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11. 发明授权

US5567594A Methods and compositions for the detection and treatment of diseases associated with antigens of microorganisms 失效
标题翻译：用于检测和治疗与微生物抗原有关的疾病的方法和组合物
公开(公告)号：US5567594A
公开(公告)日：1996-10-22
申请号：US170017
申请日：1993-12-20
申请人： Emanuel Calenoff
发明人： Emanuel Calenoff
IPC分类号： A61K39/02 , A61K39/35 , A61K39/395 , A61P31/04 , A61P37/08 , C12P21/08 , G01N33/48 , G01N33/53 , G01N33/569 , G01N33/68 , G01N33/554
CPC分类号： G01N33/6854 , G01N33/569 , G01N33/56922 , G01N2333/205 , Y10S435/822 , Y10S435/883 , Y10S435/975
摘要： A library of isolated and purified antigens specific for a microorganism is a set of individual molecules. The library forms antigen-antibody complexes useful in the context of diagnosing and treating conditions associated with a specific microorganism such as H. pylori-induced gastro-duodenal disease. For the antigen-antibody complexes in question the antibody is an immunoglobulin, which is IgE if the antigens are allergens. Complexes with IgA, IgG and IgM are also useful. By this multivariate approach, a specific condition is diagnosed with high sensitivity and specificity by determining whether complexes form between a specific antigen library and a biological sample which contains immunoglobulins from an individual. Such libraries also are useful for immunotherapy.
摘要翻译：分离和纯化的微生物特异性抗原文库是一组单独的分子。该文库形成抗原 - 抗体复合物，其用于诊断和治疗与幽门螺杆菌诱导的胃十二指肠疾病等特定微生物相关的病症。对于所讨论的抗原 - 抗体复合物，抗体是免疫球蛋白，如果抗原是过敏原，则为IgE。与IgA，IgG和IgM的复合物也是有用的。通过这种多变量方法，通过确定特异性抗原文库和含有来自个体的免疫球蛋白的生物样品之间的复合物是否形成复合体，通过高灵敏度和特异性诊断特定病症。这些文库也可用于免疫治疗。

12. 发明授权

US5084379A Fluorometric assay of chymopapain hypersensitivity and reagents therefor 失效
标题翻译：木瓜凝乳蛋白酶超敏反应的荧光测定法及其试剂
公开(公告)号：US5084379A
公开(公告)日：1992-01-28
申请号：US529784
申请日：1990-05-25
申请人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , Myron A. Beigler
发明人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , Myron A. Beigler
IPC分类号： G01N33/543 , G01N33/573 , G01N33/58
CPC分类号： G01N33/543 , G01N33/573 , G01N33/582
摘要： A method for identifying and quantifying chymopapain-specific IgE antibody levels in patient serum comprising binding chymopapain-specific IgE, if any, in the serum with chymopapain adhering to an insoluble support, conjugating the serum IgE with a labeled anti-IgE antibody, and measuring the level of labeled compound bound to the insoluble support or in the solution removed therefrom. Special reagents and their manufacture are also disclosed.
摘要翻译：一种用于鉴定和定量患者血清中木瓜凝乳蛋白酶原特异性IgE抗体水平的方法，其包括在凝血酶中粘附木瓜凝乳蛋白酶特异性IgE（如果有的话），粘附在不溶性支持物上的木瓜凝乳蛋白酶，将血清IgE与标记的抗IgE抗体缀合，与不溶性载体结合的标记化合物的水平或从其中除去的溶液中。还公开了特殊试剂及其制造。

