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1. 发明授权

US07879077B2 Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
标题翻译：通过可插入热交换导管来控制患者体温的方法和系统
公开(公告)号：US07879077B2
公开(公告)日：2011-02-01
申请号：US11674119
申请日：2007-02-12
申请人： Timothy R. MacHold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. MacHold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/00
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
摘要翻译：包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和15“冷却。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

2. 发明授权

US10085880B2 Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
公开(公告)号：US10085880B2
公开(公告)日：2018-10-02
申请号：US13164648
申请日：2011-06-20
申请人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/00 , A61F7/12 , A61M25/10 , A61B17/00 , A61B17/22 , A61F7/10
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

3. 发明授权

US07175649B2 Method and system for control of a patient's body temperature by way of transluminally insertable heat exchange catheter 有权
标题翻译：通过可插入热交换导管控制患者体温的方法和系统
公开(公告)号：US07175649B2
公开(公告)日：2007-02-13
申请号：US10645891
申请日：2003-08-20
申请人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/00
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
摘要翻译：包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环流动管线，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和冷却。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可重复使用的控制单元内的泵驱动机构接合的整体泵头。可以设置多个控制单元以接收相同的热交换盒，使得最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

4. 发明授权

US06620189B1 Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
标题翻译：通过可插入热交换导管来控制患者体温的方法和系统
公开(公告)号：US06620189B1
公开(公告)日：2003-09-16
申请号：US09707257
申请日：2000-11-06
申请人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F700
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
摘要翻译：包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和冷却。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

5. 发明申请

US20120095536A1 METHOD AND SYSTEM FOR CONTROL OF A PATIENT'S BODY TEMPERATURE BY WAY OF A TRANSLUMINALLY INSERTABLE HEAT EXCHANGE CATHETER 审中-公开
标题翻译：方法和系统通过一个透明的热交换导管的方式控制患者身体温度
公开(公告)号：US20120095536A1
公开(公告)日：2012-04-19
申请号：US13164648
申请日：2011-06-20
申请人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/12
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
摘要翻译：包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和15“冷却。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

6. 发明授权

US07963986B2 Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
标题翻译：通过可插入热交换导管来控制患者体温的方法和系统
公开(公告)号：US07963986B2
公开(公告)日：2011-06-21
申请号：US10645755
申请日：2003-08-20
申请人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/12
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
摘要翻译：包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环流动管线，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和冷却。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。可以设置多个控制单元以接收相同的热交换盒，使得最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

7. 发明授权

US07258662B2 Method and system for control of a patient's body temperature by way of transluminally insertable heat exchange catheter 有权
公开(公告)号：US07258662B2
公开(公告)日：2007-08-21
申请号：US10645263
申请日：2003-08-20
申请人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. Machold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/00
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

8. 发明授权

US08177824B2 Disposable cassette for intravenous heat exchange catheter 有权
标题翻译：一次性胶囊用于静脉换热导管
公开(公告)号：US08177824B2
公开(公告)日：2012-05-15
申请号：US11781892
申请日：2007-07-23
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , David J. Scott , Jose Alejandro , Edward A. Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , David J. Scott , Jose Alejandro , Edward A. Oliver
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

9. 发明授权

US07658755B2 Disposable cassette for intravascular heat exchange catheter 有权
标题翻译：一次性用于血管内热交换导管
公开(公告)号：US07658755B2
公开(公告)日：2010-02-09
申请号：US10627487
申请日：2003-07-25
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Edward A. Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Edward A. Oliver
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

10. 发明授权

US06890347B2 Disposable cassette for intravascular heat exchange catheter 有权
标题翻译：一次性用于血管内热交换导管
公开(公告)号：US06890347B2
公开(公告)日：2005-05-10
申请号：US10628055
申请日：2003-07-25
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , Dave J. Scott , Jose Alejandro , Ed Oliver
IPC分类号： A61B17/00 , A61B17/22 , A61F2/958 , A61F7/00 , A61F7/10 , A61F7/12
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

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