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1. 发明授权

US4716120A Stable allergenic extracts and methods 失效
标题翻译：稳定的过敏提取物和方法
公开(公告)号：US4716120A
公开(公告)日：1987-12-29
申请号：US801649
申请日：1985-11-25
申请人： Yuh-Geng Tsay , Myron A. Beigler , Emanuel Calenoff , Gerald L. Friesen , James L. Nichols
发明人： Yuh-Geng Tsay , Myron A. Beigler , Emanuel Calenoff , Gerald L. Friesen , James L. Nichols
IPC分类号： A61K39/35 , A61K39/00 , G01N33/53
CPC分类号： A61K39/35 , Y10S436/809
摘要： A storage-stable, high potency allergenic extract is prepared by ultrafiltration, retaining fractions having molecular weights of from 1000 to 100,000, and treating the solution with gel polymer and/or carbon absorbents. The extract is dried to a moisture content of less than one weight percent water. The purified solution and aqueous reconstituted solutions of the dried extract provide a transparent, colorless solution which has greatly increased stability, remaining transparent and colorless for extended periods.
摘要翻译：通过超滤制备储存稳定的高效力过敏原提取物，保留分子量为1000至100,000的级分，并用凝胶聚合物和/或碳吸收剂处理溶液。将提取物干燥至含水量小于1重量％的水分。干燥提取物的纯化溶液和水性重构溶液提供透明的无色溶液，其具有大大增加的稳定性，长时间保持透明和无色。

2. 发明授权

US4963356A Stable antigenic extracts methods 失效
标题翻译：稳定的抗原提取方法
公开(公告)号：US4963356A
公开(公告)日：1990-10-16
申请号：US40216
申请日：1987-04-20
申请人： Emanuel Calenoff , Myron A. Beigler , Gerald L. Friesen , James L. Nichols
发明人： Emanuel Calenoff , Myron A. Beigler , Gerald L. Friesen , James L. Nichols
IPC分类号： A61K39/35
CPC分类号： A61K39/35
摘要： A storage-stable, high potency allergenic extract is prepared by ultrafiltration, retaining fractions having molecular weights of from 1000 to 100,000, and drying the retained fraction to a moisture content of less than one weight percent. The extract can also be pretreated with amylase before ultrafiltration, treated with affinity chromatography before drying, and/or treated with gamma radiation after drying.
摘要翻译：通过超滤制备储存稳定的高效力过敏原提取物，保留分子量为1000至100,000的级分，并将残留的级分干燥至小于1重量％的含水量。提取物也可以在超滤之前用淀粉酶进行预处理，在干燥之前用亲和层析处理，和/或干燥后用γ辐射处理。

3. 发明授权

US4499065A Chymopapain allergen and method 失效
标题翻译：木瓜凝乳蛋白酶过敏原和方法
公开(公告)号：US4499065A
公开(公告)日：1985-02-12
申请号：US489898
申请日：1983-04-29
申请人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , Myron A. Beigler
发明人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , Myron A. Beigler
IPC分类号： A61K38/00 , A61K39/35 , A61K49/00 , C12N9/50 , C12N9/99
CPC分类号： A61K49/0006 , A61K39/35 , C12N9/50 , C12N9/99 , A61K38/00
摘要： A chymopapain derivative having the enzymatic activity reduced by at least 95% while retaining the original allergenic activity of at least 90% is suitable for skin testing to detect allergic hypersensitivity to chymopapain and for treating patients exhibiting allergic hypersensitivity to chymopapain. The enzymatic activity can be blocked by reacting thiol groups of the enzyme with and iodoacetic acid, bromoacetic acid, or a salt, ester or amide derivative thereof, under conditions which block the undesirable enzymatic activity while retaining the desired allergenic activity.
摘要翻译：具有降低至少95％的酶活性并且保持至少90％的原始致敏活性的木瓜凝乳蛋白酶衍生物适用于皮肤测试以检测对木瓜凝乳蛋白酶的过敏性超敏反应，并且用于治疗对木瓜凝乳蛋白酶表现出过敏性过敏的患者。通过使酶的硫醇基与碘乙酸，溴乙酸或其盐，酯或酰胺衍生物在阻碍不期望的酶活性同时保留所需的变应原活性的条件下，可以阻止酶活性。

