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11. 发明申请

US20090264308A1 BIOSENSOR SOLID SUBSTRATE WITH INTEGRATED TEMPERATURE CONTROL AND A METHOD TO MAKE THE SAME 审中-公开
标题翻译：具有集成温度控制的生物传感器固体基板及其制造方法
公开(公告)号：US20090264308A1
公开(公告)日：2009-10-22
申请号：US12301645
申请日：2007-05-22
申请人： Dirk Jan Broer , Roel Penterman , Ralph Kurt , Emiel Peeters , Hendrik Roelof Stapert , Anke Pierik , Aleksey Kolesnychenko , Hendrik De Koning
发明人： Dirk Jan Broer , Roel Penterman , Ralph Kurt , Emiel Peeters , Hendrik Roelof Stapert , Anke Pierik , Aleksey Kolesnychenko , Hendrik De Koning
IPC分类号： C40B30/04 , C12Q1/68 , C12M1/34 , C40B40/06
CPC分类号： G01K11/16 , B01L3/508 , B01L2200/147 , B01L2300/0636 , B01L2300/0663
摘要： This invention provides a biosensor solid or hydrogel substrate comprising one or more temperature indicating agents, each of said one or more temperature indicating agents operating by changing its optical properties and being deposited in and/or at the surface of the biosensor solid or hydrogel substrate as one or more layers and/or spots
摘要翻译：本发明提供了包含一种或多种温度指示剂的生物传感器固体或水凝胶基质，所述一种或多种温度指示剂中的每一种通过改变其光学性质并沉积在生物传感器固体或水凝胶基质的表面和/ 一个或多个层和/或点

12. 发明申请

US20080255007A1 Substrate Material For Handling and Analyzing Samples 审中-公开
标题翻译：用于处理和分析样品的基材
公开(公告)号：US20080255007A1
公开(公告)日：2008-10-16
申请号：US12064670
申请日：2006-08-17
申请人： Dirk Jan Broer , Roel Penterman , Emiel Peeters , Ralph Kurt
发明人： Dirk Jan Broer , Roel Penterman , Emiel Peeters , Ralph Kurt
IPC分类号： C40B60/12 , G01N21/01 , F15B21/00 , G01N33/48
CPC分类号： C09K19/00 , B01L3/50273 , B01L2200/0647 , B01L2300/089 , B01L2400/0472 , B01L2400/0677 , B01L2400/082 , C09K19/16 , C09K19/22 , C09K19/24 , F04B19/006 , F04B19/24 , Y10T137/2082
摘要： The invention relates to a substrate material for analyzing one or more fluid samples for the presence, amount or identity of one or more analytes in the samples, whereby the substrate material is adapted in that way that a flow of the sample or parts thereof in and/or with the substrate material is influenced and/or caused by phase transitions, preferably photoinducable phase transitions, in selected areas of the substrate material.
摘要翻译：本发明涉及一种用于分析一种或多种流体样品中用于样品中一种或多种分析物的存在，量或同一性的基底材料，由此基底材料以这种方式适应于样品或其部分的流动 /或衬底材料受到衬底材料的选定区域中的相变，优选光致诱导相变的影响和/或引起。

13. 发明授权

US09784805B2 MRI radio frequency receiver comprising digital down converter with connector that passes analog signal being contained within radio frequency receiver coil unit 有权
公开(公告)号：US09784805B2
公开(公告)日：2017-10-10
申请号：US12665336
申请日：2008-06-16
申请人： Marc Paul Saes , Johan Samuel Van Den Brink , Filips Van Liere , Roel Penterman , Ralph Kurt , Emiel Peeters , Dirk Jan Broer , Michel Paul Barbara Van Bruggen , Hans Van Zon , Miha Fuderer
发明人： Marc Paul Saes , Johan Samuel Van Den Brink , Filips Van Liere , Roel Penterman , Ralph Kurt , Emiel Peeters , Dirk Jan Broer , Michel Paul Barbara Van Bruggen , Hans Van Zon , Miha Fuderer
IPC分类号： G01R33/341 , G01R33/3415 , G01R33/36
CPC分类号： G01R33/341 , G01R33/3415 , G01R33/3621 , G01R33/3692
摘要： The invention relates to a nuclear magnetic resonance imaging radio frequency-receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analog signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analog-digital converter (118; 226) to convert the analog pre-amplified magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).

