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11. 发明授权

US08180454B2 Fitting a neural prosthesis using impedance and electrode height 有权
标题翻译：使用阻抗和电极高度拟合神经假体
公开(公告)号：US08180454B2
公开(公告)日：2012-05-15
申请号：US11607201
申请日：2006-12-01
申请人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/18
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。

12. 发明申请

US20080058897A1 Visual Prosthesis Fitting 有权
标题翻译：视觉假体拟合
公开(公告)号：US20080058897A1
公开(公告)日：2008-03-06
申请号：US11927258
申请日：2007-10-29
申请人： Matthew McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Horsager , Avraham Caspi , Kelly McClure , Robert Greenberg
发明人： Matthew McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Horsager , Avraham Caspi , Kelly McClure , Robert Greenberg
IPC分类号： A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37247
摘要： Methods and devices for fitting a visual prosthesis are described. In one of the methods, threshold levels and maximum levels for the electrodes of the prosthesis are determined and a map of brightness to electrode stimulation levels is later formed. A fitting system for a visual prosthesis is also discussed, together with a computer-operated system having a graphical user interface showing visual prosthesis diagnostic screens and visual prosthesis configuration screens.
摘要翻译：描述了用于装配视觉假体的方法和装置。在其中一种方法中，确定假体电极的阈值水平和最大水平，并且稍后形成亮度与电极刺激水平的图。还讨论了用于视觉假体的装配系统，以及具有显示视觉假体诊断屏幕和视觉假体配置屏幕的图形用户界面的计算机操作系统。

13. 发明授权

US10780272B2 Visual prosthesis fitting 有权
公开(公告)号：US10780272B2
公开(公告)日：2020-09-22
申请号：US13590011
申请日：2012-08-20
申请人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
发明人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
摘要： The present invention is a fitting system with a graphical interface with specific interface screens for specific functions. Methods and devices for fitting a visual prosthesis are described. In one of the methods, threshold levels and maximum levels for the electrodes of the prosthesis are determined and a map of brightness to electrode stimulation levels is later formed. A fitting system for a visual prosthesis is also discussed, together with a computer-operated system having a graphical user interface showing visual prosthesis diagnostic screens and visual prosthesis configuration screens.

14. 发明授权

US08706244B2 Fitting of brightness as a function of current amplitude in a visual prosthesis 有权
标题翻译：在视觉假体中将亮度拟合为电流幅度的函数
公开(公告)号：US08706244B2
公开(公告)日：2014-04-22
申请号：US12561025
申请日：2009-09-16
申请人： Scott H. Greenwald , Matthew J. McMahon , Ione Fine
发明人： Scott H. Greenwald , Matthew J. McMahon , Ione Fine
IPC分类号： A61N1/00 , A61B13/00
CPC分类号： A61N1/36046 , A61N1/0543
摘要： To accurately represent a visual scene a visual prosthesis must convey luminance information across a range of brightness levels. To do this, the brightness of phosphenes produced by an individual electrode should scale appropriately with luminance, and the same luminance should produce equivalently bright phosphenes across the entire electrode array. Given that the function relating current to brightness varies across electrodes, it is necessary to develop a fitting procedure that will permit brightness to be equated across an entire array. The current invention describes a method of performing a brightness fitting that normalizes brightness across electrodes. The method determines a set of parameters that are stored in the subjects Video Configuration File—the look-up table that converts the video camera input to stimulation profiles for each electrode. One electrode would be specified as the standard. Brightness rating would be carried out on that electrode so “rating” as a function of current amplitude was known for that electrode.
摘要翻译：为了准确地表示视觉场景，视觉假体必须在亮度级别范围内传达亮度信息。为了做到这一点，单个电极产生的磷光体的亮度应该用亮度适当地调节，并且相同的亮度应该在整个电极阵列上产生等同的亮的磷光体。假设电流与亮度相关的功能在电极之间变化，则有必要开发一种拟合程序，这将允许整个阵列的亮度相等。本发明描述了执行使电极之间的亮度标准化的亮度拟合的方法。该方法确定存储在被摄体视频配置文件（将视频摄像机输入转换为每个电极的刺激曲线）的查找表中存储的一组参数。一个电极将被指定为标准。在该电极上将进行亮度等级，因此对于该电极已知作为电流幅度的函数的“额定值”。

