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11. 发明申请

US20050079543A1 Receptor recognition factors, protein sequences and methods of use thereof 失效
标题翻译：受体识别因子，蛋白质序列及其使用方法
公开(公告)号：US20050079543A1
公开(公告)日：2005-04-14
申请号：US10639617
申请日：2003-08-12
申请人： James Darnell , Christian Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James Darnell , Christian Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： A61K38/00 , A61K38/21 , C07K14/47 , C07K16/28 , C12N15/113 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705 , Y02A50/473 , A61K2300/00
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFNα and IFNγ. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFNγ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

12. 发明授权

US09445624B2 Anti-fatigue composition of plant material and preparation method, use and products thereof 有权
标题翻译：植物材料抗疲劳组合物及其制备方法，用途及其产品
公开(公告)号：US09445624B2
公开(公告)日：2016-09-20
申请号：US13814129
申请日：2010-08-05
申请人： Chen Xie , Zhong Zhong
发明人： Chen Xie , Zhong Zhong
IPC分类号： A61K36/185 , A61K36/41 , A61K36/42 , A61K36/81 , A23L2/52 , A23L1/30 , A61K36/424 , A61K36/815
CPC分类号： A23L2/52 , A23L33/105 , A61K36/41 , A61K36/424 , A61K36/815 , A61K2300/00
摘要： The present invention provides a composition of a plant material with anti-fatigue activity, its preparation method, usage and related products. The said composition is manufactured from the following plant materials: 20-80% from the genus Rhodiola; 10-60% Gynostemma; 10-60% Lycium. The said composition can be used to manufacture health product, food or anti-fatigue medicine which is able to significantly reduce the fatigue symptoms of those people suffering from fatigue, improve sleeping quality with no impact on normal body physiology. It is shown that the medicine derived from the present is invention exerts its anti-fatigue effect through improving the functions of erythrocytes and thrombocytes to enhance the body's ability of supplying oxygen. The medicinal composition of the present invention is characterized by the small effective dose and good water solubility and thus suitable to be made into a variety of dosage forms for use.
摘要翻译：本发明提供具有抗疲劳活性的植物材料的组合物，其制备方法，用途及相关产品。所述组合物由以下植物材料制成：来自红景天属的20-80％; 绞股蓝10-60％ 10-60％枸杞子。所述组合物可用于制造健康产品，食品或抗疲劳药物，其能够显着降低患有疲劳的人的疲劳症状，改善睡眠质量，而不影响正常身体生理。表明本发明的药物是通过改善红细胞和血栓细胞的功能而发挥其抗疲劳作用，提高身体供氧的能力。本发明的药物组合物的特征在于有效剂量小，水溶性好，因此适于制成各种使用剂型。

13. 发明授权

US08724776B2 Two-axis sagittal focusing monochromator 失效
标题翻译：双轴矢状聚焦单色仪
公开(公告)号：US08724776B2
公开(公告)日：2014-05-13
申请号：US13227517
申请日：2011-09-08
申请人： Edwin G. Haas , Christopher Stelmach , Zhong Zhong
发明人： Edwin G. Haas , Christopher Stelmach , Zhong Zhong
IPC分类号： G21K1/06
CPC分类号： G21K1/06 , G21K2201/062 , G21K2201/064
摘要： An x-ray focusing device and method for adjustably focusing x-rays in two orthogonal directions simultaneously. The device and method can be operated remotely using two pairs of orthogonal benders mounted on a rigid, open frame such that x-rays may pass through the opening in the frame. The added x-ray flux allows significantly higher brightness from the same x-ray source.
摘要翻译：一种用于可同时在两个正交方向上可调整地聚焦X射线的X射线聚焦装置和方法。该装置和方法可以使用安装在刚性开放框架上的两对正交弯曲器远程操作，使得X射线可以穿过框架中的开口。添加的X射线通量允许来自相同x射线源的明显更高的亮度。

