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11. 发明授权

US4474787A 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof 失效
标题翻译： 7,6二氧代-4H，6H-吡喃并[3,2-g]喹啉二羧酸及其抗过敏用途
公开(公告)号：US4474787A
公开(公告)日：1984-10-02
申请号：US344982
申请日：1982-02-02
申请人： Hugh Cairns , David Cox
发明人： Hugh Cairns , David Cox
IPC分类号： C07D215/48 , C07D311/24 , C07D491/04 , C07D491/052 , C08J7/00 , A61K31/47
CPC分类号： C07D491/04 , C07D215/48 , C07D311/24
摘要： There are described compounds of formula I ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl,Rg is hydrogen, alkyl, alkenyl or phenyl-alkyl, andE is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述了式I的化合物，其中相邻的一对R 5，R 6，R 7和R 8形成链-COCH = CE-O-，其余的R5，R6，R7和R8可以是相同或不同，各自表示氢，羟基，烷基，卤素，烯基，烷氧基或-NR 1 R 2，其中R 1和R 2相同或不同，各自为氢或烷基，R g为氢，烷基，烯基或苯基 - 烷基，E为-COOH，5-四唑基或（N-四唑-5-基）甲酰胺基及其药学上可接受的衍生物。还描述了制备化合物和药物的方法，例如。抗过敏剂，含有这些化合物的组合物。

12. 发明授权

US4211788A Compounds 失效
标题翻译：化合物
公开(公告)号：US4211788A
公开(公告)日：1980-07-08
申请号：US904794
申请日：1978-05-11
申请人： Hugh Cairns , Anthony R. Payne
发明人： Hugh Cairns , Anthony R. Payne
IPC分类号： C07D311/94 , A61K31/355 , C07D311/22
CPC分类号： C07C45/60 , C07C45/62 , C07C45/67 , C07C45/71 , C07D311/94
摘要： There are described compounds of formula I, ##STR1## in which E is a --COOH, a 5-tetrazolyl or an (N-tetrazol-5-yl) carboxamido group,R.sub.3 is hydrogen or alkyl,an adjacent pair of W, X, Y and Z form a 5 membered chain comprising alkylene groups and optionally one or two oxygen atoms, the chain optionally being substituted by one or two alkyl groups,the remaining substituents W, X, Y or Z are hydrogen; halogen; alkyl optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy; alkenyl optionally substituted by phenyl; hydroxy; alkoxy; alkanoyloxy; alkenyloxy; nitro; --NR.sub.1 R.sub.2 or hydroxyalkoxy,R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen or alkyl,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述了式I的化合物，其中E是-COOH，5-四唑基或（N-四唑-5-基）甲酰氨基，R 3是氢或烷基，相邻的一对W， X，Y和Z形成包含亚烷基和任选的一个或两个氧原子的5元链，该链任选被一个或两个烷基取代，其余的取代基W，X，Y或Z是氢; 卤素; 任选被一个或多个羟基，卤素，羰基氧，苯基或烷氧基取代的烷基; 任选被苯基取代的烯基; 羟基; 烷氧基烷酰氧基; 链烯氧基硝基 -NR1R2或羟基烷氧基，R1和R2可以相同或不同，各自为氢或烷基，及其药学上可接受的衍生物。还描述了制备化合物和药物的方法，例如。抗过敏剂，含有这些化合物的组合物。

13. 发明授权

US4156726A 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds 失效
标题翻译：用作抗过敏化合物的4-氧代-2-羧基喹啉衍生物
公开(公告)号：US4156726A
公开(公告)日：1979-05-29
申请号：US635615
申请日：1975-11-26
申请人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
发明人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
IPC分类号： C07D215/26 , C07D215/28 , C07D215/32 , C07D215/48 , C07D221/08 , C07D221/10 , C07D471/04 , A61K31/47
CPC分类号： C07D471/04 , C07D215/48 , C07D221/08 , C07D221/10
摘要： There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述式I的化合物，其中R 5至R 8可以是多种取代基，或者R 5，R 6，R 7和R 8的相邻对形成链-COCH = C（COOH）NR h - ，OR R 5，R 6，R 7和R 8中的一个形成式II，其中R a，R b和R c具有与R 5，R 6，R 7和R 8相同的含义的基团，X是任选中断或取代的烃链， Rg和Rh可以相同或不同，分别为烷基，烯基，苯基 - 烷基，烷酰基，苯甲酰基或苯基烷酰基，OR Rg和R 8和/或式II中的Rh和R c一起形成链 - （CH 2）n - ，n为2,3或4。

