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1. 发明授权

US08434766B2 Turbine engine seals 有权
标题翻译：涡轮发动机密封
公开(公告)号：US08434766B2
公开(公告)日：2013-05-07
申请号：US12858701
申请日：2010-08-18
申请人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
发明人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
IPC分类号： F16J15/447
CPC分类号： F01D11/001 , F01D11/02 , F05D2250/232 , F16J15/441 , F16J15/4472
摘要： A seal is provided for preventing axial leakage through a radial gap between a stationary structure and a rotating structure. The radial gap is defined by an inner radial surface opposing an outer radial surface across the radial gap. The seal includes at least one land disposed on one of the inner radial surface and outer radial surface. At least one first tooth and at least one second tooth project from the other of the radial surfaces. The second tooth is shorter than the first tooth. At least one of the first tooth and second tooth, is configured to extend at an angle upstream. This angle is defined between a radial surface from which the first or second tooth projects and an upstream surface of the same tooth. The angle is less than or equal to about 80 degrees.
摘要翻译：提供密封件以防止通过固定结构和旋转结构之间的径向间隙的轴向泄漏。径向间隙由跨越径向间隙的与外径向表面相对的内径向表面限定。密封件包括设置在内径向表面和外径向表面中的一个上的至少一个区域。至少一个第一齿和至少一个第二齿从另一个径向表面突出。第二个齿比第一个牙齿短。第一齿和第二齿中的至少一个构造成在上游以一定角度延伸。该角度限定在第一或第二齿突出的径向表面与同一牙齿的上游表面之间。该角度小于或等于约80度。

2. 发明申请

US20120043728A1 TURBINE ENGINE SEALS 有权
标题翻译：涡轮发动机密封
公开(公告)号：US20120043728A1
公开(公告)日：2012-02-23
申请号：US12858701
申请日：2010-08-18
申请人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
发明人： Xiaoqiang Zeng , Jonathon Edward Slepski , Tao Guo , Joshy John , Sudhakar Neeli
IPC分类号： F16J15/447
CPC分类号： F01D11/001 , F01D11/02 , F05D2250/232 , F16J15/441 , F16J15/4472
摘要： A seal is provided for preventing axial leakage through a radial gap between a stationary structure and a rotating structure. The radial gap is defined by an inner radial surface opposing an outer radial surface across the radial gap. The seal includes at least one land disposed on one of the inner radial surface and outer radial surface. At least one first tooth and at least one second tooth project from the other of the radial surfaces. The second tooth is shorter than the first tooth. At least one of the first tooth and second tooth, is configured to extend at an angle upstream. This angle is defined between a radial surface from which the first or second tooth projects and an upstream surface of the same tooth. The angle is less than or equal to about 80 degrees.
摘要翻译：提供密封件以防止通过固定结构和旋转结构之间的径向间隙的轴向泄漏。径向间隙由跨越径向间隙的与外径向表面相对的内径向表面限定。密封件包括设置在内径向表面和外径向表面中的一个上的至少一个区域。至少一个第一齿和至少一个第二齿从另一个径向表面突出。第二个齿比第一个牙齿短。第一齿和第二齿中的至少一个构造成在上游以一定角度延伸。该角度限定在第一或第二齿突出的径向表面与同一牙齿的上游表面之间。该角度小于或等于约80度。

3. 发明申请

US20100329853A1 MOISTURE REMOVAL PROVISIONS FOR STEAM TURBINE 审中-公开
标题翻译：蒸汽涡轮水分去除条款
公开(公告)号：US20100329853A1
公开(公告)日：2010-12-30
申请号：US12494419
申请日：2009-06-30
申请人： Tao Guo , Xiaoyue Liu , Jonathon Edward Slepski
发明人： Tao Guo , Xiaoyue Liu , Jonathon Edward Slepski
IPC分类号： F01D25/32
CPC分类号： F01D25/32 , F01D9/065 , F05D2220/31 , F05D2260/602
摘要： Disclosed herein is a moisture removal system for a steam turbine including at least one perforated ring in an outer casing enclosing a stage of the steam turbine. The ring is configured to allow moisture to pass therethrough out of a steam path of the steam turbine.
摘要翻译：本文公开了一种用于蒸汽轮机的除湿系统，其包括在外壳中的至少一个穿孔环，其包围蒸汽轮机的阶段。环被配置为允许水分从蒸汽轮机的蒸汽路径中通过。

