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11. 发明授权

US07138263B2 Endoglucanase enzyme NCE5 and cellulase preparations containing the same 有权
标题翻译：内切葡聚糖酶NCE5和含有相同的纤维素酶制剂
公开(公告)号：US07138263B2
公开(公告)日：2006-11-21
申请号：US10276779
申请日：2001-05-22
申请人： Koichiro Murashima , Naomi Sumida , Akitaka Nakane , Koji Yanai , Tomoko Nishimura , Jinichiro Koga , Takeshi Murakami , Toshiaki Kono
发明人： Koichiro Murashima , Naomi Sumida , Akitaka Nakane , Koji Yanai , Tomoko Nishimura , Jinichiro Koga , Takeshi Murakami , Toshiaki Kono
IPC分类号： C12N9/42 , C12N15/00 , D21B1/08 , C11D3/00 , C07H21/04
CPC分类号： C12N9/2437 , C11D3/38 , C11D3/38645 , C12Y302/01004 , D06M16/003 , D06P5/02 , D21C5/005 , D21C5/027 , D21C9/002 , Y02W30/648
摘要： There is provided an endoglucanase enzyme, which is useful for reducing fuzz of regenerated cellulose-containing fabrics, improving the touch and appearance, color clarification, localized variation in color, reducing stiffness and using it as components of a detergent, as well as deinking waste paper and improving freeness of paper pulp. A cDNA coding for the endoglucanase enzyme NCE5 was cloned and its DNA sequence and amino acid sequence derived from it were determined.
摘要翻译：提供了内切葡聚糖酶，其可用于减少再生含纤维素织物的绒毛，改善触感和外观，颜色澄清，颜色局部变化，降低刚度并将其用作洗涤剂的组分，以及脱墨废物纸张，提高纸浆的游离度。克隆编码内切葡聚糖酶NCE5的cDNA，并测定其DNA序列和氨基酸序列。

12. 发明授权

US06921655B1 Endoglucanases and cellulase preparations containing the same 有权
标题翻译：内切葡聚糖酶和含有其的纤维素酶制剂
公开(公告)号：US06921655B1
公开(公告)日：2005-07-26
申请号：US09807933
申请日：1999-10-25
申请人： Yuko Nakamura , Tatsuki Moriya , Yuko Baba , Koji Yanai , Naomi Sumida , Tomoko Nishimura , Kouichirou Murashima , Akitaka Nakane , Takashi Yaguchi , Jinichiro Koga , Takeshi Murakami , Toshiaki Kono
发明人： Yuko Nakamura , Tatsuki Moriya , Yuko Baba , Koji Yanai , Naomi Sumida , Tomoko Nishimura , Kouichirou Murashima , Akitaka Nakane , Takashi Yaguchi , Jinichiro Koga , Takeshi Murakami , Toshiaki Kono
IPC分类号： C11D3/386 , C12N9/42 , C12N15/56 , C12P21/06 , C07H21/04 , C12N9/00 , C12N9/24
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01004
摘要： It is an object of the present invention to provide enzymes that have high endoglucanase activity and yet exhibit high activity even under alkaline conditions, and genes encoding the same. The enzyme according to the invention has the following properties: a) exhibiting endoglucanase activity; and b) capable of completely removing fuzz from regenerated cellulose fabrics at a concentration of 1 mg of the protein/L or below. The enzyme of the invention having endoglucanase activity is a protein comprising the amino acid sequence as shown in SEQ ID NO: 1, 3, 5, 7, 9 or 11; a modified protein thereof exhibiting endoglucanase activity; or a homologue of the protein or the modified protein.
摘要翻译：本发明的目的是提供具有高内切葡聚糖酶活性并且即使在碱性条件下也表现出高活性的酶，以及编码该酶的基因。根据本发明的酶具有以下性质：a）显示内切葡聚糖酶活性; 和b）能够以1mg蛋白质/ L或以下的浓度从再生纤维素织物中完全除去绒毛。具有内切葡聚糖酶活性的本发明的酶是包含如SEQ ID NO：1,3,5,7,9或11所示的氨基酸序列的蛋白质; 其表现出内切葡聚糖酶活性的修饰蛋白质; 或蛋白质或修饰蛋白质的同系物。

