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11. 发明授权

US09074204B2 Nucleic acid encoding reactions 有权
标题翻译：核酸编码反应
公开(公告)号：US09074204B2
公开(公告)日：2015-07-07
申请号：US13476911
申请日：2012-05-21
申请人： Megan Anderson , Peilin Chen , Brian Fowler , Robert C. Jones , Fiona Kaper , Ronald Lebofsky , Andrew May
发明人： Megan Anderson , Peilin Chen , Brian Fowler , Robert C. Jones , Fiona Kaper , Ronald Lebofsky , Andrew May
IPC分类号： C12Q1/68 , C12N15/10 , C12N15/65 , C12N15/66
CPC分类号： C12Q1/6855 , C12N15/10 , C12N15/1065 , C12N15/65 , C12N15/66 , C12Q1/686 , C12Q1/6874
摘要： Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput DNA sequencing are generated. In other embodiments, information about a reaction mixture is encoded into a reaction product. Also described herein are methods and kits useful for amplifying one or more target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing. In particular embodiments, methods of the invention entail additionally carrying out bidirectional DNA sequencing. Also described herein are methods for encoding and detecting and/or quantifying alleles by primer extension.
摘要翻译：本文所描述的方法可用于掺入一个或多个衔接子和/或核苷酸标签和/或条形码核苷酸序列，一个或多个靶核苷酸序列。在具体实施方案中，产生具有适配器（例如适合用于高通量DNA测序）的核酸片段。在其它实施方案中，关于反应混合物的信息被编码成反应产物。本文还描述了可用于扩增一种或多种靶核酸以准备应用如双向核酸测序的方法和试剂盒。在具体实施方案中，本发明的方法还需要进行双向DNA测序。本文还描述了通过引物延伸来编码和检测和/或定量等位基因的方法。

12. 发明授权

US07426867B2 Electromagnetic acoustic transducers for use in ultrasound inspection systems 有权
标题翻译：用于超声检查系统的电磁换能器
公开(公告)号：US07426867B2
公开(公告)日：2008-09-23
申请号：US11240056
申请日：2005-09-30
申请人： Roman Heinrich Koch , Andrew May , Jian Li
发明人： Roman Heinrich Koch , Andrew May , Jian Li
IPC分类号： G01N9/24 , G01N27/72
CPC分类号： G01N29/2412 , B06B1/04 , G01N2291/0422
摘要： An ultrasound system for inspecting an object is provided. The ultrasound system includes an electromagnetic acoustic transducer (EMAT) and a pulser-receiver system. The EMAT is configured to generate acoustic signals representative of the area being inspected and comprises a flux concentrating non-conductive pole piece separating a radio frequency (RF) coil and a magnet. The pulser-receiver system is coupled to the EMAT and configured to receive the acoustic signals and convert the acoustic signal to electrical signals.
摘要翻译：提供了一种用于检查物体的超声波系统。超声系统包括电磁声换能器（EMAT）和脉冲发生器 - 接收器系统。 EMAT被配置为产生表示被检查区域的声学信号，并且包括分离射频（RF）线圈和磁体的磁通集中非导电极片。脉冲发生器 - 接收器系统耦合到EMAT并且被配置为接收声信号并将声信号转换成电信号。

13. 发明申请

US20070074572A1 Electromagnetic acoustic transducers for use in ultrasound inspection systems 有权
标题翻译：用于超声检查系统的电磁换能器
公开(公告)号：US20070074572A1
公开(公告)日：2007-04-05
申请号：US11240056
申请日：2005-09-30
申请人： Roman Koch , Andrew May , Jian Li
发明人： Roman Koch , Andrew May , Jian Li
IPC分类号： G01N29/00
CPC分类号： G01N29/2412 , B06B1/04 , G01N2291/0422
摘要： An ultrasound system for inspecting an object is provided. The ultrasound system includes an electromagnetic acoustic transducer (EMAT) and a pulser-receiver system. The EMAT is configured to generate acoustic signals representative of the area being inspected and comprises a flux concentrating non-conductive pole piece separating a radio frequency (RF) coil and a magnet. The pulser-receiver system is coupled to the EMAT and configured to receive the acoustic signals and convert the acoustic signal to electrical signals.
摘要翻译：提供了一种用于检查物体的超声波系统。超声系统包括电磁声换能器（EMAT）和脉冲发生器 - 接收器系统。 EMAT被配置为产生表示被检查区域的声学信号，并且包括分离射频（RF）线圈和磁体的磁通集中非导电极片。脉冲发生器 - 接收器系统耦合到EMAT并且被配置为接收声信号并将声信号转换成电信号。

