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1. 发明申请

US20050169912A1 Immunogenic peptides and uses thereof 审中-公开
标题翻译：免疫原性肽及其用途
公开(公告)号：US20050169912A1
公开(公告)日：2005-08-04
申请号：US10979890
申请日：2004-11-02
申请人： Emanuel Calenoff , Charles Ditlow
发明人： Emanuel Calenoff , Charles Ditlow
IPC分类号： G10H1/00 , A61K39/395 , A61K39/00 , C07K14/47 , C07K16/18 , G01N33/53
CPC分类号： G10H1/0041 , G10H2240/061 , G10H2240/305
摘要： Novel general methods and compositions provide specific or highly associated antigenic peptides useful for diagnosis and treatment of diseases caused by microorganisms, allergens or other proteins. Specific or highly associated peptide antigens are also useful for diagnosis, treatment and prevention of auto-immune diseases, allergens and other diseases.
摘要翻译：新的一般方法和组合物提供用于诊断和治疗由微生物，变应原或其它蛋白质引起的疾病的特异性或高度相关的抗原肽。特异性或高度相关的肽抗原也可用于诊断，治疗和预防自身免疫疾病，变应原和其他疾病。

2. 发明申请

US20050048588A1 Immunogenic cancer peptides and uses thereof 审中-公开
公开(公告)号：US20050048588A1
公开(公告)日：2005-03-03
申请号：US10894359
申请日：2004-07-19
申请人： Emanuel Calenoff , Charles Ditlow
发明人： Emanuel Calenoff , Charles Ditlow
IPC分类号： A61K38/02 , C07K14/47 , C12P21/08 , G01N33/574 , C12Q1/68
CPC分类号： C07K14/4748 , A61K38/02 , G01N33/57484 , G01N33/57492
摘要： This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.

3. 发明授权

US06892140B1 Immunogenic cancer peptides and uses thereof 失效
标题翻译：免疫原性癌肽及其用途
公开(公告)号：US06892140B1
公开(公告)日：2005-05-10
申请号：US09723307
申请日：2000-11-27
申请人： Emanuel Calenoff , Charles Ditlow
发明人： Emanuel Calenoff , Charles Ditlow
IPC分类号： A61K38/02 , C07K14/47 , C12P21/08 , G01N33/574 , G01N33/48 , A01N63/00 , A61K38/14 , A61K39/00 , A61K45/00
CPC分类号： C07K14/4748 , A61K38/02 , G01N33/57484 , G01N33/57492
摘要： This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.
摘要翻译：本发明涉及提供可用于诊断和治疗癌症的癌症特异性或高度癌症相关抗原的新的一般方法和组合物。

4. 发明授权

US5763164A Immunogenic cancer proteins and peptides and methods of use 失效
标题翻译：免疫原性癌蛋白和肽及其使用方法
公开(公告)号：US5763164A
公开(公告)日：1998-06-09
申请号：US191338
申请日：1994-02-03
申请人： Emanuel Calenoff
发明人： Emanuel Calenoff
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61P37/00 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/70 , C07K14/82 , C12N15/09 , C12P21/00 , C12P21/02 , C12Q1/68 , C07H21/02 , G01N33/53 , C07K15/28
CPC分类号： C07K14/82 , Y10S436/818
摘要： The present invention relates to tumor specific antigens and functional proteins of a tumor cell preparable by identifying protein presents in the tumor cell that are selectively immunogenic for tumor patients. The present invention still further provides a process of making a peptide library of tumor specific humoral antigens, a process of increasing the immunogenic specificity of a tumor-associated antigen, an assay kit for detecting the presence of an antibody immunoreactive with a tumor-specific antigen, and a process of making T cells sensitized to a tumor-specific antigen.
摘要翻译：本发明涉及肿瘤细胞的肿瘤特异性抗原和功能性蛋白，该肿瘤细胞通过鉴定在肿瘤细胞中存在对肿瘤患者有选择性免疫原性的蛋白质而可制备。本发明还提供了制备肿瘤特异性体液抗原肽文库的方法，增加肿瘤相关抗原的免疫原性特异性的方法，用于检测与肿瘤特异性抗原免疫反应性的抗体的存在的测定试剂盒，以及使肿瘤特异性抗原致敏的过程。