15. 发明授权

US07818064B2 Fitting of brightness in a visual prosthesis 有权
标题翻译：在视觉假体中配合亮度
公开(公告)号：US07818064B2
公开(公告)日：2010-10-19
申请号：US11924334
申请日：2007-10-25
申请人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
发明人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
IPC分类号： A61N1/36
CPC分类号： A61F9/08 , A61N1/36046
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. The perceptual response to electrical neural stimulation varies from patient to patient and the response to electrical neural stimulation varies from patient to patient and the relationship between current and perceived brightness is often non-linear. It is necessary to determine this relationship to fit the prosthesis settings for each patient. It is advantageous to map the perceptual responses to stimuli. The method of mapping of the present invention is to provide a plurality of stimuli that vary in current, voltage, pulse duration, frequency, or some other dimension; measuring and recording the response to those stimuli; deriving a formula or equation describing the map from the individual points; storing the formula; and using that formula to map future stimulation.
摘要翻译：本发明是一种将电极阵列自动调整为单个患者的神经特征的方法。对电神经刺激的感知反应因患者而异，并且对电神经刺激的响应随病人而变化，并且电流和感知亮度之间的关系通常是非线性的。需要确定这种关系以适应每个患者的假体设置。将感知反应映射到刺激是有利的。本发明的映射方法是提供在电流，电压，脉冲持续时间，频率或某些其他维度上变化的多个刺激; 测量和记录对这些刺激的反应; 从各个点得出描述地图的公式或方程; 存储公式; 并使用该公式来映射未来的刺激。

16. 发明授权

US07738962B2 Fitting of brightness in a visual prosthesis 有权
标题翻译：在视觉假体中配合亮度
公开(公告)号：US07738962B2
公开(公告)日：2010-06-15
申请号：US11357680
申请日：2006-02-16
申请人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
发明人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61F9/08 , A61N1/36046
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. The perceptual response to electrical neural stimulation varies from patient to patient and The response to electrical neural stimulation varies from patient to patient and the relationship between current and perceived brightness is often non-linear. It is necessary to determine this relationship to fit the prosthesis settings for each patient. It is advantageous to map the perceptual responses to stimuli. The method of mapping of the present invention is to provide a plurality of stimuli that vary in current, voltage, pulse duration, frequency, or some other dimension; measuring and recording the response to those stimuli; deriving a formula or equation describing the map from the individual points; storing the formula; and using that formula to map future stimulation.
摘要翻译：本发明是一种将电极阵列自动调整为单个患者的神经特征的方法。对电神经刺激的感知反应因患者而异，并且对电神经刺激的响应因患者而异，并且电流和感知亮度之间的关系通常是非线性的。需要确定这种关系以适应每个患者的假体设置。将感知反应映射到刺激是有利的。本发明的映射方法是提供在电流，电压，脉冲持续时间，频率或某些其他维度上变化的多个刺激; 测量和记录对这些刺激的反应; 从各个点得出描述地图的公式或方程; 存储公式; 并使用该公式来映射未来的刺激。

17. 发明申请

US20080188908A1 FITTING OF BRIGHTNESS IN A VISUAL PROSTHESIS 有权
标题翻译：在视觉展现中配备亮度
公开(公告)号：US20080188908A1
公开(公告)日：2008-08-07
申请号：US11924334
申请日：2007-10-25
申请人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
发明人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
IPC分类号： A61N1/08
CPC分类号： A61F9/08 , A61N1/36046
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. The perceptual response to electrical neural stimulation varies from patient to patient and The response to electrical neural stimulation varies from patient to patient and the relationship between current and perceived brightness is often non-linear. It is necessary to determine this relationship to fit the prosthesis settings for each patient. It is advantageous to map the perceptual responses to stimuli. The method of mapping of the present invention is to provide a plurality of stimuli that vary in current, voltage, pulse duration, frequency, or some other dimension; measuring and recording the response to those stimuli; deriving a formula or equation describing the map from the individual points; storing the formula; and using that formula to map future stimulation.
摘要翻译：本发明是一种将电极阵列自动调整为单个患者的神经特征的方法。对电神经刺激的感知反应因患者而异，并且对电神经刺激的响应因患者而异，并且电流和感知亮度之间的关系通常是非线性的。需要确定这种关系以适应每个患者的假体设置。将感知反应映射到刺激是有利的。本发明的映射方法是提供在电流，电压，脉冲持续时间，频率或某些其他维度上变化的多个刺激; 测量和记录对这些刺激的反应; 从各个点得出描述地图的公式或方程; 存储公式; 并使用该公式来映射未来的刺激。

