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11. 发明申请

US20100172800A1 ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES 审中-公开
标题翻译：具有电导率促销分子的静电抗体检测和测量传感器
公开(公告)号：US20100172800A1
公开(公告)日：2010-07-08
申请号：US12652419
申请日：2010-01-05
申请人： Shiming Lin , Shih-Yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
发明人： Shiming Lin , Shih-Yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
IPC分类号： G01N30/00
CPC分类号： G01N33/5438
摘要： A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, a layer of antibody immobilized on the surface of at least one of said electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules are conjugated with the antibody to improve electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.
摘要翻译：公开了一种用于在测试样品中电敏感抗原的传感器。该传感器具有彼此电隔离并物理分离的两个电极，一层抗体固定在至少一个所述电极的表面上。抗体与抗原具有特异性结合活性。电导率促进分子与抗体缀合以改善两个电极之间的导电特性。抗体捕获与在与抗体填充的电极接触的缓冲溶液中混合的测试样品中存在的抗原。这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

12. 发明授权

US11800985B2 Electrocardiographic monitoring device and blood pressure monitoring system using the same 有权
公开(公告)号：US11800985B2
公开(公告)日：2023-10-31
申请号：US16465370
申请日：2017-11-30
申请人： BIV MEDICAL, LTD. , Shiming Lin
发明人： Shiming Lin , Shih-Wei Chiang , Cheng-Yan Guo , Tai-Cun Lin , Wei-Chih Huang , Chun-Nan Chen , Ya-Ting Chang
IPC分类号： A61B5/00 , A61B5/021 , A61B5/25 , A61B5/024 , A61B5/022 , A61B7/04 , A61B5/30 , A61B5/282 , A61B5/332
CPC分类号： A61B5/02108 , A61B5/0006 , A61B5/02116 , A61B5/02225 , A61B5/02438 , A61B5/02444 , A61B5/282 , A61B5/30 , A61B5/332 , A61B5/681 , A61B5/6823 , A61B5/6824 , A61B5/6841 , A61B7/04 , A61B5/02416 , A61B5/25 , A61B2562/0204 , A61B2562/0209 , A61B2562/0247
摘要： The present invention provides an electrocardiographic monitoring device comprising a device body configured to be attached to a user's chest; a plurality of electrodes provided on the device body; and a controller provided on the device body and connected to the electrodes in order to obtain the user's electrocardiographic signal waveforms. The electrocardiographic monitoring device of the invention can be applied in a blood pressure monitoring system for monitoring a user's blood pressure.

13. 发明授权

US08877022B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08877022B2
公开(公告)日：2014-11-04
申请号：US13165464
申请日：2011-06-21
申请人： Shiming Lin , Bor-Ching Sheu , Luan-Yin Chang , Chih-Chen Lin
发明人： Shiming Lin , Bor-Ching Sheu , Luan-Yin Chang , Chih-Chen Lin
IPC分类号： G01N27/327 , G01N33/543
CPC分类号： G01N33/5438 , G01N27/3276
摘要： Embodiments of the present disclosure set forth a biosensor for detecting a target. One example sensor includes a first electrode. The first electrode includes a first electron conducting molecule and a first probe. The first probe includes a second electron conducting molecule. The first probe is configured to bind to the target of interest in solution. The first and second electron conducting molecules are different.
摘要翻译：本公开的实施例提出了用于检测目标的生物传感器。一个示例性传感器包括第一电极。第一电极包括第一电子传导分子和第一探针。第一探针包括第二电子传导分子。第一个探针被配置为绑定到解决方案中的感兴趣的目标。第一和第二电子传导分子是不同的。

14. 发明申请

US20110158288A1 Apparatus With Temperature Self-Compensation And Method Thereof 有权
标题翻译：带温度自补偿装置及其方法
公开(公告)号：US20110158288A1
公开(公告)日：2011-06-30
申请号：US12789289
申请日：2010-05-27
申请人： Long-Sun Huang , Yu-Fu Ku , Yi-Kuang Yen , Shu Kuan , Kuang-Chong Wu , Shiming Lin , Ping-Yen Lin
发明人： Long-Sun Huang , Yu-Fu Ku , Yi-Kuang Yen , Shu Kuan , Kuang-Chong Wu , Shiming Lin , Ping-Yen Lin
IPC分类号： G01K7/16
CPC分类号： G01N29/022
摘要： A system for compensating a thermal effect is provided and includes a substrate structure and a microcantilever. The substrate structure includes a first piezoresistor. The first piezoresistor is buried in the substrate structure and has a first piezoresistance having a first relation to a first variable temperature. The microcantilever has the thermal effect and a second piezoresistance having a second relation to the first variable temperature, wherein the thermal effect is compensated based on the first and the second relations.
摘要翻译：提供了用于补偿热效应的系统，并且包括衬底结构和微悬臂梁。衬底结构包括第一压电电阻器。第一压电电阻器被埋在衬底结构中，并且具有与第一可变温度具有第一关系的第一压电阻。微悬臂梁具有热效应和与第一可变温度具有第二关系的第二压阻，其中基于第一和第二关系补偿热效应。

