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1. 发明申请

US20090005544A1 Process for Making Soy Protein Isolates 审中-公开
标题翻译：制作大豆蛋白分离物的方法
公开(公告)号：US20090005544A1
公开(公告)日：2009-01-01
申请号：US12145776
申请日：2008-06-25
申请人： Louis I. Ndife , Chad R. Cole , Jeffrey H. Baxter
发明人： Louis I. Ndife , Chad R. Cole , Jeffrey H. Baxter
IPC分类号： C07K1/30
CPC分类号： A23J3/16 , A23J1/14 , A23L11/07 , A23L11/32 , A23L33/165 , A23L33/185 , A23V2002/00 , A23V2250/5488 , A23V2250/1578 , A23V2250/1612
摘要： Disclosed is a process comprising: mixing a soy protein-containing material with an aqueous medium; removing the non-solubilized solids from the slurry to form an alkaline liquid containing solubilized soy protein; adjusting the pH of the solubilized soy protein liquid to between about 3.8 and about 6.6, to precipitate soy protein from the liquid; separating the precipitated soy protein from the pH-adjusted soy protein liquid; resolubilizing the separated soy protein precipitate in an aqueous medium at a pH of from about 1.8 to 3.2; treating the resolubilized soy protein with at least one water-soluble calcium salt to form a calcium-enriched soy protein mixture; precipitating soy protein from the calcium-enriched soy protein mixture by adjusting the pH of the mixture to between about 3.8 and about 6.6; separating the precipitated soy protein from the calcium-enriched soy protein mixture; and washing to form calcium-enriched soy protein isolate having selectively reduced manganese concentrations.
摘要翻译：公开了一种方法，其包括：将含大豆蛋白的材料与水性介质混合; 从浆液中除去未溶解的固体以形成含有溶解大豆蛋白的碱性液体; 将溶解的大豆蛋白液体的pH调节至约3.8至约6.6，以从液体中沉淀大豆蛋白; 将沉淀的大豆蛋白与pH调节的大豆蛋白液体分离; 将分离的大豆蛋白沉淀物在约1.8至3.2的pH下在水性介质中重新溶解; 用至少一种水溶性钙盐处理所述再溶解的大豆蛋白以形成富含钙的大豆蛋白混合物; 通过将混合物的pH调节至约3.8至约6.6，从富钙大豆蛋白混合物中沉淀大豆蛋白; 将沉淀的大豆蛋白与富钙大豆蛋白混合物分离; 并洗涤以形成具有选择性还原的锰浓度的富钙大豆蛋白分离物。

2. 发明申请

US20120189716A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR TREATING DISEASE-ASSOCIATED WASTING 有权
标题翻译：使用β-羟基-β-甲基丁酸酯治疗疾病相关废物的方法
公开(公告)号：US20120189716A1
公开(公告)日：2012-07-26
申请号：US13348024
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/205 , A61K31/355 , A61P3/00 , A61K33/04 , A61P29/00 , A61P35/00 , A61K31/702 , A61K31/375
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

3. 发明申请

US20130011498A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR REDUCING TUMOR GROWTH RATE 失效
标题翻译：使用β-羟基-β-甲基丁酸酯降低肿瘤生长速率的方法
公开(公告)号：US20130011498A1
公开(公告)日：2013-01-10
申请号：US13348026
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
IPC分类号： A61K31/202 , A61P35/00 , A61K31/355 , A61K33/04 , A61K31/205 , A61K31/702
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。

4. 发明申请

US20120196829A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR THE PREVENTION AND TREATMENT OF DISEASE CONDITIONS 有权
标题翻译：使用β-羟基 - 甲基丁酸酯预防和治疗疾病条件的方法
公开(公告)号：US20120196829A1
公开(公告)日：2012-08-02
申请号：US13347877
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/702 , A61K31/20 , A61P35/00 , A61P31/18 , A61P3/00 , A61P19/02 , A61P1/16 , A61P1/00 , A61P13/12 , A61P11/00 , A61K31/19 , A61P37/00
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

5. 发明授权

US08778994B2 Method of using beta-hydroxy-beta-methylbutyrate and fatty acids for treating disease-associated wasting 有权
标题翻译：使用β-羟基-β-甲基丁酸酯和脂肪酸治疗疾病相关性消耗的方法
公开(公告)号：US08778994B2
公开(公告)日：2014-07-15
申请号：US13348035
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。

6. 发明授权

US08778993B2 Method of using β-hydroxy-β-methylbutyrate for the treatment of disease conditions 有权
标题翻译：用于治疗疾病的方法 - 用于治疗疾病的方法 - 羟基 - 甲基丁酸酯
公开(公告)号：US08778993B2
公开(公告)日：2014-07-15
申请号：US13347877
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

7. 发明申请

US20120189717A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE AND FATTY ACIDS FOR TREATING DISEASE-ASSOCIATED WASTING 有权
标题翻译：使用β-羟基 - 甲基丁酸酯与脂肪酸处理疾病相关的废物的方法
公开(公告)号：US20120189717A1
公开(公告)日：2012-07-26
申请号：US13348035
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
IPC分类号： A61K31/202 , A61K31/205 , A61P21/00 , A61K31/355 , A61K31/375 , A61K33/04 , A61K31/201 , A61K31/702
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。

8. 发明申请

US20120189715A1 COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE AND USES THEREOF 审中-公开
标题翻译：包括β-羟基-β-甲基丁酸酯的组合物及其用途
公开(公告)号：US20120189715A1
公开(公告)日：2012-07-26
申请号：US13347978
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/702 , A61K31/375 , A61K33/04 , A61K31/717 , A61P35/00 , A61P11/00 , A61P31/18 , A61P19/02 , A61P1/16 , A61P1/00 , A61P13/12 , A61K31/355 , A61P3/00
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

9. 发明申请

US20120189714A1 COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE 有权
标题翻译：包括β-羟基 - 甲基丁酸酯的组合物
公开(公告)号：US20120189714A1
公开(公告)日：2012-07-26
申请号：US13347956
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/205 , A61K31/355 , A61P3/00 , A61K33/04 , A61P29/00 , A61P35/00 , A61K31/702 , A61K31/375
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

10. 发明申请

US20120177752A1 NUTRITIONAL COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE 审中-公开
标题翻译：包含β-羟基 - 甲基丁酸酯的营养组合物
公开(公告)号：US20120177752A1
公开(公告)日：2012-07-12
申请号：US13347985
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/702 , A61P3/04 , A61P29/00 , A61P35/00 , A61K31/70 , A61K33/04
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

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