13. 发明授权

US4963356A Stable antigenic extracts methods 失效
标题翻译：稳定的抗原提取方法
公开(公告)号：US4963356A
公开(公告)日：1990-10-16
申请号：US40216
申请日：1987-04-20
申请人： Emanuel Calenoff , Myron A. Beigler , Gerald L. Friesen , James L. Nichols
发明人： Emanuel Calenoff , Myron A. Beigler , Gerald L. Friesen , James L. Nichols
IPC分类号： A61K39/35
CPC分类号： A61K39/35
摘要： A storage-stable, high potency allergenic extract is prepared by ultrafiltration, retaining fractions having molecular weights of from 1000 to 100,000, and drying the retained fraction to a moisture content of less than one weight percent. The extract can also be pretreated with amylase before ultrafiltration, treated with affinity chromatography before drying, and/or treated with gamma radiation after drying.
摘要翻译：通过超滤制备储存稳定的高效力过敏原提取物，保留分子量为1000至100,000的级分，并将残留的级分干燥至小于1重量％的含水量。提取物也可以在超滤之前用淀粉酶进行预处理，在干燥之前用亲和层析处理，和/或干燥后用γ辐射处理。

14. 发明授权

US4675286A Fetal cell separation and testing 失效
标题翻译：胎儿细胞分离和检测
公开(公告)号：US4675286A
公开(公告)日：1987-06-23
申请号：US695971
申请日：1985-01-28
申请人： Emanuel Calenoff
发明人： Emanuel Calenoff
IPC分类号： A61B10/00 , A61B10/02 , C12Q1/24 , G01N33/569 , G01N33/543 , G01N33/554 , G01N33/577
CPC分类号： A61B10/02 , C12Q1/24 , G01N33/56966 , Y10T436/25375 , Y10T436/255
摘要： A method for obtaining fetal cells for diagnostic examination comprises removing detached cells from the uterine cavity and outer surface of the amnionic sac. The cells are then incubated in the presence of a separation antibody which binds preferentially to either fetal cell antigens or maternal cell antigens for a time sufficient to permit antibody-antigen binding to occur. Cells having said separation antibody bound thereto are separated for the mixture. The separation antibody can be an anitbody binding preferentially to fetal cell antigens and not significantly to maternal cell antigens or it can be an antibody binding preferentially to maternal cell antigens and not significantly to fetal cell antigens. The antibody can be bound to an insoluble support prior to the incubation, and separation can be effected by separating the insoluble support from the cell mixture following the incubation. Alternatively, the separation antibody can be fluorescent labeled, and cells conjugated with fluorescent labeled antibody can be removed using a cell sorter. The isolated fetal cells are then propagated to obtain a population sufficient for diagnostic examination.
摘要翻译：用于获得用于诊断检查的胎儿细胞的方法包括从子宫腔和羊膜囊的外表面去除分离的细胞。然后将细胞在分离抗体存在下孵育，所述分离抗体优先结合胎儿细胞抗原或母体细胞抗原足以允许发生抗体 - 抗原结合的时间。分离具有与之结合的分离抗体的细胞用于混合物。分离抗体可以是优先结合胎儿细胞抗原的抗体，而不是显着地与母体细胞抗原结合，或者它可以是优先与母体细胞抗原结合的抗体，而不是显着地与胎儿细胞抗原结合。在孵育之前，抗体可以结合到不溶性载体上，并且可以通过在孵育后从细胞混合物中分离不溶性载体来进行分离。或者，分离抗体可以是荧光标记的，并且可以使用细胞分选机除去与荧光标记抗体缀合的细胞。然后将分离的胎儿细胞繁殖以获得足以进行诊断检查的群体。

15. 发明申请

US20050169912A1 Immunogenic peptides and uses thereof 审中-公开
标题翻译：免疫原性肽及其用途
公开(公告)号：US20050169912A1
公开(公告)日：2005-08-04
申请号：US10979890
申请日：2004-11-02
申请人： Emanuel Calenoff , Charles Ditlow
发明人： Emanuel Calenoff , Charles Ditlow
IPC分类号： G10H1/00 , A61K39/395 , A61K39/00 , C07K14/47 , C07K16/18 , G01N33/53
CPC分类号： G10H1/0041 , G10H2240/061 , G10H2240/305
摘要： Novel general methods and compositions provide specific or highly associated antigenic peptides useful for diagnosis and treatment of diseases caused by microorganisms, allergens or other proteins. Specific or highly associated peptide antigens are also useful for diagnosis, treatment and prevention of auto-immune diseases, allergens and other diseases.
摘要翻译：新的一般方法和组合物提供用于诊断和治疗由微生物，变应原或其它蛋白质引起的疾病的特异性或高度相关的抗原肽。特异性或高度相关的肽抗原也可用于诊断，治疗和预防自身免疫疾病，变应原和其他疾病。

