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11. 发明申请

US20100298293A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE 失效
标题翻译：替代奥昔洛芬及其使用
公开(公告)号：US20100298293A1
公开(公告)日：2010-11-25
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/553 , A01N1/02 , A61K31/5377 , A61K31/497 , A61K31/513 , A61K31/454 , A61K31/4439 , C07D413/12 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译：本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

12. 发明申请

US20090176842A1 SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS 有权
标题翻译：作为抗病毒剂的取代的芳香烃化物
公开(公告)号：US20090176842A1
公开(公告)日：2009-07-09
申请号：US12203793
申请日：2008-09-03
申请人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
发明人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
IPC分类号： A61K31/4439 , C07D413/04 , C07D213/73 , A61P31/12
CPC分类号： C07D413/04 , C07D213/73
摘要： The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的取代芳基磺酰胺及其制备方法及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

13. 发明授权

US07517354B2 Medical instrument 有权
标题翻译：医疗仪器
公开(公告)号：US07517354B2
公开(公告)日：2009-04-14
申请号：US10872846
申请日：2004-06-21
申请人： Dieter Lang
发明人： Dieter Lang
IPC分类号： A61B17/28
CPC分类号： A61B17/29 , A61B10/06 , A61B17/1608 , A61B2017/2939
摘要： The invention relates to a medical instrument having a hollow shaft (2) and, positioned on its proximal end, a handle (3) consisting of at least two gripping members (3a, 3b) and, on its distal end, a tool consisting of at least two jaw members (5a, 5b). The instrument's jaw members (5a, 5b) are stationed at a lateral angle to the longitudinal axis of the shaft (2) so that at least one jaw member (5a) of the tool (5) can be moved for opening and closing by means of a gripping member (3b) of the handle (3) that can be rotated with respect to the at least one other jaw member (5b) of the tool (5) and the at least one movable jaw member (5a) and the corresponding gripping member (3b) of the handle (3) serving to move the jaw member (5a) are connected to one another by a compression-tension element (8) positioned in the hollow shaft (2). To ensure that power is transmitted precisely and without free play to the tool, it is proposed with the invention that the compression-tension element (8) and the respective jaw member (5a) of the tool (5) are connected to one another by a transmission lever (7).
摘要翻译：本发明涉及一种具有中空轴（2）的医疗器械，并且在其近端处设置有由至少两个夹持构件（3a，3b）组成的手柄（3），并且在其远端上包括由至少两个钳口构件（5a，5b）。仪器的钳口构件（5a，5b）以与轴（2）的纵向轴线成横向的角度安置，使得工具（5）的至少一个钳口构件（5a）可以通过装置移动以打开和关闭手柄（3）的夹持构件（3b）可相对于工具（5）的至少一个其它钳口构件（5b）旋转，并且至少一个可移动钳口构件（5a）和相应的用于移动钳口构件（5a）的手柄（3）的夹持构件（3b）通过位于空心轴（2）中的压缩张力元件（8）彼此连接。为了确保功率精确地传递并且没有自由地传播到工具，本发明提出了压缩张力元件（8）和工具（5）的相应的钳口构件（5a）通过传动杆（7）。

14. 发明授权

US07427617B2 Morpoline-bridged indazole derivatives 失效
标题翻译：吗啉桥联吲唑衍生物
公开(公告)号：US07427617B2
公开(公告)日：2008-09-23
申请号：US10528601
申请日：2003-09-16
申请人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard König , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
发明人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard König , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
IPC分类号： C07D413/14 , A61K31/5386
CPC分类号： C07D471/04
摘要： The present invention relates to novel morpholine-bridged indazole derivatives having the formula which stimulate soluble guanylate cyclase, to a process for the preparation thereof, and to pharmaceutical compositions containing them. These compounds are useful for the treatment of disorders of the central nervous system.
摘要翻译：本发明涉及具有刺激可溶性鸟苷酸环化酶的式的新型吗啉桥连吲唑衍生物，其制备方法和含有它们的药物组合物。这些化合物可用于治疗中枢神经系统疾病。

15. 发明授权

US07410973B2 4-amino-substituted pyrimidine derivatives 失效
标题翻译： 4-氨基取代的嘧啶衍生物
公开(公告)号：US07410973B2
公开(公告)日：2008-08-12
申请号：US10521540
申请日：2003-07-07
申请人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard König , Johannes-Peter Stasch , Elke Stahl , Rudy Schreiber , Frank Wunder , Dieter Lang
发明人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard König , Johannes-Peter Stasch , Elke Stahl , Rudy Schreiber , Frank Wunder , Dieter Lang
IPC分类号： C07D471/04 , A61K31/505
CPC分类号： C07D471/04
摘要： The present invention relates to novel 4-amino-substituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of central nervous system diseases.
摘要翻译：本发明涉及刺激可溶性鸟苷酸环化酶的新型4-氨基取代的嘧啶衍生物，其制备方法及其用于制备药物的用途，特别是用于治疗中枢神经系统疾病的药物。