13. 发明授权

US06910745B2 Check valve with vibration prevention function 失效
标题翻译：止回阀具有防振功能
公开(公告)号：US06910745B2
公开(公告)日：2005-06-28
申请号：US10458276
申请日：2003-06-11
申请人： Shozo Inage , Kaneyoshi Nagatani , Koji Yanai , Nobuhiko Yoshioka
发明人： Shozo Inage , Kaneyoshi Nagatani , Koji Yanai , Nobuhiko Yoshioka
IPC分类号： B60T8/34 , B60T8/48 , F04B53/10 , F16K15/04 , B60T8/42
CPC分类号： B60T8/4872 , B60T8/341 , Y10T137/7928
摘要： In a check valve of the present invention, when a pressure action direction of a fluid on a valve body is assumed to be X, a spring receiving surface that abuts with a seat surface that is at one end in an axial direction of the helical compression spring is made to incline with respect to a surface perpendicular to the pressure action direction X. Accordingly, an urging force of the helical compression spring on the valve body acts obliquely with respect to the pressure action direction X. Thus the valve body is pressed to a side wall surface when the valve is opened, and vibration of the valve body is inhibited. Accordingly, it is possible to embody the invention with an extremely simple structure in which the spring receiving surface is inclined with respect to the surface perpendicular to the pressure action direction X.
摘要翻译：在本发明的止回阀中，当将阀体上的流体的压力作用方向设为X时，弹簧接收面与螺旋压缩轴向一端的座面相接触使弹簧相对于与压力方向X垂直的面倾斜。因此，螺旋压缩弹簧对阀体的作用力相对于压力作用方向X倾斜地施加。因此，阀体被按压当阀打开时的侧壁表面，并且阀体的振动被抑制。因此，可以以非常简单的结构体现本发明，其中弹簧接收表面相对于垂直于压力作用方向X的表面倾斜。

14. 发明授权

US08569033B2 Surfactant tolerant cellulase and method for modification thereof 有权
标题翻译：表面活性剂耐受性纤维素酶及其修饰方法
公开(公告)号：US08569033B2
公开(公告)日：2013-10-29
申请号：US10582002
申请日：2004-12-07
申请人： Manabu Watanabe , Koji Yanai , Yumiko Tsuyuki
发明人： Manabu Watanabe , Koji Yanai , Yumiko Tsuyuki
IPC分类号： C12N9/42 , C12N9/26 , C12N1/00 , C12N15/00 , C12P21/06 , C07H21/04
CPC分类号： C12N9/2437 , C12Y302/01004
摘要： A method for suppressing a reduction in an endoglucanase activity in the presence of a surfactant, characterized by modifying a protein having the endoglucanase activity in which the N-terminus is an amino acid other than pyroglutamic acid, to a protein having the N-terminus of pyroglutamic acid, is disclosed. Further, a modified protein having an endoglucanase activity wherein the N-terminal amino acid is converted into pyroglutamic acid by an amino acid modification, a polynucleotide encoding the protein, an expression vector comprising the polynucleotide, a host cell transformed with the expression vector, and a process for producing the protein by cultivating the host cell, are disclosed.
摘要翻译：一种抑制表面活性剂存在下内切葡聚糖酶活性降低的方法，其特征在于将具有N-端是除焦谷氨酸以外的氨基酸的具有内切葡聚糖酶活性的蛋白质修饰为具有N末端的蛋白质焦谷氨酸。此外，具有内切葡聚糖酶活性的修饰蛋白质，其中N-末端氨基酸通过氨基酸修饰转化为焦谷氨酸，编码该蛋白质的多核苷酸，包含该多核苷酸的表达载体，用表达载体转化的宿主细胞，以及公开了通过培养宿主细胞产生蛋白质的方法。