4. 发明授权

US5084379A Fluorometric assay of chymopapain hypersensitivity and reagents therefor 失效
标题翻译：木瓜凝乳蛋白酶超敏反应的荧光测定法及其试剂
公开(公告)号：US5084379A
公开(公告)日：1992-01-28
申请号：US529784
申请日：1990-05-25
申请人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , Myron A. Beigler
发明人： Emanuel Calenoff , Ruth M. Jones , Yuh-Geng Tsay , Myron A. Beigler
IPC分类号： G01N33/543 , G01N33/573 , G01N33/58
CPC分类号： G01N33/543 , G01N33/573 , G01N33/582
摘要： A method for identifying and quantifying chymopapain-specific IgE antibody levels in patient serum comprising binding chymopapain-specific IgE, if any, in the serum with chymopapain adhering to an insoluble support, conjugating the serum IgE with a labeled anti-IgE antibody, and measuring the level of labeled compound bound to the insoluble support or in the solution removed therefrom. Special reagents and their manufacture are also disclosed.
摘要翻译：一种用于鉴定和定量患者血清中木瓜凝乳蛋白酶原特异性IgE抗体水平的方法，其包括在凝血酶中粘附木瓜凝乳蛋白酶特异性IgE（如果有的话），粘附在不溶性支持物上的木瓜凝乳蛋白酶，将血清IgE与标记的抗IgE抗体缀合，与不溶性载体结合的标记化合物的水平或从其中除去的溶液中。还公开了特殊试剂及其制造。

5. 发明授权

US06372803B1 Non-hazardous pest control 失效
公开(公告)号：US06372803B1
公开(公告)日：2002-04-16
申请号：US09469770
申请日：1999-12-22
申请人： Steven M. Bessette , Myron A. Beigler
发明人： Steven M. Bessette , Myron A. Beigler
IPC分类号： A01N3106
CPC分类号： A01N61/00 , A01N25/08 , A01N31/04 , A01N31/06 , A01N31/08 , A01N31/14 , A01N31/16 , A01N35/06 , A01N37/02 , A01N59/04 , Y10S424/08 , Y10S424/11 , A01N43/16 , A01N2300/00
摘要： A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.

6. 发明授权

US4592370A Ear canal electrode for auditory testing 失效
标题翻译：耳道电极用于听觉测试
公开(公告)号：US4592370A
公开(公告)日：1986-06-03
申请号：US444624
申请日：1982-11-26
申请人： John J. Lee , Arthur F. Avila , Hal C. Danby , Myron A. Beigler
发明人： John J. Lee , Arthur F. Avila , Hal C. Danby , Myron A. Beigler
IPC分类号： A61B5/042 , A61B5/12
CPC分类号： A61B5/6817 , A61B5/042 , A61B5/12
摘要： A non-invasive, external ear canal electrode and connector therefor useful for transmitting sound stimulus to an ear canal and for conducting electrical signals picked up from the ear canal epidermal surface. The electrode comprises an electro-conductive tube having resilient plastic foam elements attached to the end to be placed in the ear. One foam element is electro-conductive and impregnated with an electrolytically conductive medium, and the cells of the other sound absorbing elements are filled with air.
摘要翻译：一种非侵入性的外耳道电极及其连接器，其用于将声音刺激传送到耳道并用于进行从耳道表皮表面拾取的电信号。电极包括导电管，其具有附接到端部的弹性塑料泡沫元件以放置在耳朵中。一个泡沫元件是导电的并且用电解导电介质浸渍，并且其它吸声元件的单元被空气填充。

7. 发明授权

US07250175B2 Synergistic and residual pesticidal compositions containing plant essential oils 有权
标题翻译：含植物精油的协同和残留农药组合物
公开(公告)号：US07250175B2
公开(公告)日：2007-07-31
申请号：US11046239
申请日：2005-01-31
申请人： Steven M. Bessette , Myron A. Beigler
发明人： Steven M. Bessette , Myron A. Beigler
IPC分类号： A01N25/02 , A01N65/00 , A01N31/04
CPC分类号： A01N65/00 , A01N31/02 , A01N31/04 , A01N31/08 , A01N31/14 , A01N37/02 , A01N37/28 , A01N41/02 , A01N65/12 , Y10S424/10 , A01N31/16 , A01N49/00 , A01N65/22 , A01N35/06 , A01N37/08 , A01N37/42 , A01N41/10 , A01N43/08 , A01N43/16 , A01N53/00 , A01N63/02 , A01N47/22 , A01N57/12
摘要： Synergistic and residual pesticidal compositions containing synergistic and residual mixtures of plant essential oils and/or their constituents, plant essential oils and/or their constituents in admixture with known active pesticidal compounds or plant essential oils and/or their constituents in admixture with other compounds not previously used as active ingredients in pesticidal formulations, such as, for example, so called signal transduction modulators. In addition, the present invention is directed to a method for controlling pests by applying a pesticidally effective amount of the above synergistic and residual pesticidal compositions to a locus where pest control is desired.
摘要翻译：包含植物精油和/或其成分的协同和残留混合物的协同和残留农药组合物，植物精油和/或其组分与已知的活性杀虫化合物或植物精油和/或其组分与其它化合物混合而不是以前用作农药制剂中的活性成分，例如所谓的信号转导调节剂。此外，本发明涉及通过将杀虫有效量的上述协同和残留农药组合物施用于需要害虫控制的场所来控制害虫的方法。

