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11. 发明授权

US08148391B2 Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors 有权
标题翻译： 2,4-二氨基嘧啶作为ALK和c-Met抑制剂的稠合双环衍生物
公开(公告)号：US08148391B2
公开(公告)日：2012-04-03
申请号：US12162851
申请日：2007-10-23
申请人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。

12. 发明授权

US07700603B2 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US07700603B2
公开(公告)日：2010-04-20
申请号：US11149027
申请日：2005-06-09
申请人： Zhaoning Zhu , Brian A McKittrick , Zhong-Yue Sun , Yuanzan C Ye , Johannes H Voigt , Corey Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert Mazzola , John Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X. H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Gang Qian , Dawit Tadesse
发明人： Zhaoning Zhu , Brian A McKittrick , Zhong-Yue Sun , Yuanzan C Ye , Johannes H Voigt , Corey Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert Mazzola , John Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X. H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Gang Qian , Dawit Tadesse
IPC分类号： A01N43/54 , C07D239/02 , C07D239/42 , C07D401/04
CPC分类号： C07D233/46 , C07D233/70 , C07D233/88 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

13. 发明申请

US20090258868A1 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 有权
标题翻译：异源ASPARTYL蛋白酶抑制剂
公开(公告)号：US20090258868A1
公开(公告)日：2009-10-15
申请号：US12331787
申请日：2008-12-10
申请人： Zhaoning Zhu , Brian A. McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert Mazzola , John Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X.H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
发明人： Zhaoning Zhu , Brian A. McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert Mazzola , John Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X.H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
IPC分类号： A61K31/5355 , C07D401/02 , A61K31/4439 , C07D233/02 , A61K31/4166 , C07D239/24 , A61K31/505 , C07D241/10 , A61K31/497 , C07D261/02 , A61K31/42 , A61K31/454 , C07D277/20 , A61K31/426 , C07D235/04 , A61K31/4184 , C07D211/00 , A61K31/4545 , C07D471/02 , A61K31/4375 , C07D413/14 , A61K31/5377 , C07D487/02 , A61K31/519 , C07D271/06 , A61K31/4245 , C07D273/04 , A61P9/00 , A61P25/00
CPC分类号： C07D233/46 , C07D233/70 , C07D233/88 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中W是键，-C（-S） - ， - S（O） - ， - S（O） -C（ - ） - ， - O - ， - C（R6）（R7） - ， - N（R5） - 或-C（-N（R5） X是-O - ， - N（R 5） - 或-C（R 6）（R 7） - ; 条件是当X是-O-时，U不是-O-，-S（O） - ， - S（O）2 - ， - C（-O） - 或-C（-NR 5） - ; U是一个键，-S（O） - ， - S（O）2 - ， - C（O） - ， - O - ， - （O）（OR 15） - ， - （C（R6）（R7））b-或-N（R5） - ; 其中b为1或2; 条件是当W是-S（O） - ， - S（O）2 - ， - O-或-N（R 5） - 时，U不是-S（O） - ， - S（O） -O-或-N（R 5） - ; 条件是当X为-N（R5） - 且W为-S（O） - ， - S（O）2 - ， - O-或-N（R5） - 时，则U不为键; 并且R1，R2，R3，R4，R5，R6和R7如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D 和原生动物酶。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

14. 发明申请

US20080015775A1 Road exit modeling using aerial image 审中-公开
标题翻译：使用航空图像的道路出口建模
公开(公告)号：US20080015775A1
公开(公告)日：2008-01-17
申请号：US11822629
申请日：2007-07-09
申请人： Tao Guo , Kazuaki Iwamura
发明人： Tao Guo , Kazuaki Iwamura
IPC分类号： G01C21/30
CPC分类号： G09B29/106 , G01C11/00 , G01C21/26
摘要： To improve map accuracy by a new method that represents a road exit, there is provided a map generating apparatus for drawing a road map from digital data of a road map and a photographic image of a region that includes a region depicted by the road map, in which: a provided photographic image and a provided road map are geographically aligned with each other; a start point and an end point of an exit line which separates a main road and a branch road are extracted from the aligned photographic image; an exit line connecting the extracted start point and the extracted end point is determined; and a position of an exit branch is identified based on the determined exit line.
摘要翻译：为了通过代表道路出口的新方法来提高地图准确度，提供了一种用于从道路地图的数字数据和包括路线图所示的区域的区域的摄影图像中绘制路线图的地图生成装置，其中：提供的摄影图像和所提供的路线图在地理上彼此对准; 从对准的摄影图像中提取分离主路和分支路的出线的起点和终点; 确定连接提取的开始点和提取的终点的退出线; 并且基于所确定的出口线来识别出口分支的位置。