15. 发明申请

US20130116416A1 KETOREDUCTASE MUTANT 有权
标题翻译： KETOREDUCTASE突变体
公开(公告)号：US20130116416A1
公开(公告)日：2013-05-09
申请号：US13699206
申请日：2010-05-21
申请人： Fusuke Mazuka , Takayoshi Fukushima , Naomi Sumida , Koji Yanai
发明人： Fusuke Mazuka , Takayoshi Fukushima , Naomi Sumida , Koji Yanai
IPC分类号： C12N9/02 , C12N1/20
CPC分类号： C12P19/56 , C12N9/0006 , C12Y101/01184
摘要： Disclosed are a ketoreductase mutant which can be used for an efficient production of daunorubicin derivatives, a DNA encoding the mutant, a transformant prepared by introducing the DNA thereinto to produce a daunorubicin derivative, and a process of producing a daunorubicin derivative using the transformant. The ketoreductase mutant has an amino acid sequence in which one amino acid residue or two or more amino acid residues selected from the group consisting of amino acids located at positions corresponding to the 42nd, 149th, 153rd, 270th, and 306th amino acids in the amino acid sequence of a ketoreductase (EvaE) from a chlororemomycin-producing bacterium (Amycolatopsis orientalis) are substituted with another amino acid residues.
摘要翻译：公开了可用于有效生产柔红霉素衍生物的酮还原酶突变体，编码突变体的DNA，通过将DNA引入其中以产生柔红霉素衍生物而制备的转化体，以及使用转化体产生柔红霉素衍生物的方法。酮还原酶突变体具有氨基酸序列，其中选自氨基酸中的一个氨基酸残基或两个或更多个氨基酸残基，所述氨基酸位于与氨基酸中第42,149,153,270和306位氨基酸相对应的位置的氨基酸来自产生氯霉素的细菌（Amycolatopsis orientalis）的酮还原酶（EvaE）的酸序列被另一个氨基酸残基取代。

16. 发明授权

US08383392B2 Transformant and method for production of non-natural antibiotic 有权
标题翻译：用于生产非天然抗生素的转化体和方法
公开(公告)号：US08383392B2
公开(公告)日：2013-02-26
申请号：US12678101
申请日：2008-09-12
申请人： Naomi Sumida , Manabu Watanabe , Koji Yanai
发明人： Naomi Sumida , Manabu Watanabe , Koji Yanai
IPC分类号： C12N1/15 , C12P29/00
CPC分类号： C12P19/56 , C12N9/0006 , C12P17/06 , C12P19/44
摘要： Disclosed is a transformant prepared by introducing a ketoreductase gene involved in the biosynthesis of L-epivancosamine into an actinobacterium originally capable of producing daunorubicin. Also disclosed is a process of efficiently producing a non-natural daunorubicin derivative using the transformant. The transformant is capable of efficiently producing a non-natural daunorubicin derivative such as epidaunorubicin.
摘要翻译：公开了通过将参与L-赖氨替康的生物合成的酮还原酶基因导入本来能够产生柔红霉素的放线杆菌中制备的转化体。还公开了使用转化体有效生产非天然柔红霉素衍生物的方法。转化体能够有效地产生非天然柔红霉素衍生物如表柔比星。

17. 发明申请

US20100255543A1 METHOD FOR PRODUCTION OF NON-NATURAL ANTIBIOTIC 有权
标题翻译：生产非天然抗生素的方法
公开(公告)号：US20100255543A1
公开(公告)日：2010-10-07
申请号：US12678101
申请日：2008-09-12
申请人： Naomi Sumida , Manabu Watanabe , Koji Yanai
发明人： Naomi Sumida , Manabu Watanabe , Koji Yanai
IPC分类号： C12P19/56 , C12N1/21
CPC分类号： C12P19/56 , C12N9/0006 , C12P17/06 , C12P19/44
摘要： Disclosed is a transformant prepared by introducing a ketoreductase gene involved in the biosynthesis of L-epivancosamine into an actinobacterium originally capable of producing daunorubicin. Also disclosed is a process of efficiently producing a non-natural daunorubicin derivative using the transformant. The transformant is capable of efficiently producing a non-natural daunorubicin derivative such as epidaunorubicin.
摘要翻译：公开了通过将参与L-赖氨替康的生物合成的酮还原酶基因导入本来能够产生柔红霉素的放线杆菌中制备的转化体。还公开了使用转化体有效生产非天然柔红霉素衍生物的方法。转化体能够有效地产生非天然柔红霉素衍生物如表柔比星。