16. 发明申请

US20050048588A1 Immunogenic cancer peptides and uses thereof 审中-公开
公开(公告)号：US20050048588A1
公开(公告)日：2005-03-03
申请号：US10894359
申请日：2004-07-19
申请人： Emanuel Calenoff , Charles Ditlow
发明人： Emanuel Calenoff , Charles Ditlow
IPC分类号： A61K38/02 , C07K14/47 , C12P21/08 , G01N33/574 , C12Q1/68
CPC分类号： C07K14/4748 , A61K38/02 , G01N33/57484 , G01N33/57492
摘要： This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.

17. 发明授权

US5955584A Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof 失效
标题翻译：动脉粥样硬化斑块特异性抗原，抗体及其用途
公开(公告)号：US5955584A
公开(公告)日：1999-09-21
申请号：US053451
申请日：1993-04-26
申请人： Charles C. Ditlow , Francis W. Chen , Emanuel Calenoff
发明人： Charles C. Ditlow , Francis W. Chen , Emanuel Calenoff
IPC分类号： A61K38/00 , A61K41/00 , A61K47/48 , C07C401/00 , C07J9/00 , C07J31/00 , C07K14/47 , C07K14/78 , C07K16/18 , C07K16/44 , C07K16/46 , G01N33/533 , G01N33/543 , G01N33/544 , G01N33/564 , G01N33/68 , G01N33/92 , C12P21/08
CPC分类号： A61K41/0057 , A61K47/4843 , A61K47/48538 , A61K47/48676 , C07C401/00 , C07J31/006 , C07J9/00 , C07K14/47 , C07K14/78 , C07K16/18 , C07K16/44 , C07K16/468 , G01N33/533 , G01N33/543 , G01N33/544 , G01N33/564 , G01N33/686 , G01N33/92 , A61K38/00 , C07K2317/24 , G01N2800/323
摘要： The subject invention provides a naturally occurring antigen indicative of the presence of atherosclerotic plaque. The subject invention provides a murine-human chimeric monoclonal antibody which specifically binds to an antigen indicative of the presence of atherosclerotic plaque; and methods and reagents involving the use of the murine-human chimeric monoclonal antibody. The subject invention provides a CDR-grafted antibody; and methods and reagents involving the use of the CDR-grafted antibody. The subject invention provides a surrogate antigen; methods and reagents involving the use of the surrogate antigen, preparation of the surrogate antigen, antibodies generated from the surrogate antigen.
摘要翻译：本发明提供了表明存在动脉粥样硬化斑块的天然存在的抗原。本发明提供了一种特异性结合表达动脉粥样硬化斑块存在的抗原的鼠 - 人嵌合单克隆抗体; 以及涉及使用鼠 - 人嵌合单克隆抗体的方法和试剂。本发明提供了CDR-移植的抗体; 以及涉及使用CDR-移植抗体的方法和试剂。本发明提供了替代抗原; 涉及使用替代抗原的方法和试剂，替代抗原的制备，由替代抗原产生的抗体。

