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11. 发明授权

US06890347B2 Disposable cassette for intravascular heat exchange catheter 有权
标题翻译：一次性用于血管内热交换导管
公开(公告)号：US06890347B2
公开(公告)日：2005-05-10
申请号：US10628055
申请日：2003-07-25
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
IPC分类号： A61B17/00 , A61B17/22 , A61F2/958 , A61F7/00 , A61F7/10 , A61F7/12
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

12. 发明授权

US06679906B2 Catheter system with on-board temperature probe 有权
公开(公告)号：US06679906B2
公开(公告)日：2004-01-20
申请号：US09905389
申请日：2001-07-13
申请人： Amy L. Hammack , Jeff P. Callister , Paul M. Stull , Alex T. Roth , William S. Tremulis
发明人： Amy L. Hammack , Jeff P. Callister , Paul M. Stull , Alex T. Roth , William S. Tremulis
IPC分类号： A61F712
CPC分类号： A61F7/12 , A61B2017/00084 , A61B2017/00088 , A61B2017/00867 , A61F2007/0054 , A61F2007/0096 , A61F2007/126
摘要： A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a temperature probe having a distal end that extends from the catheter body, thereby monitoring the temperature of blood flowing within the blood vessel.

13. 发明授权

US06401720B1 Method and apparatus for thoracoscopic intracardiac procedures 失效
公开(公告)号：US06401720B1
公开(公告)日：2002-06-11
申请号：US09411095
申请日：1999-10-04
申请人： John H. Stevens , Bruce A. Reitz , Alex T. Roth , William S. Peters , Hanson S. Gifford
发明人： John H. Stevens , Bruce A. Reitz , Alex T. Roth , William S. Peters , Hanson S. Gifford
IPC分类号： A61B1900
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/2909 , A61B17/320016 , A61B17/3211 , A61B17/3417 , A61B17/3468 , A61B18/1442 , A61B18/1482 , A61B18/1492 , A61B90/37 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00349 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00867 , A61B2017/00907 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/2946 , A61B2017/306 , A61B2017/3405 , A61B2017/3486 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00898 , A61B2018/00982 , A61B2018/1465 , A61F2/2427 , A61M25/1011 , A61M39/0247 , A61M2025/028 , A61M2039/0279 , A61M2039/0297 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , Y10S623/904
摘要： Devices, systems, and methods are provided for accessing the interior of the heart and performing procedures therein while the heart is beating. In one embodiment, a tubular access device having an inner lumen is provided for positioning through a penetration in a muscular wall of the heart, the access device having a means for sealing within the penetration to inhibit leakage of blood through the penetration. The sealing means may comprise a balloon or flange on the access device, or a suture placed in the heart wall to gather the heart tissue against the access device. An obturator is removably positionable in the inner lumen of the access device, the obturator having a cutting means at its distal end for penetrating the muscular wall of the heart. The access device is preferably positioned through an intercostal space and through the muscular wall of the heart. Elongated instruments may be introduced through the tubular access device into an interior chamber of the heart to perform procedures such as septal defect repair and electrophysiological mapping and ablation. A method of septal defect repair includes positioning a tubular access device percutaneously through an intercostal space and through a penetration in a muscular wall of the heart, passing one or more instruments through an inner lumen of the tubular access device into an interior chamber of the heart, and using the instruments to close the septal defect. Devices and methods for closing the septal defect with either sutures or with patch-type devices are disclosed.