14. 发明授权

US4328230A N-Substituted-quinolin-4-one-2-carboxic acid derivatives 失效
标题翻译： N-取代的喹啉-4-酮-2-羧酸衍生物
公开(公告)号：US4328230A
公开(公告)日：1982-05-04
申请号：US17612
申请日：1979-03-05
申请人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
发明人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
IPC分类号： C07D215/26 , C07D215/28 , C07D215/32 , C07D215/48 , C07D221/08 , C07D221/10 , C07D471/04 , A61K31/47 , C07D215/58
CPC分类号： C07D471/04 , C07D215/48 , C07D221/08 , C07D221/10
摘要： There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain--COCH.dbd.C(COOH)NRh--,or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述了式I，其中R 5至R 8可以是多种取代基的式I化合物，或相邻的一对R 5，R 6，R 7和R 8形成链-COCH = C（COOH）NRh-，或 R 5，R 6，R 7和R 8中的一个形成式II，其中R a，R b和R c与R 5，R 6，R 7和R 8具有相同的含义，X是任选中断或取代的烃链， Rg和Rh可以相同或不同，分别为烷基，烯基，苯基 - 烷基，烷酰基，苯甲酰基或苯基烷酰基，或式II中的R g和R 8和/或Rh和R c一起形成链 - （CH 2）n - 和n为2,3或4.还描述了制备化合物和药物的方法，例如抗过敏剂，含有这些化合物的组合物。

15. 发明授权

US3952104A Benzopyran-2-carboxylic acids in the prevention of asthmatic symptoms 失效
标题翻译：苯并吡喃-2-羧酸预防哮喘症状
公开(公告)号：US3952104A
公开(公告)日：1976-04-20
申请号：US382642
申请日：1973-07-26
申请人： Hugh Cairns , Albert Chambers , Thomas Brian Lee
发明人： Hugh Cairns , Albert Chambers , Thomas Brian Lee
IPC分类号： C07C59/68 , C07D311/24 , A61K31/35
CPC分类号： C07C45/46 , C07C45/71 , C07C59/68 , C07D311/24 , Y10S514/826
摘要： There are described certain mono-chromone-2-carboxylic acids of formula, ##SPC1##Having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmacetuical compositions, for the treatment of asthma, containing the compounds.
摘要翻译：描述了某些具有式的单色酮-2-羧酸，在5或6位置具有一个取代基或在5,6,7或8个位置中具有2个或更多个取代基。还描述了制备含有化合物的化合物和药物组合物用于治疗哮喘的方法。

16. 发明授权

US4409237A Pharmaceutical compositions containing sodium chromoglycate and .beta.2 selective bronchodilators 失效
标题翻译：含有重铬酸钠和β2选择性支气管扩张剂的药物组合物
公开(公告)号：US4409237A
公开(公告)日：1983-10-11
申请号：US256021
申请日：1981-04-21
申请人： Hugh Cairns , Peter M. Greenhalgh , Brian Howlett
发明人： Hugh Cairns , Peter M. Greenhalgh , Brian Howlett
IPC分类号： A61K31/35
CPC分类号： A61K31/35
摘要： There are described salts of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol with certain long acting or .beta.2 selective bronchodilators.There are also described certain pharmaceutical mixtures comprising(a) one or more of 1,3-bis(2-carboxychromon-5-yloxy)-propan-2-ol, or a pharmaceutically acceptable salt thereof, in combination with(b) one or more .beta.2 selective or long acting bronchodilators, or a pharmaceutically acceptable salt thereof.
摘要翻译：描述了具有某些长效或β2选择性支气管扩张剂的1,3-双（2-羧基色酮-5-基氧基）丙-2-醇的盐。还描述了一些药物混合物，其包含（a）一种或多种1,3-双（2-羧基色酮-5-基氧基） - 丙-2-醇或其药学上可接受的盐与（b）一种或更多的β2选择性或长效支气管扩张剂或其药学上可接受的盐。

