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11. 发明申请

US20080206151A1 Liposomes 审中-公开
标题翻译：脂质体
公开(公告)号：US20080206151A1
公开(公告)日：2008-08-28
申请号：US11912206
申请日：2006-04-25
申请人： Alan Cuthbertson
发明人： Alan Cuthbertson
IPC分类号： A61K49/18 , A61K9/127 , C07F9/06
CPC分类号： A61K49/0466 , A61K49/1812 , A61K51/1234
摘要： The present invention relates to a process for the manufacture of targeting liposomes comprising vector compounds conjugated to the hydrophilic part of modified phospholipids. The present invention provides the modified phospholipids and liposomes containing said modified phospholipids.
摘要翻译：本发明涉及制备靶向脂质体的方法，其包含与改性磷脂的亲水部分缀合的载体化合物。本发明提供了含有所述修饰的磷脂的改性磷脂和脂质体。

12. 发明申请

US20080095715A1 Peptide Based-Compounds 失效
标题翻译：基于肽的化合物
公开(公告)号：US20080095715A1
公开(公告)日：2008-04-24
申请号：US11570156
申请日：2005-06-15
申请人： Alan Cuthbertson , Robert James Nairne
发明人： Alan Cuthbertson , Robert James Nairne
IPC分类号： A61K49/00 , C07K7/64
CPC分类号： A61K49/0056 , A61K49/0032 , C07K5/0817 , C07K5/126 , C07K14/70546 , G01N33/533
摘要： The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labelled with at least one cyanine dye reporter and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.
摘要翻译：本发明涉及新的基于肽的化合物及其在诊断光学成像技术中的应用。更具体地，本发明涉及这种基于肽的化合物作为与血管发生相关的受体结合的靶向载体的用途。该化合物用至少一种花青染料报告物进行标记，并可用作造影剂用于诊断血管发生相关疾病的光学成像。

13. 发明申请

US20080095701A1 Diagnostic Compounds 有权
标题翻译：诊断化合物
公开(公告)号：US20080095701A1
公开(公告)日：2008-04-24
申请号：US11575163
申请日：2005-09-14
申请人： Magne Solbakken , Bente Ardo , Alan Cuthbertson , Alexander Gibson
发明人： Magne Solbakken , Bente Ardo , Alan Cuthbertson , Alexander Gibson
IPC分类号： A61K51/08 , C07K7/04
CPC分类号： A61K51/088
摘要： The invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译：本发明涉及式（III）或（IIIa）的缀合物或其盐，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。

14. 发明申请

US20070148647A1 Purification methods 失效
标题翻译：净化方法
公开(公告)号：US20070148647A1
公开(公告)日：2007-06-28
申请号：US10560508
申请日：2005-05-11
申请人： Sajinder Luthra , Frank Brady , Nicholas Jeffery , Erik Arstad , Alexander Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
发明人： Sajinder Luthra , Frank Brady , Nicholas Jeffery , Erik Arstad , Alexander Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
IPC分类号： C12Q1/68
CPC分类号： C07B59/00 , C07B63/00 , C07B2200/11
摘要： The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme:
摘要翻译：本发明涉及使用固体支持结合清除剂组来纯化放射性标记的示踪剂的新方法。计划说明的一般概念：