14. 发明授权

US5814016A Endovascular system for arresting the heart 失效
公开(公告)号：US5814016A
公开(公告)日：1998-09-29
申请号：US797229
申请日：1997-02-07
申请人： Kirsten L. Valley , David W. Snow , Timothy C. Corvi , Brian S. Donlon , Stephen W. Boyd , Sylvia W. Fan , Alex T. Roth , William S. Peters , Richard J. Mueller, Jr. , Hanson S. Gifford, III
发明人： Kirsten L. Valley , David W. Snow , Timothy C. Corvi , Brian S. Donlon , Stephen W. Boyd , Sylvia W. Fan , Alex T. Roth , William S. Peters , Richard J. Mueller, Jr. , Hanson S. Gifford, III
IPC分类号： A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61M1/00 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0147 , A61B17/00234 , A61B17/0218 , A61B17/0469 , A61B17/06061 , A61B18/1492 , A61B90/50 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0028 , A61M25/0041 , A61M25/0152 , A61M25/0155 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M25/1011 , A61M25/1029 , A61M25/1038 , A61M39/0247 , A61B17/0467 , A61B17/2909 , A61B2017/00243 , A61B2017/00247 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61B2090/306 , A61M1/3621 , A61M2025/0002 , A61M2025/0004 , A61M2025/0031 , A61M2025/0046 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/105 , A61M2025/1052 , A61M2025/1059 , A61M2025/1077 , A61M2025/1095 , A61M2202/047 , A61M2205/11 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/125 , A61M2210/127 , A61M25/0023 , A61M25/0032 , A61M25/0054 , A61M25/0125 , A61M25/1034
摘要： Devices and methods are provided for temporarily inducing cardioplegic arrest in the heart of a patient and for establishing cardiopulmonary bypass in order to facilitate surgical procedures on the heart and its related blood vessels. Specifically, a catheter based system is provided for isolating the heart and coronary blood vessels of a patient from the remainder of the arterial system and for infusing a cardioplegic agent into the patient's coronary arteries to induce cardioplegic arrest in the heart. The system includes an endoaortic partitioning catheter having an expandable balloon at its distal end which is expanded within the ascending aorta to occlude the aortic lumen between the coronary ostia and the brachiocephalic artery. Means for centering the catheter tip within the ascending aorta include specially curved shaft configurations, eccentric or shaped occlusion balloons and a steerable catheter tip, which may be used separately or in combination. The shaft of the catheter may have a coaxial or multilumen construction. The catheter may further include piezoelectric pressure transducers at the distal tip of the catheter and within the occlusion balloon. Means to facilitate nonfluoroscopic placement of the catheter include fiberoptic transillumination of the aorta and a secondary balloon at the distal tip of the catheter for atraumatically contacting the aortic valve. The system further includes a dual purpose arterial bypass cannula and introducer sheath for introducing the catheter into a peripheral artery of the patient.

15. 发明授权

US5618306A Endoscopic microsurgical instruments and methods 失效
标题翻译：内窥镜显微外科手术和方法
公开(公告)号：US5618306A
公开(公告)日：1997-04-08
申请号：US560441
申请日：1995-11-17
申请人： Alex T. Roth , Scott H. Miller
发明人： Alex T. Roth , Scott H. Miller
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B17/128 , A61B17/28
CPC分类号： A61B17/2909 , A61B17/1285 , A61B17/0469 , A61B2017/00243 , A61B2017/2845 , A61B2017/2912 , A61B2017/2919 , A61B2017/2926 , A61B2017/2946 , A61B2017/305
摘要： The invention provides devices and method for performing extremely small-scale, minimally-invasive microsurgery such as thoracoscopic coronary artery bypass grafting. The instruments of the invention utilize a symmetrical, forcep-like actuator which provides extremely precise actuator and control of the instrument and which mimics the feel of instruments used in conventional open surgical procedures. The instruments generally include a pair of coaxially arranged shafts, an end-effector at the distal ends of the shafts, and an actuator at the proximal ends of the shafts. The actuator includes a pair of arms pivotally coupled to one of either the outer or inner shalt, and a pair of links pivotally coupled at one end to the arms, and at a second end to the other of the shafts. The links are coupled to a proximal portion of the arms to maximize mechanical advantage and reduce interference. The actuator may be easily adapted for either pull-type or push-type actuation, and for either outer shaft or inner shaft translation. The end-effectors may have a variety of configurations, including needle drivers, forceps, scissors, and clip appliers.
摘要翻译：本发明提供了用于进行极小规模，微创显微外科手术如胸腔镜冠状动脉旁路移植术的装置和方法。本发明的仪器使用对称的强力致动器，其提供极其精确的致动器和仪器的控制，并模拟常规开放式外科手术中使用的仪器的感觉。仪器通常包括一对同轴布置的轴，在轴的远端处的末端执行器和在轴的近端处的致动器。致动器包括一对臂，其可枢转地联接到外部或内部之一中的一个，以及在一端枢转地联接到臂的一对连杆，并且在另一端处连接到另一个轴。连杆联接到臂的近端部分以最大化机械优点并减少干扰。致动器可以容易地适用于拉式或推式致动，以及用于外轴或内轴平移。末端执行器可以具有各种配置，包括针驱动器，镊子，剪刀和夹具装置。

