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1. 发明授权

US4328230A N-Substituted-quinolin-4-one-2-carboxic acid derivatives 失效
标题翻译： N-取代的喹啉-4-酮-2-羧酸衍生物
公开(公告)号：US4328230A
公开(公告)日：1982-05-04
申请号：US17612
申请日：1979-03-05
申请人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
发明人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
IPC分类号： C07D215/26 , C07D215/28 , C07D215/32 , C07D215/48 , C07D221/08 , C07D221/10 , C07D471/04 , A61K31/47 , C07D215/58
CPC分类号： C07D471/04 , C07D215/48 , C07D221/08 , C07D221/10
摘要： There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain--COCH.dbd.C(COOH)NRh--,or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述了式I，其中R 5至R 8可以是多种取代基的式I化合物，或相邻的一对R 5，R 6，R 7和R 8形成链-COCH = C（COOH）NRh-，或 R 5，R 6，R 7和R 8中的一个形成式II，其中R a，R b和R c与R 5，R 6，R 7和R 8具有相同的含义，X是任选中断或取代的烃链， Rg和Rh可以相同或不同，分别为烷基，烯基，苯基 - 烷基，烷酰基，苯甲酰基或苯基烷酰基，或式II中的R g和R 8和/或Rh和R c一起形成链 - （CH 2）n - 和n为2,3或4.还描述了制备化合物和药物的方法，例如抗过敏剂，含有这些化合物的组合物。

2. 发明授权

US4211788A Compounds 失效
标题翻译：化合物
公开(公告)号：US4211788A
公开(公告)日：1980-07-08
申请号：US904794
申请日：1978-05-11
申请人： Hugh Cairns , Anthony R. Payne
发明人： Hugh Cairns , Anthony R. Payne
IPC分类号： C07D311/94 , A61K31/355 , C07D311/22
CPC分类号： C07C45/60 , C07C45/62 , C07C45/67 , C07C45/71 , C07D311/94
摘要： There are described compounds of formula I, ##STR1## in which E is a --COOH, a 5-tetrazolyl or an (N-tetrazol-5-yl) carboxamido group,R.sub.3 is hydrogen or alkyl,an adjacent pair of W, X, Y and Z form a 5 membered chain comprising alkylene groups and optionally one or two oxygen atoms, the chain optionally being substituted by one or two alkyl groups,the remaining substituents W, X, Y or Z are hydrogen; halogen; alkyl optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy; alkenyl optionally substituted by phenyl; hydroxy; alkoxy; alkanoyloxy; alkenyloxy; nitro; --NR.sub.1 R.sub.2 or hydroxyalkoxy,R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen or alkyl,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述了式I的化合物，其中E是-COOH，5-四唑基或（N-四唑-5-基）甲酰氨基，R 3是氢或烷基，相邻的一对W， X，Y和Z形成包含亚烷基和任选的一个或两个氧原子的5元链，该链任选被一个或两个烷基取代，其余的取代基W，X，Y或Z是氢; 卤素; 任选被一个或多个羟基，卤素，羰基氧，苯基或烷氧基取代的烷基; 任选被苯基取代的烯基; 羟基; 烷氧基烷酰氧基; 链烯氧基硝基 -NR1R2或羟基烷氧基，R1和R2可以相同或不同，各自为氢或烷基，及其药学上可接受的衍生物。还描述了制备化合物和药物的方法，例如。抗过敏剂，含有这些化合物的组合物。

3. 发明授权

US4156726A 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds 失效
标题翻译：用作抗过敏化合物的4-氧代-2-羧基喹啉衍生物
公开(公告)号：US4156726A
公开(公告)日：1979-05-29
申请号：US635615
申请日：1975-11-26
申请人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
发明人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
IPC分类号： C07D215/26 , C07D215/28 , C07D215/32 , C07D215/48 , C07D221/08 , C07D221/10 , C07D471/04 , A61K31/47
CPC分类号： C07D471/04 , C07D215/48 , C07D221/08 , C07D221/10
摘要： There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述式I的化合物，其中R 5至R 8可以是多种取代基，或者R 5，R 6，R 7和R 8的相邻对形成链-COCH = C（COOH）NR h - ，OR R 5，R 6，R 7和R 8中的一个形成式II，其中R a，R b和R c具有与R 5，R 6，R 7和R 8相同的含义的基团，X是任选中断或取代的烃链， Rg和Rh可以相同或不同，分别为烷基，烯基，苯基 - 烷基，烷酰基，苯甲酰基或苯基烷酰基，OR Rg和R 8和/或式II中的Rh和R c一起形成链 - （CH 2）n - ，n为2,3或4。

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