15. 发明申请

US20050127530A1 Structure and method for fabricating a bond pad structure 有权
标题翻译：用于制造接合焊盘结构的结构和方法
公开(公告)号：US20050127530A1
公开(公告)日：2005-06-16
申请号：US10735117
申请日：2003-12-13
申请人： Zhang Fan , Zhang Chao , Liu Wuping , Chok Liep , Hsia Choo , Lim Kheng , Alan Cuthbertson , Tan Boom
发明人： Zhang Fan , Zhang Chao , Liu Wuping , Chok Liep , Hsia Choo , Lim Kheng , Alan Cuthbertson , Tan Boom
IPC分类号： H01L21/60 , H01L23/485 , H01L23/532 , H01L29/40
CPC分类号： H01L24/06 , H01L23/53223 , H01L24/03 , H01L24/05 , H01L24/11 , H01L2224/0401 , H01L2224/04042 , H01L2224/05559 , H01L2224/05572 , H01L2224/05624 , H01L2224/05647 , H01L2224/13099 , H01L2924/0002 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01019 , H01L2924/01022 , H01L2924/01024 , H01L2924/01029 , H01L2924/01033 , H01L2924/01073 , H01L2924/01074 , H01L2924/01082 , H01L2924/05042 , H01L2924/14 , H01L2224/05552
摘要： A structure and method for an improved a bond pad structure. We provide a top wiring layer and a top dielectric (IMD) layer over a semiconductor structure. The buffer dielectric layer is formed over the top wiring layer and the top dielectric (IMD) layer. We form a buffer opening in the buffer dielectric layer exposing at least of portion of the top wiring layer. We form a barrier layer over the buffer dielectric layer, and the top wiring layer in the buffer opening. A conductive buffer layer is formed over the barrier layer. We planarize the conductive buffer layer to form a buffer pad in the buffer opening. We form a passivation layer over the buffer pad and the buffer dielectric layer. We form a bond pad opening in the passivation layer over at least a portion of the buffer pad. We form a bond pad support layer over the buffer pad and the buffer dielectric layer. We form a bond pad layer over the a bond pad support layer. The bond pad layer and the bond pad support layer are patterned to form a bond pad and bond pad support.
摘要翻译：一种改进接合焊盘结构的结构和方法。我们在半导体结构上提供顶部布线层和顶部电介质（IMD）层。缓冲电介质层形成在顶部布线层和顶部电介质（IMD）层上。我们在缓冲介电层中形成缓冲开口，露出至少部分顶部布线层。我们在缓冲介质层上形成阻挡层，缓冲开口中形成顶部布线层。导电缓冲层形成在阻挡层上。我们平面化导电缓冲层以在缓冲开口中形成缓冲垫。我们在缓冲垫和缓冲电介质层上形成钝化层。我们在缓冲垫的至少一部分上在钝化层中形成接合焊盘开口。我们在缓冲垫和缓冲电介质层上形成接合焊盘支撑层。我们在接合垫支撑层上形成接合垫层。将接合焊盘层和接合焊盘支撑层图案化以形成接合焊盘和接合焊盘支撑。

16. 发明申请

US20050090095A1 Method to fabricate aligned dual damascene openings 有权
公开(公告)号：US20050090095A1
公开(公告)日：2005-04-28
申请号：US10690998
申请日：2003-10-22
申请人： Yeow Lim , Wuping Liu , Tae Lee , Bei Zhang , Juan Tan , Alan Cuthbertson , Chin Neo
发明人： Yeow Lim , Wuping Liu , Tae Lee , Bei Zhang , Juan Tan , Alan Cuthbertson , Chin Neo
IPC分类号： H01L21/4763 , H01L21/768 , H01L29/06
CPC分类号： H01L21/76807 , H01L21/76829 , H01L21/76834
摘要： A method of forming an aligned dual damascene opening, comprising including the following sequential steps. A structure having a metal structure formed thereover is provided. A layer stack is formed over the metal structure. The layer stack comprises, in ascending order: a bottom etch stop layer; a lower dielectric material layer; a middle etch stop layer; a middle dielectric material layer; and an upper dielectric layer. The upper dielectric layer is patterned to form an opening exposing a portion of the underlying middle dielectric material layer. The opening having a width. A patterned mask layer is formed over the patterned upper dielectric layer leaving exposed opposing portions of the patterned upper dielectric layer. The middle dielectric material layer is patterned to form an opening therein using the patterned mask layer and the exposed portions of the upper dielectric layer as masks. The middle dielectric material layer opening exposing a portion of the middle etch stop layer. The middle etch stop layer is removed at its exposed portion to form a patterned middle etch stop layer having an opening exposing a portion of the lower dielectric material layer. Simultaneously patterning: the patterned middle dielectric material layer using the patterned upper dielectric layer as a mask to form an inchoate upper trench opening; and the lower dielectric material layer using the patterned mask layer and the patterned middle etch stop layer as masks to form an inchoate lower via opening aligned with the inchoate upper trench opening. The inchoate lower via opening exposing a portion of the underlying bottom etch stop layer. The patterned mask layer is removed. The patterned upper dielectric material layer, the exposed portions of the patterned middle etch stop layer and the exposed portion of the bottom etch stop layer are removed to convert: the inchoate upper trench opening into a final upper trench opening; and the inchoate lower via opening into a final lower via opening to form the dual damascene opening.

