专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20120122819A1 GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS 审中-公开
标题翻译： GUANINE RIBOSWITCH BINDING化合物及其作为抗生素的用途
公开(公告)号：US20120122819A1
公开(公告)日：2012-05-17
申请号：US13377052
申请日：2010-06-14
申请人： Jérôme Mulhbacher , Daniel Lafontaine , François Malouin , Marianne Allard , Eric Marsault
发明人： Jérôme Mulhbacher , Daniel Lafontaine , François Malouin , Marianne Allard , Eric Marsault
IPC分类号： A61K31/675 , A61K31/513 , C07D279/06 , A61K31/54 , C07D265/06 , A61K31/535 , C07D213/73 , A61K31/4412 , A61K31/505 , C07F9/6533 , C07D487/04 , C07D498/04 , A61K31/519 , C07F9/6584 , A61K31/5383 , G01N33/50 , A61P31/04 , C12Q1/68 , C07D239/50
CPC分类号： A61K31/675 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/519 , A61K31/535 , A61K31/5383 , A61K31/54 , A61K31/542 , C07D239/46 , C07D239/48 , C07D239/50 , C07D498/04 , C07D513/04 , Y10T436/141111 , Y10T436/143333
摘要： The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.
摘要翻译：本发明包括所述化合物的新化合物和药学上可接受的制剂，其对具有控制guaA基因表达的鸟嘌呤核糖开关的微生物具有抗生素活性，包括对某些抗生素家族具有抗性的生物体，并且其可用作抗细菌剂治疗或预防动物或人类的细菌感染，特别是但不限于乳腺感染，或其作为防腐剂的用途，用于灭菌或消毒的试剂。

12. 发明申请

US20080140006A1 THERAPEUTIC CATHETER WITH DISPLACEMENT SENSING TRANSDUCER 有权
标题翻译：带位移感应传感器的治疗导管
公开(公告)号：US20080140006A1
公开(公告)日：2008-06-12
申请号：US11941472
申请日：2007-11-16
申请人： Alan Eskuri , Daniel Lafontaine
发明人： Alan Eskuri , Daniel Lafontaine
IPC分类号： A61M25/095
CPC分类号： A61B5/00 , A61B5/061 , A61B5/6848 , A61B8/12 , A61B17/3478 , A61B18/24 , A61B2017/0003 , A61B2017/00247 , A61B2018/00392 , A61B2090/062 , A61B2090/0811 , A61M5/46 , A61M25/0084
摘要： A catheter device having a proboscis, such as a needle, and a transducer which detects the axial displacement of the proboscis in relation to the distal tip of the catheter. The transducer is positioned at a distal portion of the catheter and may comprise an induction coil or a potentiometer. Axial displacement of the proboscis changes the amount of inductance or resistance in the transducer. This change in inductance or resistance can be calibrated to the amount of axial displacement of the proboscis and provided as feedback to the user.
摘要翻译：具有诸如针的长鼻子的导管装置和检测长鼻相对于导管的远端的轴向位移的换能器。换能器定位在导管的远端部分，并且可以包括感应线圈或电位计。长鼻子的轴向位移会改变传感器的电感或电阻。电感或电阻的这种变化可以校准到长鼻子的轴向位移量，并作为反馈提供给用户。

