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1. 发明授权

US5410412A Gel electrophoresis system 失效
标题翻译：凝胶电泳系统
公开(公告)号：US5410412A
公开(公告)日：1995-04-25
申请号：US178035
申请日：1994-01-06
申请人： Erich A. Gombocz , Robert R. Clappier , Wilhelm Kerth , David H. Rammler , Alex T. Roth
发明人： Erich A. Gombocz , Robert R. Clappier , Wilhelm Kerth , David H. Rammler , Alex T. Roth
IPC分类号： G01N27/447 , G01N21/25
CPC分类号： G01N27/44721 , G01N27/44704 , G01N27/44782
摘要： An electrophoretic system is provided which allows for carrying out electrophoresis while monitoring and regulating the temperature and the electrical field gradient in the gel. In addition, photometric monitoring is provided so as to monitor the progress of the electrophoretic separation and vary conditions to change the progress as desired. A computer is employed which receives the signals from the electrophoretic and photometric apparatuses and regulates temperature and voltage to either maintain conditions, or change the conditions to vary the progress of the electrophoresis. Gel molds are provided for forming the lanes in a gel plate, as well as a light module, for reading the bands present in the gel lanes with the photometer.
摘要翻译：提供了一种电泳系统，其允许进行电泳，同时监测和调节凝胶中的温度和电场梯度。此外，提供光度监测以监测电泳分离的进展并改变条件以根据需要改变进展。使用计算机，其接收来自电泳和光度测量装置的信号并调节温度和电压以维持条件，或改变条件以改变电泳进程。提供凝胶模具用于在凝胶板中形成通道以及光模块，用于通过光度计读取凝胶通道中存在的条带。

2. 发明授权

US5275710A Gel electrophoresis system including optical stage, sample applicator and sample retriever 失效
标题翻译：凝胶电泳系统，包括光学平台，样品涂布器和样品回收器
公开(公告)号：US5275710A
公开(公告)日：1994-01-04
申请号：US837067
申请日：1992-02-14
申请人： Erich A. Gombocz , Alex T. Roth
发明人： Erich A. Gombocz , Alex T. Roth
IPC分类号： G01N27/447 , G01N27/26 , B01D57/02
CPC分类号： G01N27/44704 , G01N27/44721 , G01N27/44782
摘要： An electrophoretic system is provided which allows for carrying out electrophoresis while monitoring and regulating the temperature and the electrical field gradient in the gel. In addition, photometric monitoring, including use of an optical stage, is provided so as to monitor the progress of the electrophoretic separation and vary conditions to change the progress as desired. A computer is employed which receives the signals from the electrophoretic and photometric apparatuses and regulates temperature and voltage to either maintain conditions, or change the conditions to vary the progress of the electrophoresis and to store the separation results. A sample applicator and a sample retriever are also provided, to provide even and consistent application of sample to the gel and to allow recovery of portions of the sample without destroying or removing pieces from the gel. Gel molds are provided for forming the lanes in a gel plate, as well as a light module, for reading the bands present in the gel lanes with the photometer.
摘要翻译：提供了一种电泳系统，其允许进行电泳，同时监测和调节凝胶中的温度和电场梯度。此外，提供包括使用光学级的光度监测，以监视电泳分离的进展并改变条件以根据需要改变进展。接收来自电泳和测光装置的信号并调节温度和电压以维持条件或改变条件以改变电泳进程并存储分离结果的计算机。还提供样品施加器和样品回收器，以将样品均匀且一致地应用于凝胶并允许回收部分样品而不破坏或从凝胶中除去碎片。提供凝胶模具用于在凝胶板中形成通道以及光模块，用于通过光度计读取凝胶通道中存在的条带。

