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1. 发明申请

US20110049346A1 METHODS AND APPARATUS FOR FILLING AN ION DETECTOR CELL 有权
标题翻译：用于填充离子检测器细胞的方法和装置
公开(公告)号：US20110049346A1
公开(公告)日：2011-03-03
申请号：US12547335
申请日：2009-08-25
申请人： Gregory J. Wells
发明人： Gregory J. Wells
IPC分类号： H01J49/26
CPC分类号： H01J49/38 , H01J49/04 , H01J49/062
摘要： In a mass spectrometer, a dual stage axial extraction field is applied to transport ions from an accumulator with a shutter and an ion guide to a detector cell. Ions of the same mass may be transported to the detector cell or a point axially preceding the detector cell at the same time by selecting the relative strengths of a first axial electric field applied to the accumulator and a second axial electric field applied to the shutter and further by selecting relative axial lengths of the accumulator, shutter, and an ion guide. A dual stage decelerating field may also be applied to slow ion down prior to and after entering the detector cell.
摘要翻译：在质谱仪中，应用双级轴向提取场，将具有快门和离子导向器的蓄能器的离子输送到检测器单元。相同质量的离子可以通过选择施加到蓄能器的第一轴向电场的相对强度和施加到闸门的第二轴向电场而被同时运送到检测器单元或轴向在检测器单元之前的点，以及进一步通过选择蓄能器，快门和离子导向器的相对轴向长度。还可以在进入检测器单元之前和之后，将双级减速场应用于减慢离子。

2. 发明申请

US20090159791A1 Charge control for ionic charge accumulation devices 有权
公开(公告)号：US20090159791A1
公开(公告)日：2009-06-25
申请号：US12004136
申请日：2007-12-19
申请人： Gregory J. Wells
发明人： Gregory J. Wells
IPC分类号： B01D59/44
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/067
摘要： A method for controlling charge flux into a charge accumulation device includes determining a charge accumulation time during which charges are to be accumulated in the charge accumulation device, measuring a charge flux of a first ion beam produced from an ion source, determining a target number of charges to be accumulated in the charge accumulation device during the charge accumulation time based on the measured charge flux and, based on the determined target number of charges, modulating a second ion beam produced from the ion source to cause the target number of charges from the second ion beam to be accumulated in the charge accumulation device during the charge accumulation time. An ion processing device is configured for controlling the charge flux. An ion beam modulator modulates the ion beam.

3. 发明授权

US06710336B2 Ion trap mass spectrometer using pre-calculated waveforms for ion isolation and collision induced dissociation 有权
标题翻译：离子阱质谱仪使用预先计算的离子离子和碰撞诱导离解波形
公开(公告)号：US06710336B2
公开(公告)日：2004-03-23
申请号：US10066276
申请日：2002-01-30
申请人： Gregory J. Wells
发明人： Gregory J. Wells
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/428
摘要： In a quadrupole ion trap mass spectrometer, a library of optimized notched waveforms are pre-calculated, optimized and stored in a fast memory such as semiconductor RAM. Computer controlled apparatus selectively applies the pre-calculated waveforms to end caps of the quadrupole ion trap for isolating an ion with a specific mass to charge ratio. The pre-calculated waveforms are optimized notch waveforms with each waveform being pre-calculated for a specific mass. The memory further stores a library of single frequency CID waveforms for use in collision induced dissociation of an isolated ion. By providing the pre-calculated waveforms, a method is provided to isolate and dissociate a selected ion.
摘要翻译：在四极离子阱质谱仪中，预先计算，优化并存储在诸如半导体RAM的快速存储器中的优化的缺口波形库。计算机控制的设备选择性地将预计算的波形应用于四极离子阱的端盖，以分离具有特定质荷比的离子。预先计算的波形是针对特定质量预先计算每个波形的最佳陷波波形。存储器还存储用于分离离子的碰撞诱导解离的单频CID波形库。通过提供预先计算的波形，提供了隔离和离解选定离子的方法。