16. 发明授权

US5410412A Gel electrophoresis system 失效
标题翻译：凝胶电泳系统
公开(公告)号：US5410412A
公开(公告)日：1995-04-25
申请号：US178035
申请日：1994-01-06
申请人： Erich A. Gombocz , Robert R. Clappier , Wilhelm Kerth , David H. Rammler , Alex T. Roth
发明人： Erich A. Gombocz , Robert R. Clappier , Wilhelm Kerth , David H. Rammler , Alex T. Roth
IPC分类号： G01N27/447 , G01N21/25
CPC分类号： G01N27/44721 , G01N27/44704 , G01N27/44782
摘要： An electrophoretic system is provided which allows for carrying out electrophoresis while monitoring and regulating the temperature and the electrical field gradient in the gel. In addition, photometric monitoring is provided so as to monitor the progress of the electrophoretic separation and vary conditions to change the progress as desired. A computer is employed which receives the signals from the electrophoretic and photometric apparatuses and regulates temperature and voltage to either maintain conditions, or change the conditions to vary the progress of the electrophoresis. Gel molds are provided for forming the lanes in a gel plate, as well as a light module, for reading the bands present in the gel lanes with the photometer.
摘要翻译：提供了一种电泳系统，其允许进行电泳，同时监测和调节凝胶中的温度和电场梯度。此外，提供光度监测以监测电泳分离的进展并改变条件以根据需要改变进展。使用计算机，其接收来自电泳和光度测量装置的信号并调节温度和电压以维持条件，或改变条件以改变电泳进程。提供凝胶模具用于在凝胶板中形成通道以及光模块，用于通过光度计读取凝胶通道中存在的条带。

17. 发明授权

US5275710A Gel electrophoresis system including optical stage, sample applicator and sample retriever 失效
标题翻译：凝胶电泳系统，包括光学平台，样品涂布器和样品回收器
公开(公告)号：US5275710A
公开(公告)日：1994-01-04
申请号：US837067
申请日：1992-02-14
申请人： Erich A. Gombocz , Alex T. Roth
发明人： Erich A. Gombocz , Alex T. Roth
IPC分类号： G01N27/447 , G01N27/26 , B01D57/02
CPC分类号： G01N27/44704 , G01N27/44721 , G01N27/44782
摘要： An electrophoretic system is provided which allows for carrying out electrophoresis while monitoring and regulating the temperature and the electrical field gradient in the gel. In addition, photometric monitoring, including use of an optical stage, is provided so as to monitor the progress of the electrophoretic separation and vary conditions to change the progress as desired. A computer is employed which receives the signals from the electrophoretic and photometric apparatuses and regulates temperature and voltage to either maintain conditions, or change the conditions to vary the progress of the electrophoresis and to store the separation results. A sample applicator and a sample retriever are also provided, to provide even and consistent application of sample to the gel and to allow recovery of portions of the sample without destroying or removing pieces from the gel. Gel molds are provided for forming the lanes in a gel plate, as well as a light module, for reading the bands present in the gel lanes with the photometer.
摘要翻译：提供了一种电泳系统，其允许进行电泳，同时监测和调节凝胶中的温度和电场梯度。此外，提供包括使用光学级的光度监测，以监视电泳分离的进展并改变条件以根据需要改变进展。接收来自电泳和测光装置的信号并调节温度和电压以维持条件或改变条件以改变电泳进程并存储分离结果的计算机。还提供样品施加器和样品回收器，以将样品均匀且一致地应用于凝胶并允许回收部分样品而不破坏或从凝胶中除去碎片。提供凝胶模具用于在凝胶板中形成通道以及光模块，用于通过光度计读取凝胶通道中存在的条带。