15. 发明授权

US07487686B2 High-precision vortex flow meter 有权
标题翻译：高精度涡流流量计
公开(公告)号：US07487686B2
公开(公告)日：2009-02-10
申请号：US11790702
申请日：2007-04-27
申请人： An-Bang Wang , Ming-Hsun Wu , Yi-Hua Wang , I-Chun Lin , Chia-Chih Chen , Shiming Lin
发明人： An-Bang Wang , Ming-Hsun Wu , Yi-Hua Wang , I-Chun Lin , Chia-Chih Chen , Shiming Lin
IPC分类号： G01F1/32
CPC分类号： G01F1/3218 , G01F1/3209 , G01F15/024 , G01F25/0007
摘要： A high-precision vortex flow meter includes a blunt body having a predetermined dimension and being arranged inside a fluid channel to serve as a vortex shedder. The vortex flow meter also includes a temperature detecting device for detecting the vortex shedder temperature and a temperature control element for adjusting the vortex shedder temperature. A frequency measuring device is arranged in the downstream section of the blunt body for detecting the vortex shedding frequency. From the measured temperatures of the upstream fluid flow and that of the blunt body, an effective temperature and a temperature ratio are calculated. The kinematic viscosity of the fluid is looked up from database. By using the relationship between the Strouhal number and Reynolds number, the fluid flow rate is calculated. By employing different blunt body temperature, the measurement range of the flow meter can be broadly extended.
摘要翻译：高精度涡流流量计包括具有预定尺寸的钝体并且布置在流体通道内用作涡流脱落器。涡流流量计还包括用于检测涡流脱落器温度的温度检测装置和用于调节涡流脱落器温度的温度控制元件。在钝体的下游部分设置有频率测量装置，用于检测涡流脱落频率。从测量的上游流体的温度和钝体的温度，计算有效的温度和温度比。从数据库中查找流体的运动粘度。通过使用Strouhal数和雷诺数之间的关系，计算流体流量。通过采用不同的体温，可以大幅度地扩展流量计的测量范围。

16. 发明授权

US11690523B2 Carotid artery blood pressure detecting device 有权
公开(公告)号：US11690523B2
公开(公告)日：2023-07-04
申请号：US16630663
申请日：2018-07-10
申请人： Shiming Lin , BIV MEDICAL, LTD.
发明人： Shiming Lin
IPC分类号： A61B5/00 , A61B5/0245 , A61B5/021 , A61B5/024 , A61B8/04 , A61B7/04 , A61B5/0507 , A61B5/02
CPC分类号： A61B5/0245 , A61B5/002 , A61B5/0004 , A61B5/02007 , A61B5/02108 , A61B5/02125 , A61B5/02438 , A61B5/0507 , A61B5/684 , A61B5/6823 , A61B5/6824 , A61B5/6833 , A61B5/7275 , A61B7/04 , A61B8/04 , A61B5/02416 , A61B2562/0247
摘要： The present invention provides a carotid blood pressure detection device, comprising: a first sensing unit, a second sensing unit, and a controller connected or coupled to the first sensing unit and the second sensing unit. The first sensing unit is disposed on a subject's neck and adjacent to a first position of the subject's carotid arteries. The second sensing unit is disposed on the subject's neck and adjacent to a second position of the subject's carotid arteries. The controller derives a mean arterial pressure of a section of the subject's carotid arteries that lies between the first position and the second position of the subject's carotid arteries from pulse wave data measured and obtained by the first sensing unit and pulse wave data measured and obtained by the second sensing unit.