14. 发明申请

US20090205961A1 SEPARATION DEVICE COMPRISING A SURFACTANT RELEASING MEANS 审中-公开
标题翻译：包含表面活性剂释放装置的分离装置
公开(公告)号：US20090205961A1
公开(公告)日：2009-08-20
申请号：US12302926
申请日：2007-05-22
申请人： Dirk Jan Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
发明人： Dirk Jan Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
IPC分类号： G01N27/447 , C25B9/00 , C25B15/00
CPC分类号： C07K1/26 , C07K1/285 , G01N27/44717
摘要： To improve automation, especially in 2D gel electrophoresis of proteins, DNA etc., a separation device (1) has a physically activatable means for releasing surfactant, eg. SDS, into the gel fr SDS-PAGE. In one embodiment, surfactant-bound polymer is photolytically cleaved; in another, a barrier layer (30) is melted/destroyed to allow surfactant from reservoir (20) to reach the separation area (10). The barrier layer may comprise a novolac.
摘要翻译：为了改善自动化，特别是在蛋白质，DNA等的2D凝胶电泳中，分离装置（1）具有用于释放表面活性剂的物理活化装置，例如， SDS，进入凝胶fr SDS-PAGE。在一个实施方案中，表面活性剂结合的聚合物被光解裂解; 在另一方面，阻挡层（30）被熔化/破坏以允许储存器（20）的表面活性剂到达分离区域（10）。阻挡层可以包括酚醛清漆。

15. 发明申请

US20080220437A1 Substrate Material for Handling and Analysing Samples 审中-公开
标题翻译：用于处理和分析样品的基材
公开(公告)号：US20080220437A1
公开(公告)日：2008-09-11
申请号：US12064652
申请日：2006-08-17
申请人： Dirk Jan Broer , Roel Penterman , Emiel Peeters , Ralph Kurt
发明人： Dirk Jan Broer , Roel Penterman , Emiel Peeters , Ralph Kurt
IPC分类号： C09K19/12 , G01N33/483
CPC分类号： B01L3/50273 , B01L3/5027 , B01L2300/0819 , B01L2300/0861 , B01L2300/089 , B01L2300/1822 , B01L2400/0677 , C09K19/00 , C09K19/12 , F16K99/0001 , F16K99/0032 , F16K99/0044 , F16K2099/0084
摘要： The invention relates to a substrate material for analyzing one or more fluid samples for the presence, amount or identity of one or more analytes in the samples, whereby the substrate material is adapted in that way that a flow of the sample or parts thereof in and/or with the substrate material is influenced and/or caused by phase transitions, preferably temperature-inducible phase transitions, in selected areas of the substrate material.
摘要翻译：本发明涉及一种用于分析一种或多种流体样品中用于样品中一种或多种分析物的存在，量或同一性的基底材料，由此基底材料以这种方式适应于样品或其部分的流动 /或衬底材料受到衬底材料的选定区域中的相变，优选温度诱导相变的影响和/或引起。

