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    • 8. 发明授权
    • Atherosclerotic plaque specific antigens, antibodies thereto, and uses
thereof
    • 动脉粥样硬化斑块特异性抗原,抗体及其用途
    • US6025477A
    • 2000-02-15
    • US386221
    • 1995-02-09
    • Emanuel Calenoff
    • Emanuel Calenoff
    • A61K38/00A61K41/00A61K47/48C07K14/47C07K14/78C07K16/18C07K16/46C12N5/18G01N33/533G01N33/543G01N33/544G01N33/564G01N33/68G01N33/92C07K17/00
    • A61K47/48538A61K47/4843A61K47/48676C07K14/47C07K14/78C07K16/18C07K16/468G01N33/533G01N33/543G01N33/544G01N33/564G01N33/686G01N33/92A61K38/00G01N2800/323
    • This invention provides purified antigens which are indicative of the presence of atherosclerotic plaque. Different concentrations of these antigens have been found to coincide with the progression of atherosclerosis. The subject invention also provides different hybridoma cell lines which produce monoclonal antibodies directed to antigens associated with atherosclerosis and a hybridoma cell line which produces monoclonal antibodies directed to antigen associated with normal artery and not with plaque. The atherosclerotic plaque antigen, and monoclonal antibodies made thereto, are used in various methods for detecting in a biological sample an antigen present in, and indicative of the presence of, atherosclerotic plaque. The monoclonal antibodies are also used in methods of imaging atherosclerotic plaque, and treating atherosclerosis. The methods of treating atherosclerosis include a method of digesting atherosclerotic plaque with enzymes, and a method of ablating atherosclerotic plaque using radiation. The subject invention also provides a method of treating atherosclerotic plaque by directly delivering a drug to the plaque. The subject invention further provides a method for treating atherosclerosis by blocking the synthesis of atherosclerotic plaque or by blocking binding of antibodies to the antigen.
    • 本发明提供了指示存在动脉粥样硬化斑块的纯化抗原。 已经发现不同浓度的这些抗原与动脉粥样硬化的进展相一致。 本发明还提供了不同的杂交瘤细胞系,其产生针对与动脉粥样硬化相关的抗原的单克隆抗体和产生针对与正常动脉相关的抗原而不与斑块相关的抗原的单克隆抗体的杂交瘤细胞系。 动物动脉粥样硬化斑块抗原及其制备的单克隆抗体用于各种方法用于在生物样品中检测存在于动脉粥样硬化斑块中并存在动脉粥样硬化斑块的抗原。 单克隆抗体也用于成像动脉粥样硬化斑块和治疗动脉粥样硬化的方法。 治疗动脉粥样硬化的方法包括用酶消化动脉粥样硬化斑块的方法,以及使用辐射消融动脉粥样硬化斑块的方法。 本发明还提供了通过将药物直接递送至斑块来治疗动脉粥样硬化斑块的方法。 本发明还提供了通过阻断动脉粥样硬化斑块的合成或通过阻断抗体与抗原的结合来治疗动脉粥样硬化的方法。