17. 发明授权

US08507367B2 Separation of semiconductor devices 有权
标题翻译：分离半导体器件
公开(公告)号：US08507367B2
公开(公告)日：2013-08-13
申请号：US12667418
申请日：2008-07-03
申请人： Xuejun Kang , Shu Yuan , Jenny Lam , Shiming Lin
发明人： Xuejun Kang , Shu Yuan , Jenny Lam , Shiming Lin
IPC分类号： H01L21/36 , H01L21/20
CPC分类号： H01L29/2003 , H01L21/6835 , H01L33/0079 , H01L33/0095 , H01L33/32 , H01L33/38 , H01L33/40 , H01L33/44 , H01L33/46 , H01L2221/6835 , H01L2933/0016
摘要： A method of fabricating semiconductor devices is disclosed. The method comprises providing a substrate with a plurality of epitaxial layers mounted on the substrate and separating the substrate from the plurality of epitaxial layers while the plurality of epitaxial layers is intact. This preserves the electrical, optical, and mechanical properties of the plurality of epitaxial layers.
摘要翻译：公开了制造半导体器件的方法。所述方法包括：提供具有安装在所述衬底上的多个外延层的衬底，并且所述衬底与所述多个外延层分离，同时所述多个外延层是完整的。这保持了多个外延层的电学，光学和机械特性。

18. 发明申请

US20100171487A1 ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT METHOD 审中-公开
标题翻译：静电抗原检测和测量方法
公开(公告)号：US20100171487A1
公开(公告)日：2010-07-08
申请号：US12652543
申请日：2010-01-05
申请人： Shiming Lin , Shih-yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
发明人： Shiming Lin , Shih-yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
IPC分类号： G01R1/06
CPC分类号： G01N33/5438
摘要： A method of electrosensing an antigen in a test sample using a sensor is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other and a layer of antibody immobilized on the surface of at least one of the electrodes. The antibody has specific binding reactivity with the antigen. The method comprises tethering conductivity promotion molecules over and/or distributing between the antibody-populated electrodes for improving electrical conductivity characteristics across the two electrodes, and measuring electrically across the electrodes after the test sample comes into contact with the antibody-populated electrodes. The antibody captures the antigen present in the test sample thereby altering the improved electrical conductivity characteristic across the two electrodes in which an amount representative of the altering providing an indication for electrosensing of the antigen.
摘要翻译：公开了使用传感器对测试样品中的抗原进行电感应的方法。传感器具有两个电极彼此电断开并物理分离，并且固定在至少一个电极的表面上的一层抗体。抗体与抗原具有特异性结合活性。该方法包括在抗体填充的电极之间和/或分布之间连接导电促进分子，以改善两个电极之间的导电特性，以及在测试样品与抗体填充的电极接触之后跨电极测量。抗体捕获存在于测试样品中的抗原，从而改变跨越两个电极的改善的导电特性，其中代表改变的量提供抗原电感应的指示。

19. 发明申请

US20100170792A1 ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR 审中-公开
标题翻译：静电抗原探测和测量传感器
公开(公告)号：US20100170792A1
公开(公告)日：2010-07-08
申请号：US12652579
申请日：2010-01-05
申请人： Shiming Lin , Shih-yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
发明人： Shiming Lin , Shih-yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
IPC分类号： G01N27/327 , C25B11/04
CPC分类号： G01N33/5438
摘要： A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, and a layer of antibody is immobilized on the surface of at least one of the electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules may be tethered over and/or distributed between the antibody-populated electrodes for improving electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.
摘要翻译：公开了一种用于在测试样品中电敏感抗原的传感器。传感器具有两个彼此电断开并物理分离的电极，并且一层抗体被固定在至少一个电极的表面上。抗体与抗原具有特异性结合活性。电导率促进分子可以束缚在抗体填充的电极之间和/或分布在抗体填充的电极之间，以改善跨两个电极的导电特性。抗体捕获与在与抗体填充的电极接触的缓冲溶液中混合的测试样品中存在的抗原。这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

20. 发明申请

US20100170788A1 ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR USING CONDUCTIVITY PROMOTION BUFFER 审中-公开
标题翻译：使用电导率促销缓冲器的静电抗体探测和测量传感器
公开(公告)号：US20100170788A1
公开(公告)日：2010-07-08
申请号：US12652497
申请日：2010-01-05
申请人： Shiming Lin , Shih-yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
发明人： Shiming Lin , Shih-yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
IPC分类号： G01N27/327
CPC分类号： G01N33/5438
摘要： A sensor system for electrosensing an antigen in a test sample is disclosed. The sensor system has two electrodes electrically disconnected and physically separated from each other, and a layer of antibody is immobilized on the surface of the electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules suspended in a buffer solution may be distributed over and/or between the antibody-populated electrodes for improving electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in the buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.
摘要翻译：公开了一种用于对测试样品中的抗原进行电感应的传感器系统。传感器系统具有两个彼此电隔离并物理分离的电极，并且一层抗体固定在电极的表面上。抗体与抗原具有特异性结合活性。悬浮在缓冲溶液中的电导率促进分子可以分布在抗体填充的电极之上和/或之间，以改善两个电极之间的导电特性。抗体捕获混合在与抗体填充电极接触的缓冲溶液中的测试样品中存在的抗原。这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

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