4. 发明授权

US06288231B1 Peptide-containing &agr;-ketoamide cysteine and serine protease inhibitors 失效
标题翻译：含肽的α-酮酰胺半胱氨酸和丝氨酸蛋白酶抑制剂
公开(公告)号：US06288231B1
公开(公告)日：2001-09-11
申请号：US09527540
申请日：2000-03-16
申请人： Sankar Chatterjee , John P. Mallamo , Ron Bihovsky , Gregory J. Wells
发明人： Sankar Chatterjee , John P. Mallamo , Ron Bihovsky , Gregory J. Wells
IPC分类号： C07D20702
CPC分类号： C07D207/08 , C07C311/06 , C07C311/46 , C07C311/48 , C07D207/20 , C07D207/48 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/74 , C07D235/06 , C07D239/42 , C07D275/06 , C07D277/40 , C07D277/54 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07K5/0202 , C07K5/06069
摘要： This invention relates to peptide-containing &agr;-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.
摘要翻译：本发明涉及半胱氨酸和丝氨酸蛋白酶的含肽α-酮酰胺抑制剂，制备这些化合物的方法及其使用方法。

5. 发明授权

US06274867B1 Multiple liquid flow electrospray interface 有权
标题翻译：多液流电喷雾界面
公开(公告)号：US06274867B1
公开(公告)日：2001-08-14
申请号：US09162259
申请日：1998-09-28
申请人： Gregory J. Wells , Roger C. Tong , Peter P. Yee
发明人： Gregory J. Wells , Roger C. Tong , Peter P. Yee
IPC分类号： H01J4900
CPC分类号： H01J49/165 , H01J49/0431
摘要： An apparatus for electrospray ionization of a liquid sample matrix to prepare the sample for introduction into a mass spectrometer. The inventive electrospray interface is arranged between a source of a liquid sample matrix and an electrospray ionization needle. The interface includes a central chamber which contains elements for passively mixing the liquid sample flow with a modifying liquid added to the central chamber through a side channel. The side channel is isolated from the central chamber by a flow restrictor and the modifying liquid is provided to the side channel through a valve. A second valve, side channel, and flow restrictor are used to permit introduction of a calibration fluid into the central chamber through the first side channel. The inventive interface permits mixing of a modifying liquid with the liquid sample matrix to assist in nebulization of the liquid sample by reducing the surface tension of the sample containing fluid.
摘要翻译：用于液体样品基质的电喷雾电离以制备用于引入质谱仪的样品的装置。本发明的电喷雾界面布置在液体样品基质的源和电喷雾离子化针之间。该界面包括中央室，其包含用于被动地将液体样品流与通过侧通道加到中央室的改性液体混合的元件。侧通道通过限流器与中心室隔离，并且修改液体通过阀提供给侧通道。第二阀，侧通道和限流器用于允许通过第一侧通道将校准流体引入中心室。本发明的界面允许改性液体与液体样品基质混合，以通过降低含有液体样品的表面张力来帮助液体样品的雾化。

