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1. 发明申请

US20050079543A1 Receptor recognition factors, protein sequences and methods of use thereof 失效
标题翻译：受体识别因子，蛋白质序列及其使用方法
公开(公告)号：US20050079543A1
公开(公告)日：2005-04-14
申请号：US10639617
申请日：2003-08-12
申请人： James Darnell , Christian Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James Darnell , Christian Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： A61K38/00 , A61K38/21 , C07K14/47 , C07K16/28 , C12N15/113 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705 , Y02A50/473 , A61K2300/00
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFNα and IFNγ. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFNγ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

2. 发明授权

US06820759B1 Rail vehicle for passenger transportation, especially for local traffic 失效
标题翻译：用于客运的铁路车辆，特别是当地交通
公开(公告)号：US06820759B1
公开(公告)日：2004-11-23
申请号：US10130802
申请日：2002-09-03
申请人： Christian Schindler , Manfred Buerger , Karl-Eberhard Geyer , Ryszard Zielinski
发明人： Christian Schindler , Manfred Buerger , Karl-Eberhard Geyer , Ryszard Zielinski
IPC分类号： B65D5502
CPC分类号： B61G11/16 , B61D17/10
摘要： A rail vehicle for passenger transportation, especially for local traffic, is provided with shock absorption units (1) at at least one of its ends. Said shock absorber units (1) are supported on a sandwich part (2) containing deformable metallic foam, in the longitudinal direction of the vehicle, said sandwich part forming a partial area of the floor (3) of the driver compartment (4), as a supporting structural element.
摘要翻译：用于客运的铁路车辆，特别是用于当地交通的轨道车辆，在其至少一端具有减震单元（1）。所述减震器单元（1）在车辆的纵向方向上支撑在包含可变形金属泡沫的夹层部分（2）上，所述夹层部分形成驾驶室（4）的地板（3）的局部区域，作为支撑结构元件。

3. 发明授权

US07420311B2 Brush arrangement for an electric machine 有权
标题翻译：刷机布置电机
公开(公告)号：US07420311B2
公开(公告)日：2008-09-02
申请号：US10556597
申请日：2004-05-14
申请人： Bernhard Rupp , Christian Schindler , Mili Tarek
发明人： Bernhard Rupp , Christian Schindler , Mili Tarek
IPC分类号： H02K5/14 , H01R39/38
CPC分类号： H01R39/381
摘要： A brush device for an electric machine having at least one brush and at least one element such as a helical, scroll, or plunger spring for pressing each brush against a rotating contact element, for example a commutator. In at least one further element for example a spring tab, counteracts a lifting of each brush away from the contact element. To this end, the spring tab is inclined at an angle, as a result of which it exerts a weaker action when the brush moves in the direction toward the contact element than it does counter to this direction. As a result, the brush can be repositioned, but is prevented from lifting away from the contact element. This also reduces the danger of vibrations.
摘要翻译：一种用于电机的刷装置，其具有至少一个刷子和至少一个元件，例如用于将每个刷子压靠在旋转接触元件例如换向器上的螺旋，涡旋或柱塞弹簧。在至少一个另外的元件例如弹簧片中，抵抗每个刷子离开接触元件的提升。为此，弹簧片以一定的角度倾斜，其结果是，当电刷朝着接触元件的方向移动时，电刷的作用相对于该方向相反。结果，刷子可以重新定位，但是防止了从接触元件抬起。这也减少了振动的危险。

4. 发明申请

US20070013257A1 Brush arrangement for an electric machine 有权
标题翻译：刷机布置电机
公开(公告)号：US20070013257A1
公开(公告)日：2007-01-18
申请号：US10556597
申请日：2004-05-14
申请人： Bernhard Rupp , Christian Schindler , Mili Tarek
发明人： Bernhard Rupp , Christian Schindler , Mili Tarek
IPC分类号： H01R39/40 , H01R39/38
CPC分类号： H01R39/381
摘要： A brush device for an electric machine having at least one brush and at least one element such as a helical, scroll, or plunger spring for pressing each brush against a rotating contact element, for example a commutator. In at least one further element for example a spring tab, counteracts a lifting of each brush away from the contact element. To this end, the spring tab is inclined at an angle, as a result of which it exerts a weaker action when the brush moves in the direction toward the contact element than it does counter to this direction. As a result, the brush can be repositioned, but is prevented from lifting away from the contact element. This also reduces the danger of vibrations.
摘要翻译：一种用于电机的刷装置，其具有至少一个刷子和至少一个元件，例如用于将每个刷子压靠在旋转接触元件例如换向器上的螺旋，涡旋或柱塞弹簧。在至少一个另外的元件例如弹簧片中，抵抗每个刷子离开接触元件的提升。为此，弹簧片以一定的角度倾斜，其结果是，当电刷朝着接触元件的方向移动时，电刷的作用相对于该方向相反。结果，刷子可以重新定位，但是防止了从接触元件抬起。这也减少了振动的危险。

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