13. 发明授权

US07148044B1 Nucleic acid enzyme for RNA cleavage 失效
标题翻译：用于RNA切割的核酸酶
公开(公告)号：US07148044B1
公开(公告)日：2006-12-12
申请号：US09699667
申请日：2000-10-30
申请人： Jean-Pierre Perreault , Sirinart Ananvoranich , Daniel Lafontaine
发明人： Jean-Pierre Perreault , Sirinart Ananvoranich , Daniel Lafontaine
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/123
摘要： A method is described for cleaving a nucleic acid substrate with a nucleic acid enzyme at a cleavage site comprising mixing the substrate with the enzyme, wherein the substrate includes a 7 nucleotide sequence with at least 6 nucleotides 3′ to the cleavage site and at least 1 nucleotide 5′ to the cleavage site and of formula: 5′-H′GNNHNN-3′ wherein each N is a nucleotide which may be the same or different, H is a nucleotide selected from the group consisting of A, U, C, and T, and is the site of cleavage, and H′ is a ribonucleotide selected from the group consisting of A, U, and C, wherein (i) the first nucleotide 3′ to the cleavage site is capable of forming a wobble pair with the enzyme, (ii) the second, third, fifth, and sixth nucleotides 3′ to the cleavage site are capable of forming conventional Watson-Crick base pairs with the enzyme, (iii) the fourth nucleotide 3′ to the cleavage site is capable of forming a non-conventional Watson-Crick base pair with the enzyme, and (iv) the first nucleotide 5′ to the cleavage site does not form a base pair with the enzyme; and the enzyme comprises a substrate binding portion which is capable of base pairing to the 6 nucleotides 3′ to the cleavage site of the substrate and which binding portion comprises the sequence: 3′-UNNXNN-5′ wherein each N is a nucleotide which may be the same or different, and X is a nucleotide selected from the group consisting of T, U, A, and G, whereby binding of the substrate to the enzyme effects cleavage of the substrate at the cleavage site.
摘要翻译：描述了一种用于在切割位点用核酸酶切割核酸底物的方法，包括将底物与酶混合，其中所述底物包含与切割位点具有至少6个核苷酸3'的7个核苷酸序列和至少1个核苷酸5'至切割位点，并具有下式：<？in-line-formula description =“In-line formula”end =“lead”？> 5'-H'GNNHNN-3'<？in-line-formula description =“内联式”末端=“尾”→其中每个N是可以相同或不同的核苷酸，H是选自A，U，C和T的核苷酸，并且是切割位点，H'是选自A，U和C的核糖核苷酸，其中（i）切割位点的第一个核苷酸3'能够与酶形成摆动对，（ii）切割位点的第二，第三，第五和第六核苷酸3'能够与酶形成常规的沃森 - 克里克碱基对，（iii）第四核到切割位点的3'能够与酶形成非常规的Watson-Crick碱基对，和（iv）切割位点的第一个核苷酸5'不与酶形成碱基对; 并且该酶包括能够与基底的切割位点的6'核苷酸3'碱基配对的底物结合部分，并且该结合部分包含以下序列：<？in-line-formula description =“In-line Formulas” end =“lead”？> 3'-UNNXNN-5'<？in-line-formula description =“In-line Formulas”end =“tail”？>其中每个N是可以相同或不同的核苷酸，并且X是选自T，U，A和G的核苷酸，由此底物与酶的结合在切割位点处影响底物的切割。

14. 发明申请

US20060085039A1 Leadless cardiac stimulation systems 有权
公开(公告)号：US20060085039A1
公开(公告)日：2006-04-20
申请号：US10971550
申请日：2004-10-20
申请人： Roger Hastings , William Drassler , Daniel Lafontaine , Anupama Sadasiva , Scott Smith
发明人： Roger Hastings , William Drassler , Daniel Lafontaine , Anupama Sadasiva , Scott Smith
IPC分类号： A61N1/36
CPC分类号： A61N1/3756 , A61N1/0587 , A61N1/059 , A61N1/08 , A61N1/3627 , A61N1/365 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37241 , A61N1/37288 , A61N1/375 , A61N1/3787
摘要： Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrodes that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Each of the electrodes contains a source of electrical energy for pacing the myocardium and is adapted to receive electromagnetic energy from a source outside the myocardium. The system also includes a source adapted for placement outside the myocardium and that uses locally measured electrocardiograms to synchronize pacing of the heart by sending electromagnetic commands to the electrodes to pace the myocardium surrounding the electrodes. Also disclosed is various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

15. 发明申请

US20080314394A9 Percutaneous myocardial revascularization 失效
标题翻译：经皮心肌血运重建
公开(公告)号：US20080314394A9
公开(公告)日：2008-12-25
申请号：US11191056
申请日：2005-07-28
申请人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
发明人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
IPC分类号： A61B19/00 , A61B18/18
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译：在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。合适的渠道模式包括线和阵列。一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。另一种方法是利用多线射频燃烧探头，同时形成多个通道。另一种方法利用液氮引起局部组织死亡。

16. 发明申请

US20060235509A1 Valve apparatus, system and method 有权
公开(公告)号：US20060235509A1
公开(公告)日：2006-10-19
申请号：US11107162
申请日：2005-04-15
申请人： Daniel Lafontaine
发明人： Daniel Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61M25/1011
摘要： A cardiac valve with a first anchor frame and a cover on the first anchor frame for unidirectional flow of a liquid through the valve.

