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11. 发明授权

US3978863A Expanding tip embolectomy catheter with indicator balloon 失效
标题翻译：带指示器气囊扩张尖端止血导管
公开(公告)号：US3978863A
公开(公告)日：1976-09-07
申请号：US550703
申请日：1975-02-18
申请人： Bruce E. Fettel , Samuel Burd
发明人： Bruce E. Fettel , Samuel Burd
IPC分类号： A61B17/12 , A61B19/00 , A61F2/958 , A61M25/01 , A61M25/00
CPC分类号： A61M25/0108 , A61B17/12109 , A61B17/12136 , A61M25/09033 , A61M25/1018 , A61B90/39 , A61M2025/09166 , A61M2025/09183 , A61M2025/109
摘要： A surgical catheter, exemplified in the preferred embodiment as an embolectomy catheter, which has an expandable tip, an X-ray opaque position indicator, and an expandable balloon to indicate when the expandable tip is inflated is disclosed.
摘要翻译：公开了一种手术导管，其在优选实施例中示例为具有可扩张尖端，X射线不透明位置指示器和可膨胀气囊的可选择性插入导管，以指示可膨胀尖端何时膨胀。

12. 发明授权

US06902703B2 Integrated sample-processing system 失效
标题翻译：综合样本处理系统
公开(公告)号：US06902703B2
公开(公告)日：2005-06-07
申请号：US09777343
申请日：2001-02-05
申请人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Lev J. Leytes , Samuel Burd
发明人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Lev J. Leytes , Samuel Burd
IPC分类号： B01L3/00 , C07F15/00 , C12Q1/68 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , B01L3/02
CPC分类号： G01N35/028 , B01L3/50853 , C07F15/0053 , C12Q1/6816 , C12Q1/6827 , G01N21/253 , G01N21/645 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , Y10T436/11 , Y10T436/119163 , Y10T436/25 , Y10T436/2575 , C12Q2565/107
摘要： The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.
摘要翻译：本发明提供了用于制备和/或分析样品的综合样品处理系统及其组件。组件可以包括传输模块，流体模块和分析模块等。

13. 发明授权

US5164064A HPE capillary cartridge with exposed retractable capillary ends 失效
标题翻译： HPE毛细管筒带有可伸缩的毛细管末端
公开(公告)号：US5164064A
公开(公告)日：1992-11-17
申请号：US686644
申请日：1991-04-17
申请人： Rand Dill , Samuel Burd
发明人： Rand Dill , Samuel Burd
IPC分类号： G01N27/447
CPC分类号： G01N27/44708 , G01N27/44704
摘要： A capillary cartridge for high performance electrophoresis is constructed in two parts--an internal cooling block and an external housing, both constructed to permit sliding of the cooling block within the housing to provide two positions, one of which is a retracted position in which the exposed ends of the capillary, which protrude from the cooling block, are protected by the housing, and the other an extended position in which the exposed ends of the capillary extend beyond the cooling block for access for sample loading and connections to electrode buffers. An improved coolant flow channel inside the cartridge is also included.
摘要翻译：用于高性能电泳的毛细管盒分成两部分：一个内部冷却块和一个外部壳体，它们均构造成允许冷却块在壳体内滑动以提供两个位置，其中一个位置处于缩回位置，毛细管的从冷却块突出的端部被壳体保护，另一个是毛细管的暴露端延伸超出冷却块的延伸位置，用于进行样品加载和连接到电极缓冲器。还包括在筒内的改进的冷却剂流动通道。

14. 发明授权

US4699706A Method and apparatus for extraction of species from electrophoresis media 失效
标题翻译：从电泳介质提取物种的方法和装置
公开(公告)号：US4699706A
公开(公告)日：1987-10-13
申请号：US868964
申请日：1986-05-30
申请人： Samuel Burd , Daniel Y. Chu
发明人： Samuel Burd , Daniel Y. Chu
IPC分类号： G01N27/447 , G01N27/28 , B01D13/00 , B01D35/06
CPC分类号： G01N27/4473
摘要： Electrophoretic extraction of molecular species from a separation medium such as a gel segment is achieved by placing the separation medium in a tube closed at one end by a retaining material such as glass frit, and sealing the closed end of the tube against the mouth of a receiving cup which has a semi-permeable membrane (such as a dialysis membrane) for its bottom. The tube with receiving cup attached is inserted in a tube electrophoresis cell such as those commonly used in analytical laboratories. As current passes through the tube, the molecular species migrates from the separation medium to pass through the retaining frit and collect on the membrane for subsequent recovery.
摘要翻译：通过将分离介质放置在一端通过保持材料如玻璃料封闭的管中，将分离介质从凝胶片段分离介质进行电泳提取，并将管的封闭端密封在一端用于其底部具有半透膜（例如透析膜）的接收杯。将带有接收杯的管插入管式电泳池，如分析实验室常用的那些。当电流通过管时，分子物质从分离介质迁移通过保留玻璃料并收集在膜上用于随后的回收。