16. 发明申请

US20070293478A1 Substituted quinolones 有权
标题翻译：取代喹诺酮类
公开(公告)号：US20070293478A1
公开(公告)日：2007-12-20
申请号：US11655589
申请日：2007-01-19
申请人： Holger Zimmermann , Rudolph Schohe-loop , Kerstin Henninger , Daniela Paulsen , Thomas Roelle , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Johannes Koebberling , Marcus Bauser
发明人： Holger Zimmermann , Rudolph Schohe-loop , Kerstin Henninger , Daniela Paulsen , Thomas Roelle , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Johannes Koebberling , Marcus Bauser
IPC分类号： A61K31/497 , A61K31/5377 , A61K31/5513 , A61P31/22 , C07D243/08 , C07D401/02 , C07D413/14
CPC分类号： C07D215/56 , C07D401/04
摘要： The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

17. 外观设计

USD548836S1 Medical probe 有权
公开(公告)号：USD548836S1
公开(公告)日：2007-08-14
申请号：US29244328
申请日：2005-12-08
申请人： Dieter Lang , Michael J Strobel , Rich Hart
设计人： Dieter Lang , Michael J Strobel , Rich Hart

18. 发明授权

US07229456B2 Medical instrument for dissecting tissue 有权
标题翻译：用于解剖组织的医疗器械
公开(公告)号：US07229456B2
公开(公告)日：2007-06-12
申请号：US10196109
申请日：2002-07-16
申请人： Dieter Lang , Uwe Bacher , Fridolin Anders
发明人： Dieter Lang , Uwe Bacher , Fridolin Anders
IPC分类号： A61B17/32
CPC分类号： A61B17/1611 , A61B17/1688 , A61B2017/2902 , A61B2017/2904
摘要： A medical instrument for dissecting tissue in the human or animal body comprises a shaft. At least one movable tool is arranged at a distal end of the shaft. At least one movable grip element is arranged at a proximal end of the shaft. A force transmission element extends along the shaft, which force transmission element is movable relative to the latter and transmits thrust and/or tension forces and whose proximal end is non-positively joined to the at least one movable grip element and whose distal end is non-positively joined to the at least one movable tool. The shaft is further provided with a bend at least one point between the distal end and the proximal end. The force transmission element is configured, at least in the region of the bend, as a flexible tubular element conforming to the bend, which is guided in contact with the shaft. According to a second variant, a flattened and flexible configuration is given to the force transmission element in the region of the bend, at least locally transversely to the plane of curvature of the bend, and the force transmission element extends continuously in axial direction, transversely to the plane of curvature, at least over the inner diameter of the shaft in the region of the bend.
摘要翻译：用于解剖人或动物体中的组织的医疗器械包括轴。至少一个可移动工具布置在轴的远端。至少一个可动夹紧元件布置在轴的近端。力传递元件沿着轴延伸，该力传递元件相对于该传动元件可移动，并且传递推力和/或张力，并且其近端与所述至少一个可动把手元件非正向接合，并且其远端不是 - 正向连接到所述至少一个可移动工具。轴还在远端和近端之间至少有一个点设有弯曲部。至少在弯曲区域中，力传递元件被构造为与弯曲部接触的引导件的柔性管状元件。根据第二种变型，在弯曲区域中至少部分横向于弯曲曲面的局部向力传递元件施加平坦且柔性的构造，并且力传递元件在轴向方向上连续延伸至少在弯曲区域内的轴的内径上。

19. 发明授权

US07196086B2 Substituted dihydroquinazolines 有权
公开(公告)号：US07196086B2
公开(公告)日：2007-03-27
申请号：US10832109
申请日：2004-04-26
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süssmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Dieter Lang , Peter Nell
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süssmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Dieter Lang , Peter Nell
IPC分类号： A61K31/517 , C07D43/04
CPC分类号： C07D239/84
摘要： The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

20. 发明申请

US20060241127A1 Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效
标题翻译：杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂
公开(公告)号：US20060241127A1
公开(公告)日：2006-10-26
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
IPC分类号： A61K31/519 , A61K31/513 , A61K31/506 , C07D487/04 , C07D403/02
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译：本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。本发明化合物抑制Rho-激酶。

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