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11. 发明申请

US20060105461A1 Nanopore analysis system 审中-公开
标题翻译：纳米分析系统
公开(公告)号：US20060105461A1
公开(公告)日：2006-05-18
申请号：US10971966
申请日：2004-10-22
申请人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
发明人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
IPC分类号： G01N35/00
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6825 , C12Q1/6869 , Y10T436/11 , C12Q2565/631
摘要： Nanopore analysis systems, methods of preparing nanopore analysis systems, and methods of automating the analysis of samples using nanopore analysis systems, are provided.
摘要翻译：提供纳米孔分析系统，制备纳米孔分析系统的方法以及使用纳米孔分析系统自动分析样品的方法。

12. 发明申请

US20060219637A1 Devices, systems and methods for liquid chromatography 审中-公开
标题翻译：液相色谱仪的设备，系统和方法
公开(公告)号：US20060219637A1
公开(公告)日：2006-10-05
申请号：US11093605
申请日：2005-03-29
申请人： Kevin Killeen , Hongfeng Yin , Karsten Kraiczek
发明人： Kevin Killeen , Hongfeng Yin , Karsten Kraiczek
IPC分类号： B01D15/08
CPC分类号： G01N30/10 , G01N30/20 , G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/385
摘要： Devices comprising a mechanism for selectively diverting a portion of a mobile phase flowing through a mobile-phase transporting conduit to a fluid-transporting conduit comprising a stationary phase for separating sample components are disclosed, as well as systems and methods for using the same.
摘要翻译：公开了一种用于选择性地将流过流动相输送管道的流动相的一部分转移到包括用于分离样品组分的固定相的流体输送导管的机构的装置，以及用于分离样品组分的系统和方法。

13. 发明申请

US20060097153A1 Electrospray devices for mass spectrometry 有权
标题翻译：用于质谱的电喷雾装置
公开(公告)号：US20060097153A1
公开(公告)日：2006-05-11
申请号：US11001268
申请日：2004-11-30
申请人： Karen Seaward , Hongfeng Yin , Kevin Killeen , Daniel Sobek , Daniel Roitman
发明人： Karen Seaward , Hongfeng Yin , Kevin Killeen , Daniel Sobek , Daniel Roitman
IPC分类号： H01J49/10
CPC分类号： H01J49/167 , G01N30/7266
摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion.
摘要翻译：描述了用于质谱系统的电喷雾装置。电喷雾装置包括主体部分和从主体部分延伸的尖端部分。尖端部分包括聚合材料。电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。

14. 发明授权

US07372023B2 Ion source frequency feedback device and method 失效
标题翻译：离子源频率反馈装置及方法
公开(公告)号：US07372023B2
公开(公告)日：2008-05-13
申请号：US11333213
申请日：2006-01-18
申请人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
发明人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
IPC分类号： H01J49/10
CPC分类号： H01J49/165
摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.
摘要翻译：描述了用于分析仪器的离子源。离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端电极接口。反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

15. 发明授权

US07138062B2 Mobile phase gradient generation microfluidic device 有权
公开(公告)号：US07138062B2
公开(公告)日：2006-11-21
申请号：US11224904
申请日：2005-09-12
申请人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
发明人： Hongfeng Yin , Kevin Killeen , Daniel Sobek
IPC分类号： B01D15/08
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/285
摘要： The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

16. 发明授权

US07128876B2 Microdevice and method for component separation in a fluid 有权
公开(公告)号：US07128876B2
公开(公告)日：2006-10-31
申请号：US09908231
申请日：2001-07-17
申请人： Hongfeng Yin , Kevin Killeen
发明人： Hongfeng Yin , Kevin Killeen
IPC分类号： B01L3/02 , B01L11/00 , G01N21/00 , G01N30/02 , B01D15/08
CPC分类号： B29C66/02 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L2200/0689 , B01L2200/12 , B01L2300/123 , B01L2400/0622 , B01L2400/0644 , B29C43/56 , B29C59/02 , B29C59/14 , B29C59/142 , B29C65/48 , B29C65/4835 , B29C66/54 , B29C66/71 , B29C66/72321 , B29C66/73752 , B29C66/73756 , B29C66/73921 , B29C66/73941 , B29C66/7465 , B29C2071/022 , B29K2071/00 , B29K2079/08 , B29K2309/08 , B29K2995/0039 , B29K2995/0041 , B29L2031/756 , B81B1/00 , B81C1/00357 , B81C2201/019 , G01N27/44791 , G01N30/6052 , G01N30/6095 , Y10T137/86863 , Y10T436/25375 , Y10T436/2575 , B29K2077/00 , B29K2075/00 , B29K2069/00 , B29K2067/00 , B29K2055/02 , B29K2033/12 , B29K2033/08 , B29K2027/12 , B29K2025/06 , B29K2023/00
摘要： The present invention relates to a microdevice for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, and, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. A sample inlet port in fluid communication with the conduit allows a fluid sample introduced from a sample source to be conveyed in a defined sample flow path such that the sample fluid travels, in order, through the sample inlet port, the separation conduit and a sample outlet port. The microdevice also includes an integrated introducing means for controllably introducing a volume of the fluid sample from a sample source into the sample inlet port and through the separation conduit. A method for separating the components of a fluid sample using the microdevice is also provided.