6. 发明授权

US06207955B1 Pneumatically assisted electrospray device with alternating pressure gradients for mass spectrometry 失效
标题翻译：用于质谱的交替压力梯度的气动辅助电喷设备
公开(公告)号：US06207955B1
公开(公告)日：2001-03-27
申请号：US09162261
申请日：1998-09-28
申请人： Gregory J. Wells , Roger C. Tong , Peter P. Yee
发明人： Gregory J. Wells , Roger C. Tong , Peter P. Yee
IPC分类号： B01D5944
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/045
摘要： An apparatus for producing gas-phase ions from a sample compound in a carrier liquid. The electrospray needle (or capillary) of the present invention includes a central metal tube which carries the liquid containing the sample compound. The central tube is surrounded by a plurality of tubes which transport a nebulizing gas. The nebulizing gas tubes are placed symmetrically around the outside of the liquid containing tube. The nebulizer of the present invention produces a symmetric, non-annular gas flow which has variations in pressure around the circumference of the central tube. The pressure variations of the nebulizing gas flow produce additional shear forces on the liquid emerging from the central tube. This assists in forming a uniform electrospray of droplets from the liquid at lower nebulizing gas flow rates, thereby reducing the disadvantageous effects of the higher gas flow rates used in the art. The symmetric arrangement of the nebulizing gas tubes provides support for the central sample carrying tube, thereby reducing the alignment problems found in prior art devices, and enhancing uniformity of the electrospray.
摘要翻译：一种用于从载液中的样品化合物产生气相离子的装置。本发明的电喷针（或毛细管）包括携带含有样品化合物的液体的中心金属管。中心管被输送雾化气体的多个管围绕。雾化气体管围绕液体容纳管的外侧对称放置。本发明的雾化器产生对称的非环形气流，其在中心管的圆周周围具有压力变化。喷雾气流的压力变化在从中心管出来的液体上产生额外的剪切力。这有助于以较低的雾化气体流速从液体形成均匀的液滴电喷雾，从而减少本领域中使用的较高气体流速的不利影响。雾化气体管的对称布置为中心样品承载管提供支撑，从而减少现有技术装置中发现的对准问题，并增强电喷雾的均匀性。

7. 发明授权

US5640011A Method of detecting selected ion species in a quadrupole ion trap 失效
标题翻译：检测四极离子阱中选定离子种类的方法
公开(公告)号：US5640011A
公开(公告)日：1997-06-17
申请号：US726758
申请日：1996-10-09
申请人： Gregory J. Wells
发明人： Gregory J. Wells
IPC分类号： G01N27/62 , H01J49/34 , H01J49/42
CPC分类号： H01J49/424 , H01J49/427
摘要： A method of detecting ions of a single ion species that have been selectively stored in a quadrupole ion trap mass spectrometer is disclosed. After the selected ion species is isolated the trapping field in rapidly changed to cause ions to leave the ion trap in the axial direction where they are detected using a conventional detector. Preferably, a dipole pulse is applied to the ion trap simultaneously with the reduction of the trapping field, such that all of the ions are caused to leave the trap in a single direction, doubling the ion current over prior art methods. The method of the invention allows ejection of all of the ions in a time period which is nearly twenty times faster than the prior art resonance ejection scanning technique, and without the artifacts in the signal current caused by frequency beating.
摘要翻译：公开了一种检测已经选择性地存储在四极离子阱质谱仪中的单一离子种的离子的方法。在选择的离子物质被分离之后，捕获场迅速变化，导致离子沿轴向离开离子阱，使用传统的检测器检测它们。优选地，偶极脉冲与捕获场的减少同时施加到离子阱，使得所有离子被引起在单个方向上离开阱，使离子电流比现有技术方法加倍。本发明的方法允许在比现有技术的共振喷射扫描技术快近二十倍的时间段内喷射所有的离子，并且不会由频率跳动引起的信号电流中的伪影。

8. 发明授权

US5639732A Phosphorous-containing cysteine and serine protease inhibitors 失效
标题翻译：含磷的半胱氨酸和丝氨酸蛋白酶抑制剂
公开(公告)号：US5639732A
公开(公告)日：1997-06-17
申请号：US679342
申请日：1996-07-10
申请人： John P. Mallamo , Ron Bihovsky , Ming Tao , Gregory J. Wells
发明人： John P. Mallamo , Ron Bihovsky , Ming Tao , Gregory J. Wells
IPC分类号： A61K38/00 , C07F9/09 , C07F9/32 , C07F9/40 , C07F9/572 , C07F9/6533 , C07F9/6571 , C07F9/6574 , C07K5/06 , A61K31/66 , C07F9/30
CPC分类号： C07F9/5721 , C07F9/091 , C07F9/3211 , C07F9/3252 , C07F9/3264 , C07F9/4006 , C07F9/4065 , C07F9/4075 , C07F9/6533 , C07F9/657163 , C07F9/65742 , C07K5/06191 , A61K38/00
摘要： The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
摘要翻译：本发明涉及新颖的含磷抑制剂的半胱氨酸或丝氨酸蛋白酶。还描述了使用蛋白酶抑制剂的方法。