15. 发明授权

US4184489A Infusion tube access site 失效
标题翻译：输液管检查点
公开(公告)号：US4184489A
公开(公告)日：1980-01-22
申请号：US856383
申请日：1977-12-01
申请人： Samuel Burd
发明人： Samuel Burd
IPC分类号： A61M39/04 , A61M5/00 , A61M1/03 , F16L11/12
CPC分类号： A61M39/04
摘要： An extra corporeal blood tube injection site comprising a smooth blood conduit or tube, an elongated elastomeric sleeve surrounding a section of the tube, and a C-shaped needle-impenetrable member extending along and partially surrounding the sleeve which generates forces within the portion of the sleeve that is not covered by the C-shaped member sufficient to prevent air leakage into, or blood leakage from, the tube during needle penetration or after withdrawal of a needle.
摘要翻译：一个额外的体液血管注射部位，包括一个光滑的血液导管或管，围绕管的一部分的细长的弹性体套筒，以及沿该套筒延伸并且部分围绕该套筒的C形针不可渗透构件，其在该部分内产生力套筒不被C形构件覆盖，足以防止在针穿透期间或在抽针之后空气泄漏到管中或从管中泄漏。

16. 发明授权

US09243288B2 Cartridge with lysis chamber and droplet generator 有权
标题翻译：带裂解室和液滴发生器的筒
公开(公告)号：US09243288B2
公开(公告)日：2016-01-26
申请号：US13250815
申请日：2011-09-30
申请人： Kevin Dean Ness , Samuel Burd , Benjamin Joseph Hindson , Phillip Belgrader , Billy W. Colston, Jr.
发明人： Kevin Dean Ness , Samuel Burd , Benjamin Joseph Hindson , Phillip Belgrader , Billy W. Colston, Jr.
IPC分类号： C12Q1/68 , C12M3/00 , B01F3/08 , B01F13/00 , B01L3/02 , B01L3/00 , G01N21/3563 , G01N21/64 , B01L7/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus, methods, compositions, kits, and software, for preparing, reacting, detecting, and/or analyzing samples in droplet-based assay systems, among others. The disclosure emphasizes, but is not limited to, a disposable cartridge with lysis chamber and droplet chamber, particularly for use in droplet-based assays.
摘要翻译：用于制备，反应，检测和/或分析基于液滴的测定系统中的样品的装置，方法，组合物，试剂盒和软件等。本公开强调但不限于具有裂解室和液滴室的一次性盒，特别用于基于液滴的测定。

17. 发明授权

US08236255B2 Slide treatment apparatus and methods for use 有权
标题翻译：滑动治疗仪和使用方法
公开(公告)号：US08236255B2
公开(公告)日：2012-08-07
申请号：US11002164
申请日：2004-12-02
申请人： Glenn K. Takayama , Ken K. Tseung , Norman K. Rhett , Wai Bun Wong , Samuel Burd , George A. Harter , Douglas C. Morrison
发明人： Glenn K. Takayama , Ken K. Tseung , Norman K. Rhett , Wai Bun Wong , Samuel Burd , George A. Harter , Douglas C. Morrison
IPC分类号： B01L3/00
CPC分类号： G01N1/312
摘要： An apparatus for treating slides has a base with a cavity, and a heater is located on a surface of the cavity. A tank, which supports a slide rack with the slides submerged in a slide treatment solution, is placed in the cavity with a tank surface immediately adjacent the heater. A temperature sensor is mounted in the base and is operable to provide a feedback signal representing a temperature of the liquid in the tank. A cover is removably hinged on the base to cover the tank. A control system is connected to the heater and the temperature sensor and has a user input/output that is operable to select a set temperature of the liquid and a cycle time.
摘要翻译：一种用于处理滑块的装置具有带空腔的基座，并且加热器位于空腔的表面上。支撑滑动架的油箱，其中滑块浸没在滑动处理溶液中，并且与紧邻加热器的罐表面放置在空腔中。温度传感器安装在基座中并且可操作以提供表示罐中的液体的温度的反馈信号。盖可拆卸地铰接在基座上以覆盖水箱。控制系统连接到加热器和温度传感器，并且具有可操作以选择液体的设定温度和循环时间的用户输入/输出。