16. 发明申请

US20110293712A1 COAXIALLY ENCAPSULATED CELL SUSPENSIONS AND MICROTISSUES 审中-公开
标题翻译：同时包被的细胞悬浮液和微量元素
公开(公告)号：US20110293712A1
公开(公告)日：2011-12-01
申请号：US13132534
申请日：2009-11-26
申请人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
发明人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
IPC分类号： A61K9/48 , A61K35/12 , C12M1/00
CPC分类号： B01J13/04 , A61K2035/126 , A61L27/38 , A61L27/58
摘要： The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.
摘要翻译：本发明提供了在单个细长隔室中的多个电池的同轴封装。通过这种封装，细胞被至少一层分离材料保护并保持紧密接触，这导致包封的细胞更好的活力，从而导致更高的形成微组织的机会。在细胞，组织治疗和组织工程中公开了用于生产这种包封的细胞室的方法和装置以及这些隔室的医学用途。

17. 发明授权

US07847885B2 Mechanical structure including a layer of polymerised liquid crystal and method of manufacturing such 有权
标题翻译：包括聚合液晶层的机械结构及其制造方法
公开(公告)号：US07847885B2
公开(公告)日：2010-12-07
申请号：US10597569
申请日：2005-01-27
申请人： Dirk Jan Broer , Christiane Maria Rosette De Witz , Grietje Neeltje Mol , Roel Penterman
发明人： Dirk Jan Broer , Christiane Maria Rosette De Witz , Grietje Neeltje Mol , Roel Penterman
IPC分类号： G02F1/1333
CPC分类号： G02B26/02 , B81B3/0024 , B81B2201/032 , B81B2201/047 , Y10T156/11
摘要： A mechanical structure comprises an element which is moveable by nonmechanical means, such as heat or radiation, between a first state having a first shape and a second state having a second shape different. To this end, the element includes a layer of oriented polymerized liquid crystal which exhibits an anisotropic expansion when subjected to such means. In order to facilitate manufacture the element is positioned on a substrate which has a region of high adhesiveness and a region of low adhesiveness for polymerized liquid crystal. To manufacture such structures a layer of oriented polymerizable liquid crystal is formed on a substrate (201) which is provided with a patterned surface that provides adhesive regions (204) with high adhesiveness to polymerized liquid crystal and nonadhesive regions (203) with low adhesiveness to polymerized liquid crystal. After polymerization, for example a thermal shock is applied which causes the layer of polymerized liquid crystal to delaminate at the non-adhering region while remaining fixed to the adhesive regions. Thus, the method does not require time-consuming under-etching steps.
摘要翻译：机械结构包括可在诸如热或辐射之间的非机械装置在具有第一形状的第一状态和具有第二形状的第二状态之间移动的元件。为此，元件包括定向聚合的液晶层，当经受这种方法时，其呈现各向异性膨胀。为了便于制造，元件位于具有高粘合性区域的基底和聚合液晶的低粘合性区域。为了制造这样的结构，在基板（201）上形成定向聚合性液晶层，该基板（201）设置有图案化表面，该图案表面向聚合液晶和非粘附区域（203）提供对粘合性高的粘合性区域（204），其粘合性低聚合液晶。聚合后，例如进行热冲击，使得聚合液晶层在非粘附区域分层，同时保持固定在粘合剂区域上。因此，该方法不需要耗时的蚀刻下步骤。