17. 发明申请

US20050178974A1 Ion source frequency feedback device and method 失效
标题翻译：离子源频率反馈装置及方法
公开(公告)号：US20050178974A1
公开(公告)日：2005-08-18
申请号：US10896981
申请日：2004-07-23
申请人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
发明人： Daniel Sobek , Jing Cai , Kevin Killeen , Hongfeng Yin
IPC分类号： H01J27/02 , H01J49/04 , H01J49/10 , H01J49/16 , H01J27/00
CPC分类号： H01J49/165
摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.
摘要翻译：描述了用于分析仪器的离子源。离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端电极接口。反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

18. 发明申请

US20050066747A1 MICROFLUIDIC BULK FLOW DETERMINATIONS BASED ON CONVERTING HEAT TRACER MEASUREMENTS 失效
标题翻译：基于转换热追踪器测量的微流量大流量测定
公开(公告)号：US20050066747A1
公开(公告)日：2005-03-31
申请号：US10675037
申请日：2003-09-30
申请人： Daniel Sobek , Hongfeng Yin , Roy Rocklin , Kevin Killeen
发明人： Daniel Sobek , Hongfeng Yin , Roy Rocklin , Kevin Killeen
IPC分类号： G01F1/708
CPC分类号： G01F1/7084
摘要： The fluid flow rate within a microfluidic passageway of a microfabricated device is determined by measuring the time-of-flight of a heat pulse coupled into the fluid. Since the propagation velocity of the heat trace is generally slower than the mean flow rate of the flow, additional processing provides the appropriate scaling needed to obtain an accurate fluid flow rate measurement. The scaling factor is based on the geometry of the structure and the thermal properties of the fluid and the materials used for the device.
摘要翻译：通过测量耦合到流体中的热脉冲的飞行时间来确定微加工装置的微流体通道内的流体流速。由于热迹线的传播速度通常比流动的平均流速慢，所以额外的处理提供了获得准确的流体流量测量所需的适当的缩放比例。缩放因子基于结构的几何形状和流体和用于该装置的材料的热性质。

19. 发明申请

US20110114549A1 MICROFLUIDIC DEVICE COMPRISING SEPARATION COLUMNS 审中-公开
标题翻译：包含分离柱的微流体装置
公开(公告)号：US20110114549A1
公开(公告)日：2011-05-19
申请号：US12617926
申请日：2009-11-13
申请人： Hongfeng Yin , Kevin Killeen , Karsten Kraiczek
发明人： Hongfeng Yin , Kevin Killeen , Karsten Kraiczek
IPC分类号： B01D15/22
CPC分类号： G01N30/6004 , B01L3/502753 , B01L2300/0816 , B01L2300/0838 , B01L2300/0883 , G01N30/6095
摘要： A microfluidic chip comprises a first substantially linear separation column having a first length, the first separation column comprising a first stationary phase particle density distribution along the first length; and a second substantially linear separation column having a second length connected in series with the first separation column, the second separation column comprising a second stationary phase particle density distribution along the second length.
摘要翻译：微流体芯片包括具有第一长度的第一基本线性分离柱，所述第一分离柱包括沿着所述第一长度的第一固定相颗粒密度分布; 以及具有与所述第一分离柱串联连接的第二长度的第二基本线性分离柱，所述第二分离塔包括沿所述第二长度的第二固定相颗粒密度分布。

20. 发明申请

US20060171855A1 Devices,systems and methods for multi-dimensional separation 审中-公开
标题翻译：用于多维分离的设备，系统和方法
公开(公告)号：US20060171855A1
公开(公告)日：2006-08-03
申请号：US11051587
申请日：2005-02-03
申请人： Hongfeng Yin , Kevin Killeen
发明人： Hongfeng Yin , Kevin Killeen
IPC分类号： G01N1/10
CPC分类号： G01N30/463 , B01L3/0268 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2400/0622 , B01L2400/0644 , G01N30/7266
摘要： Disclosed is a multi-substrate microfluidic device for performing multi-dimensional separation of sample components, as well as systems and methods for using the same.
摘要翻译：公开了一种用于执行样品组分的多维分离的多基底微流体装置，以及用于使用其的系统和方法。

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