14. 发明申请

US20080247512A1 Sagittal Focusing Laue Monochromator 失效
标题翻译：矢状焦点Laue Monromromator
公开(公告)号：US20080247512A1
公开(公告)日：2008-10-09
申请号：US11693900
申请日：2007-03-30
申请人： Zhong Zhong , Jonathan Hanson , Jerome Hastings , Chi-Chang Kao , Anthony Lenhard , David Peter Siddons , Hui Zhong
发明人： Zhong Zhong , Jonathan Hanson , Jerome Hastings , Chi-Chang Kao , Anthony Lenhard , David Peter Siddons , Hui Zhong
IPC分类号： G21K1/06
CPC分类号： G21K1/06 , G21K2201/062 , G21K2201/064
摘要： An x-ray focusing device generally includes a slide pivotable about a pivot point defined at a forward end thereof, a rail unit fixed with respect to the pivotable slide, a forward crystal for focusing x-rays disposed at the forward end of the pivotable slide and a rearward crystal for focusing x-rays movably coupled to the pivotable slide and the fixed rail unit at a distance rearward from the forward crystal. The forward and rearward crystals define reciprocal angles of incidence with respect to the pivot point, wherein pivoting of the slide about the pivot point changes the incidence angles of the forward and rearward crystals while simultaneously changing the distance between the forward and rearward crystals.
摘要翻译： X射线聚焦装置通常包括可围绕限定在其前端处的枢转点枢转的滑块，相对于可枢转滑动件固定的轨道单元，用于聚焦设置在可枢转滑动件的前端的x射线的前方晶体以及用于将与前方晶体后方距离可移动地联接到可枢转滑动件和固定轨道单元的X射线聚焦的后方晶体。向前和向后的晶体限定了相对于枢转点的入射角，其中滑动件围绕枢转点的枢转改变了前后晶体的入射角，同时改变了前后晶体之间的距离。

15. 发明申请

US20070291896A1 Systems and methods for detecting an image of an object by use of an X-ray beam having a polychromatic distribution 失效
标题翻译：通过使用具有多色分布的X射线束检测物体的图像的系统和方法
公开(公告)号：US20070291896A1
公开(公告)日：2007-12-20
申请号：US11657391
申请日：2007-01-24
申请人： Christopher Parham , Zhong Zhong , Etta Pisano , Dean Connor , Leroy Chapman
发明人： Christopher Parham , Zhong Zhong , Etta Pisano , Dean Connor , Leroy Chapman
IPC分类号： G01N23/04 , A61B6/12
CPC分类号： G01N23/046 , A61B6/508 , A61B6/583 , G01N2223/419
摘要： Systems and methods for detecting an image of an object using an X-ray beam having a polychromatic energy distribution are disclosed. According to one aspect, a method can include detecting an image of an object. The method can include generating a first X-ray beam having a polychromatic energy distribution. Further, the method can include positioning a single monochromator crystal in a predetermined position to directly intercept the first X-ray beam such that a second X-ray beam having a predetermined energy level is produced. Further, an object can be positioned in the path of the second X-ray beam for transmission of the second X-ray beam through the object and emission from the object as a transmitted X-ray beam. The transmitted X-ray beam can be directed at an angle of incidence upon a crystal analyzer. Further, an image of the object can be detected from a beam diffracted from the analyzer crystal.
摘要翻译：公开了使用具有多色能量分布的X射线束检测物体的图像的系统和方法。根据一个方面，一种方法可以包括检测对象的图像。该方法可以包括产生具有多色能量分布的第一X射线束。此外，该方法可以包括将单个单色器晶体定位在预定位置以直接截取第一X射线束，使得产生具有预定能级的第二X射线束。此外，物体可以位于第二X射线束的路径中，用于通过物体传输第二X射线束并将其作为透射的X射线束从物体发射。透射的X射线束可以以一个入射角指向晶体分析仪。此外，可以从分析器晶体衍射的光束检测物体的图像。