14. 发明授权

US07044103B2 Fuel quantity modulation in pilot ignited engines 有权
标题翻译：先导点火发动机燃油量调制
公开(公告)号：US07044103B2
公开(公告)日：2006-05-16
申请号：US10919419
申请日：2004-08-16
申请人： Andrew May
发明人： Andrew May
IPC分类号： F02B3/00 , F02M21/02 , F02M43/00
CPC分类号： F02D41/3047 , F02D19/10 , F02D41/0025 , F02D41/008 , F02D41/3094 , Y02T10/36
摘要： An engine system includes a first fuel regulator adapted to control an amount of a first fuel supplied to the engine, a second fuel regulator adapted to control an amount of a second fuel supplied to the engine concurrently with the first fuel being supplied to the engine, and a controller coupled to at least the second fuel regulator. The controller is adapted to determine the amount of the second fuel supplied to the engine in a relationship to the amount of the first fuel supplied to the engine to operate in igniting the first fuel at a specified time in steady state engine operation and adapted to determine the amount of the second fuel supplied to the engine in a manner different from the relationship at steady state engine operation in transient engine operation.
摘要翻译：发动机系统包括适于控制供应到发动机的第一燃料的量的第一燃料调节器，适于控制与供应给发动机的第一燃料同时供应给发动机的第二燃料的量的第二燃料调节器，以及耦合到至少第二燃料调节器的控制器。控制器适于确定供应给发动机的第二燃料的量与供应给发动机的第一燃料的量相关联，以在稳定状态的发动机运行中在指定时间点燃第一燃料以操作，并适于确定在瞬时发动机运转中以与稳态发动机运转的关系不同的方式供给发动机的第二燃料的量。

15. 发明授权

US07005851B2 Methods and apparatus for inspection utilizing pulsed eddy current 失效
标题翻译：使用脉冲涡流检查的方法和装置
公开(公告)号：US07005851B2
公开(公告)日：2006-02-28
申请号：US10675822
申请日：2003-09-30
申请人： Andrew May , Changting Wang , Yuri Alexeyevich Plotnikov
发明人： Andrew May , Changting Wang , Yuri Alexeyevich Plotnikov
IPC分类号： G01N27/72
CPC分类号： G01N27/9046
摘要： In some aspects, the present invention provides a method for estimating at least one measurement/object property of a metal object. The method includes generating a time-varying eddy current in a wall of the metal object utilizing a pulsed-signal transmitter. The method further includes measuring the time-varying eddy current, fitting the time-varying measured eddy current to a parameterized polynomial, and interpreting the parameterized polynomial to determine one or more measurement/object properties of the metal object.
摘要翻译：在一些方面，本发明提供了一种用于估计金属物体的至少一个测量/物体特性的方法。该方法包括利用脉冲信号发射器在金属物体的壁上产生时变涡流。该方法还包括测量时变涡流，将随时间变化的测量的涡流拟合到参数化多项式，以及解释参数化多项式以确定金属物体的一个或多个测量/物体特性。

16. 发明授权

US08422632B2 Method and system for crystallization and X-ray diffraction screening 有权
$Method and system for crystallization and X-ray diffraction screening$
标题翻译：用于结晶和X射线衍射筛选的方法和系统
公开(公告)号：US08422632B2
公开(公告)日：2013-04-16
申请号：US13168041
申请日：2011-06-24
申请人： Brian Fowler , Andrew May
发明人： Brian Fowler , Andrew May
IPC分类号： G01N23/20
CPC分类号： G01N23/20025
摘要： An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.
摘要翻译：集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。第一结构被配置为提供通过多个通道的一种或多种材料的流动。集成流体回路还包括耦合到衬底层的第二结构。第二结构包括被配置为接收致动压力的多个控制通道。集成流体回路的特征在于厚度小于1.5mm。