8. 发明授权

US06841577B2 Pesticidal activity of plant essential oils and their constituents 失效
标题翻译：植物精油及其成分的杀虫活性
公开(公告)号：US06841577B2
公开(公告)日：2005-01-11
申请号：US10023145
申请日：2001-12-18
申请人： Steven M. Bessette , Myron A. Beigler
发明人： Steven M. Bessette , Myron A. Beigler
IPC分类号： A01N25/02 , A01N25/04 , A01N25/06 , A01N25/12 , A01N31/04 , A01N31/08 , A01N31/14 , A01N31/16 , A01N35/06 , A01N37/02 , A01N37/40 , A01N49/00 , A01N65/00 , A01N27/00
CPC分类号： A01N65/00 , A01N27/00 , A01N31/04 , A01N31/08 , A01N31/14 , A01N31/16 , A01N35/06 , A01N37/02 , A01N37/40 , A01N49/00 , A01N53/00 , A01N65/22 , A01N2300/00
摘要： A pesticide for cockroaches and larvae which is based on purified naturally occurring plant substances. Phenethyl propionate; methyl salicylate; pulegone; carvacrol; thymol; thyme oil; citronellal; a three-blend of eugenol, α-terpineol and cinnamic alcohol; a four-blend of benzyl alcohol, phenethyl alcohol, phenethyl propionate and α-terpineol; and a five-blend of thymol, t-anethole, α-terpineol, eugenol and citronellal have been used as the pesticide. The pesticide affects the octopamine receptor site in the cockroach. The five-blend has been used as a pesticide for Asian armyworms and green peach aphid nymphs. Methods of use of the pesticides are disclosed.
摘要翻译：基于纯化的天然存在的植物物质的蟑螂和幼虫的杀虫剂。丙酸苯乙酯水杨酸甲酯; p one 香芹素百里酚百里香油; 香茅素丁香酚，α-萜品醇和肉桂醇的三种混合物; 苯甲醇，苯乙醇，丙酸苯乙酯和α-萜品醇的四混合物; 麝香草酚，t-anethole，α-萜品醇，丁子香酚和香茅醛的五元混合物已被用作农药。农药影响蟑螂的章鱼胺受体位点。五混合物已被用作亚洲粘虫和绿桃蚜虫的农药。公开了使用农药的方法。

9. 发明授权

US06372801B1 Non-hazardous pest control 失效
标题翻译：无害虫防治
公开(公告)号：US06372801B1
公开(公告)日：2002-04-16
申请号：US09469766
申请日：1999-12-22
申请人： Steven M. Bessette , Myron A. Beigler
发明人： Steven M. Bessette , Myron A. Beigler
IPC分类号： A01N3500
CPC分类号： A01N61/00 , A01N25/08 , A01N31/04 , A01N31/06 , A01N31/08 , A01N31/14 , A01N31/16 , A01N35/06 , A01N37/02 , A01N59/04 , Y10S424/08 , Y10S424/11 , A01N43/16 , A01N2300/00
摘要： A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affect or utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.
摘要翻译：杀虫剂和使用杀虫剂杀死无脊椎动物，特别是昆虫，蜘蛛和幼虫的方法。该方法是制备载体与农药的混合物，并将混合物施用于昆虫，蜘蛛和幼虫及其栖息地。农药是一种神经递质，影响或利用昆虫，蜘蛛和幼虫中的章鱼胺受体位点。感染剂是具有在其上取代至少一个氧化官能团的六元碳环的化学物质。感染剂是植物精油的化学成分，是天然存在的。将本发明的化学物质沉积在表面上提供长达30天的残留毒性。公开了各种用于感染剂的载体。本发明的化学物质阻止了昆虫，蜘蛛和幼虫的饲养，并且还阻碍了昆虫和蜘蛛的幼虫的生长。

10. 发明授权

US06342536B1 Non-hazardous pest control 失效
标题翻译：无害虫防治
公开(公告)号：US06342536B1
公开(公告)日：2002-01-29
申请号：US09469772
申请日：1999-12-22
申请人： Steven M. Bessette , Myron A. Beigler
发明人： Steven M. Bessette , Myron A. Beigler
IPC分类号： A01N3108
CPC分类号： A01N61/00 , A01N25/08 , A01N31/04 , A01N31/06 , A01N31/08 , A01N31/14 , A01N31/16 , A01N35/06 , A01N37/02 , A01N59/04 , Y10S424/08 , Y10S424/11 , A01N43/16 , A01N2300/00
摘要： A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.
摘要翻译：杀虫剂和使用杀虫剂杀死无脊椎动物，特别是昆虫，蜘蛛和幼虫的方法。该方法是制备载体与农药的混合物，并将混合物施用于昆虫，蜘蛛和幼虫及其栖息地。农药是在昆虫，蜘蛛和幼虫中利用章鱼胺受体位点的神经递质。感染剂是具有在其上取代至少一个氧化官能团的六元碳环的化学物质。感染剂是植物精油的化学成分，是天然存在的。将本发明的化学物质沉积在表面上提供长达30天的残留毒性。公开了各种用于感染剂的载体。本发明的化学物质阻止了昆虫，蜘蛛和幼虫的饲养，并且还阻碍了昆虫和蜘蛛的幼虫的生长。

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