15. 发明申请

US20060287294A1 Aspartyl protease inhibitors 有权
标题翻译：天冬氨酰蛋白酶抑制剂
公开(公告)号：US20060287294A1
公开(公告)日：2006-12-21
申请号：US11451195
申请日：2006-06-12
申请人： Zhaoning Zhu , Brian McKittrick , Andrew Stamford , Tao Guo , Thuy Le
发明人： Zhaoning Zhu , Brian McKittrick , Andrew Stamford , Tao Guo , Thuy Le
IPC分类号： A61K31/554 , A61K31/553 , A61K31/551 , C07D285/36 , C07D243/10 , C07D223/14
CPC分类号： C07D471/10 , C07D239/70 , C07D487/10 , C07D491/10 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein U, W, A, R, R1, R2, R6a and R7, are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中U，W，A，R，R 1，R 2， R 6a和R 7如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m 1激动剂或m 2 H 2拮抗剂组合治疗认知或神经变性疾病的方法。

16. 发明申请

US20050119227A1 Cyclic amine bace-1 inhibitors having a benzamide substituent 有权
标题翻译：具有苯甲酰胺取代基的环胺类Bace-1抑制剂
公开(公告)号：US20050119227A1
公开(公告)日：2005-06-02
申请号：US10910987
申请日：2004-08-04
申请人： Jared Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie , Kurt Saionz , Suresh Babu
发明人： Jared Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie , Kurt Saionz , Suresh Babu
IPC分类号： A61K31/55 , A61K31/553 , A61K31/554 , A61K31/675 , C07D207/09 , C07D211/26 , C07D217/18 , C07D241/04 , C07D243/08 , C07D401/06 , C07D403/12 , C07D403/14 , C07D413/06 , C07F9/38
CPC分类号： C07D243/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/26 , C07D209/52 , C07D211/26 , C07D211/46 , C07D217/18 , C07D233/32 , C07D241/04 , C07D241/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/12 , C07D413/06
摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is —C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
摘要翻译：公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中R 1是R是-C（O）-N（R 27） > 28 ）或其余变量如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经变性疾病的药物组合物和方法，其包含式I化合物与除式I以外的β-分泌酶抑制剂，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，甾族抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂或抗淀粉样蛋白抗体。

17. 发明申请

US20050069302A1 Mist iron 有权
标题翻译：薄雾铁
公开(公告)号：US20050069302A1
公开(公告)日：2005-03-31
申请号：US10498770
申请日：2002-12-03
申请人： Nyik Wong , Yong Jiang , Tao Guo , Kumar Asok S/O Kasevan
发明人： Nyik Wong , Yong Jiang , Tao Guo , Kumar Asok S/O Kasevan
IPC分类号： D06F75/10 , D06F75/22 , F22B1/30
CPC分类号： D06F75/22 , D06F75/10
摘要： An iron comprising a housing (1), a heatable soleplate (4) and means for generating very fine liquid droplets to be expelled from at least one discharge opening (9) of the iron, said means comprising at least one air passage (8) for pressurized air supply and at least one liquid passage (13) for pressurized liquid supply, said air passage (8) and said liquid passage (13) communicating with each other for mixing air and liquid, said mixture of air and liquid being supplied to the discharge opening (9). To improve the generation of fine liquid droplets (mist) an outlet of the liquid passage (8) ends into the air passage (13) upstream of the discharge opening (9) to introduce liquid into the air passage and an outlet of the air passage is provided with a nozzle (10) having said discharge opening (9). Preferably the pressurized air and liquid supply is obtained by means of electric pumps (6,7). The liquid may be water or a (diluted) additive liquid.
摘要翻译：一种熨斗，包括壳体（1），可加热底板（4）和用于产生要从铁的至少一个排放开口（9）排出的非常细的液滴的装置，所述装置包括至少一个空气通道（8）用于加压空气供应和用于加压液体供应的至少一个液体通道（13），所述空气通道（8）和所述液体通道（13）彼此连通以混合空气和液体，所述空气和液体混合物供应到排出口（9）。为了改善细液滴（雾）的产生，液体通道（8）的出口在排出口（9）的上游端部进入空气通道（13），以将液体引入空气通道和空气通道的出口设置有具有所述排出口（9）的喷嘴（10）。优选地，加压空气和液体供应通过电动泵（6,7）获得。液体可以是水或（稀释的）添加剂液体。