18. 发明申请

US20120028311A1 CARTRIDGE WITH LYSIS CHAMBER AND DROPLET GENERATOR 有权
标题翻译：带有LYSIS CHAMBER和DROPLET发电机的盒子
公开(公告)号：US20120028311A1
公开(公告)日：2012-02-02
申请号：US13250815
申请日：2011-09-30
申请人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Samuel Burd , Phillip Belgrader
发明人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Samuel Burd , Phillip Belgrader
IPC分类号： C12P19/34 , C12M1/40
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus, methods, compositions, kits, and software, for preparing, reacting, detecting, and/or analyzing samples in droplet-based assay systems, among others. The disclosure emphasizes, but is not limited to, a disposable cartridge with lysis chamber and droplet chamber, particularly for use in droplet-based assays.
摘要翻译：用于制备，反应，检测和/或分析基于液滴的测定系统中的样品的装置，方法，组合物，试剂盒和软件等。本公开强调但不限于具有裂解室和液滴室的一次性盒，特别用于基于液滴的测定。

19. 发明申请

US20120028298A1 System and method for automated tissue slide processing and data management 审中-公开
标题翻译：自动组织幻灯片处理和数据管理的系统和方法
公开(公告)号：US20120028298A1
公开(公告)日：2012-02-02
申请号：US12804833
申请日：2010-07-28
申请人： Glenn Takayama , Xiangchun Ye , Samuel Burd , George Harter , Douglas C. Morrison , Roger McIntosh
发明人： Glenn Takayama , Xiangchun Ye , Samuel Burd , George Harter , Douglas C. Morrison , Roger McIntosh
IPC分类号： G01N1/30 , G01N1/31
CPC分类号： G01N1/312 , G01N35/00732 , G01N2035/00782
摘要： To simplify the process of preparing tissue specimens on slides, an advanced automated slide processing device is disclosed. The automated slide processing device comprises a robotic arm that both senses input and delivers output. The input sensing may include sensing radio frequency identifiers (RFIDs). The output includes arm movements, the acquisition and delivery of reagents. A control program runs on a computer system for controlling the robotic arm. The robotic arm delivers reagents to individual slide modules that each feature a controllable heating element and a controllable chamber unit that can form a small chamber on the top of a slide for retaining chemical reagents.
摘要翻译：为了简化在载玻片上制备组织标本的过程，公开了一种先进的自动化载玻片处理装置。自动幻灯片处理装置包括一个既能感测输入又输出输出的机器人手臂。输入感测可以包括感测射频标识符（RFID）。产量包括手臂运动，采集和交付试剂。控制程序在用于控制机器臂的计算机系统上运行。机器手臂将试剂递送到单独的滑动模块，每个滑动模块具有可控制的加热元件和可控制的腔室单元，其可以在滑块的顶部上形成用于保留化学试剂的小室。

20. 发明授权

US4985129A Apparatus for capillary electrophoresis 失效
标题翻译：毛细管电泳仪
公开(公告)号：US4985129A
公开(公告)日：1991-01-15
申请号：US279382
申请日：1988-12-02
申请人： Samuel Burd
发明人： Samuel Burd
IPC分类号： G01N27/447
CPC分类号： G01N27/44743 , G01N27/44704 , G01N27/44721
摘要： A capillary tube for use in high performance capillary electrophoresis is enclosed in a cartridge of generally planar configuration, formed by two flat plates joined together along raised edges to define a shallow enclosed chamber to retain the looped capillary tube, the plates having aligned windows between which a segment of the capillary tube passes, thereby forming a light path for zone detection. The termini of the capillary are embedded in fittings extending from the exterior of the cartridge, which mate with complementary fittings on inlet and outlet blocks which contain buffer reservoirs with controlled hydrostatic heads. The inlet block is specially equipped with ducts and fittings to permit filling of the capillary, injection of the sample into the capillary, changing of the solution in the buffer reservoir, and flushing out of the entire block without disconnecting the block from the capillary cartridge. By securing the cartridge containing the capillary tube into its holder, the capillary tube is correctly aligned in the detector light path.
摘要翻译：用于高性能毛细管电泳的毛细管被封装在大体上平面构型的盒中，由沿着凸起边缘连接在一起的两个平板形成，以限定一个浅的封闭室，以保持环状的毛细管，毛细管的一段通过，从而形成用于区域检测的光路。毛细管的末端嵌入从筒的外部延伸的配件中，该配件与入口和出口块上的互补配件相配合，该配件包含具有受控流体静压头的缓冲储存器。入口块特别配备有管道和配件，以允许填充毛细管，将样品注入毛细管，改变缓冲液储存器中的溶液，并从整个块中冲洗，而不要将块与毛细管柱断开。通过将含有毛细管的药筒固定到其保持器中，毛细管在检测器光路中正确对准。

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