18. 发明授权

US5089387A DNA probe diffraction assay and reagents 失效
$DNA probe diffraction assay and reagents$
标题翻译： DNA探针衍生物测定和试剂
公开(公告)号：US5089387A
公开(公告)日：1992-02-18
申请号：US216691
申请日：1988-07-07
申请人： Yuh-Geng Tsay , Emanuel Calenoff , Eric K. Gustafson , Rick Trebino , John Lee
发明人： Yuh-Geng Tsay , Emanuel Calenoff , Eric K. Gustafson , Rick Trebino , John Lee
IPC分类号： G01N21/47 , C12Q1/68 , G01N21/77 , G01N33/543 , G02B5/18
CPC分类号： G01N21/4788 , C12Q1/6825 , G01N33/54373 , G01N2021/757
摘要： The assay of the subject invention uses DNA sequences as probes in a nucleic acid hybridization diffraction assay, to detect specific DNA sequences in a sample. Diffraction assay methodologies are applied to determine the presence and amount of analyte.This invention involves a discovery in the areas of supporting surfaces for a biogrid or biograting which provide greatly reduced non-specific hybridization and binding. A preferred process of this invention involves manufacturing a biograting for use in a light diffraction assay, and comprises adhering a uniform layer of hybridizing reagent comprising a nucleotide sequence on a smooth, solid surface and exposing the surface to UV radiation through a shadow mask with a diffraction grating pattern of lines to selectively deactivate the hybridizing reagent, leaving a biological diffraction grating design of lines of active hybridizing reagent. The smooth, solid surface is preferably selected from the group consisting of polysilicon and single crystalline silicon surfaces.The diffraction hybridizing assay method of this invention for determining the presence or quantity of an analyte in an aqueous sample comprises contacting a nucleic acid sequence diffraction biogrid with the sample under proper circumstances and for a sufficient time to permit nucleic acid hybridization between a nucleic acid sequence probe and an analyte; separating the biogrid from the sample; illuminating the biogrid with light from a light source; and determining the light diffracted by the diffraction hybridization assay surface.

19. 发明授权

US4845027A Fluorometric assay of allergic reactions 失效
标题翻译：过敏反应的荧光测定
公开(公告)号：US4845027A
公开(公告)日：1989-07-04
申请号：US144737
申请日：1988-01-15
申请人： Emanuel Calenoff , Ruth M. Johnson , Yuh-Geng Tsay , John Scott
发明人： Emanuel Calenoff , Ruth M. Johnson , Yuh-Geng Tsay , John Scott
IPC分类号： G01N33/545 , G01N33/58 , G01N33/68
CPC分类号： G01N33/545 , G01N33/582 , G01N33/6854 , G01N33/686 , Y10S435/968 , Y10S436/809
摘要： A method for identifying and quantifying allergen specific IgE levels in patient serum by conjugating the serum IgE with allergens on an insoluble support, conjugating the serum IgE with an enzyme labeled anti-IgE antibody, contacting the enzyme with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme, and measuring the level of fluoresence in the solution.
摘要翻译：通过将血清IgE与变应原缀合在不溶性载体上，将血清IgE与酶标记的抗IgE抗体缀合，使酶与底物溶液接触，从而将患者血清中的变应原特异性IgE水平鉴定和定量的方法在酶存在下的荧光产物，并测量溶液中的荧光水平。

20. 发明授权

US4844966A Assaying total IgE levels with fluorogenic enzyme labeled antibody 失效
标题翻译：用荧光酶标记的抗体测定总IgE水平
公开(公告)号：US4844966A
公开(公告)日：1989-07-04
申请号：US144738
申请日：1988-01-15
申请人： Emanuel Calenoff , Tsay Yuh-Geng , Ruth M. Jones , John R. Scott
发明人： Emanuel Calenoff , Tsay Yuh-Geng , Ruth M. Jones , John R. Scott
IPC分类号： G01N33/543 , G01N33/545 , G01N33/58 , G01N33/68
CPC分类号： G01N33/54393 , G01N33/545 , G01N33/582 , G01N33/6854 , Y10S435/968 , Y10S436/809
摘要： A method for identifying and quantifying total IgE levels in patient serum by conjugating the IgE in the serum with anti-IgE antibody adhering to an insoluble support, conjugating the serum IgE with an enzyme labeled anti-IgE antibody, contacting the enzyme label with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme, and measuring the level of fluoresence in the solution. Special reagents and their manufacture are also disclosed.
摘要翻译：通过将血清中的IgE与粘附于不溶性载体的抗IgE抗体缀合，将血清IgE与酶标记的抗IgE抗体缀合，将酶标记与溶液接触来鉴定和定量患者血清中的总IgE水平的方法的底物，其将在酶的存在下产生荧光产物，并测量溶液中的荧光水平。还公开了特殊试剂及其制造。

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