18. 发明授权

US07123319B2 Liquid crystal display laminate and method of manufacturing such comprising a stratified-phase-separated composite 失效
标题翻译：液晶显示层叠体及其制造方法，包括层状相分离复合体
公开(公告)号：US07123319B2
公开(公告)日：2006-10-17
申请号：US10203574
申请日：2001-12-10
申请人： Dirk Jan Broer , Roel Penterman
发明人： Dirk Jan Broer , Roel Penterman
IPC分类号： G02F1/1333
CPC分类号： C09K19/00 , C09K19/38 , C09K19/544 , G02F1/133377 , G02F1/13394 , G02F1/1341 , G02F1/1347 , G02F2001/133368 , Y10T428/3162 , Y10T428/31794
摘要： A liquid crystal display laminate comprises a liquid crystal layer and a single substrate for confining that layer, allowing the liquid crystal layer to be provided using a wet deposition method such as printing or coating. To improve mechanical stability and provide protection and keep the liquid crystal layer in place, a cover layer may be provided on the liquid crystal layer. The cover layer and liquid crystal layer may together form a stratified-phase-separated composite in which case the liquid crystal layer and the cover layer are provided simultaneously. The display laminate is very thin and light weight. The display laminate may include or be combined with further layers such as orientation layers, electrode layers, polarizers and/or retarders layer to form a fully functional, high contrast display device.
摘要翻译：液晶显示层叠体包括液晶层和用于限制该层的单个基板，允许使用诸如印刷或涂布之类的湿沉积方法提供液晶层。为了提高机械稳定性并提供保护并将液晶层保持在适当位置，可以在液晶层上设置覆盖层。覆盖层和液晶层可以一起形成分层相分离的复合物，在这种情况下，同时设置液晶层和覆盖层。显示层压板非常薄，重量轻。显示层压板可以包括或与另外的层例如取向层，电极层，偏振器和/或延迟层组合，以形成完全功能的高对比度显示装置。

19. 发明授权

US06764614B2 Stratified phase-separated composite having cross-linked polymeric layer 失效
标题翻译：具有交联聚合物层的分层相分离复合材料
公开(公告)号：US06764614B2
公开(公告)日：2004-07-20
申请号：US10203575
申请日：2002-08-09
申请人： Roel Penterman , Stephen Isadore Klink , Dirk Jan Broer
发明人： Roel Penterman , Stephen Isadore Klink , Dirk Jan Broer
IPC分类号： C09K1900
CPC分类号： C09K19/00 , C09K19/38 , C09K19/544 , G02F1/133377 , G02F1/13394 , G02F1/1341 , G02F1/1347 , G02F2001/133368 , Y10T428/3162 , Y10T428/31794
摘要： A stratified-phase-separated composite comprises a liquid layer, such as a liquid crystal layer, and a polymeric layer. In order to obtain a more complete stratification resulting in less liquid being present in the polymeric layer, the polymeric layer is crosslinked. The stratified composite is preferably obtained by photo-polymerization induced phase-separation of a phase-separable composition provided on a single substrate or dispersed between two opposite substrates.
摘要翻译：分层相分离的复合材料包括诸如液晶层的液体层和聚合物层。为了获得更完整的分层，导致聚合物层中存在较少的液体，聚合物层是交联的。分层复合物优选通过光聚合诱导相分离在单个基底上提供的相分离组合物或分散在两个相对的基底之间而获得。

20. 发明授权

US06818152B2 Stratified phase-separated composite comprising a photo-polymerization dye 失效
标题翻译：包含光聚合染料的分层相分离复合材料
公开(公告)号：US06818152B2
公开(公告)日：2004-11-16
申请号：US10203576
申请日：2002-08-09
申请人： Roel Penterman , Dirk Jan Broer
发明人： Roel Penterman , Dirk Jan Broer
IPC分类号： G02F1333
CPC分类号： C09K19/00 , C09K19/38 , C09K19/544 , G02F1/133377 , G02F1/13394 , G02F1/1341 , G02F1/1347 , G02F2001/133368 , Y10T428/3162 , Y10T428/31794
摘要： A stratified-phase-separated composite comprising a polymeric layer and a liquid layer is obtained by photo-polymerizing a composition comprising a liquid and a photo-polymerizable monomer. In order to obtain well-stratified composites which may contain liquid which does not absorb radiation used to photo-polymerize, the composition and composite comprises a dye which is adapted to absorb radiation used to carry out the photo-polymerization and which selectively accumulates in the polymeric layer.
摘要翻译：通过光聚合包含液体和可光聚合单体的组合物，获得包含聚合物层和液体层的分层相分离复合物。为了获得可能含有不吸收用于光聚合的辐射的液体的良好分层的复合材料，组合物和复合材料包括适于吸收用于进行光聚合的辐射的染料，并且其选择性地积聚在聚合物层。

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