5. 发明申请

US20050272097A1 Methods and compositions for detecting and treating autoimmune diseases 审中-公开
标题翻译：检测和治疗自身免疫性疾病的方法和组合物
公开(公告)号：US20050272097A1
公开(公告)日：2005-12-08
申请号：US11062186
申请日：2005-02-18
申请人： Emanuel Calenoff
发明人： Emanuel Calenoff
IPC分类号： A61K39/00 , C07K14/47 , G01N33/53 , G01N33/564 , G01N33/567
CPC分类号： G01N33/564 , A61K39/0008 , G01N2800/285
摘要： Diseases caused by or affected by specific antibodies and/or T lymphocytes that complex with self-molecules in a subject are detected by identifying antigen specific antibodies and/or effector T lymphocytes against the antigen, in a biological fluid of an affected subject. This identification opens up treatment possibilities, for example, by desensitization.
摘要翻译：通过在受影响的受试者的生物液体中鉴定针对抗原的抗原特异性抗体和/或效应T淋巴细胞来检测由受试者中与自身分子复合的特异性抗体和/或T淋巴细胞引起或受其影响的疾病。这种识别打开了治疗的可能性，例如通过脱敏。

6. 发明授权

US4716120A Stable allergenic extracts and methods 失效
标题翻译：稳定的过敏提取物和方法
公开(公告)号：US4716120A
公开(公告)日：1987-12-29
申请号：US801649
申请日：1985-11-25
申请人： Yuh-Geng Tsay , Myron A. Beigler , Emanuel Calenoff , Gerald L. Friesen , James L. Nichols
发明人： Yuh-Geng Tsay , Myron A. Beigler , Emanuel Calenoff , Gerald L. Friesen , James L. Nichols
IPC分类号： A61K39/35 , A61K39/00 , G01N33/53
CPC分类号： A61K39/35 , Y10S436/809
摘要： A storage-stable, high potency allergenic extract is prepared by ultrafiltration, retaining fractions having molecular weights of from 1000 to 100,000, and treating the solution with gel polymer and/or carbon absorbents. The extract is dried to a moisture content of less than one weight percent water. The purified solution and aqueous reconstituted solutions of the dried extract provide a transparent, colorless solution which has greatly increased stability, remaining transparent and colorless for extended periods.
摘要翻译：通过超滤制备储存稳定的高效力过敏原提取物，保留分子量为1000至100,000的级分，并用凝胶聚合物和/或碳吸收剂处理溶液。将提取物干燥至含水量小于1重量％的水分。干燥提取物的纯化溶液和水性重构溶液提供透明的无色溶液，其具有大大增加的稳定性，长时间保持透明和无色。

7. 发明申请

US20140134197A1 Mimotopic Peptides for the Diagnosis and Treatment of Multiple sclerosis 审中-公开
标题翻译：用于多发性硬化症诊断和治疗的Mimotopic多肽
公开(公告)号：US20140134197A1
公开(公告)日：2014-05-15
申请号：US13423119
申请日：2012-03-16
申请人： Emanuel Calenoff
发明人： Emanuel Calenoff
IPC分类号： C07K2/00 , G01N33/68
CPC分类号： G01N33/6896 , A61K38/00 , C07K7/06 , C07K14/4713 , G01N33/6854 , G01N2800/285
摘要： The present invention provides peptides and methods for diagnosing and treating multiple sclerosis and wherein the method can also be applicable to the diagnosis and treatment of other immune disorders.
摘要翻译：本发明提供了用于诊断和治疗多发性硬化症的肽和方法，并且其中该方法也可以应用于其他免疫疾病的诊断和治疗。

