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11. 发明授权

US08785495B2 Compositions including beta-hydroxy-beta-methylbutyrate 有权
标题翻译：组合物包括β-羟基-β-甲基丁酸酯
公开(公告)号：US08785495B2
公开(公告)日：2014-07-22
申请号：US13347956
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含有游离氨基酸。

12. 发明授权

US08609725B2 Method of using beta-hydroxy-beta-methylbutyrate for reducing tumor growth rate 失效
标题翻译：使用β-羟基-β-甲基丁酸酯降低肿瘤生长速度的方法
公开(公告)号：US08609725B2
公开(公告)日：2013-12-17
申请号：US13348026
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
IPC分类号： A61K31/19 , A61K31/70 , A61K31/355 , A61K31/34 , A61K31/20
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者是单独或者与二十碳五烯酸（20:5ω-3），FOS，肉毒碱及其混合物组合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

13. 发明授权

US08217077B2 HMB uses thereof 有权
标题翻译： HMB使用它
公开(公告)号：US08217077B2
公开(公告)日：2012-07-10
申请号：US11025466
申请日：2004-12-29
申请人： Jeffrey H. Baxter , Pradip Mukerji , Anne C. Voss , Michael J. Tisdale
发明人： Jeffrey H. Baxter , Pradip Mukerji , Anne C. Voss , Michael J. Tisdale
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

14. 发明授权

US5576300A Method for inhibition of human rotavirus infection 失效
标题翻译：抑制人类轮状病毒感染的方法
公开(公告)号：US5576300A
公开(公告)日：1996-11-19
申请号：US308883
申请日：1994-09-16
申请人： Pradip Mukerji , Pedro A. Prieto , Amanda E.-Y. Seo , Jeffrey H. Baxter , Richard D. Cummings
发明人： Pradip Mukerji , Pedro A. Prieto , Amanda E.-Y. Seo , Jeffrey H. Baxter , Richard D. Cummings
IPC分类号： A23L1/305 , A61K38/00 , C07K14/47 , C07K1/00
CPC分类号： C07K14/4732 , A23L33/19 , A61K38/00 , Y10S514/867 , Y10S530/832
摘要： A method of preventing or treating infection by human rotavirus by administering an enteral nutritional product containing either bovine .kappa.-casein or human .kappa.-casein at a concentration greater than that found in human or bovine milk and sufficient to inhibit infection of mammalian cells by human rotavirus.
摘要翻译：一种预防或治疗人轮状病毒感染的方法，其通过以大于人或牛奶中发现的浓度施用含有牛κ-酪蛋白或人κ-酪蛋白的肠内营养产品，并且足以抑制人轮状病毒感染哺乳动物细胞。

15. 发明申请

US20090005544A1 Process for Making Soy Protein Isolates 审中-公开
标题翻译：制作大豆蛋白分离物的方法
公开(公告)号：US20090005544A1
公开(公告)日：2009-01-01
申请号：US12145776
申请日：2008-06-25
申请人： Louis I. Ndife , Chad R. Cole , Jeffrey H. Baxter
发明人： Louis I. Ndife , Chad R. Cole , Jeffrey H. Baxter
IPC分类号： C07K1/30
CPC分类号： A23J3/16 , A23J1/14 , A23L11/07 , A23L11/32 , A23L33/165 , A23L33/185 , A23V2002/00 , A23V2250/5488 , A23V2250/1578 , A23V2250/1612
摘要： Disclosed is a process comprising: mixing a soy protein-containing material with an aqueous medium; removing the non-solubilized solids from the slurry to form an alkaline liquid containing solubilized soy protein; adjusting the pH of the solubilized soy protein liquid to between about 3.8 and about 6.6, to precipitate soy protein from the liquid; separating the precipitated soy protein from the pH-adjusted soy protein liquid; resolubilizing the separated soy protein precipitate in an aqueous medium at a pH of from about 1.8 to 3.2; treating the resolubilized soy protein with at least one water-soluble calcium salt to form a calcium-enriched soy protein mixture; precipitating soy protein from the calcium-enriched soy protein mixture by adjusting the pH of the mixture to between about 3.8 and about 6.6; separating the precipitated soy protein from the calcium-enriched soy protein mixture; and washing to form calcium-enriched soy protein isolate having selectively reduced manganese concentrations.
摘要翻译：公开了一种方法，其包括：将含大豆蛋白的材料与水性介质混合; 从浆液中除去未溶解的固体以形成含有溶解大豆蛋白的碱性液体; 将溶解的大豆蛋白液体的pH调节至约3.8至约6.6，以从液体中沉淀大豆蛋白; 将沉淀的大豆蛋白与pH调节的大豆蛋白液体分离; 将分离的大豆蛋白沉淀物在约1.8至3.2的pH下在水性介质中重新溶解; 用至少一种水溶性钙盐处理所述再溶解的大豆蛋白以形成富含钙的大豆蛋白混合物; 通过将混合物的pH调节至约3.8至约6.6，从富钙大豆蛋白混合物中沉淀大豆蛋白; 将沉淀的大豆蛋白与富钙大豆蛋白混合物分离; 并洗涤以形成具有选择性还原的锰浓度的富钙大豆蛋白分离物。

