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1. 发明授权

US4102904A Intermediates for the preparation of antibacterial compounds 失效
标题翻译：用于制备抗菌化合物的中间体
公开(公告)号：US4102904A
公开(公告)日：1978-07-25
申请号：US803467
申请日：1977-06-06
申请人： Kong Luk , John Peter Clayton , Norman Harold Rogers
发明人： Kong Luk , John Peter Clayton , Norman Harold Rogers
IPC分类号： A61K31/335 , A61K31/35 , A61K31/435 , A61P31/04 , C07D309/10 , C07D407/06 , C07D309/06
CPC分类号： A61K31/435 , C07D407/06
摘要： A novel acid of formula: ##STR1## which is termed "monic acid" and is prepared from pseudomonic acid, is a useful intermediate for the preparation of esters thereof.
摘要翻译：一种新颖的式（Ⅰ）酸被称为“单酸”，由假单胞菌酸制备，是制备其酯的有用中间体。

2. 发明授权

US3948954A Bis-chromone-tetrazole/hydroxamic/carboxylic acids 失效
标题翻译：双色酮 - 四唑/异羟肟酸/羧酸
公开(公告)号：US3948954A
公开(公告)日：1976-04-06
申请号：US435008
申请日：1974-01-21
申请人： Hugh Cairns , Norman Harold Rogers
发明人： Hugh Cairns , Norman Harold Rogers
IPC分类号： C07D311/02
摘要： There are described compounds of formula I, ##SPC1##in whichR.sub.1, r.sub.2, r.sub.3, r.sub.4, r.sub.5 and R.sub.6, which may be the same or different, each represent hydrogen, halogen, hydroxy, alkyl C1 to 6, alkoxy C1 to 6, alkenyl C1 to 6; the alkyl and alkoxy groups optionally being substituted by hydroxy, alkoxy C1 to 6, halogen or phenyl, andX is a hydrocarbon group containing from 2 to 10 carbon atoms, which is optionally interrupted by an oxygen atom, and/or substituted by an -OH group,Ra is a group -COOH, or ##EQU1## and pharmaceutically acceptable derivatives thereof. There are also described methods of making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了式I化合物，其中可以相同或不同的R 1，R 2，R 3，R 4，R 5和R 6各自表示氢，卤素，羟基，C 1-6烷基，烷氧基C 1-6，烯基C 1 至6; 任选被羟基，烷氧基C1至6，卤素或苯基取代的烷基和烷氧基，X是含有2-10个碳原子的烃基，其任选被氧原子中断，和/或被 - OH基，R a为-COOH基团，或-CN N ANGLE-ANGLE NH +及其药学上可接受的衍生物。

3. 发明授权

US4102901A Antibacterial compounds 失效
标题翻译：抗菌化合物
公开(公告)号：US4102901A
公开(公告)日：1978-07-25
申请号：US803466
申请日：1977-06-06
申请人： Kong Luk , John Peter Clayton , Norman Harold Rogers
发明人： Kong Luk , John Peter Clayton , Norman Harold Rogers
IPC分类号： A61K31/335 , A61K31/35 , A61K31/435 , A61P31/04 , C07D309/10 , C07D407/06 , C07D309/06
CPC分类号： A61K31/435 , C07D407/06
摘要： Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
摘要翻译：被称为“单酸”的下式的酸：的酸具有抗革兰氏阳性和革兰氏阴性生物的活性。

4. 发明授权

US4085115A Carboxamido tetrazoles 失效
标题翻译：卡巴酰胺四唑
公开(公告)号：US4085115A
公开(公告)日：1978-04-18
申请号：US674732
申请日：1976-04-06
申请人： Joachim Augstein , Hugh Cairns , Norman Harold Rogers
发明人： Joachim Augstein , Hugh Cairns , Norman Harold Rogers
IPC分类号： C07D493/04 , C07D257/04 , A61K31/41
CPC分类号： C07D493/04
摘要： There are described compounds of formula Ix, ##STR1## IN WHICH ONE OR MORE ADJACENT PAIRS OF P, Q, R and T represent a chain of formula XX, ##STR2## or a group of formula X, ##STR3## in which Ba and Bb represent the pair of groups:- a carbon-carbon bond and --CRa.dbd.CRb--; or an adjacent pair of P, Q, R and T represent a group of formula XI, ##STR4## Ra and Rb and those of P, Q, R and T which do not form a chain of formula XX or a group of formula X or XI may be the same or different and each represents hydrogen; alkyl; alkoxy; alkenyl; alkenyloxy; alkyl or alkoxy, substituted by a hydroxy, alkoxy, aryl or halo group; amino; mono- or di-lower alkylamino; aminoalkoxy; aminoalkoxy substituted by a lower alkyl group; nitro; hydroxy; halogen; acyl; or aryloxy.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了式Ix的化合物，其中P，Q，R和T的一个或多个相邻对表示式XX的链， XX或一组式X， X在其中Ba和Bb代表一对基团： - 碳 - 碳键和-CRa = CRb-; 或相邻的一对P，Q，R和T表示式XI，XIAa和Rb的基团，以及不形成式XX链或式 X或XI可以相同或不同，各自表示氢; 烷基; 烷氧基烯基; 链烯氧基被羟基，烷氧基，芳基或卤代基取代的烷基或烷氧基; 氨基; 单 - 或二 - 低级烷基氨基; 氨基烷氧基被低级烷基取代的氨基烷氧基; 硝基羟基; 卤素; 酰基; 或芳氧基。

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