8. 发明授权

US6025477A Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof 失效
标题翻译：动脉粥样硬化斑块特异性抗原，抗体及其用途
公开(公告)号：US6025477A
公开(公告)日：2000-02-15
申请号：US386221
申请日：1995-02-09
申请人： Emanuel Calenoff
发明人： Emanuel Calenoff
IPC分类号： A61K38/00 , A61K41/00 , A61K47/48 , C07K14/47 , C07K14/78 , C07K16/18 , C07K16/46 , C12N5/18 , G01N33/533 , G01N33/543 , G01N33/544 , G01N33/564 , G01N33/68 , G01N33/92 , C07K17/00
CPC分类号： A61K47/48538 , A61K47/4843 , A61K47/48676 , C07K14/47 , C07K14/78 , C07K16/18 , C07K16/468 , G01N33/533 , G01N33/543 , G01N33/544 , G01N33/564 , G01N33/686 , G01N33/92 , A61K38/00 , G01N2800/323
摘要： This invention provides purified antigens which are indicative of the presence of atherosclerotic plaque. Different concentrations of these antigens have been found to coincide with the progression of atherosclerosis. The subject invention also provides different hybridoma cell lines which produce monoclonal antibodies directed to antigens associated with atherosclerosis and a hybridoma cell line which produces monoclonal antibodies directed to antigen associated with normal artery and not with plaque. The atherosclerotic plaque antigen, and monoclonal antibodies made thereto, are used in various methods for detecting in a biological sample an antigen present in, and indicative of the presence of, atherosclerotic plaque. The monoclonal antibodies are also used in methods of imaging atherosclerotic plaque, and treating atherosclerosis. The methods of treating atherosclerosis include a method of digesting atherosclerotic plaque with enzymes, and a method of ablating atherosclerotic plaque using radiation. The subject invention also provides a method of treating atherosclerotic plaque by directly delivering a drug to the plaque. The subject invention further provides a method for treating atherosclerosis by blocking the synthesis of atherosclerotic plaque or by blocking binding of antibodies to the antigen.
摘要翻译：本发明提供了指示存在动脉粥样硬化斑块的纯化抗原。已经发现不同浓度的这些抗原与动脉粥样硬化的进展相一致。本发明还提供了不同的杂交瘤细胞系，其产生针对与动脉粥样硬化相关的抗原的单克隆抗体和产生针对与正常动脉相关的抗原而不与斑块相关的抗原的单克隆抗体的杂交瘤细胞系。动物动脉粥样硬化斑块抗原及其制备的单克隆抗体用于各种方法用于在生物样品中检测存在于动脉粥样硬化斑块中并存在动脉粥样硬化斑块的抗原。单克隆抗体也用于成像动脉粥样硬化斑块和治疗动脉粥样硬化的方法。治疗动脉粥样硬化的方法包括用酶消化动脉粥样硬化斑块的方法，以及使用辐射消融动脉粥样硬化斑块的方法。本发明还提供了通过将药物直接递送至斑块来治疗动脉粥样硬化斑块的方法。本发明还提供了通过阻断动脉粥样硬化斑块的合成或通过阻断抗体与抗原的结合来治疗动脉粥样硬化的方法。

9. 发明授权

US4849337A Assaying allergen specific IgE levels with fluorogenic enzyme labeled antibody 失效
标题翻译：用荧光酶标记的抗体测定过敏原特异性IgE水平
公开(公告)号：US4849337A
公开(公告)日：1989-07-18
申请号：US144730
申请日：1988-01-14
申请人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , John R. Scott
发明人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , John R. Scott
IPC分类号： G01N33/545 , G01N33/58 , G01N33/68
CPC分类号： G01N33/582 , G01N33/545 , G01N33/6854 , Y10S435/968 , Y10S436/809
摘要： A method for identifying and quantifying allergen specific IgE levels in patent serum by conjugating the IgE in the serum with allergens adhering to an insoluble support, conjugating the serum IgE with an enzyme labeled anti-IgE antibody, contacting the enzyme label with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme, and measuring the level of fluorescence in the solution. Special reagents and their manufacture are also disclosed.
摘要翻译：通过将血清中的IgE与粘附在不溶性支持物上的过敏原缀合，将血清IgE与酶标记的抗IgE抗体缀合，使酶标记物接触到酶标记的溶液中来鉴定和定量专利血清中的变应原特异性IgE水平的方法底物，其将在酶的存在下产生荧光产物，并测量溶液中的荧光水平。还公开了特殊试剂及其制造。

10. 发明授权

US4528267A Fluorometirc enzyme inhibition immunoassay for measuring potency of allergen extracts 失效
标题翻译：荧光酶抑制免疫测定用于测定变应原提取物的效力
公开(公告)号：US4528267A
公开(公告)日：1985-07-09
申请号：US476440
申请日：1983-03-17
申请人： Emanuel Calenoff , Yuh-Geng Tsay , Ruth M. Jones , Scott, John R.
发明人： Emanuel Calenoff , Yuh-Geng Tsay , Ruth M. Jones , Scott, John R.
IPC分类号： G01N33/545 , G01N33/58 , G01N33/54
CPC分类号： G01N33/582 , G01N33/545 , Y10S436/809
摘要： An inhibition assay for measuring the potency of allergen extracts by incubating a mixture of allergen extract and reference allergen specific IgE in a buffered solution with an insoluble support to which reference allergen is adhered. The conjugated IgE adhering to the insoluble support is reacted with an enzyme labeled anti-IgE antibody and the enzyme label is contacted with a solution of a substrate which will yield a fluorescent product in the presence of the enzyme. The level of fluoresence in the solution is measured. The percentage of inhibition of the allergen specific IgE is determined from fluorescence levels measured for various extract concentrations.
摘要翻译：通过将缓冲溶液中的变应原提取物和参比变应原特异性IgE的混合物与参与变应原粘附的不溶性载体进行温育来测量变应原提取物的效力的抑制试验。附着于不溶性载体的缀合的IgE与酶标记的抗IgE抗体反应，并且酶标记物与底物的溶液接触，所述底物将在酶的存在下产生荧光产物。测量溶液中的荧光水平。由各种提取物浓度测量的荧光水平确定变应原特异性IgE的抑制百分比。

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