17. 发明申请

US20060069385A1 Methods and apparatus for tissue cryotherapy 审中-公开
标题翻译：组织冷冻治疗方法与装置
公开(公告)号：US20060069385A1
公开(公告)日：2006-03-30
申请号：US10954136
申请日：2004-09-28
申请人： Daniel Lafontaine , Boaz Avitall
发明人： Daniel Lafontaine , Boaz Avitall
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B90/39 , A61B2017/00101 , A61B2017/00243 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2090/3954
摘要： A method for performing cryotherapy on a target tissue region in a body includes positioning a first cooling element in a first location in a body adjacent a target tissue region, positioning a second cooling element in a second location in the body adjacent the target tissue region, and cooling the respective first and second cooling elements so as to cool the target tissue region.
摘要翻译：用于在身体的目标组织区域上执行冷冻治疗的方法包括将第一冷却元件定位在邻近目标组织区域的身体的第一位置，将第二冷却元件定位在邻近目标组织区域的身体的第二位置，并冷却相应的第一和第二冷却元件以冷却目标组织区域。

18. 发明申请

US20050010248A1 System for closing an opening in a body cavity 失效
标题翻译：关闭体腔内的开口的系统
公开(公告)号：US20050010248A1
公开(公告)日：2005-01-13
申请号：US10616622
申请日：2003-07-10
申请人： Daniel Lafontaine
发明人： Daniel Lafontaine
IPC分类号： A61B17/00 , A61B17/04
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00292 , A61B2017/00637 , A61B2017/00659
摘要： A closure device closes an opening in a body cavity. The closure device includes an elongate delivery member and a closure component which is removably connected to the distal end of the delivery member. The closure component has a collapsible backing movable between a non-collapsed position and a collapsed position. The closure component also includes a plurality of fibrous tissue engaging members disposed on the backing and oriented in a non-engaging orientation when traveling in a distal direction and in an engaging orientation when traveling in a proximal direction. The fibrous tissue engaging members become entangled in the backing when the backing is in the collapsed position.
摘要翻译：闭合装置关闭体腔中的开口。闭合装置包括细长的传送构件和闭合部件，其可移除地连接到传送构件的远端。封闭部件具有可折叠背衬，其可在非折叠位置和折叠位置之间移动。所述封闭部件还包括多个布置在所述背衬上的纤维组织接合构件，并且当沿近端方向行进时沿远侧方向行进并且处于接合方向时以非接合方向定向。当背衬处于折叠位置时，纤维组织接合构件变得缠绕在背衬中。

19. 发明申请

US20070150009A1 Electrode apparatus, systems and methods 有权
标题翻译：电极装置，系统和方法
公开(公告)号：US20070150009A1
公开(公告)日：2007-06-28
申请号：US11316120
申请日：2005-12-22
申请人： Graig Kveen , Roger Hastings , Anupama Sadasiva , Vitaly Shapovalov , Daniel Lafontaine
发明人： Graig Kveen , Roger Hastings , Anupama Sadasiva , Vitaly Shapovalov , Daniel Lafontaine
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61F2/88 , A61F2002/828 , A61F2250/0001 , A61N1/0565 , A61N1/057 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： Apparatus, system, and method that include a pacing apparatus having a stent electrode through which pulses of electrical current can be delivered. Stent electrodes receive energy for generating the electrical current from a variety of sources. Sources include from one or more induction coils that can form at least a portion of the stent. Sources can also include an implantable pulse generator coupled to a lead through which pulses of the electrical current are supplied to the stent electrodes.
摘要翻译：包括具有支架电极的起搏装置的装置，系统和方法，通过该支架电极可以输送电流脉冲。支架电极接收来自各种来源的电流的产生能量。来源包括可以形成至少一部分支架的一个或多个感应线圈。源还可以包括耦合到引线的可植入脉冲发生器，电流脉冲通过该引线提供给支架电极。

20. 发明申请

US20060088404A1 Automated order mixing system 有权
标题翻译：自动订单混合系统
公开(公告)号：US20060088404A1
公开(公告)日：2006-04-27
申请号：US11258091
申请日：2005-10-26
申请人： Daniel Lafontaine
发明人： Daniel Lafontaine
IPC分类号： B65G1/00
CPC分类号： B65G1/08 , B65G1/1376 , B65G37/02 , B65G47/647 , B65G47/8823 , B65G2201/025
摘要： An automated order mixing system includes a mixing sub-system having a plurality of angled vertically stacked product guides feeding a mixing conveyor whereon a client's order of product cases is processed, the vertical stacking enabling the creation of a number of product feed paths within a relatively small floor space.
摘要翻译：自动化订单混合系统包括混合子系统，该混合子系统具有多个倾斜的垂直堆叠的产品引导件，该产品引导件供给混合输送机，其中处理客户的产品箱的顺序，垂直堆叠使得能够在相对占地面积小。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式