18. 发明授权

US10085880B2 Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
公开(公告)号：US10085880B2
公开(公告)日：2018-10-02
申请号：US13164648
申请日：2011-06-20
申请人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/00 , A61F7/12 , A61M25/10 , A61B17/00 , A61B17/22 , A61F7/10
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

19. 发明授权

US09427353B2 Catheter system with on-board temperature probe 有权
公开(公告)号：US09427353B2
公开(公告)日：2016-08-30
申请号：US11871931
申请日：2007-10-12
申请人： Amy L. Hammack , Jeff P. Callister , Paul M. Stull , Alex T. Roth , William S. Tremulis
发明人： Amy L. Hammack , Jeff P. Callister , Paul M. Stull , Alex T. Roth , William S. Tremulis
IPC分类号： A61F7/12 , A61B17/00
CPC分类号： A61F7/12 , A61B2017/00084 , A61B2017/00088 , A61B2017/00867 , A61F2007/0054 , A61F2007/0096 , A61F2007/126
摘要： A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a temperature probe having a distal end that extends from the catheter body, thereby monitoring the temperature of blood flowing within the blood vessel.

20. 发明授权

US09028511B2 Devices and methods for placement of partitions within a hollow body organ 有权
标题翻译：在空心体器官中放置隔板的装置和方法
公开(公告)号：US09028511B2
公开(公告)日：2015-05-12
申请号：US10797439
申请日：2004-03-09
申请人： Gary Weller , Alex T. Roth , Christopher Julian , Jamy Gannoe , Andrew H. Hancock , Craig Gerbi
发明人： Gary Weller , Alex T. Roth , Christopher Julian , Jamy Gannoe , Andrew H. Hancock , Craig Gerbi
IPC分类号： A61B17/08 , A61B17/072 , A61F5/00 , A61B17/00 , A61B17/30
CPC分类号： A61B17/072 , A61B17/07207 , A61B2017/003 , A61B2017/07214 , A61B2017/306 , A61F5/0083
摘要： Devices and methods for tissue acquisition and fixation, or gastroplasty, are described. Generally, the devices of the system may be advanced in a minimally invasive manner within a patient's body, e.g., transorally, endoscopically, percutaneously, etc., to create one or several divisions or plications within the hollow body organ. Such divisions or plications can form restrictive barriers within a organ, or can be placed to form a pouch, or gastric lumen, smaller than the remaining stomach volume to essentially act as the active stomach such as the pouch resulting from a surgical Roux-En-Y gastric bypass procedure. Moreover, the system is configured such that once acquisition of the tissue by the gastroplasty device is accomplished, any manipulation of the acquired tissue is unnecessary as the device is able to automatically configure the acquired tissue into a desired configuration.
摘要翻译：描述用于组织采集和固定或胃成形术的装置和方法。通常，系统的装置可以在患者体内以微创方式进行，例如经由内窥镜，经皮等进行，从而在空心体器官内产生一个或多个分裂或or肿。这样的分裂或痉挛可以在器官内形成限制性障碍，或者可以放置成小于剩余胃体积的小袋或胃腔，以基本上充当活动性胃，例如由外科手术Roux-En- Y胃旁路手术。此外，该系统被配置为使得一旦完成了由成形术装置获取的组织，对于所获取的组织的任何操纵都是不必要的，因为该装置能够将获取的组织自动配置成所需的构造。

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