4. 发明申请

US20150361101A1 TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C 有权
标题翻译：四环杂环化合物及其用于治疗乙型肝炎的方法
公开(公告)号：US20150361101A1
公开(公告)日：2015-12-17
申请号：US14766462
申请日：2014-02-03
申请人： Xing DAI , Anandan PALANI , Shuwen HE , Linda L. BROCKUNIER , Ravi NARGUND , Karen MARCANTONO , Nicolas Zorn , Dong XIAO , Xuanjia PENG , Tao GUO , MERCK SHARP & DOHME CORP.
发明人： Xing Dai , Hong Liu , Anandan Palani , Shuwen He , Linda L. Brockunier , Ravi Nargund , Karen Marcantonio , Nicolas Zorn , Dong Xiao , Xuanjia Peng , Peng Li , Tao Guo
IPC分类号： C07D519/00 , C07D471/14 , A61K31/4375 , A61K31/5025 , A61K31/438 , A61K31/55 , C07D471/22 , C07D471/04 , C07D471/20 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/4375 , A61K31/438 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/14 , C07D471/20 , C07D471/22 , C07D487/14 , A61K2300/00
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的用途的式I化合物和抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。

5. 发明授权

US08691831B2 Heterocyclic aspartyl protease inhibitors 有权
标题翻译：杂环天门冬氨酰蛋白酶抑制剂
公开(公告)号：US08691831B2
公开(公告)日：2014-04-08
申请号：US13416140
申请日：2012-03-09
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula I are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中式I中的每个变量如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经退行性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

6. 发明授权

US08568090B2 System for reducing the level of erosion affecting a component 有权
标题翻译：降低影响组件的侵蚀水平的系统
公开(公告)号：US08568090B2
公开(公告)日：2013-10-29
申请号：US12632152
申请日：2009-12-07
申请人： Tao Guo , Jonathon E. Slepski , Kenneth M. Koza
发明人： Tao Guo , Jonathon E. Slepski , Kenneth M. Koza
IPC分类号： F01D9/00
CPC分类号： F01D9/041 , F01D5/147 , F01D5/18 , F01D25/32 , F05D2220/31 , F05D2260/602
摘要： A system for removing moisture from a steam/water mixture engaging a stationary component of a steam turbine. The system includes an airfoil located within a flow path of a steam turbine. The airfoil is configured for removing moisture from a steam/water mixture traveling in the flow path. To this end, the airfoil includes a cavity in flow communication with the steam path through at least one inlet and outlet opening, near the leading and trailing edge of the airfoil, respectively. Moisture and steam are extracted from the surface through the inlet openings, the steam and water are separated in the cavity, the separated water flows towards the bottom end, and the dry steam flows through the outlet opening and returns to the steam path. The dry steam blowing out of the trailing edge reduces the size of secondary droplets, and thereby prevents erosion.
摘要翻译：用于从与蒸汽轮机的固定部件接合的蒸汽/水混合物除去水分的系统。该系统包括位于蒸汽轮机的流动路径内的翼型件。翼型件构造成用于从在流动路径中行进的蒸汽/水混合物中除去水分。为此，翼型件分别包括通过至少一个入口和出口开口与翼型件的前缘和后缘接近的与蒸汽通道流体连通的空腔。水分和蒸汽通过入口从表面抽出，蒸汽和水在空腔中分离，分离的水流向底端，干蒸汽流过出口，返回到蒸汽通道。从后缘吹出的干燥蒸汽减小二次液滴的尺寸，从而防止侵蚀。

7. 发明申请

US20130196974A1 COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE 有权
标题翻译：用于治疗和预防呼吸道感染病毒性疾病的化合物
公开(公告)号：US20130196974A1
公开(公告)日：2013-08-01
申请号：US13561366
申请日：2012-07-30
申请人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
发明人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
IPC分类号： C07D493/10 , C07D487/04 , C07D413/04 , C07D407/14 , C07D401/04 , C07D417/14 , C07D417/04
CPC分类号： C07D493/10 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/107
摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 10，A，Q，X和Y如说明书和权利要求中所定义，及其作为治疗或预防呼吸道合胞体药物的用途病毒病。