9. 发明授权

US5608216A Frequency modulated selected ion species isolation in a quadrupole ion trap 失效
标题翻译：在四极离子阱中调频选择的离子种类分离
公开(公告)号：US5608216A
公开(公告)日：1997-03-04
申请号：US568898
申请日：1995-11-30
申请人： Gregory J. Wells , Charles K. Huston
发明人： Gregory J. Wells , Charles K. Huston
IPC分类号： G01N27/62 , H01J49/42
CPC分类号： H01J49/427 , H01J49/428
摘要： A method of isolating selected ion species in a quadrupole ion trap mass spectrometer is disclosed. One or more ranges of masses to be eliminated from the ion trap are ejected by applying a supplemental dipole excitation waveform, sparsely populated with frequency components, while the trapping field is modulated. The spacing of the frequency components in the supplemental excitation waveform varies across the range of frequencies in the waveform. Preferably, the frequency range is divided into a plurality of subranges, and the spacing of the frequency components in each of the subranges is constant. A method of creating a master set of frequencies used for generating a supplemental excitation waveform is also shown. Likewise, a method of calculating edge frequencies defining a gap in the mass spectrum that is excited by the supplemental waveform is also shown. Modulation of the trapping field may be varied while the supplemental excitation waveform is applied to change the width of the gap in the mass spectrum.
摘要翻译：公开了在四极离子阱质谱仪中分离选择的离子物质的方法。通过在捕获场被调制的同时施加稀疏地填充有频率分量的补充偶极子激发波形，从离子阱中消除的一个或多个质量范围被排出。补充激励波形中的频率分量的间隔在波形的频率范围内变化。优选地，频率范围被分成多个子范围，并且每个子范围中的频率分量的间隔是恒定的。还示出了创建用于产生补充激励波形的主频率组的方法。同样地，还示出了计算边界频率的方法，其限定由补充波形激发的质谱中的间隙。捕获场的调制可以改变，同时施加补充激励波形以改变质谱中间隙的宽度。

10. 发明授权

US5521380A Frequency modulated selected ion species isolation in a quadrupole ion trap 失效
标题翻译：在四极离子阱中调频选择的离子种类分离
公开(公告)号：US5521380A
公开(公告)日：1996-05-28
申请号：US297680
申请日：1994-08-29
申请人： Gregory J. Wells , Charles K. Huston
发明人： Gregory J. Wells , Charles K. Huston
IPC分类号： G01N27/62 , H01J49/42
CPC分类号： H01J49/427 , H01J49/428
摘要： A method of isolating selected ion species in a quadrupole ion trap mass spectrometer is disclosed. One or more ranges of masses to be eliminated from the ion trap are ejected by applying a supplemental dipole excitation waveform, sparsely populated with frequency components, while the trapping field is modulated. The spacing of the frequency components in the supplemental excitation waveform varies across the range of frequencies in the waveform. Preferably, the frequency range is divided into a plurality of subranges, and the spacing of the frequency components in each of the subranges is constant. A method of creating a master set of frequencies used for generating a supplemental excitation waveform is also shown. Likewise, a method of calculating edge frequencies defining a gap in the mass spectrum that is excited by the supplemental waveform is also shown. Modulation of the trapping field may be varied while the supplemental excitation waveform is applied to change the width of the gap in the mass spectrum.
摘要翻译：公开了在四极离子阱质谱仪中分离选择的离子物质的方法。通过在捕获场被调制的同时施加稀疏地填充有频率分量的补充偶极子激发波形，从离子阱中消除的一个或多个质量范围被排出。补充激励波形中的频率分量的间隔在波形的频率范围内变化。优选地，频率范围被分成多个子范围，并且每个子范围中的频率分量的间隔是恒定的。还示出了创建用于产生补充激励波形的主频率组的方法。同样地，还示出了计算边界频率的方法，其限定由补充波形激发的质谱中的间隙。捕获场的调制可以改变，同时施加补充激励波形以改变质谱中间隙的宽度。

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