18. 发明授权

US5972719A Combinatorial hydroxy-amino acid amide libraries 失效
标题翻译：组合羟基 - 氨基酸酰胺文库
公开(公告)号：US5972719A
公开(公告)日：1999-10-26
申请号：US743960
申请日：1996-11-05
申请人： Roland Ellwood Dolle, III , Tao Guo , Theodore Otto Johnson, Jr. , Hitesh K. Patel , Shiwei Tao , Zhen Min He
发明人： Roland Ellwood Dolle, III , Tao Guo , Theodore Otto Johnson, Jr. , Hitesh K. Patel , Shiwei Tao , Zhen Min He
IPC分类号： C07D207/14 , C07D207/16 , C07D241/04 , G01N33/53 , C07C23/00 , G01N33/543 , G01N33/551
CPC分类号： C07D207/14 , C07D207/16 , C07D241/04
摘要： Combinatorial chemical libraries of Formula I ##STR1## and methods for their preparation are disclosed. The libraries allow one to screen large numbers of compounds for a desired biological activity with relative ease. The libraries may be tagged or untagged. In preferred libraries, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. The use of the libraries to discover biologically active compounds is also disclosed.
摘要翻译：公开了式I的组合化学文库及其制备方法。这些文库允许相对容易地筛选大量化合物以获得所需的生物活性。库可能被标记或未标记。在优选的文库中，Y是N-酰化氨基酸，取代的4-氨基脯氨酸或取代的哌嗪烷酸的残基。还公开了使用这些文库发现生物活性化合物。

19. 发明授权

US08937093B2 Heterocyclic aspartyl protease inhibitors 有权
标题翻译：杂环天门冬氨酰蛋白酶抑制剂
公开(公告)号：US08937093B2
公开(公告)日：2015-01-20
申请号：US13402521
申请日：2012-02-22
申请人： Kurt W. Saionz , Tao Guo , Andrew W. Stamford , Zhaoning Zhu
发明人： Kurt W. Saionz , Tao Guo , Andrew W. Stamford , Zhaoning Zhu
IPC分类号： A61K31/4245 , C07D271/07 , A61K31/5377 , C07D233/46 , C07D233/70 , C07D233/88 , C07D239/22 , C07D239/70 , C07D273/00 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K45/06 , C07D295/15 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/5377 , A61K31/655 , A61K45/06 , C07D233/46 , C07D233/70 , C07D235/02 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D295/15 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06 , Y02A50/411
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W, X, U, R1, R2, R3, and R4, are as defined herein, and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中W，X，U，R 1，R 2，R 3和R 4如本文所定义，以及包含式 I.还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶的方法。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱拮抗剂组合来治疗认知或神经变性疾病的方法。

20. 发明授权

US08434766B2 Turbine engine seals 有权
标题翻译：涡轮发动机密封
公开(公告)号：US08434766B2
公开(公告)日：2013-05-07
申请号：US12858701
申请日：2010-08-18
申请人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
发明人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
IPC分类号： F16J15/447
CPC分类号： F01D11/001 , F01D11/02 , F05D2250/232 , F16J15/441 , F16J15/4472
摘要： A seal is provided for preventing axial leakage through a radial gap between a stationary structure and a rotating structure. The radial gap is defined by an inner radial surface opposing an outer radial surface across the radial gap. The seal includes at least one land disposed on one of the inner radial surface and outer radial surface. At least one first tooth and at least one second tooth project from the other of the radial surfaces. The second tooth is shorter than the first tooth. At least one of the first tooth and second tooth, is configured to extend at an angle upstream. This angle is defined between a radial surface from which the first or second tooth projects and an upstream surface of the same tooth. The angle is less than or equal to about 80 degrees.
摘要翻译：提供密封件以防止通过固定结构和旋转结构之间的径向间隙的轴向泄漏。径向间隙由跨越径向间隙的与外径向表面相对的内径向表面限定。密封件包括设置在内径向表面和外径向表面中的一个上的至少一个区域。至少一个第一齿和至少一个第二齿从另一个径向表面突出。第二个齿比第一个牙齿短。第一齿和第二齿中的至少一个构造成在上游以一定角度延伸。该角度限定在第一或第二齿突出的径向表面与同一牙齿的上游表面之间。该角度小于或等于约80度。

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