18. 发明授权

US07599189B2 Board-housing case and fluid pressure control device including thereof 失效
标题翻译：板壳体及其压力控制装置
公开(公告)号：US07599189B2
公开(公告)日：2009-10-06
申请号：US12003873
申请日：2008-01-03
申请人： Kosei Nishimoto , Koji Yanai , Takahiro Naganuma
发明人： Kosei Nishimoto , Koji Yanai , Takahiro Naganuma
IPC分类号： H05K5/00
CPC分类号： H05K5/0047 , B60T8/3675 , H05K1/0263 , H05K3/32 , H05K3/3447 , H05K7/142 , H05K2201/1003 , H05K2201/10295 , H05K2201/10424 , H05K2201/10962
摘要： A resin case main body includes a connector housing, a component housing, and a joint portion. A busbar includes a reinforcement plate portion which is orthogonal to a plane of a board and is parallel to an alignment direction of the connector housing, the joint portion, and the component housing. The reinforcement plate portion is formed by insert molding in the joint portion.
摘要翻译：树脂壳体主体包括连接器壳体，部件壳体和接头部分。母线包括与板的平面正交并且平行于连接器壳体，接头部分和部件壳体的对准方向的加强板部分。加强板部分通过在连接部分中嵌入成型而形成。

19. 发明授权

US06566111B1 &bgr;-fructofuranosidase and gene thereof 失效
标题翻译： β-呋喃果糖苷酶及其基因
公开(公告)号：US06566111B1
公开(公告)日：2003-05-20
申请号：US09508264
申请日：2000-03-09
申请人： Koji Yanai , Akitaka Nakane , Toshiaki Kono
发明人： Koji Yanai , Akitaka Nakane , Toshiaki Kono
IPC分类号： C12N924
CPC分类号： C12N9/2408 , C12Y302/01026
摘要： A novel &bgr;-fructofuranosidase and its gene are disclosed. A polypeptide comprising the amino acid sequence of SEQ ID No. 1 or No. 3 is an enzyme having &bgr;-fructofuranosidase activity and high transferase activity, and is capable of efficiently producing fructooligosaccharides.
摘要翻译：公开了一种新颖的β-呋喃果糖苷酶及其基因。包含SEQ ID No.1或3的氨基酸序列的多肽是具有β-呋喃果糖苷酶活性和高转移酶活性的酶，并且能够有效地产生低聚果糖。

20. 发明授权

US09469863B2 Aminoglycoside antibiotics, process for producing the same, and pharmaceutical use thereof 有权
标题翻译：氨基糖苷类抗生素，其制造方法及其药物用途
公开(公告)号：US09469863B2
公开(公告)日：2016-10-18
申请号：US12734848
申请日：2008-12-01
申请人： Naomi Sumida , Koji Yanai , Masato Tani , Takayoshi Fukushima , Yasumasa Ota , Shuichi Gomi , Akitaka Nakane
发明人： Naomi Sumida , Koji Yanai , Masato Tani , Takayoshi Fukushima , Yasumasa Ota , Shuichi Gomi , Akitaka Nakane
IPC分类号： C07H15/234 , C12P19/48 , A61K31/7036 , C12R1/465
CPC分类号： A61K31/7036 , C07H15/234 , C12P19/485 , C12R1/465 , Y02A50/473
摘要： The present invention relates to novel aminoglycoside antibiotics, a process for producing the same, and pharmaceutical use thereof. More specifically, the present invention relates to compounds represented by formula (I), a process for producing the same, and use of the same as antimicrobial agents. wherein R represents amino or hydroxyl.
摘要翻译：本发明涉及新的氨基糖苷类抗生素，其制备方法及其药物用途。更具体地说，本发明涉及由式（I）表示的化合物，其制备方法及其作为抗微生物剂的用途。其中R表示氨基或羟基。

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