16. 发明申请

US20070224615A1 METHODS FOR ASSAYING PROTEIN-PROTEIN INTERACTIONS 审中-公开
标题翻译：测定蛋白质 - 蛋白质相互作用的方法
公开(公告)号：US20070224615A1
公开(公告)日：2007-09-27
申请号：US11687549
申请日：2007-03-16
申请人： Kevin Lee , Brian Pollok , Zhong Zhong
发明人： Kevin Lee , Brian Pollok , Zhong Zhong
IPC分类号： C12Q1/68 , C12Q1/37
CPC分类号： C12Q1/6897
摘要： The invention relates, in part, to methods for detecting, monitoring, measuring or assessing an interaction between at least two proteins. The invention also relates, in part, to methods for determining if a test compound, or a mix of compounds, modulates an interaction between at least two proteins. In some embodiments, determination is made possible via the use of two recombinant molecules, e.g., one of which contains a first protein cleavage site for a proteolytic molecules, and an activator of a gene. A second recombinant molecule may include a second protein and the proteolytic molecule. Various other formats are provided by the invention. In some embodiments, if the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
摘要翻译：本发明部分地涉及用于检测，监测，测量或评估至少两种蛋白质之间相互作用的方法。本发明还部分涉及用于确定测试化合物或化合物混合物是否调节至少两种蛋白质之间的相互作用的方法。在一些实施方案中，通过使用两个重组分子（例如其中一个含有蛋白水解分子的第一蛋白切割位点）和基因的活化剂来进行测定。第二重组分子可以包括第二蛋白质和蛋白水解分子。本发明提供了各种其他格式。在一些实施方案中，如果测试化合物与第一种蛋白质结合，则开始反应，由此激活剂被切割，并激活报告基因。

17. 发明申请

US20060148007A1 Method for using division arrested cells in screening assays 审中-公开
标题翻译：在筛选试验中使用分裂的细胞的方法
公开(公告)号：US20060148007A1
公开(公告)日：2006-07-06
申请号：US11363983
申请日：2006-02-27
申请人： Thomas Livelli , Zhong Zhong , Mark Federici , Mei Cong
发明人： Thomas Livelli , Zhong Zhong , Mark Federici , Mei Cong
IPC分类号： G01N33/567 , C12N5/08 , C12N15/87 , G01N33/53
CPC分类号： G01N33/6872 , C12Q1/025 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5041
摘要： Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.
摘要翻译：分割的细胞被用于筛选测定以确定感兴趣的物质对细胞的影响。该细胞可以用于药物筛选测定，信号转导测定，特别适用于大规模，高通量测定。

18. 发明申请

US20140057002A1 ANTI-FATIGUE COMPOSITION OF PLANT MATERIAL AND PREPARATION METHOD, USE AND PRODUCTS THEREOF 审中-公开
标题翻译：植物材料的抗疲劳组合物和制备方法，其使用和产品
公开(公告)号：US20140057002A1
公开(公告)日：2014-02-27
申请号：US13814129
申请日：2010-08-05
申请人： Chen Xie , Zhong Zhong
发明人： Chen Xie , Zhong Zhong
IPC分类号： A61K36/815 , A23L2/52 , A23L1/30 , A61K36/41 , A61K36/424
CPC分类号： A23L2/52 , A23L33/105 , A61K36/41 , A61K36/424 , A61K36/815 , A61K2300/00
摘要： The present invention provides a composition of a plant material with anti-fatigue activity, its preparation method, usage and related products. The said composition is manufactured from the following plant materials: 20-80% from the genus Rhodiola; 10-60% Gynostemma; 10-60% Lycium. The said composition can be used to manufacture health product, food or anti-fatigue medicine which is able to significantly reduce the fatigue symptoms of those people suffering from fatigue, improve sleeping quality with no impact on normal body physiology. It is shown that the medicine derived from the present is invention exerts its anti-fatigue effect through improving the functions of erythrocytes and thrombocytes to enhance the body's ability of supplying oxygen. The medicinal composition of the present invention is characterized by the small effective dose and good water solubility and thus suitable to be made into a variety of dosage forms for use.
摘要翻译：本发明提供具有抗疲劳活性的植物材料的组合物，其制备方法，用途及相关产品。所述组合物由以下植物材料制成：来自红景天属的20-80％; 绞股蓝10-60％ 10-60％枸杞子。所述组合物可用于制造健康产品，食品或抗疲劳药物，其能够显着降低患有疲劳的人的疲劳症状，改善睡眠质量，而不影响正常身体生理。表明本发明的药物是通过改善红细胞和血栓细胞的功能而发挥其抗疲劳作用，提高身体供氧的能力。本发明的药物组合物的特征在于有效剂量小，水溶性好，因此适于制成各种使用剂型。

