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1. 发明授权

US08529874B2 Peptide imaging agents 有权
标题翻译：肽成像剂
公开(公告)号：US08529874B2
公开(公告)日：2013-09-10
申请号：US12600265
申请日：2008-05-16
申请人： Edvin Wilhelm Johannesen , Alan Cuthbertson
发明人： Edvin Wilhelm Johannesen , Alan Cuthbertson
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0056 , A61B5/0071 , A61B5/4842 , A61K49/0032
摘要： The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
摘要翻译：本发明涉及适用于体内光学成像的标记的cMet结合肽。肽用适于在红色至近红外区域成像的光学报告基团标记。还公开了药物组合物和试剂盒，以及体内成像方法，特别是用于检测，分期，诊断，监测疾病进展或监测结肠直肠癌（CRC）的治疗。

2. 发明申请

US20100150843A1 PEPTIDE IMAGING AGENTS 有权
标题翻译：肽成像剂
公开(公告)号：US20100150843A1
公开(公告)日：2010-06-17
申请号：US12600265
申请日：2008-05-16
申请人： Edvin Wilhelm Johannesen , Alan Cuthbertson
发明人： Edvin Wilhelm Johannesen , Alan Cuthbertson
IPC分类号： A61K49/00 , C07K7/08
CPC分类号： A61K49/0056 , A61B5/0071 , A61B5/4842 , A61K49/0032
摘要： The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
摘要翻译：本发明涉及适用于体内光学成像的标记的cMet结合肽。肽用适于在红色至近红外区域成像的光学报告基团标记。还公开了药物组合物和试剂盒，以及体内成像方法，特别是用于检测，分期，诊断，监测疾病进展或监测结肠直肠癌（CRC）的治疗。

3. 发明授权

US08361443B2 Peptide-based compounds 失效
公开(公告)号：US08361443B2
公开(公告)日：2013-01-29
申请号：US11570090
申请日：2005-06-15
申请人： Alan Cuthbertson
发明人： Alan Cuthbertson
IPC分类号： A61K49/04
CPC分类号： A61K51/088 , A61K47/60 , A61K47/62 , A61K47/64 , A61K51/082 , C07K7/02 , C07K7/06 , C07K14/70546 , C07K14/78
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.

4. 发明申请

US20120251449A1 ALDH: A COMPOUND FOR CANCER STEM CELL IMAGING 审中-公开
标题翻译： ALDH：用于癌症干细胞成像的化合物
公开(公告)号：US20120251449A1
公开(公告)日：2012-10-04
申请号：US13510398
申请日：2010-12-22
申请人： Vijaya Raj Kuniyil Kulangara , Alan Cuthbertson , Peter Iveson , Chitralekha Rangaswamy , Veena Rao , Rajiv Bhalla
发明人： Vijaya Raj Kuniyil Kulangara , Alan Cuthbertson , Peter Iveson , Chitralekha Rangaswamy , Veena Rao , Rajiv Bhalla
IPC分类号： A61K51/04 , C07C47/55 , A61P35/00 , C07C223/06 , C07C223/04 , C07C47/353
CPC分类号： A61K31/136 , A61K51/04
摘要： The present invention claims fluoro- & iodo-containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain ring. ALDH activity was monitored either by the formation of acid-product or consumption of aldehyde substrates.
摘要翻译：本发明要求氟 - 碘基醛作为ALDH底物用作诊断显像剂或作为治疗剂。醛直接和间接连接到芳环或直链环上。通过酸产物的形成或醛底物的消耗来监测ALDH活性。

5. 发明授权

US08273325B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US08273325B2
公开(公告)日：2012-09-25
申请号：US12519183
申请日：2007-12-19
申请人： Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
发明人： Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0056
摘要： The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.
摘要翻译：本发明提供含有这些化合物的新化合物和药物组合物，其中化合物对蛋白聚糖具有亲和力。所述化合物包含与带正电荷部分连接的基于氨基酸的核心单元。所述化合物还包含在体内成像中可检测的至少一个成像部分，使得该化合物可用作蛋白聚糖成像的诊断造影剂，例如硫酸乙酰肝素蛋白聚糖。

6. 发明授权

US08216548B2 Radiofluorination methods 失效
标题翻译：放射性氟化方法
公开(公告)号：US08216548B2
公开(公告)日：2012-07-10
申请号：US12518728
申请日：2007-12-27
申请人： Alan Cuthbertson , Magne Solbakken , Hege Karlsen
发明人： Alan Cuthbertson , Magne Solbakken , Hege Karlsen
IPC分类号： A61K51/00
CPC分类号： A61K51/08 , A61K51/088 , C07B59/001
摘要： The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译：本发明涉及式（Ⅴ）或（Ⅵ）的结合物，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。

