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11. 发明授权

US09140624B2 Systems and methods reducing coherence effect in narrow line-width light sources 有权
标题翻译：系统和方法降低窄线宽光源的相干效应
公开(公告)号：US09140624B2
公开(公告)日：2015-09-22
申请号：US13541146
申请日：2012-07-03
申请人： Jun Bao , Michael Haidar Shahine , Hua Jiao , Jean-Luc Archambault
发明人： Jun Bao , Michael Haidar Shahine , Hua Jiao , Jean-Luc Archambault
IPC分类号： G01N21/55 , G01M11/00
CPC分类号： G01M11/3118 , G01N21/55
摘要： Systems and methods are described for reducing coherence effect in narrow line-width light sources through various modulation techniques. The systems and methods can include a narrow line-width laser source with a thermoelectric cooler thermally coupled thereto and a controller communicatively coupled to the thermoelectric cooler. The controller is configured to provide a varied input signal to the thermoelectric cooler to reduce coherence of the narrow line-width laser source by artificially broadening the narrow line-width on a time averaged basis. The systems and methods can also include direct modulation of the narrow line-width laser source. The systems and methods can include a narrow line-width Optical Time Domain Reflectometer (OTDR). The systems and methods can also include direct modulation of the narrow line-width laser source with or without the varied input signal to the thermoelectric cooler.
摘要翻译：描述了通过各种调制技术降低窄线宽光源的相干效应的系统和方法。该系统和方法可以包括具有热耦合到其上的热电冷却器的窄线宽激光源和通信地耦合到热电冷却器的控制器。控制器被配置为向热电冷却器提供变化的输入信号，以通过以时间平均的方式人为地加宽窄线宽来减小窄线宽激光源的相干性。系统和方法还可以包括对窄线宽激光源的直接调制。系统和方法可以包括窄线宽光时域反射计（OTDR）。这些系统和方法还可以包括对具有或不具有到热电冷却器的变化的输入信号的窄线宽激光源的直接调制。

12. 发明申请

US20140289882A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR REPAIRING CARTILAGE DAMAGE 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，不进行遗传修饰以修复损伤
公开(公告)号：US20140289882A1
公开(公告)日：2014-09-25
申请号：US14233390
申请日：2012-07-19
申请人： Yong Zhu , Shili Wu , Jun Bao , Cong-Qiu Chu
发明人： Yong Zhu , Shili Wu , Jun Bao , Cong-Qiu Chu
IPC分类号： C07K17/06 , C12N5/074 , G01N33/50 , A61K47/48
CPC分类号： C07K17/06 , A61K38/00 , A61K47/64 , A61K47/645 , A61L27/3612 , A61L27/3654 , C07K14/4702 , C07K14/4703 , C07K14/4716 , C07K2319/21 , C07K2319/60 , C12N5/0637 , C12N5/0655 , C12N5/0676 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/14 , G01N33/5073
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于其他细胞（例如胚胎干细胞（ESCs），诱导多能干细胞（iPSCs），MSC，成纤维细胞，造血干细胞，内皮干细胞，脂肪细胞，软骨细胞，成骨细胞的重编程的组合物和方法，破骨细胞和内皮细胞）成软骨形成细胞，而不向样品中引入外源基因。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

13. 发明申请

US20130316379A1 MOESIN FRAGMENTS ASSOCIATED WITH IMMUNE THROMBOCYTOPENIA 有权
标题翻译：与免疫性血栓形成相关的MOESIN片段
公开(公告)号：US20130316379A1
公开(公告)日：2013-11-28
申请号：US13878237
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao
发明人： Yue Zhang , Jun Bao
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K14/52 , C07K2319/02 , C07K2319/50 , G01N33/564 , G01N2800/222 , G01N2800/52
摘要： The present application provides compositions and methods useful for detecting and monitoring immune thrombocytopenia.
摘要翻译：本申请提供了用于检测和监测免疫血小板减少症的组合物和方法。

14. 发明申请

US20130266537A1 MOESIN MODULATORS AND USES THEREOF 有权
公开(公告)号：US20130266537A1
公开(公告)日：2013-10-10
申请号：US13878232
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
发明人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
IPC分类号： C07K7/08 , A61K38/08 , A61K38/20 , A61K45/06 , A61K38/19 , C07K7/06 , A61K38/10
CPC分类号： A61K39/3955 , A61K38/08 , A61K38/10 , A61K38/191 , A61K38/2006 , A61K38/204 , A61K38/2086 , A61K45/06 , C07K7/06 , C07K7/08 , C07K16/18 , C07K16/28 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.