17. 发明授权

US06451687B1 Intermetal dielectric layer for integrated circuits 有权
公开(公告)号：US06451687B1
公开(公告)日：2002-09-17
申请号：US09721898
申请日：2000-11-24
申请人： Huang Liu , John Sudijono , Juan Boon Tan , Edwin Goh , Alan Cuthbertson , Arthur Ang , Feng Chen , Qiong Li , Peter Chew
发明人： Huang Liu , John Sudijono , Juan Boon Tan , Edwin Goh , Alan Cuthbertson , Arthur Ang , Feng Chen , Qiong Li , Peter Chew
IPC分类号： H01L214763
CPC分类号： H01L21/76826 , H01L21/31612 , H01L21/31629 , H01L21/76831
摘要： An intermetal dielectric structure for integrated circuits and a manufacturing method therefore is provided having a premetal dielectric and a metal line thereon, with a SRO liner on the premetal dielectric layer and the metal lines, a FGS dielectric layer over the SRO liner, a SRO film over the FGS dielectric layer, and a TEOS dielectric layer over the SRO film. Vias through the FGS dielectric layer are treated to have fluorine-free regions around the vias. The structure is not subject to fluorine attack on the metal lines or vias while having a stable FGS dielectric layer with less fluorine out-gassing and out-diffusion.

18. 发明授权

US08529874B2 Peptide imaging agents 有权
标题翻译：肽成像剂
公开(公告)号：US08529874B2
公开(公告)日：2013-09-10
申请号：US12600265
申请日：2008-05-16
申请人： Edvin Wilhelm Johannesen , Alan Cuthbertson
发明人： Edvin Wilhelm Johannesen , Alan Cuthbertson
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0056 , A61B5/0071 , A61B5/4842 , A61K49/0032
摘要： The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
摘要翻译：本发明涉及适用于体内光学成像的标记的cMet结合肽。肽用适于在红色至近红外区域成像的光学报告基团标记。还公开了药物组合物和试剂盒，以及体内成像方法，特别是用于检测，分期，诊断，监测疾病进展或监测结肠直肠癌（CRC）的治疗。

19. 发明授权

US08404802B2 Peptide-based compounds 有权
公开(公告)号：US08404802B2
公开(公告)日：2013-03-26
申请号：US12053829
申请日：2008-03-24
申请人： Alan Cuthbertson , Bard Indrevoll
发明人： Alan Cuthbertson , Bard Indrevoll
IPC分类号： C07K7/64
CPC分类号： A61K51/082 , A61K47/60 , A61K47/62 , A61K47/64 , A61K51/088 , C07K7/02 , C07K7/06 , C07K14/78
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise a targeting vector which binds to receptors associated with integrin receptors.

20. 发明授权

US08221720B2 Purification methods 失效
标题翻译：净化方法
公开(公告)号：US08221720B2
公开(公告)日：2012-07-17
申请号：US10560508
申请日：2005-05-11
申请人： Sajinder Kaur Luthra , Frank Brady , Nicholas Toby Jeffery , Erik Arstad , Alexander Mark Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
发明人： Sajinder Kaur Luthra , Frank Brady , Nicholas Toby Jeffery , Erik Arstad , Alexander Mark Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07B59/00 , C07B63/00 , C07B2200/11
摘要： The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme:
摘要翻译：本发明涉及使用固体支持结合清除剂组来纯化放射性标记的示踪剂的新方法。计划说明的一般概念：

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