19. 发明授权

US08315358B2 Strain matching of crystals and horizontally-spaced monochromator and analyzer crystal arrays in diffraction enhanced imaging systems and related methods 有权
$Strain matching of crystals and horizontally-spaced monochromator and analyzer crystal arrays in diffraction enhanced imaging systems and related methods$
标题翻译：晶体和水平间隔单色仪和分析仪晶体阵列在衍射增强成像系统及相关方法中的应变匹配
公开(公告)号：US08315358B2
公开(公告)日：2012-11-20
申请号：US12793228
申请日：2010-06-03
申请人： Dean Connor , Zhong Zhong , Christopher Parham , Etta Pisano
发明人： Dean Connor , Zhong Zhong , Christopher Parham , Etta Pisano
IPC分类号： G21K1/06
CPC分类号： A61B6/032 , A61B6/06 , A61B6/4035 , A61B6/4208 , A61B6/482 , A61B6/483 , A61B6/502 , A61B6/542 , G21K1/06 , G21K2201/062 , G21K2207/005 , H01J2235/068 , H01J2235/08
摘要： Strain matching of crystals and horizontally-spaced monochromator and analyzer crystal arrays in diffraction enhanced imaging systems and related methods are disclosed. A DEI system, including strain matched crystals can comprise an X-ray source configured to generate a first X-ray beam. A first monochromator crystal can be positioned to intercept the first X-ray beam for producing a second X-ray beam. A second monochromator crystal can be positioned to intercept the second X-ray beam to produce a third X-ray beam for transmission through an object. The second monochromator crystal has a thickness selected such that a mechanical strain on a side of the first monochromator crystal is the same as a mechanical strain on the second monochromator crystal. An analyzer crystal has a thickness selected such that a mechanical strain on a side of the first monochromator crystal is the same as a mechanical strain on the analyzer crystal.
摘要翻译：公开了晶体和水平间隔单色仪和分析器晶体阵列在衍射增强成像系统和相关方法中的应变匹配。包括应变匹配晶体的DEI系统可以包括被配置为产生第一X射线束的X射线源。可以将第一单色仪晶体定位成截取第一X射线束以产生第二X射线束。第二单色器晶体可以被定位成截取第二X射线束以产生用于透过物体的第三X射线束。第二单色器晶体具有选择的厚度，使得第一单色仪晶体侧的机械应变与第二单色仪晶体上的机械应变相同。分析器晶体的厚度被选择为使得第一单色仪晶体侧的机械应变与分析器晶体上的机械应变相同。

20. 发明授权

US08133695B2 Fluorescence polarization hERG assay 有权
标题翻译：荧光偏振hERG测定
公开(公告)号：US08133695B2
公开(公告)日：2012-03-13
申请号：US12394605
申请日：2009-02-27
申请人： David Piper , Kurt Vogel , Mohammed Saleh Shekhani , Stephen Hess , Steve Duff , Thomas Livelli , Zhong Zhong
发明人： David Piper , Kurt Vogel , Mohammed Saleh Shekhani , Stephen Hess , Steve Duff , Thomas Livelli , Zhong Zhong
IPC分类号： G01N33/53 , G01N33/532 , G01N33/533
CPC分类号： G01N33/582 , C07D491/107 , G01N33/6872 , Y10T436/13
摘要： Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.
摘要翻译：公开了用于筛选测试化合物在受试者中诱导心脏毒性的能力的测定，方法和试剂盒。特别地，测试化合物是否具有延长通过人心电图测量的Q-T间期的作用。本文公开的测定法，方法和试剂盒利用新型荧光示踪剂和hERG K +通道之间的结合相互作用以及测试化合物影响该结合相互作用的倾向。

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