15. 发明授权

US07400443B1 Method and apparatus for optical amplifying device gain control with gain threshold 有权
标题翻译：具有增益阈值的光放大器件增益控制方法和装置
公开(公告)号：US07400443B1
公开(公告)日：2008-07-15
申请号：US10716609
申请日：2003-11-20
申请人： Balakrishnan Sridhar , Jun Bao
发明人： Balakrishnan Sridhar , Jun Bao
IPC分类号： H04B10/17
CPC分类号： H04B10/2935 , H04B10/2931
摘要： Optical amplifying method and apparatus are proposed. Constant gain amplifiers operate such that the output power of the amplifier generally tracks the input power. However, optical systems are not perfect and the input to the optical amplifier stage includes not only the desired signal, but also includes accumulated effects of the imperfections. The imperfections include losses of the fiber sections, variations in laser powers, and drifts. Thus, simple amplification not only amplifies the desired signal, but also amplifies accumulated imperfections. Such imperfections occur over time and are generally small in magnitude. By operating the amplifier such that amplification of small variations is suppressed while allowing for tracking of large input variations, amplifying the accumulated imperfections is minimized.
摘要翻译：提出了光放大方法和装置。恒定增益放大器工作，使得放大器的输出功率通常跟踪输入功率。然而，光学系统不是完美的，并且光放大器级的输入不仅包括期望的信号，而且还包括缺陷的累积效应。缺陷包括光纤段的损耗，激光功率的变化和漂移。因此，简单的放大不仅放大了期望的信号，而且放大了累积的缺陷。这种缺陷随着时间的推移而发生，并且通常在数量上是小的。通过操作放大器，使得抑制小变化的放大，同时允许跟踪大的输入变化，放大积累的缺陷被最小化。

16. 发明授权

US07092148B1 Optical communication system having dynamic gain equalization 有权
公开(公告)号：US07092148B1
公开(公告)日：2006-08-15
申请号：US10144082
申请日：2002-05-13
申请人： Charles W. Haggans , Jun Bao , Harshad Sardesai , Michael Y. Frankel , Mahir Nayfeh , Balakrishnan Sridhar , Vipul Bhatnagar
发明人： Charles W. Haggans , Jun Bao , Harshad Sardesai , Michael Y. Frankel , Mahir Nayfeh , Balakrishnan Sridhar , Vipul Bhatnagar
IPC分类号： H01S3/00
CPC分类号： H04B10/296
摘要： An optical communication device, and related method, are provided for reducing ripple in WDM systems. In particular, the optical communication device includes a dynamic gain equalization (DGE) circuit is coupled to an optical communication path carrying the WDM optical signals. The DGE circuit adjusts the powers associated with each channel on a channel-by-channel basis so that the WDM optical signal has a desired power spectrum. The DGE is controlled in response to sense signals generated by an optical performance monitoring (OPM) circuit located downstream from the DGE or substantially co-located with the DGE. The OPM monitors the WDM spectrum for optical signal power variations and outputs the sense signal when the variations fall outside a given tolerance. Typically, one DGE is associated with a group of concatenated amplifiers so that multiple DGEs are provided in a system having many groups of such amplifiers. Likewise, multiple OPMs are provided in such systems, each corresponding to a respective DGE, so that ripple can be reduced and desired WDM optical signal powers can be achieved in the WDM system.

17. 发明申请

US20050094252A1 Optical communication system having dynamic gain equalization 有权
标题翻译：具有动态增益均衡的光通信系统
公开(公告)号：US20050094252A1
公开(公告)日：2005-05-05
申请号：US10986817
申请日：2004-11-15
申请人： Charles Haggans , Jun Bao , Harshad Sardesai , Michael Frankel , Mahir Nayfeh , Balakrishnan Sridhar
发明人： Charles Haggans , Jun Bao , Harshad Sardesai , Michael Frankel , Mahir Nayfeh , Balakrishnan Sridhar
IPC分类号： H01S3/00 , H04B10/17
CPC分类号： H04B10/296
摘要： An optical communication device, and related method, are provided for reducing ripple in WDM systems. In particular, the optical communication device includes a dynamic gain equalization (DGE) circuit is coupled to an optical communication path carrying the WDM optical signals. The DGE circuit adjusts the powers associated with each channel on a channel-by-channel basis so that the WDM optical signal has a desired power spectrum. The DGE is controlled in response to sense signals generated by an optical performance monitoring (OPM) circuit located downstream from the DGE or substantially co-located with the DGE. The OPM monitors the WDM spectrum for optical signal power variations and outputs the sense signal when the variations fall outside a given tolerance. Typically, one DGE is associated with a group of concatenated amplifiers so that multiple DGEs are provided in a system having many groups of such amplifiers. Likewise, multiple OPMs are provided in such systems, each corresponding to a respective DGE, so that ripple can be reduced and desired WDM optical signal powers can be achieved in the WDM system.
摘要翻译：提供了一种光通信设备及相关方法，用于减少WDM系统中的纹波。特别地，光通信设备包括动态增益均衡（DGE）电路耦合到承载WDM光信号的光通信路径。 DGE电路在逐个通道的基础上调整与每个通道相关联的功率，使得WDM光信号具有所需的功率谱。响应由位于DGE下游的光学性能监视（OPM）电路产生的感测信号或与DGE基本上同一位置来控制DGE。 OPM监视WDM频谱的光信号功率变化，并在变化值超出给定公差时输出感测信号。通常，一个DGE与一组级联放大器相关联，使得在具有许多这种放大器组的系统中提供多个DGE。类似地，在这样的系统中提供多个OPM，每个对应于相应的DGE，使得纹波可以减少，并且可以在WDM系统中实现期望的WDM光信号功率。