7. 发明授权

US07875701B2 Diagnostic compounds 有权
标题翻译：诊断化合物
公开(公告)号：US07875701B2
公开(公告)日：2011-01-25
申请号：US11575163
申请日：2005-09-14
申请人： Magne Solbakken , Bente Arbo , Alan Cuthbertson , Alexander Gibson
发明人： Magne Solbakken , Bente Arbo , Alan Cuthbertson , Alexander Gibson
IPC分类号： A61K38/04
CPC分类号： A61K51/088
摘要： The invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译：本发明涉及式（III）或（IIIa）的缀合物或其盐，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。

8. 发明授权

US07785566B2 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US07785566B2
公开(公告)日：2010-08-31
申请号：US10559886
申请日：2004-11-05
申请人： Alan Cuthbertson , Bard Indrevoll , Morten Eriksen
发明人： Alan Cuthbertson , Bard Indrevoll , Morten Eriksen
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/08 , A61K38/085 , A61K49/0043 , A61K49/0056 , A61K51/088 , C07K7/14
摘要： The invention comprises pharmaceuticals of formula (I) Z-(L)n-V, wherein V denotes a peptide, L denotes an optional linker, Z denotes a group that optionally can carry an imaging moiety M, n denotes 0 or 1. The pharmaceuticals are active as therapeutic agents for the treatment of heart failure, cardiac arrhythmias and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis and are also useful as diagnostic agents for the diagnosis of heart failure and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis.
摘要翻译：本发明包括式（I）Z-（L）nV的药物，其中V表示肽，L表示任选的接头，Z表示任选可携带成像部分M的基团，n表示0或1.药物为作为治疗心力衰竭的治疗剂，心律失常和疾病的纤维化是COPD，肝纤维化和动脉粥样硬化的突出特征，也可用作诊断心力衰竭的诊断剂，并且纤维化是突出的如COPD，肝纤维化和动脉粥样硬化。

9. 发明申请

US20100019349A1 METHOD FOR FABRICATING CONDUCTING PLATES FOR A HIGH-Q MIM CAPACITOR 有权
标题翻译：用于制造高Q MIM电容器的导电板的方法
公开(公告)号：US20100019349A1
公开(公告)日：2010-01-28
申请号：US12569750
申请日：2009-09-29
申请人： Isaiah O. Oladeji , Alan Cuthbertson
发明人： Isaiah O. Oladeji , Alan Cuthbertson
IPC分类号： H01L29/92
CPC分类号： H01L27/0805 , H01L21/76838 , H01L28/75
摘要： A method of forming one or more capacitors on or in a substrate and a capacitor structure resulting therefrom is disclosed. The method includes forming a trench in the substrate, lining the trench with a first copper-barrier layer, and substantially filling the trench with a first copper layer. The first copper layer is substantially chemically isolated from the substrate by the first copper-barrier layer. A second copper-barrier layer is formed over the first copper layer and a first dielectric layer is formed over the second copper-barrier layer. The dielectric layer is substantially chemically isolated from the first copper layer by the second copper-barrier layer. A third copper-barrier layer is formed over the dielectric layer and a second copper layer is formed over the third copper-barrier layer. The second copper layer is formed in a non-damascene process.
摘要翻译：公开了一种在衬底上或衬底中形成一个或多个电容器的方法以及由此产生的电容器结构。该方法包括在衬底中形成沟槽，用第一铜阻挡层衬套沟槽，并用第一铜层基本上填充沟槽。第一铜层通过第一铜阻挡层与衬底基本上化学隔离。在第一铜层上形成第二铜阻挡层，在第二铜阻挡层上形成第一电介质层。电介质层通过第二铜阻挡层与第一铜层基本上化学隔离。在电介质层上形成第三铜阻挡层，在第三铜阻挡层上形成第二铜层。第二铜层以非镶嵌工艺形成。

10. 发明申请

US20090203584A1 Peptide-based Compounds 有权
标题翻译：基于肽的化合物
公开(公告)号：US20090203584A1
公开(公告)日：2009-08-13
申请号：US12423953
申请日：2009-04-15
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
IPC分类号： A61K38/12 , C07K7/64 , A61P35/00
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译：本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

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