3. 发明授权

US08454503B2 Remote tissue retraction device 有权
公开(公告)号：US08454503B2
公开(公告)日：2013-06-04
申请号：US11282320
申请日：2005-11-17
申请人： Alex T. Roth , Craig Gerbi , Andrew H. Hancock , Gary Weller , Christopher Julian , James Gannoe
发明人： Alex T. Roth , Craig Gerbi , Andrew H. Hancock , Gary Weller , Christopher Julian , James Gannoe
IPC分类号： A61B1/32
CPC分类号： A61B17/0218 , A61B17/072 , A61B2017/003 , A61B2017/00314 , A61B2017/00323 , A61B2017/00827 , A61B2017/07214 , A61B2017/306
摘要： A medical device for managing tissue in an organ, such as the stomach, for retracting or positioning tissue and related organs to allow certain regions of the stomach to be acquired for a gastroplasty procedure. The medical device includes an elongated body having a proximal end and a distal end, and a tissue treatment device attached to the distal end of the elongated body. The tissue treatment device includes a first jaw opposite a second jaw, and each jaw is adapted to acquire tissue. A retractor is disposed along the tissue treatment device and adapted to be moveable from a delivery position to a retraction position to move or manage the tissue of the stomach. The medical device also includes a collapsible barrier disposed between the first and second jaws of the tissue treatment device to direct tissue into the first and second jaws separately.

4. 发明授权

US08177824B2 Disposable cassette for intravenous heat exchange catheter 有权
标题翻译：一次性胶囊用于静脉换热导管
公开(公告)号：US08177824B2
公开(公告)日：2012-05-15
申请号：US11781892
申请日：2007-07-23
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , David J. Scott , Jose Alejandro , Edward A. Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , David J. Scott , Jose Alejandro , Edward A. Oliver
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

5. 发明授权

US07879077B2 Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
标题翻译：通过可插入热交换导管来控制患者体温的方法和系统
公开(公告)号：US07879077B2
公开(公告)日：2011-02-01
申请号：US11674119
申请日：2007-02-12
申请人： Timothy R. MacHold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. MacHold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/00
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
摘要翻译：包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和15“冷却。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

6. 发明授权

US07658755B2 Disposable cassette for intravascular heat exchange catheter 有权
标题翻译：一次性用于血管内热交换导管
公开(公告)号：US07658755B2
公开(公告)日：2010-02-09
申请号：US10627487
申请日：2003-07-25
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Edward A. Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Edward A. Oliver
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

7. 发明授权

US06890347B2 Disposable cassette for intravascular heat exchange catheter 有权
标题翻译：一次性用于血管内热交换导管
公开(公告)号：US06890347B2
公开(公告)日：2005-05-10
申请号：US10628055
申请日：2003-07-25
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
IPC分类号： A61B17/00 , A61B17/22 , A61F2/958 , A61F7/00 , A61F7/10 , A61F7/12
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

8. 发明授权

US06679906B2 Catheter system with on-board temperature probe 有权
公开(公告)号：US06679906B2
公开(公告)日：2004-01-20
申请号：US09905389
申请日：2001-07-13
申请人： Amy L. Hammack , Jeff P. Callister , Paul M. Stull , Alex T. Roth , William S. Tremulis
发明人： Amy L. Hammack , Jeff P. Callister , Paul M. Stull , Alex T. Roth , William S. Tremulis
IPC分类号： A61F712
CPC分类号： A61F7/12 , A61B2017/00084 , A61B2017/00088 , A61B2017/00867 , A61F2007/0054 , A61F2007/0096 , A61F2007/126
摘要： A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a temperature probe having a distal end that extends from the catheter body, thereby monitoring the temperature of blood flowing within the blood vessel.