8. 发明授权

US08483425B2 Geospatial information creating system and geospatial information creating method 有权
标题翻译：地理空间信息创建系统和地理空间信息创建方法
公开(公告)号：US08483425B2
公开(公告)日：2013-07-09
申请号：US12850816
申请日：2010-08-05
申请人： Tao Guo , Yoriko Kazama , Takashi Hino , Yoshiaki Kagawa
发明人： Tao Guo , Yoriko Kazama , Takashi Hino , Yoshiaki Kagawa
IPC分类号： G06K9/00
CPC分类号： G06K9/00637 , G06T7/12 , G06T7/73 , G06T17/05 , G06T2207/10032 , G06T2207/30184
摘要： To be precisely extracted a house footprint. There is provided a geospatial information creating system for extracting a footprint of a house from an aerial photograph, comprising a processor for executing a program, a memory for storing data required for executing the program, and a storage unit for storing the aerial photograph. The processor detects edges of an image based on a characteristic quantity of neighboring pixels in the aerial photograph stored in the storage unit; extracts an orientation of the house by analyzing directions of the detected edges; and generates a polygon of an outline of the house by using linear lines of the extracted orientation of the house.
摘要翻译：准确提取房屋足迹。提供了一种用于从空中照片提取房屋的占地面积的地理空间信息创建系统，包括用于执行程序的处理器，用于存储执行程序所需的数据的存储器和用于存储航空照片的存储单元。处理器基于存储在存储单元中的空中照片中的相邻像素的特征量来检测图像的边缘; 通过分析检测到的边缘的方向来提取房屋的方位; 并且通过使用所提取的房屋取向的线性线来生成房屋的轮廓的多边形。

9. 发明授权

US08433526B2 Method and system for steam quality monitoring 有权
标题翻译：蒸汽质量监测方法与系统
公开(公告)号：US08433526B2
公开(公告)日：2013-04-30
申请号：US12945680
申请日：2010-11-12
申请人： Binayak Roy , Tao Guo
发明人： Binayak Roy , Tao Guo
IPC分类号： G06F19/00
CPC分类号： G01N15/0205 , F01D21/003 , F22B35/16 , G01N21/534
摘要： A method of determining a steam quality of a wet steam located in an interior of a steam turbine includes emitting from an optical probe a plurality of wavelengths through the wet steam, measuring with the optical probe a wet steam intensity corresponding to each of the plurality of wavelengths emitted through the wet steam, determining an intensity ratio vector by dividing the wet steam intensity by a corresponding dry steam intensity for each of the plurality of wavelengths, successively applying scaling factors to the intensity ratio vector to obtain a scaled intensity ratio vector, calculating a suitable value for each of the scaling factors to obtain a plurality of residuals, determining a minimum residual of the plurality of residuals, determining a droplet size distribution by calculating the droplet number density corresponding to the minimum residual, and determining the steam quality based on the droplet size distribution.
摘要翻译：确定位于蒸汽涡轮机内部的湿蒸汽的蒸汽质量的方法包括通过湿蒸汽从光学探针发射多个波长，用光学探针测量与多个通过湿蒸汽发射的波长，通过将湿蒸汽强度除以对于多个波长中的每一个的相应的干蒸汽强度来确定强度比矢量，连续地将比例因子应用于强度比矢量，以获得比例的强度比矢量，计算用于获得多个残差的每个缩放因子的合适值，确定多个残差的最小残差，通过计算对应于最小残差的液滴数密度来确定液滴尺寸分布，以及基于液滴尺寸分布。

10. 发明申请

US20130018066A1 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 有权
公开(公告)号：US20130018066A1
公开(公告)日：2013-01-17
申请号：US13551315
申请日：2012-07-17
申请人： Zhaoning Zhu , Brian A. McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert Mazzola , John Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X.H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
发明人： Zhaoning Zhu , Brian A. McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert Mazzola , John Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X.H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
IPC分类号： A61K31/4245 , A61P9/00 , A61P25/00 , C07D413/10 , A61P31/18 , A61P33/02 , A61K31/505 , C07D271/07 , A61K31/4439 , A61P25/28
CPC分类号： C07D233/46 , C07D233/70 , C07D233/88 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

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