18. 发明申请

US20060184062A1 Fitting of brightness in a visual prosthesis 有权
公开(公告)号：US20060184062A1
公开(公告)日：2006-08-17
申请号：US11357680
申请日：2006-02-16
申请人： Robert Greenberg , Ione Fine , Arup Roy , Matthew McMahon
发明人： Robert Greenberg , Ione Fine , Arup Roy , Matthew McMahon
IPC分类号： A61B19/00
CPC分类号： A61F9/08 , A61N1/36046
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. The perceptual response to electrical neural stimulation varies from patient to patient and The response to electrical neural stimulation varies from patient to patient and the relationship between current and perceived brightness is often non-linear. It is necessary to determine this relationship to fit the prosthesis settings for each patient. It is advantageous to map the perceptual responses to stimuli. The method of mapping of the present invention is to provide a plurality of stimuli that vary in current, voltage, pulse duration, frequency, or some other dimension; measuring and recording the response to those stimuli; deriving a formula or equation describing the map from the individual points; storing the formula; and using that formula to map future stimulation.

19. 发明申请

US20050058351A1 Surface segmentation from luminance and color differences 失效
标题翻译：亮度和色差的表面分割
公开(公告)号：US20050058351A1
公开(公告)日：2005-03-17
申请号：US10881966
申请日：2004-06-29
申请人： Ione Fine , Geoffrey Boynton
发明人： Ione Fine , Geoffrey Boynton
IPC分类号： G06K9/00 , G06K9/46 , G06T5/00
CPC分类号： G06T7/143 , G06T7/11 , G06T2207/10036 , G06T2207/30188
摘要： A method for determining if a first pixel and a second pixel belong to a same surface includes: determining a spatial-difference value for the first pixel and the second pixel; determining one or more vision-difference values for the first pixel and the second pixel; determining, from the spatial-difference value, an initial same-surface probability value for if the first pixel and the second pixel belong to the same surface; determining, from the one or more vision-difference values, a first vision-difference probability value for if the first pixel and the second pixel belong to the same surface; determining, from the spatial-difference value and the one or more vision-difference values, a second vision-difference probability value; determining, from the initial same-surface probability value, the first vision-difference probability value and the second vision-difference probability value, an improved same-surface probability value for if the first pixel and the second pixel belong to the same surface.
摘要翻译：一种用于确定第一像素和第二像素是否属于相同表面的方法包括：确定第一像素和第二像素的空间差值; 确定所述第一像素和所述第二像素的一个或多个视差值; 从所述空间差值确定如果所述第一像素和所述第二像素属于相同表面的初始相同面概率值; 从所述一个或多个视差值确定如果所述第一像素和所述第二像素属于相同表面的第一视差概率值; 从所述空间差值和所述一个或多个视差值确定第二视差概率值; 从所述初始相同概率值确定所述第一视差概率值和所述第二视差概率值，如果所述第一像素和所述第二像素属于相同表面，则确定改进的相同概率值。

20. 发明授权

US08554327B2 Method and apparatus for predicting and controlling the percepts induced by a visual prosthesis 有权
公开(公告)号：US08554327B2
公开(公告)日：2013-10-08
申请号：US13304128
申请日：2011-11-23
申请人： Devyani Nanduri , Ione Fine , Robert J. Greenberg , Jessy Dorn
发明人： Devyani Nanduri , Ione Fine , Robert J. Greenberg , Jessy Dorn
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/36046
摘要： Here we present the first model that quantitatively predicts the apparent spatial position and shape of percepts elicited by retinal electrical stimulation in humans based on the known anatomy of the retina. This model successfully predicts both the shape of percepts elicited by single electrode stimulation and the shape and relative positions of percepts elicited by multiple electrode stimulation. Model fits to behavioral data show that sensitivity to electrical stimulation is not confined to the axon initial segment, but does fall off rapidly with the distance between stimulation and the initial segment. Using the model, it is possible to compensate, preferably with a look up table, to match percepts to a desired image.

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