4，R5，R6和Z1如上定义; 在含有元素周期表中第12族金属元素的化合物存在下进行。

19. 发明申请

US20090270516A1 Process for Producing Optically Active Theaspirane 失效
标题翻译：生产光学活性Theaspirane的过程
公开(公告)号：US20090270516A1
公开(公告)日：2009-10-29
申请号：US11992067
申请日：2006-09-08
申请人： Makoto Harada , Hiroyuki Matsuda , Kenya Ishida , Yuichiro Yamazaki
发明人： Makoto Harada , Hiroyuki Matsuda , Kenya Ishida , Yuichiro Yamazaki
IPC分类号： A61K47/22 , C12P17/04 , A23L1/222 , A23L2/56 , C11B9/02
CPC分类号： C12P17/04 , A23L2/56 , A23L27/2052 , A61K8/4973 , A61Q19/00 , C07B53/00 , C07D307/94 , C11B9/0076 , C12P41/005
摘要： A simplified production method of stereoisomer of theaspiran having high optical purity has been desired. An alcohol compound having a specific skeleton is enantioselectively esterified with an enzyme, or an ester compound having a specific skeleton is enantioselectively hydrolyzed with an enzyme. The resultant optically active ester or optically active alcohol is used. Thus, optically active theaspiran having a desired configuration and having a high optical purity is obtained in a satisfactory yield.
摘要翻译：期望具有高光学纯度的阿司匹兰的立体异构体的简化制备方法。具有特定骨架的醇化合物用酶对映体选择性酯化，或者具有特定骨架的酯化合物用酶对映体选择性水解。使用所得光学活性酯或光学活性醇。因此，以令人满意的产率获得光学活性的具有所需构型并具有高光学纯度的阿司匹林。

20. 发明申请

US20090208427A1 Vanillin Acetals and Sensory Stimulant Composition Containing the Same 有权
标题翻译：香草醛缩醛和感官刺激成分含有它
公开(公告)号：US20090208427A1
公开(公告)日：2009-08-20
申请号：US11988237
申请日：2006-07-05
申请人： Kenya Ishida , Takashi Aida
发明人： Kenya Ishida , Takashi Aida
IPC分类号： A61K8/49 , C07D317/10 , A23L1/226 , A61K31/357 , A61Q11/00
CPC分类号： C07D317/22
摘要： The invention relates to a sensory stimulant composition containing one or more of vanillin acetals represented by the general formula (1), and a flavor and fragrance composition, a beverage or food product, a fragrance or cosmetic product, a daily utensil product, an oral composition, or a pharmaceutical product containing the sensory stimulant composition with a warming sensation agent or cooling sensation substance, if necessary. Vanillin acetals represented by the general formula (1) show an excellent pungent and/or warming sensation effect and a cooling sensation-emphasizing effect.
摘要翻译：本发明涉及含有一种或多种由通式（1）表示的香草醛缩醛的感官刺激剂组合物，以及香料和香料组合物，饮料或食品，香料或化妆品，日常用具产品，口服组合物或含有感觉刺激剂组合物的药物产品，如果需要，加热感觉剂或冷却感觉物质。由通式（1）表示的香草醛缩醛显示出极好的刺激性和/或加温感觉效果和冷却感觉强调效果。

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