18. 发明授权

US09345764B2 Moesin modulators and uses thereof 有权
标题翻译：莫辛调节剂及其用途
公开(公告)号：US09345764B2
公开(公告)日：2016-05-24
申请号：US13878232
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
发明人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
IPC分类号： C07K7/08 , A61K38/08 , A61K38/20 , A61K45/06 , A61K38/19 , A61K38/10 , C07K7/06 , A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： A61K39/3955 , A61K38/08 , A61K38/10 , A61K38/191 , A61K38/2006 , A61K38/204 , A61K38/2086 , A61K45/06 , C07K7/06 , C07K7/08 , C07K16/18 , C07K16/28 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.
摘要翻译：本申请提供了用于治疗和诊断与moesin活化相关的疾病和病症的组合物和方法。

19. 发明授权

US08867912B2 Optical service channel systems and methods over high loss links 有权
标题翻译：高损耗链路的光业务通道系统和方法
公开(公告)号：US08867912B2
公开(公告)日：2014-10-21
申请号：US13606975
申请日：2012-09-07
申请人： Balakrishnan Sridhar , Jun Bao
发明人： Balakrishnan Sridhar , Jun Bao
IPC分类号： H04J14/02 , H04B10/08 , H04B17/00 , H04L12/26 , H04L12/413
CPC分类号： H04J14/0275 , H04B10/071
摘要： Optical service channel (OSC) systems and methods over high loss links are described utilizing redundant telemetry channels. A first telemetry channel provides a low bandwidth communication channel used when Raman amplification is unavailable on a high loss link for supporting a subset of operations, administration, maintenance, and provisioning (OAM&P) communication. A second telemetry channel provides a high bandwidth communication channel for when Raman amplification is available to support full OAM&P communication. The first and second telemetry operate cooperatively ensuring nodal OAM&P communication over high loss links (e.g., 50 dB) regardless of operational status of Raman amplification.
摘要翻译：利用冗余遥测信道描述了通过高损耗链路的光服务信道（OSC）系统和方法。当用于支持操作，管理，维护和供应（OAM＆P）通信的子集的高损耗链路上拉曼放大不可用时，第一遥测通道提供低带宽通信信道。第二个遥测通道提供高带宽通信信道，用于当拉曼放大可用于支持完整的OAM＆P通信时。第一和第二遥测工作协调地确保无论拉曼放大的操作状态如何，通过高损耗链路（例如，50dB）确保节点OAM＆P通信。

20. 发明申请

US20130320973A1 METHOD OF ATTENUATION CORRECTION OF POSITRON EMISSION TOMOGRAPHY DATA AND COMBINED POSITRON EMISSION TOMOGRAPHY AND MAGNETIC RESONANCE TOMOGRAPHY SYSTEM 有权
标题翻译：排气校正数据和组合位置放射造影和磁共振成像系统的衰减校正方法
公开(公告)号：US20130320973A1
公开(公告)日：2013-12-05
申请号：US13483454
申请日：2012-05-30
申请人： Matthias Fenchel , Kirstin Jattke , Jun Bao , Alto Stemmer , William Curtis Howe
发明人： Matthias Fenchel , Kirstin Jattke , Jun Bao , Alto Stemmer , William Curtis Howe
IPC分类号： G01T1/164 , G01R33/48
CPC分类号： A61B5/055 , A61B5/0035 , A61B5/7285 , A61B6/037 , A61B6/4417 , A61B6/5205 , A61B6/5247 , A61B6/5258 , A61B6/5264 , A61B6/527 , A61B6/5288 , A61B6/548 , G01R33/481
摘要： Various embodiments relate to a method of attenuation correction of Positron Emission Tomography (PET) data based on Magnetic Resonance Tomography (MRT) data. A method of at least one embodiment further includes determining further data being indicative of an iterative cycle of a physiological observable of a patient and matching the PET data with the MRT data based on the further data.
摘要翻译：各种实施方案涉及基于磁共振层析成像（MRT）数据的正电子发射断层扫描（PET）数据的衰减校正方法。至少一个实施例的方法还包括确定指示患者的生理可观察的迭代循环的另外的数据，并且基于进一步的数据将PET数据与MRT数据进行匹配。

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