9. 发明授权

US06401720B1 Method and apparatus for thoracoscopic intracardiac procedures 失效
公开(公告)号：US06401720B1
公开(公告)日：2002-06-11
申请号：US09411095
申请日：1999-10-04
申请人： John H. Stevens , Bruce A. Reitz , Alex T. Roth , William S. Peters , Hanson S. Gifford
发明人： John H. Stevens , Bruce A. Reitz , Alex T. Roth , William S. Peters , Hanson S. Gifford
IPC分类号： A61B1900
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/2909 , A61B17/320016 , A61B17/3211 , A61B17/3417 , A61B17/3468 , A61B18/1442 , A61B18/1482 , A61B18/1492 , A61B90/37 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00349 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00867 , A61B2017/00907 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/2946 , A61B2017/306 , A61B2017/3405 , A61B2017/3486 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00898 , A61B2018/00982 , A61B2018/1465 , A61F2/2427 , A61M25/1011 , A61M39/0247 , A61M2025/028 , A61M2039/0279 , A61M2039/0297 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , Y10S623/904
摘要： Devices, systems, and methods are provided for accessing the interior of the heart and performing procedures therein while the heart is beating. In one embodiment, a tubular access device having an inner lumen is provided for positioning through a penetration in a muscular wall of the heart, the access device having a means for sealing within the penetration to inhibit leakage of blood through the penetration. The sealing means may comprise a balloon or flange on the access device, or a suture placed in the heart wall to gather the heart tissue against the access device. An obturator is removably positionable in the inner lumen of the access device, the obturator having a cutting means at its distal end for penetrating the muscular wall of the heart. The access device is preferably positioned through an intercostal space and through the muscular wall of the heart. Elongated instruments may be introduced through the tubular access device into an interior chamber of the heart to perform procedures such as septal defect repair and electrophysiological mapping and ablation. A method of septal defect repair includes positioning a tubular access device percutaneously through an intercostal space and through a penetration in a muscular wall of the heart, passing one or more instruments through an inner lumen of the tubular access device into an interior chamber of the heart, and using the instruments to close the septal defect. Devices and methods for closing the septal defect with either sutures or with patch-type devices are disclosed.

10. 发明授权

US5814016A Endovascular system for arresting the heart 失效
公开(公告)号：US5814016A
公开(公告)日：1998-09-29
申请号：US797229
申请日：1997-02-07
申请人： Kirsten L. Valley , David W. Snow , Timothy C. Corvi , Brian S. Donlon , Stephen W. Boyd , Sylvia W. Fan , Alex T. Roth , William S. Peters , Richard J. Mueller, Jr. , Hanson S. Gifford, III
发明人： Kirsten L. Valley , David W. Snow , Timothy C. Corvi , Brian S. Donlon , Stephen W. Boyd , Sylvia W. Fan , Alex T. Roth , William S. Peters , Richard J. Mueller, Jr. , Hanson S. Gifford, III
IPC分类号： A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61M1/00 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0147 , A61B17/00234 , A61B17/0218 , A61B17/0469 , A61B17/06061 , A61B18/1492 , A61B90/50 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0028 , A61M25/0041 , A61M25/0152 , A61M25/0155 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M25/1011 , A61M25/1029 , A61M25/1038 , A61M39/0247 , A61B17/0467 , A61B17/2909 , A61B2017/00243 , A61B2017/00247 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61B2090/306 , A61M1/3621 , A61M2025/0002 , A61M2025/0004 , A61M2025/0031 , A61M2025/0046 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/105 , A61M2025/1052 , A61M2025/1059 , A61M2025/1077 , A61M2025/1095 , A61M2202/047 , A61M2205/11 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/125 , A61M2210/127 , A61M25/0023 , A61M25/0032 , A61M25/0054 , A61M25/0125 , A61M25/1034
摘要： Devices and methods are provided for temporarily inducing cardioplegic arrest in the heart of a patient and for establishing cardiopulmonary bypass in order to facilitate surgical procedures on the heart and its related blood vessels. Specifically, a catheter based system is provided for isolating the heart and coronary blood vessels of a patient from the remainder of the arterial system and for infusing a cardioplegic agent into the patient's coronary arteries to induce cardioplegic arrest in the heart. The system includes an endoaortic partitioning catheter having an expandable balloon at its distal end which is expanded within the ascending aorta to occlude the aortic lumen between the coronary ostia and the brachiocephalic artery. Means for centering the catheter tip within the ascending aorta include specially curved shaft configurations, eccentric or shaped occlusion balloons and a steerable catheter tip, which may be used separately or in combination. The shaft of the catheter may have a coaxial or multilumen construction. The catheter may further include piezoelectric pressure transducers at the distal tip of the catheter and within the occlusion balloon. Means to facilitate nonfluoroscopic placement of the catheter include fiberoptic transillumination of the aorta and a secondary balloon at the distal tip of the catheter for atraumatically contacting the aortic valve. The system further includes a dual purpose arterial bypass cannula and introducer sheath for introducing the catheter into a peripheral artery of the patient.

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