16. 发明授权

US5700590A Nutritional formula with ribo-nucleotides 失效
标题翻译：具有核糖核苷酸的营养配方
公开(公告)号：US5700590A
公开(公告)日：1997-12-23
申请号：US585221
申请日：1996-01-11
申请人： Marc Leif Masor , James Lee Leach , Bruce Edward Molitor , John Durand Benson , Jeffrey H. Baxter
发明人： Marc Leif Masor , James Lee Leach , Bruce Edward Molitor , John Durand Benson , Jeffrey H. Baxter
IPC分类号： A23D9/00 , A23L1/29 , A23L1/30 , A61K31/7088 , A61K45/06 , A23L1/305 , A61K31/70
CPC分类号： A23D9/00 , A23L33/115 , A23L33/13 , A23L33/40 , A61K31/70 , A61K31/7088 , A61K45/06 , Y10S426/801
摘要： An improved enteral formula containing ribo-nucleotide equivalents (RNA, mono-, di- and triphosphate nucleotides, nucleosides and adducts such as activated sugars) at a level of at least 10 mg/100 Kcal (kilocalorie) of formula. More specifically, an infant formula containing at least 10 milligrams of nucleotide equivalents per 100 Kcal of formula where the nucleotide equivalents consist of RNA; mono-, di-, and triphosphate esters of adenosine, cytidine, guanosine, and uridine, and the d-ribose adducts thereof; and wherein the weight ratio of said cytidine nucleotide equivalents to said uridine nucleotide equivalents is 1.5:1 to 2.6:1; of said cytidine nucleotide equivalent to said adenosine nucleotide equivalents is 2:1 to 3.9:1; and of said cytidine nucleotide equivalents to said guanosine nucleotide equivalents is 1.75:1 to 2.8:1, is disclosed. The formula comprises carbohydrates, lipids, proteins, vitamins and minerals and four (4) ribo-nucleotide equivalents at specific levels and ratios. This invention also provides a dietary formula that enhances the immune system and alleviates diarrhea.
摘要翻译：含有核糖核苷酸当量（RNA，单，二和三磷酸核苷酸，核苷和加合物如活性糖）的改进的肠内配方，其含量至少为10mg / 100千卡（kilocalorie）。更具体地说，一种含有至少10毫克核苷酸当量/ 100Kcal配方的婴儿配方，其中核苷酸当量由RNA组成; 腺苷，胞苷，鸟苷和尿苷的单，二和三磷酸酯及其d-核糖加合物; 并且其中所述胞苷核苷酸当量与所述尿苷核苷酸当量的重量比为1.5:1至2.6:1; 所述胞苷核苷酸等同于所述腺苷核苷酸当量为2:1至3.9:1; 和所述鸟苷核苷酸等效物的所述胞苷核苷酸当量为1.75:1至2.8:1。该配方包括碳水化合物，脂质，蛋白质，维生素和矿物质以及四（4）核糖核苷酸等同物在特定水平和比例下。本发明还提供了增强免疫系统并减轻腹泻的饮食配方。

17. 发明授权

US5492899A Infant nutritional formula with ribo-nucleotides 失效
标题翻译：具有核糖核苷酸的婴儿营养配方
公开(公告)号：US5492899A
公开(公告)日：1996-02-20
申请号：US178687
申请日：1994-01-10
申请人： Marc L. Masor , James L. Leach , Bruce E. Molitor , John D. Benson , Jeffrey H. Baxter
发明人： Marc L. Masor , James L. Leach , Bruce E. Molitor , John D. Benson , Jeffrey H. Baxter
IPC分类号： A23D9/00 , A23L1/29 , A23L1/30 , A61K31/7088 , A61K45/06 , A61K31/70
CPC分类号： A61K31/70 , A23D9/00 , A23L33/13 , A23L33/40 , A61K31/7088 , A61K45/06 , Y10S426/801
摘要： An improved enteral nutritional formula containing ribo-nucleotide equivalents (RNA, mono-, di- and triphosphate nucleotides, nucleosides and adjuncts such as activated sugars) at a level of at least 10 mg/100 Kcal (kilocalorie) of formula is disclosed. The formula comprises carbohydrates, lipids, proteins, vitamins and minerals and four (4) ribo-nucleotide equivalents at specific levels and ratios. The invention also discloses novel methods of production and analytical techniques. An infant formula containing cytidine nucleotide equivalents in the range of 29 to 39 mg/liter of formula, uridine nucleotide equivalents in the range of 15 to 20 mg/liter of formula, adenosine nucleotide equivalents in the range of 10 to 15 mg/liter of formula and guanosine nucleotide equivalents in the range of 14 to 20 mg/liter of formula provides a dietary formula that enhances the immune system and alleviates diarrhea.
摘要翻译：公开了含有核糖核苷酸当量（RNA，单，二磷酸和三磷酸核苷酸，核苷和辅助物例如活性糖）的改进的肠内营养配方，其含量至少为10mg / 100千卡（kilocalorie）。该配方包括碳水化合物，脂质，蛋白质，维生素和矿物质以及四（4）核糖核苷酸等同物在特定水平和比例下。本发明还公开了新的生产方法和分析技术。一种含有胞苷核苷酸当量在29至39mg /升式中的婴儿配方，尿苷核苷酸当量在15至20mg /升配方范围内，腺苷核苷酸当量在10至15mg /升范围内配方和鸟苷核苷酸当量在14至20mg /升范围内提供了增强免疫系统和减轻腹泻的膳食配方。

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