17. 发明授权

US4293541A Compounds 失效
标题翻译：化合物
公开(公告)号：US4293541A
公开(公告)日：1981-10-06
申请号：US143627
申请日：1980-04-25
申请人： Hugh Cairns , Thomas B. Lee
发明人： Hugh Cairns , Thomas B. Lee
IPC分类号： C07D493/04 , A61K31/35 , A61L9/04 , C07D311/24
CPC分类号： C07D493/04
摘要： There is described a salt of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran with a pharmaceutically acceptable organic cation, the salt having a solubility of less than 31 w/w in water a 20.5.degree. C.There are also described processes for making the salts and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了具有药学上可接受的有机阳离子的2,8-二羧基-4,6-二氧代-10-丙基-4H，6H-苯并（1,2-b：5,4-b'）二吡喃的盐，在水中具有小于31w / w的溶解度的盐，20.5℃。还描述了制备盐和药物的方法，例如抗过敏，含有它们的组合物。

18. 发明授权

US4239748A Inorganic salts of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran useful for the treatment of asthma and hay fever 失效
标题翻译：可用于治疗哮喘和花粉症的2,8-二羧基-4,6-二氧代-10-丙基-4H，6H-苯并（1,2-b：5,4-b'）二吡喃的无机盐
公开(公告)号：US4239748A
公开(公告)日：1980-12-16
申请号：US963813
申请日：1978-11-27
申请人： Hugh Cairns , Kenneth Brown , Roger E. C. Altouyan
发明人： Hugh Cairns , Kenneth Brown , Roger E. C. Altouyan
IPC分类号： C07D493/04 , A61L9/04 , A61K31/35 , C07D311/78
CPC分类号： C07D493/04 , Y10S514/826
摘要： There is described a salt of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran with a pharmaceutically acceptable inorganic cation, the salt having a solubility of less than 3% w/w in water a 20.5.degree. C.There are also described processes for making the salts and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了具有药学上可接受的无机阳离子的2,8-二羧基-4,6-二氧代-10-丙基-4H，6H-苯并（1,2-b：5,4-b'）二吡喃的盐，在水中的溶解度小于3％w / w的盐，20.5℃。还描述了制备盐和药物的方法，例如抗过敏，含有它们的组合物。

19. 发明授权

US3948954A Bis-chromone-tetrazole/hydroxamic/carboxylic acids 失效
标题翻译：双色酮 - 四唑/异羟肟酸/羧酸
公开(公告)号：US3948954A
公开(公告)日：1976-04-06
申请号：US435008
申请日：1974-01-21
申请人： Hugh Cairns , Norman Harold Rogers
发明人： Hugh Cairns , Norman Harold Rogers
IPC分类号： C07D311/02
摘要： There are described compounds of formula I, ##SPC1##in whichR.sub.1, r.sub.2, r.sub.3, r.sub.4, r.sub.5 and R.sub.6, which may be the same or different, each represent hydrogen, halogen, hydroxy, alkyl C1 to 6, alkoxy C1 to 6, alkenyl C1 to 6; the alkyl and alkoxy groups optionally being substituted by hydroxy, alkoxy C1 to 6, halogen or phenyl, andX is a hydrocarbon group containing from 2 to 10 carbon atoms, which is optionally interrupted by an oxygen atom, and/or substituted by an -OH group,Ra is a group -COOH, or ##EQU1## and pharmaceutically acceptable derivatives thereof. There are also described methods of making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了式I化合物，其中可以相同或不同的R 1，R 2，R 3，R 4，R 5和R 6各自表示氢，卤素，羟基，C 1-6烷基，烷氧基C 1-6，烯基C 1 至6; 任选被羟基，烷氧基C1至6，卤素或苯基取代的烷基和烷氧基，X是含有2-10个碳原子的烃基，其任选被氧原子中断，和/或被 - OH基，R a为-COOH基团，或-CN N ANGLE-ANGLE NH +及其药学上可接受的衍生物。

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