17. 发明申请

US20100242936A1 Controlling Exhaust Gas Recirculation 有权
标题翻译：控制排气再循环
公开(公告)号：US20100242936A1
公开(公告)日：2010-09-30
申请号：US12415026
申请日：2009-03-31
申请人： James Richard Zurlo , Kevin Paul Konkle , Andrew May
发明人： James Richard Zurlo , Kevin Paul Konkle , Andrew May
IPC分类号： F02D41/00 , F02M25/07
CPC分类号： F02D41/0052 , F02D41/187 , F02D2200/0411 , Y02T10/47
摘要： In controlling an engine, an amount of an intake charge provided, during operation of the engine, to a combustion chamber of the engine is determined. The intake charge includes an air component, a fuel component and a diluent component. An amount of the air component of the intake charge is determined. An amount of the diluent component of the intake charge is determined utilizing the amount of the intake charge, the amount of the air component and, in some instances, the amount of the fuel component. An amount of a diluent supplied to the intake charge is adjusted based at least in part on the determined amount of diluent component of the intake charge.
摘要翻译：在控制发动机时，确定在发动机运转期间向发动机的燃烧室提供的进气量。进气装置包括空气部件，燃料部件和稀释剂部件。确定进气量的空气分量的量。使用进气量的量，空气成分的量以及在某些情况下燃料成分的量来确定进气量的稀释剂成分的量。至少部分地基于确定的进料量的稀释剂组分的量来调节供应到进气装置的稀释剂的量。

18. 发明申请

US20050075800A1 System and method for monitoring defects in structures 失效
公开(公告)号：US20050075800A1
公开(公告)日：2005-04-07
申请号：US10664196
申请日：2003-09-17
申请人： Thomas Batzinger , Andrew May , Peter Allison , Carl Lester
发明人： Thomas Batzinger , Andrew May , Peter Allison , Carl Lester
IPC分类号： G01B5/28 , G01B7/06 , G01B7/28 , G01N27/20
CPC分类号： G01B7/281
摘要： A system and method for monitoring defects in a structure are provided. The system includes a power supply for supplying an electric current to a monitoring area of the structure and a reference; a measurement circuit for measuring a potential drop across at least two contact points of the monitoring area and at least two contact points of the reference; and a processor adapted to determine a ratio of the monitoring area potential drop to the reference potential drop indicative of a percentage change in a thickness of the structure. The method includes the steps of supplying the current to the monitoring area and the reference; measuring a first potential drop across the monitoring area and the reference; and determining the ratio indicative of the percentage change in the thickness of the structure.

19. 发明授权

US09103825B2 Microfluidic assay devices and methods 有权
标题翻译：微流控测定装置及方法
公开(公告)号：US09103825B2
公开(公告)日：2015-08-11
申请号：US12764819
申请日：2010-04-21
申请人： Hany Ramez Nassef , Hou-Pu Chou , Michael Lucero , Andrew May , Kathy Yokobata
发明人： Hany Ramez Nassef , Hou-Pu Chou , Michael Lucero , Andrew May , Kathy Yokobata
IPC分类号： B01L3/00 , G01N33/543 , F16K99/00 , G01N33/53
CPC分类号： G01N33/54366 , B01J2219/00286 , B01J2219/00317 , B01J2219/00389 , B01J2219/00398 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L2300/0816 , B01L2300/0874 , B01L2300/123 , B01L2400/0487 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N33/5302
摘要： A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies.
摘要翻译：微流体装置适于执行许多同时结合测定，包括但不限于免疫学实验，例如ELISA测定，初级和第二抗体之间的最小串扰。

20. 发明申请

US20140227691A1 NUCLEIC ACID ISOLATION METHODS 审中-公开
标题翻译：核酸分离方法
公开(公告)号：US20140227691A1
公开(公告)日：2014-08-14
申请号：US13977622
申请日：2011-05-16
申请人： Andrew May , Alain Mir , Ramesh Ramakrishnan , Bernhard G. Zimmermann
发明人： Andrew May , Alain Mir , Ramesh Ramakrishnan , Bernhard G. Zimmermann
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/00
CPC分类号： C12P19/34 , C07H21/00 , C12Q1/6806 , C12Q1/6869 , C12Q2600/118 , C12Q2565/113 , C12Q2527/125 , C12Q2525/204 , C12Q2525/307 , C12Q2525/15 , C12Q2521/507
摘要： The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal DNA in a maternal sample or apoptic DNA in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.
摘要翻译：本发明提供了用于选择性富集来自癌症患者的生物样品中的母体样品中的短核酸例如胎儿DNA的生物样品或随机分析用于基因型，突变和/ 或非整倍体。

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